Displaying all 25 studies
A Study to Evaluate the Use of Esketamine in Treating Children and Adolescents at Imminent Risk of Suicide
Official Title: A Double-Blind, Randomized, Psychoactive Placebo-Controlled, Study to Evaluate the Efficacy and Safety of 3 Fixed Doses (28 mg, 56 mg and 84 mg) of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Subjects Assessed to be at Imminent Risk for Suicide
The purpose of this study is to see if esketamine is effective for treating children and adolescents 12 to 17 years of age with Major Depressive Disorder who are at imminent risk for suicide.
Official Title: RGH-MD-24: A Double-Blind, Placebo-Controlled, Randomized Withdrawal, Multicenter, Clinical Trial Evaluating the Efficacy, Safety, and Tolerability of Cariprazine in a Dose-Reduction Paradigm in the Prevention of Relapse in Patients with Schizophrenia
The purpose of this study is to look into the safety and efficacy of Cariprazine in the treatment of schizophrenia. Cariprazine is currently FDA approved for the acute treatment of schizophrenia. This study will evaluate the safety and efficacy of Carprazine to prevent relapse in individuals diagnos...
Official Title: An Experimental Investigation of Kindness, Social Activities, and Reappraisal as Well-Being Interventions
The purpose of this study is to evaluate different strategies for enhancing well-being among individuals who have been feeling sad or down, anxious, or stressed. If individuals agree to participate, they will be sent a link to answer some questions to determine if the study is a good fit for them...
Official Title: A Double-Blind, Placebo-Controlled Study of Cariprazine as an Adjunct to Antidepressants in the Treatment of Patients with Major Depressive Disorder Who Have had an Inadequate Response to Antidepressants Alone
The purpose of this study is to look into the safety and efficacy of cariprazine as an add-on medication in the treatment of major depressive disorder.
A Study to Evaluate the Safety and Effectiveness of BIIB104 in the treatment of Cognitive Impairment Associated with Schizophrenia (CIAS)
Official Title: A Phase 2, Randomized Double-Blind, Multiple-Dose, Placebo-Controlled Study to Evaluate the Safety and Efficacy of BIIB104 in Subjects With Cognitive Impairment Associated With Schizophrenia (CIAS)
The purpose of this study is to evaluate the safety and effectiveness of BIIB104 in the treatment of cognitive impairment associated with schizophrenia (CIAS). CIAS refers to some issues that people with schizophrenia may have, including having trouble remember things, paying attention, learning new...
Official Title: A Double-blind, Placebo- and Active-controlled Evaluation of the Safety and Efficacy of Levomilnacipran ER in Pediatric Patients 7-17 Years With Major Depressive Disorder
The purpose of this research study is to evaluate the drug Levomilnacipran extended-release to see how well the drug works, observe the side effects, and how well tolerated it is compared to placebo in pediatric patients with major depressive disorder.
The overall goal of this research is to examine factors such as social resources, personality characteristics, and neurocognitive functioning in relation to decision-making abilities testamentary capacity among healthy older adults. Another purpose of this research study is to evaluate the impact...
Official Title: Mindfulness-based cognitive therapy for comorbid depression and type 2 diabetes
The aim of this study is to improve mood and diabetes-related outcomes for those with type 2 diabetes mellitus (T2DM) AND symptoms of depression. The present study will examine the effect of mindfulness-based cognitive therapy (MBCT; Segal, Williams, & Teasdale, 2002) on symptoms of depression and d...
Official Title: A double-blind, placebo-controlled, randomized withdrawal, multicenter clinical trial evaluating the efficacy, safety, and tolerability of Cariprazine in a dose reduction paradigm in the prevention of relapse in bipolar i disorder patients whose current episode is manic or depressive, with or without mixed features
The purpose of this study is to evaluate the efficacy and safety of Cariprazine in the prevention of relapse in patients with bipolar I disorder whose current episode is manic or depressive, with or without mixed features.
Official Title: Anxiety Sensitivity, Fear, Emotion Dysregulation, and Sleep Behavior Among Participants in a Behavioral Weight Management Program (The WMSEE Study)
Researchers at The Ohio State University are seeking volunteers who identify as African American or Black for a study that is designed to evaluate emotional responses during exercise and the influences of emotion on sleep and eating behaviors. The goal is to identify factors that may influence healt...
A Study about Tools to Assess Mental Health for Youth with Intellectual Disabilities and Their Caregivers
Official Title: Development and Validation of a Diagnostic Interview to Assess Psychopathology in Youths with Intellectual Disabilities
This study will help researchers to learn more about mental health for youth with intellectual disabilities. The purpose of our study is to develop a diagnostic interview to assess mental health issues in youths with Intellectual Disabilities. The instrument would address a significant need and all...
Official Title: Gut Feelings: Marriage, Mood, and the Gut Microbiome
The purpose of this study is to help understand how your mood, your diet, and your life with your partner affect your gut microbiome (the bacteria in your gut) and your immune system, and to assess the degree of similarity in your partner’s microbiome and your own microbiome. Couples will rece...
Official Title: An Observational Longitudinal Study in Offspring of Parents with Bipolar Disorder to Evaluate the Relationship of Impairment in Psychosocial Functioning with the Manifestation of Mood Symptoms over 24 Months
The purpose of this clinical research study is to follow teens and young adults who have a parent with bipolar disorder. The ultimate goal will be to identify earlier in life those who may be at risk of developing bipolar disorder. This early detection may help people with bipolar disorder or people...
Official Title: A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating the Efficacy, Safety, and Pharmacokinetics of SAGE-547 Injection in the Treatment of Adult Female Subjects with Severe or Moderate Post-partum Depression
The purpose of this study is to evaluate the safety and effectiveness of an investigational medication in women with moderate to severe postpartum depression. The investigational medication is called SAGE-547 (allopregnanolone) . An investigational medication is one that is not yet approved by the U...
The main purpose of this study is to learn about the treatment of depression in cancer patients. One way that depression has been treated in the general population is through a computerized program called "Beating the Blues." This study may help determine how effective" Beating the Blues" is with ca...
The goal of this online survey study is to learn how mothers are handling both the joys and stresses of being a parent and taking care of babies. We hope to use this information to help future mothers and families live happier and healthier lives.
Official Title: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Molindone Hydrochloride Extended-Release Tablets for the Treatment of Impulsive Aggression in Pediatric Patients with Attention Deficit/Hyperactivity Disorder (ADHD) in Conjunction with Standard ADHD Treatment Objectives
The purpose of this study is to find out how well a particular medication (not yet approved) works in reducing impulsive aggressive behaviors in children with ADHD who are already taking medication for ADHD. Participants will receive medication or placebo.
Official Title: ATTENTION TRAINING FOR INDIVIDUALS WITH MULTIPLE SCLEROSIS
The purpose of this study is to see what impact attention training has on the emotional health and thinking ability of those with Multiple Sclerosis.
Official Title: A Phase-3, Multicenter, Four-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Efficacy and Safety Trial of Flexible Doses of Oral Ziprasidone in Children and Adolescents with Bipolar I Disorder (Current or Most Recent Episode Manic)
The purpose of this research study is to compare the effects of the study drug, ziprasidone (Geodon®), with a placebo to find out which is better for treating manic episodes in children with Bipolar I Disorder.
There is a lack of information on interventions for homeless youth, and no suicide prevention intervention has been tested with these youth. Such focus is critical as suicide is the leading cause of death among homeless youth. This study seeks to examine Cognitive Therapy for Suicide Prevention in t...
There is a lack of information is available regarding how best to provide treatment for substance abuse homeless mothers and their young children. The purpose of this study is to examine a Ecologically-Based Treatment (EBT) intervention for the multiple needs of this vulnerable population.
A Study for those with Autism-Essential Oils for Enhancing of Quality of Life in Autism Spectrum Disorder (ASD)
The purpose of the study is to evaluate the use of two fragrant oil formulations to enhance quality of life by increasing relaxation and sleep quality in children with Autism Spectrum Disorder (ASD). Children with ASD show difficulties communicating with others, engaging in social interaction, and m...
The purpose of this study is to develop and evaluate a family therapy aimed at improving the emotional exchanges between mothers and their young children.
The purpose of this study is to evaluate how children and adolescents with an autism spectrum disorder display anxiety. Participants will be asked to complete an online anxiety survey in which they will share some information about their child’s anxiety symptoms.
Official Title: Adolescent Involvement In Parental Substance Abuse Treatment: Evaluation Of Ecologically Based Family Therapy
The purpose of this project is to develop and evaluate an unique and effective intervention designed specifically for mothers who struggle with the difficult issues related to substance use and raising a child.