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Displaying all 21 studies


A Study for Pregnant Women with Type 1 Diabetes

Official Title: Hybrid Closed-Loop Therapy in Pregnancies Complicated by Type 1 Diabetes (T1D)

This study is for pregnant women with Type 1 diabetes. The primary aim is to learn more about a specific insulin pump when set in auto mode vs. manual mode and how both modes impact glucose control and fear of low blood sugar.

Diabetes Prevention Study for OSU Employees

Official Title: Impact of Augmented Care at the Worksite for Diabetes Prevention

To evaluate a worksite diabetes prevention program specifically for OSU employees who are at risk for developing diabetes. The study will compare the impact of two different educational programs to determine which program works better in promoting weight loss and in helping people maintain their...

A Study for those with Type 2 Diabetes AND Depression

Official Title: Mindfulness-based cognitive therapy for comorbid depression and type 2 diabetes

The aim of this study is to improve mood and diabetes-related outcomes for those with type 2 diabetes mellitus (T2DM) AND symptoms of depression. The present study will examine the effect of mindfulness-based cognitive therapy (MBCT; Segal, Williams, & Teasdale, 2002) on symptoms of depression and d...

Metabolism Research Study--Healthy Volunteers Needed

Official Title: Adipocyte-T Cell Interactions Modulate Adipose Inflammation and Insulin Sensitivity Following Weight Gain

The purpose of this research study is to better understand the role of fat tissue, how cells in fat tissue communicate, and determine what signals specific cells use to cause inflammation and insulin resistance during weight gain. This may help researchers better understand the process that happens ...

The DETECT STUDY- A Pancreas Study for Those With or Without Diabetes AND for Healthy Volunteers

Official Title: CPDPC16-04: Evaluation of a mixed meal test for Diagnosis and characterization of Type 3c diabeTes mellitus secondary to pancreatic cancer and chronic pancreatitis (DETECT)

It is now recognized that a small portion of the population with diabetes has an underlying problem with their pancreas, such as chronic pancreatitis or pancreatic cancer, that can cause their diabetes. Currently, there is no test to identify the small number of patients who have diabetes caused by...

A Study for Healthy Adolescents 12-18: Understanding Risk of Cardiovascular Disease and Diabetes

Official Title: Complement and Cardiovascular Risk in Adolescents

This is a study to find out how a part of the immune system called "Complement" affects risk of future diabetes, high blood pressure, heart disease or stroke. Evidence suggests that these diseases which are major causes of death in adults begin in adolescence. There are specific tests that may ide...

Parallax - A Study to Evaluate the Effectiveness and Safety of a Medication for Hypoparathyroidism

Official Title: An Open-Label, Randomized, Crossover Study to Assess the Pharmacokinetic and Pharmacodynamic Profiles of Once-Daily and Twice-Daily Dose Regimens of recombinant human Parathyroid Hormone (rhPTH[1-84]) Administered Subcutaneously to Subjects with Hypoparathyroidism

The Parallax study will assess the safety and effectiveness of different dosing regimes (once daily or twice daily) of and an investigational medication, recombinant human parathyroid hormone (rhPTH[1-84]) Natpara, for those with hypoparathyroidism.

A Study for Those with Type 2 Diabetes and Have or are at High Risk for Cardiovascular Disease--The Pioneer Study

Official Title: PIONEER 6 – Cardiovascular outcomes A trial investigating the cardiovascular safety of oral semaglutide in subjects with type 2 diabetes

This research study is being done to confirm treatment with oral semaglutide does not result in an increase in cardiovascular risk compared to placebo in subjects with type 2 diabetes at high risk of cardiovascular events.

The REGENERATE Study - A study to evaluate the effectiveness and safety of a medication (Obeticholic Acid) for those with NASH (nonalcoholic steatohepatitis)

Official Title: A Phase 3, Double-Blind, Randomized, Long-Term, Placebo-Controlled, Multicenter Study Evaluating the Safety and Efficacy of Obeticholic Acid in Subjects with Nonalcoholic Steatohepatitis

This research study is for those who have nonalcoholic steatohepatitis (NASH) (meaning your liver is swollen and damaged because of a buildup of fat in your liver) and some liver fibrosis (which is damaged and scarred liver tissue). Because of your condition, you may be eligible for a research study...

Effects of Topical Oxygen on Wounds Below the Knee

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The purpose of this study is to observe the effect of application of topically administered oxygen on healing rate, cost of care and rate of amputations in diabetic patients with wounds below the knees (including foot ulcers).

A Study for Those Going Through Cardiac Rehabilitation--Measurement of Mitochondrial Dysfunction in Those with and without Diabetes

Official Title: Measurement of Mitochondrial Dysfunction Using Phosphorus Magnetic Resonance Spectroscopy in Diabetic Patients Undergoing an Exercise Regimen

We are looking at parts of the cells in our bodies (called mitochondria). Mitochondria give our cells energy and help them stay healthy. People with diabetes have mitochondria which do not work as well as the mitochondria in people without diabetes. In this study, we want to see if exercise (car...

Million Hearts Wellness Research Study Seeking OSU Employees

Official Title: Improving Healthy Lifestyle Behaviors and Health Outcomes in High-Risk Individuals

The purpose of this study is to examine the effects of the online Million Hearts® wellness program modules, with or without health coaching, in comparison to health coaching alone, on the health status of Ohio State University employees who are considered pre-diabetic, hypertensive, and overweight o...

Diabetic Foot Ulcer Study Examining miR-200b

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The purpose of this study is to determine if elevated wound-edge endothelial miR-200b is a barrier to wound healing (closure) in diabetic patients.

Type 1 Diabetes infusion Study

Official Title: A Multicenter, Randomized, Partial-Blinded, Placebo-Controlled Study to Evaluate the Safety and Efficacy of a Human Plasma-Derived Alpha1-Proteinase Inhibitor in Subjects with New-Onset Type 1 Diabetes Mellitus

The purpose of this study is to evaluate the safety and effectiveness of 4 different levels of dosing of a drug vs. placebo.

Study Seeking Adults 40 and Older with Type 2 Diabetes and Cardiovascular Disease: Harmony Outcomes Trial

Official Title: A long term, randomized, double blind, placebo-controlled study to determine the effect of albiglutide, when added to standard blood glucose lowering therapies, on major cardiovascular events in patients with Type 2 diabetes mellitus: Harmony Outcomes Trial

Those diagnosed with type 2 diabetes have a higher risk of getting cardiovascular disease than people without diabetes. Cardiovascular disease may cause serious complications such as heart attack or stroke. Albiglutide is a medicine (given as a weekly injection) used to lower blood sugar levels in p...

Study for Relatives of Those Diagnosed with Type 1 Diabetes

Official Title: TrialNet Natural History Study of the Development of Type 1 Diabetes

Researchers at Nationwide Children's Hospital and The Ohio State University are screening relatives of people with type 1 diabetes to find out if they may be at risk of developing diabetes. The purpose of this study is to determine the risk factors for acquiring Type 1 Diabetes in the family members...

Wound Healing Study for Those with Type II Diabetes Examining ImmunAge Supplement

Official Title: Nutritional Regulation of Wound Inflammation: Part III

The purpose of this study is to examine the changes that result in the wound healing of those with Type II Diabetes after taking the supplement ImmunAge (Fermented Papaya Preparation (FPP) currently being treated for a wound with negative pressure therapy (wound vac therapy).

Insulin Differences Between African-American and Caucasian Female Adolescents (Ages 12-18) With Polycystic Ovary Syndrome (PCOS)

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The purpose of this study is to find out if there are differences in the way African-American and Caucasian girls with Polycystic Ovary Syndrome (PCOS) respond to a type of sugar called glucose. Differences in insulin secretion and sensitivity/resistance between African-American and Caucasian adoles...

Islet Allotransplantation in Type 1 Diabetes

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The purpose of this study is to achieve insulin-independence in patients with type 1 diabetes by tissue transplantation, as a means to eliminate the need for insulin injections to maintain normal glucose levels, lessening severe hypoglycemia and potentially decreasing the development of diabetes-rel...

Mechanisms Underlying Impaired Diabetic Wound Healing

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The purpose of this study is to better understand the wound healing process in adults with diabetes as compared to the wound healing process in adults without diabetes.

Mechanisms Regulating Wound Vascularization

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This pilot study is designed to assess the impact of physical and various stessors on wound healing by comparing the genetic make-up of specific cells types, mood and blood flow patterns to wound healing.