A Study Using the Medication Ferumoxytol to Develop an Enhanced MRI Test
Official Title: Development and Testing of Ferumoxytol-enhanced MRI Protocol in Healthy Subjects
This study is being done to develop a Magnetic resonance imaging (MRI) test that provides better-quality whole-heart pictures. MRI is a non-invasive machine that collects detailed pictures inside your body.
Healthy volunteers will be tested in the MRI scanner while being given a dose of a medicine called Ferumoxytol into an IV (intravenous catheter) that will be placed in your arm or hand. Ferumoxytol is a medicine usually used in patients with iron deficiencies and has recently been used as an alternative to other MRI contrast agents and has successfully been applied in adult and pediatric patient populations.
• Males and females ages 18 years and older
• No history of cardiovascular disease
• Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including:
• Reactions to MRI including metallic foreign body, orbital metal, cerebral aneurysm clip, pacemaker, defibrillator, coronary artery stent, neurostimulator, any other medical metallic implant
• History of cardiovascular disease or uncontrolled high blood pressure
• Inability to lie flat for up to 1 hour
• Weight exceeding 300 pounds