Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • Abbott DBS (Deep Brain Stimulation) Registry

    Official Title
    ABT-CIP-10300: Abbott DBS Registry of Outcomes for Indications over Time (ADROIT)
    Purpose

    The purpose of this study is to collect information and evaluate outcomes for Abbott Deep Brain Stimulation (DBS) systems that are approved and sold in your country.

    In order to evaluate how the DBS system performs, data will be collected before, during and after DBS implant when you visit the study doctor. The data collected will include information on your movements, feelings, daily activities, and DBS program settings.

    The information gathered in this study will add to the understanding of treatment options for future patients receiving DBS.

    Could this study be right for you?

    Inclusion Criteria:

    - You are scheduled for a new implant or IPG device replacement surgery with a market-released Abbott DBS system within 3 months

    Exclusion Criteria:

    - You are currently enrolled or plan to enroll in another study that may alter the results of this clinical investigation
    - You have another disease, conditions, or other medical, social, or psychological conditions that could limit the your ability to participate in the clinical investigation or to satisfy follow-up requirements

  • Adjusting to Life After COVID-19

    Official Title
    Adjusting to Life After COVID-19
    Purpose

    This study looks at what is helping people adjust to the changes caused by the COVID-19 pandemic so that we may understand what could help people adapt to crises in the future. This information could benefit with the understanding and improvement of treatments for conditions such as depression and anxiety.

    The study will examine the experience of psychological symptoms, adaptability, and coping over time.

    Could this study be right for you?

    You may eligible for this study if you are:
    • 18 years of age or older
    • Currently unemployed or laid off
    • Be considered high risk if infected with COVID-19 (e.g., being 65 or older or having an underlying health condition).
    • Have NOT had a positive COVID-19 test result
    • Do NOT have an immunity to COVID-19

    Age Range
    18 and up
  • Adults Helping Adults With Immune Diseases

    Official Title
    Creation of a pediatric healthy control repository for clinical diagnostic immunology test development and validation
    Purpose

    A test for healthy adults from 19 - 75 years old to develop normal values for interpretation of immunological tests in adults with disorders of the immune system.

    Voluntary participation involves blood draw at Nationwide Children's hospital. Qualified participants would be eligible to provide a sample every 2 months (not more than 6 times per year).

    Could this study be right for you?

    If you are:

    - An adult 19 years of age or older
    - Healthy with no significant medical diagnoses
    - Have no chronic conditions that can affect results of immunological studies
    - Not any medication known to alter immune status or function
    - Have not undergone recent surgery, chemotherapy, radiation or transplantation
    - Non-smoker
    - Body mass index (BMI) in healthy range
    - No infections within last 2 months

    Age Range
    19 and up
  • An Intervention Study for Subjects with Palmoplantar Pustulosis

    Official Title
    ANB019-003: A Phase II, Randomized, Placebo-controlled, Double-blind, Multiple Dose Study to Evaluate the Efficacy and Safety of ANB019 in Subjects with Palmoplantar Pustulosis
    Purpose

    This study is being done to assess the effects of the experimental study drug (ANB019) in patients with PPP.

    Could this study be right for you?

    - Must have a clinical diagnosis of PPP for at least 6 months prior to screening
    - Must have active pustules on palms and/or soles of feet
    - BMI must be within the range of 18-36 kg/m2
    - Subjects must be in otherwise good health
    - Must not have any suspected autoimmune disorder or immune deficiency
    - No major surgeries in the past 4 weeks
    - No history of malignancy in the past 5 years
    - No history of drug, alcohol, or other substance abuse

    Age Range
    18 and up
  • An Intervention Study to Evaluate a Medication (MIJ821) Used to Treat Major Depressive Disorder

    Official Title
    Study of Efficacy and Safety of MIJ821 in Addition to Comprehensive Standard of Care on the Rapid Reduction of Symptoms of Major Depressive Disorder in Subjects Who Have Suicidal Ideation With Intent
    Purpose

    The purpose of the study is to determine if the investigational study drug will rapidly reduce depression associated with thoughts of harming oneself when given in addition to standard antidepressant medication.

    Your participation in this study will last for a minimum of 14 weeks and maximum of 58 weeks.

    Could this study be right for you?

    • Aged 18-65 years old
    • Diagnosed with major depressive disorder (MDD) with a current major depressive episode
    • Having current suicidal ideation with intent
    • Already in the hospital or agree to be hospitalized voluntarily for the required period of time

    Age Range
    18 and up
  • An Observation Study to Examine the Effectiveness of Nifedipine

    Official Title
    Frequency and dosing of Long Acting Anti-Hypertensive Agent in Women with Pre-eclampsia with severe features undergoing expectant management: A Randomized Controlled Trial
    Purpose

    The purpose of this study is to compare the effectiveness of long-acting Nifedipine XL 60mg daily to 30mg twice daily among women admitted with hypertensive disorders of pregnancy and severe blood pressures.

    Participation for the duration of the study lasts 48 hours.

    Could this study be right for you?

    Inclusion Criteria:
    • Women aged 18-45 years old
    • Viable single or twin intrauterine pregnancy between 22 0/7 and 33 5/7 weeks gestation
    • Women with a hypertensive disorder of pregnancy and are undergoing expectant management (spontaneous labor) for a diagnosis of preeclampsia
    • Patient has already been started on 30mg Nifedipine XL by their primary OB provider and has been recommended to increase the daily dose to 60mg

    Exclusion Criteria:
    • Known allergy or poor reaction to Nifedipine or any medical condition where Nifedipine should not be used in ones treatment, such as galactose intolerance, severe GI stricture, and GI hypomotility disorder.
    • Participation in another trial without prior approval
    • Currently receiving a daily dose of Nifedipine XL of 60mg or greater
    • Continuation of alternate long-acting anti-hypertensive medication on admission
    • Triplet or higher order pregnancy
    (Exclusion Criteria still varies, please contact Study Coordinator for more information).

    Age Range
    18 and up
  • An Observational Study of Pregnant Individuals with Glucose Intolerance

    Official Title
    The use of continuous glucose monitors among pregnant individuals with various degrees of glucose intolerance: An observational cohort study
    Purpose

    The purpose of this study is to learn more about blood sugar levels in the third trimester among women with and without gestational diabetes.

    You and your child will be in the study from the time of enrollment through hospital discharge after delivery.

    Could this study be right for you?

    Inclusion criteria:
    • Women aged between 18 and 45 years old
    • Women with a viable singleton or twin pregnancy between 24 0/7 and 31 6/7 weeks gestation
    • Planning to deliver at OSU Wexner Medical Center

    Exclusion Criteria:
    • Known pregestational diabetes (type 1, type 2, MODY)
    • Higher order pregnancy (three or more fetuses)
    • Abnormal obstetrical ultrasound suspicious for major congenital abnormality
    (Exclusion Criteria varies, please contact Study Coordinator for more information)

    Age Range
    18 and up
  • An Observational Study to Examine School Transition after Traumatic Brain Injury

    Official Title
    STATBI: School Transitions after Traumatic Brain Injury
    Purpose

    The purpose of this study is to understand the best ways to help students return to school after brain injury of any severity. This is important to study because finding the best ways to help students go back to school right after brain injury, and over time, can help improve student success and recovery.

    Your participation in the study would take place when you/your child begins the study and then at 3 months, 6 months, 12 months, 2 years (if applicable) and 3 years (if applicable) after the study starts.

    Could this study be right for you?

    • Students aged 5 to 18 years old
    • In kindergarten through 12th grade
    • Must Speak English
    • Traumatic Brain Injury (TBI) of any severity
    • Parent/caregiver is willing to share medical and academic information with the research team (all study activities are virtual/remote)

    Age Range
    5 and up
  • Children Helping Children With Immune Diseases

    Official Title
    Creation of a pediatric healthy control repository for clinical diagnostic immunology test development and validation
    Purpose

    This study uses healthy children from newborns to 18 years old to help understand immune disorders. This study will compare healthy children and teens to children and teens with disorders of the immune system.

    Volunteers will visit Nationwide Children's Hospital (NCH) for a blood draw either one time or not more than once every three months.

    Could this study be right for you?

    If your child is:

    - Newborn to 18 years of age
    - Healthy with no significant medical diagnoses
    - Has no chronic medical conditions that can affect results of immunological studies
    - Is not on any medication known to alter immune status or function
    - Has not undergone recent surgery, chemotherapy, radiation or transplantation
    - Has had no infections within the last 2 months

  • Cognition and Brain Circuitry

    Official Title
    Cognition and Brain Circuitry
    Purpose

    The purpose of the study is to look at how our brain networks interact for different mental functions and how individual differences in brain structure and function determines individual differences in behavior.

    During this study, we use magnetic resonance imaging methods: functional magnetic resonance imaging (fMRI) and diffusion weighted imaging (DWI). Functional MRI (fMRI) and DWI are typical imaging methods that use a strong magnetic field and radio waves to make pictures of your body.

    The total length of the study will be between 3 and 4 hours, including up to 2 hours outside the MRI scanner and 2 hours in the scanner.

    Could this study be right for you?

    - Healthy adults between 18-40 years of age
    - Have normal or corrected-to-normal vision

    Age Range
    18 and up
  • Evaluating a Cell-Based Therapy in New Living Donor Kidney Transplant Recipients and Donors

    Official Title
    FREEDOM 1, A randomized, controlled, multi-center, safety and efficacy study of FCR001 cell-based therapy relative to a tacrolimus and mycophenolate-based regimen in de novo living donor renal transplant recipients, and safety in FCR001 donors
    Purpose

    The purpose of this study is to learn more about whether FCR001, an investigational cell therapy, can prevent the rejection of living donor kidney transplants without the need for lifelong anti-rejection drugs.

    Could this study be right for you?

    • Recipient age ≥ 18 years
    • Donor age ≥ 18 and ≤ 60 years
    • Recipient of a first kidney transplant from a living donor
    • Not diagnosed with or treated for any type of cancer (donor or recipient)

    Age Range
    18 and up
  • Evaluating a Mobile Health App for Cardio-Oncology Patients

    Official Title
    Mobile Health App as a Cardiotoxicity Symptom Logging Tool: Feasibility Pilot Study
    Purpose

    To evaluate the cardio-oncology patient population’s experience with using smart-phone technology as a part of self-management with their care through features such as symptom logging and education.

    Eligible patients will be asked to participate in a 30-minute virtual interview and/or a 60-minute virtual design or usability session to discuss their thoughts on a mobile app for cardio-oncology patients.

    Could this study be right for you?

    - English-speaking
    - Prior cancer diagnosis
    - Currently undergoing a cancer regimen that includes a targeted, biologic, radiation, and/or immune-based therapy
    (ex. TKIs and/or ICIs).
    - No pregnant females
    - No prisoners

    Age Range
    18 and up