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Displaying all 22 studies

A Study to Develop a New MRI Stress Test

Official Title: A Novel Exercise + Hypoxia Stress Protocol to Evaluate Myocardial Ischemia using MRI

This study is being done to develop a Magnetic Resonance Imaging (MRI) stress test that can be used in the MRI while the pictures are collected. Participants will lay flat on the MRI table and exercise using a specially designed stepper device mounted on the table while breathing air with reduced ox...

The influence of health perceptions, coping style, and decision-making on health and well-being among individuals with heart failure

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The purpose of this study is to explore the influence of patient perceptions, uncertainty, executive functioning, and coping strategies on mood, quality of life, and ability to make decisions among individuals with heart failure. The aim is to better understand patient experiences that may help to i...

MRE Study: Magnetic Resonance Elastography

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The purpose of this study is to determine if Magnetic Resonance Elastography (MRE) can be used as a noninvasive tool to diagnose various disease states by estimating the stiffness of the affected organ. MRE is FDA approved for assessing liver disease and does not use radiation or contrast dye.

ADAPTABLE: A study on different dosages of aspirin for heart disease

Official Title: Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-term Effectiveness

For more than 40 years, doctors have been telling patients with heart disease to take aspirin. For these patients, taking aspirin every day can lower the risk of heart attacks and strokes. Millions of Americans who have heart disease already take either regular (325 mg) or low‐dose (81mg) aspirin...

A Study for Healthy Adolescents 12-18: Understanding Risk of Cardiovascular Disease and Diabetes

Official Title: Complement and Cardiovascular Risk in Adolescents

This is a study to find out how a part of the immune system called "Complement" affects risk of future diabetes, high blood pressure, heart disease or stroke. Evidence suggests that these diseases which are major causes of death in adults begin in adolescence. There are specific tests that may ide...

Soy Pretzel Study

Official Title: Soy modulation of immune activation, LDL- levels, and lowering inflammation by pretzel isoflavone dietary intervention (SMALL LIPID Study)

The purpose of this study is to help researchers gain an understanding on how dietary soy will impact HIV-infected individuals who are taking Anti-retroviral medication. Two pretzels with and without soy will be used to investigate how the pretzel snacks will affect your cardiovascular disease risk,...

A Study for Those Going Through Cardiac Rehabilitation--Measurement of Mitochondrial Dysfunction in Those with and without Diabetes

Official Title: Measurement of Mitochondrial Dysfunction Using Phosphorus Magnetic Resonance Spectroscopy in Diabetic Patients Undergoing an Exercise Regimen

We are looking at parts of the cells in our bodies (called mitochondria). Mitochondria give our cells energy and help them stay healthy. People with diabetes have mitochondria which do not work as well as the mitochondria in people without diabetes. In this study, we want to see if exercise (car...

Million Hearts Wellness Research Study Seeking OSU Employees

Official Title: Improving Healthy Lifestyle Behaviors and Health Outcomes in High-Risk Individuals

The purpose of this study is to examine the effects of the online Million Hearts® wellness program modules, with or without health coaching, in comparison to health coaching alone, on the health status of Ohio State University employees who are considered pre-diabetic, hypertensive, and overweight o...

Study Seeking Adults 40 and Older with Type 2 Diabetes and Cardiovascular Disease: Harmony Outcomes Trial

Official Title: A long term, randomized, double blind, placebo-controlled study to determine the effect of albiglutide, when added to standard blood glucose lowering therapies, on major cardiovascular events in patients with Type 2 diabetes mellitus: Harmony Outcomes Trial

Those diagnosed with type 2 diabetes have a higher risk of getting cardiovascular disease than people without diabetes. Cardiovascular disease may cause serious complications such as heart attack or stroke. Albiglutide is a medicine (given as a weekly injection) used to lower blood sugar levels in p...

Small Aneurysm Coiling Trial (NANO)

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The purpose of this study is to compare the safety and efficacy of treating small aneurysms with coils specially designed for small aneurysms to historically reported rates of safety and efficacy for the treatment of larger aneurysms.

Individualized Exercise Study for Breast Cancer Survivors

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The purpose of this study is to learn if a individualized exercise program used in cardiac rehabilitation may also benefit breast cancer survivors.

Stroke Rehabilitation Study: Targeting Arm Weakness

Official Title: Intensive rehabilitation targeting upper extremity weakness: a randomized controlled trial

The purpose of this study is to compare the effectiveness of 4 different interventions for treating upper extremity weakness. The interventions are as follows: 1) in-clinic Constraint-Induced Movement therapy, 2) Intensive motor training delivered in-home through a video game with 5 hours of therapi...

Acute Venous Thromboembolism (VTE) Study: Examining the Use of Statin Therapy

Official Title: A pilot study of using statins in patients with acute venous thromboembolism

The purpose of this study is to better understand and improvement treatment for venous thromboembolism (VTE), the formation of blood clots in extremity veins (deep vein thrombosis, DVT) and/or pulmonary arteries (pulmonary embolism, PE). Anticoagulation is the current standard of care for acute VTE....

MRI Study for Healthy Adults and Those with a History of Cardiovascular Disease

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Development of new protocols and techniques for MRI procedures is essential to medical diagnosis. The purpose of this study is to evaluate these techniques in healthy adults and those with a history of cardiovascular disease to determine their usefulness.

Stroke Research Study: tDCS in Moderately Impaired Stroke

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The purpose of this study is to determine whether 20 minutes of transcranial direct current stimulation (tDCS) can increase function of the weak arm in stroke victims.

Antihypertansive Treatment of Acute Cerebral Hemorrhage (ATACH)-II

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The purpose of this study is to determine the therapeurtic benefit of intensive Systolic Blood Pressure (SBP) treatment (SBP<140 mmHg) compared with standard SBP treatment (SBP<180 mmHg) in reducing the proportion of patients with death and disability (mRS of 4-6) at Day 90 among patients with ICH t...

Cerebrovascular and Neurocritical Care Stroke Registry

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The purpose of this protocol is to establish a stroke registry for the Cerebrovascular and Neurocritical Care Division in the Department of Neurology. The purpose of the registry are: To serve as a tool to collect patient data for quality assurance and improvement purposes related to stroke care; ...

Mental Practice in Chronic, Stroke-Induced Hemiparesis

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The objective of this study is to determine the effects of a repetitive, task-specific program involving mental practice in chronic stroke. The belief is that a program combining mental practice and repetitive, task-specific practice will improve affected arm function.

Framing Eighteen Coils in Cerebral Aneurysms Trial (FEAT)

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The purpose of this study is to compare angiographic outcomes in patients receiving 0.014-0.0155" platinum framing and filling coils (larger diameter coils) versus those treated solely with coils less than 0.014" (with a standard diameter).

New Generation Hydrogel Endovascular Aneurysm Treatment Trial (HEAT)

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The purpose of this study is to test the effectiveness of a new FDA approved device, called the HydroCoil Embolic System, for treating aneurysms in comparison to the current standard device for endovascular aneurysm treatment which is bare platinum coils.

Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial

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The purpose of this study is to examine the treatment of hyperglycemic [high blood 'sugar'] acute ischemic stroke patients with targeted glucose [blood 'sugar'] concentration (80mg/dL - 130 mg/dL) and establish that this treatment will be safe and result in improved 3 month outcome after stroke.

Genetic influences on statin drug concentration in blood

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The purpose of this study is to investigate the influence of genetics on how individuals process and respond to their statin medication (i.e. cholesterol-lowering drugs), so that dose-selection strategies can be developed to decrease adverse effects and to help identify patients most likely to benef...