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Displaying studies 1 - 25 of 65 in total


A Parkinson's Disease Treatment Study

Official Title: Open-Label Safety Study of Glial Cell Line-Derived Neurotrophic Factor Gene Transfer (AAV2- GDNF) in Parkinson’s Disease

In this clinical trial, we are testing a treatment called glial cell line-derived neurotrophic factor (GDNF) to see if it helps people with Parkinson’s disease (PD). GDNF is delivered to a part of the brain involved in PD. This study will evaluate the safety of this treatment and see whether it can ...

Mind-Body Interventions for Healthy Aging

Official Title: Mind-Body Interventions for Healthy Aging (HealthyAgers)

The Clinical Neuroscience Laboratory at the Department of Psychology at OSU is conducting an intervention study to assess the impact of mind-body practices on healthy aging. Individuals will participate in 8 training sessions, with 4 booster sessions, over a 12-month period. Assessments will be cond...

A Study of ExAblate Blood-Brain Barrier Disruption for the Treatment of Patients with Probable Alzheimer’s Disease

Official Title: Assessment of Safety and Efficacy of ExAblate Blood-Brain Barrier Disruption for the Treatment of Patients with Probable Alzheimer’s Disease

This is an early stage study in which MRI guided focused ultrasound is being tested in people with Alzheimer’s disease. In this study, patients who qualify will have a non-invasive, low intensity focused ultrasound procedure targeted at the brain. The procedure will then be two and four weeks later...

Decision-Making Abilities and Testamentary Capacity Among Older Adults

Official Title:

The overall goal of this research is to examine factors such as social resources, personality characteristics, and neurocognitive functioning in relation to decision-making abilities testamentary capacity among healthy older adults. Another purpose of this research study is to evaluate the impact...

A Study of DBS-Expert system used during Deep Brain Stimulation For Parkinson's Disease

Official Title: DBS-Expert: Automated Deep Brain Stimulation Programming Using Functional Mapping Phase II

Deep Brain Stimulation (DBS) surgery is FDA approved for the treatment of Parkinson's Disease. The purpose of this study is to examine a technology (DBS-Expert system) that uses objective measurements to guide DBS programming. The DBS-Expert system analyzes motion data and provides recommendations ...

ADAPT: An Intervention Study for Parkinson's Disease

Official Title: A Randomized, Placebo Surgery Controlled, Double-blinded, Multi-center, Phase 2 Clinical Trial, Evaluating the Efficacy and Safety of VY-AADC02 in Advanced Parkinson's Disease With Motor Fluctuations

The main purpose of this study is to test the safety and efficacy (how well it works) of an experimental intervention called VY-AADC02 on the severity of Parkinson’s Disease (PD).

A Study Utilizing Functional Feedback for Focused Ultrasound Thalamotomy for Tremor Surgery

Official Title: Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy for Tremor Surgery

The goal of this study is to understand if there are any changes to the connections between the cells in the brain before and after the ultrasound surgery for the treatment of Essential Tremor. This will be done by comparing patients who have had ultrasound surgery and Essential Tremor with healthy ...

A Study Using Focused Ultrasound for the Treatment of Epilepsy

Official Title: A pilot open-label clinical trial evaluating the ExAblate Model 4000 Type-1 focused ultrasound thalamotomy for the prevention of secondary generalization in focal onset epilepsy

The purpose of this study is to see how well focused ultrasound surgery works in treating epilepsy for adults with seizures that are not controlled by medication(s).

A Study Using the ExAblate 4000 System in the treatment of Dyskinesia Symptoms of Advanced Parkinson's Disease

Official Title: A Pivotal Clinical Trial of the Management of the Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Idiopathic Parkinson's Disease With Unilateral Lesioning of the Globus Pallidum Using the ExAblate Neuro System

The purpose of this study is to show that the ExAblate 4000 system is safe and works like we think it will in the treatment of Parkinson's Disease (PD) motor symptoms . The ExAblate will be used to kill a small cluster of cells on one (unilateral) side of your brain. ExAblate uses ultrasound to de...

The ARCADIA Study -- A medication study for prevention of recurrent ischemic stroke

Official Title: AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke (ARCADIA)

The purpose of this research study is to compare the effects (good and bad) of apixaban with the effects (good and bad) of aspirin in patients with unexplained strokes and atrial cardiopathy to see which is better at prevention of future strokes.

The BAMMS Study for Multiple Sclerosis

Official Title: BEHAVIOR AND ACTIVITY MONITORING IN MULTIPLE SCLEROSIS

The Clinical Neuroscience Laboratory is conducting a 6-month intervention study requiring, minimal involvement, to potentially improve thinking in those with multiple sclerosis. Everyday factors such as, exercise, water-intake, sleep, nutrition and social support play a role in cognitive functioning...

The EQuATe Study -- For Those with Spinal Cord Injury

Official Title: Equity and Quality in Assistive Technology for Individuals with Spinal Cord Injury 2.0 (EQuATe)

This study is looking at the assistive technology used by individuals with spinal cord injury (SCI) and how the quality of assistive technology can impact outcomes. This study involves completion of a series of questionnaires on background, spinal cord injury, wheelchair and other assistive technolo...

Understanding How Children Ages 2 to 5.5 Learn Words------For Children With AND Without Autism Spectrum Disorders

Official Title: LANGUAGE DEVELOPMENT AND THE PROCESSES UNDERLYING LANGUAGE DEVELOPMENT IN CHILDREN WITH AUTISM SPECTRUM DISORDERS

This study investigates word learning in children between 2 and 5.5 years of age. We are comparing word-learning strategies of children with and without autism. The goal of the study is to help us better understand the way children with autism learn, so we can best help them.

Studying the Effect of Using Virtual Reality with Spinal Cord Stimulation to Manage Pain

Official Title: Investigating mechanisms underlying spinal cord stimulation efficacy using virtual reality and full body illusion

This study is being to see if using virtual reality (VR) along with spinal cord stimulation can help better manage pain. Research has shown that using this type of “leg illumination” virtual reality reduces pain. We hope to further this research by identifying which sensory pathway (part of the nerv...

Movement and Music Study for Those with Dementia--Age 60 and Over

Official Title: Movement and Music Intervention for Individuals with Dementia

There is some evidence that music based interventions may have a protective effect on the brain in those with dementia. There is also evidence that doing activities that engage the brain through music are beneficial. This study seeks to investigate the potential benefits of a music based interventio...

A Study for Those with Amyotrophic Lateral Sclerosis (ALS)

Official Title: A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of NP001 in Subjects with Amyotrophic Lateral Sclerosis (ALS) and Evidence of Elevated Systemic Inflammation

The purpose of this research study is to test an investigational drug called NP001. An investigational drug is one that has not yet been approved by the Food and Drug Administration (FDA) but is allowed for research use. The study will evaluate: - if NP001 has an effect on slowing the signs and ...

The aViation Study-- A Medication Study for Those with a Diagnosis of Autism Spectrum Disorder- Ages 5 to 17.

Official Title: A PHASE II MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND, 24-WEEK, 3-ARM, PARALLEL GROUP, PLACEBOCONTROLLED STUDY TO INVESTIGATE THE EFFICACY AND SAFETY OF RO5285119 IN CHILDREN AND ADOLESCENTS AGE 5-17 WITH AUTISM SPECTRUM DISORDER (ASD)

The aViation study is being done to evaluate if investigational medication (RO5285119) can improve the social communication and interaction skills of children and adolescents with ASD.

Lewy Bodies Study for Those Experiencing Visual Hallucinations (VH)

Official Title: A Phase 2, double-blind, randomized, placebo-controlled cross-over study of nelotanserin versus placebo in Lewy body dementia (LBD) subjects experiencing visual hallucinations (VH)

Purpose: To assess the safety of using a drug called nelotanserin with those who have dementia with Lewy body with visual hallucinations.

Lewy Bodies Study for Those with Sleep Behavior Disorders

Official Title: A Phase 2, double-blind, randomized, placebo-controlled study of nelotanserin versus placebo in patients with dementia with Lewy bodies (DLB) experiencing REM sleep behaviors (RBD)

The purpose of this study is to evaluate the safety of the study drug called nelotanserin and to assess the effects of nelotanserin in those experiencing frequent REM sleep behavior disorders due to dementia with Lewy bodies. Nelotanserin (study drug) is an investigational product, which means that ...

Lewy Bodies Study--Assessing the Effects of a Drug Called RVT-101

Official Title: A Phase 2b, double-blind, randomized, placebo-controlled study of RVT-101 in subjects with dementia with Lewy bodies (DLB)

Purpose of Study: This research study is being done to test a drug called RVT-101. Our researchers want to assess the effects of RVT-101 versus placebo on function including attention, working memory, reaction time, as well as other measures of cognition in patients with DLB. RVT-101 is an inv...

A Study to Better Understand Fainting--The ENCHANT Study--seeking healthy 12-20 year olds

Official Title: Electrographic and Neurohormonal Characteristics of Adolescent Nausea during Tilt Table Testing, The ENCHANT Study

Researchers are looking for healthy young volunteers in order to understand what happens when someone faints. They want to know about changes in children and teenagers who frequently faint, and compare those who faint to healthy people who do not normally faint. Researchers want to learn more...

EMERGE- A Study to Evaluate the Effectiveness and Safety of a Medication (Aducanumab) in Those with Early Alzheimer's

Official Title: A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects with Early Alzheimer's Disease Alternate Official Title: 221AD302 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease (EMERGE)

The EMERGE study will assess the safety and potential effectiveness of an investigational medication to determine whether it can slow the progression of symptoms in early Alzheimer's Disease, such as memory loss. Find on CT.gov- https://clinicaltrials.gov/ct2/show/study/NCT02484547?term=EME...

A Medication Study for Those with Relapsing Forms of Multiple Sclerosis

Official Title: A Placebo-Controlled Multi-Center Phase IIa Dose Finding Study of Ublituximab, a Third-Generation Anti-CD20 Monoclonal Antibody, in Patients with Relapsing Forms of Multiple Sclerosis.

This study is being done to determine how effective an investigational new drug (Ublituximab) is when given to those who have multiple sclerosis and what side effects may happen. Ublituximab has not yet been approved by the United States Food and Drug Administration (FDA), and is for use in clinical...

Medication Study for those with Relapsing Remitting Multiple Sclerosis (Ages 18-65)

Official Title: A Phase 3 Open Label Study to Evaluate the Long-term Safety and Tolerability of ALKS 8700 in Adults with Relapsing Remitting Multiple Sclerosis

The purpose of this study is to evaluate the long-term safety and tolerability of a drug (ALKS 8700) used to treat adults with Relapsing Remitting Multiple Sclerosis.

Medication Study for those with Remitting Relapsing Multiple Sclerosis who have not responded to other Treatments (Ages 18-55)

Official Title: AN OPEN-LABEL STUDY TO EVALUATE THE EFFECTIVENESS AND SAFETY OF OCRELIZUMAB IN PATIENTS WITH RELAPSING REMITTING MULTIPLE SCLEROSIS WHO HAVE HAD A SUBOPTIMAL RESPONSE TO AN ADEQUATE COURSE OF DISEASE-MODIFYING TREATMENT

The purpose of this study is to determine the effectiveness of the drug ocrelizumab in those with Remitting Relapsing Multiple Sclerosis who have not had good outcomes with other Disease-Modifying Treatment.