Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • Light Therapy for Impaired Sleep in Parkinson’s Disease

    Official Title
    A Dose Selection Trial of Light Therapy for Impaired Sleep in Parkinson’s Disease

    This study is being done to find out if light therapy can help people with Parkinson’s disease (PD) who experience difficulties with their sleep. We also want to find out if light therapy is safe and does not cause too many side effects.

    If you qualify to join, it will take you about 4 months to complete this research study. During this time, we will ask you
    to make 5 study visits to The Ohio State University and complete 3 phone calls.

    Could this study be right for you?

    Inclusion Criteria:
    1) Diagnosis of idiopathic PD
    2) Stable dose of all PD medications for at least 30 days prior to randomization
    3) Willingness to wear an Actiwatch and complete daily sleep logs

    Exclusion Criteria
    1) Presence of moderate depression
    2) Co-existent significant sleep apnea
    3) Co-existent symptomatic restless legs syndrome (RLS)
    4) Cognitive impairment
    5) Pregnant women

    Further inclusion/exclusion criteria exists

    Age Range
    45 and up
  • Measuring Sleep Problems in Children with Autism Spectrum Disorder (ASD)

    Official Title
    Measuring Sleep Problems in Children with Autism Spectrum Disorder (ASD)

    The purpose of this study is to get a better understanding and improve measurement of sleep problems in children with Autism Spectrum Disorder (ASD).

    Total time involved in study will be approximately 5 hours

    Could this study be right for you?

    - Parents of children with ASD, and
    - Children with ASD ages 3-12, with mild, medium or major sleep problems either currently or in the past
    - Children on medication can participate if the medicine dose is stable for at least one month

    Age Range
    3 and up
  • Movement and Music Study for Those with Dementia--Age 60 and Over

    Official Title
    Movement and Music Intervention for Individuals with Dementia

    There is some evidence that music based interventions may have a protective effect on the brain in those with dementia. There is also evidence that doing activities that engage the brain through music are beneficial. This study seeks to investigate the potential benefits of a music based intervention for individuals with dementia.

    Could this study be right for you?

    You may be eligible if you:
    - Have a diagnosis of dementia (mild to moderate)
    - Are age 60 and older
    - Able to follow simple instructions

    -Unable to walk 10 feet unassisted
    -Presence of bone disorder that impacts walking
    -Presence of other neurologic diagnosis that impacts cognitive or motor function such as stroke, Parkinson disease or traumatic brain injury

    Age Range
    60 and up
  • Perinatal Arterial Stroke: The I-ACQUIRE Study

    Official Title
    Perinatal Arterial Stroke: The I-ACQUIRE Study

    Children who suffered a stroke before or shortly after being born that was caused by blockage of blood flow in an artery, it often results in the child showing some weakness on one side of their body.

    With this study, we want to find out if a type of therapy may help children who have weakness on one side of their body due to perinatal arterial ischemic stroke, learn how to better use their weaker arm.

    All children will be in the study for about 13 - 15 months. Some children may be in the study for a longer period, depending on which treatment they receive during Phase 1 of the study. The I-ACQUIRE therapy involves fun learning and play, self-help activities, and manipulating interesting toys and objects.

    Could this study be right for you?

    - Your child must be between the ages of 8 and 36 months old when beginning this study
    - Your child must have suffered an a perinatal arterial ischemic stroke
    - Upper limb weakness
    - Parents must be able to participate at least 1x/week for therapy and 40-60 minutes/day at home

  • Registry for Shoulder Surgery Outcomes

    Official Title
    Shoulder Surgery Outcomes Registry

    This registry will collect outcomes data of patients undergoing shoulder surgery with Dr. Jonathan Barlow or Dr. Julie Bishop. The purpose of this registry is to provide a way to collect and store data for patients undergoing shoulder surgery to support the conduct of future research in an effort to improve patient outcomes.

    Could this study be right for you?

    - A patient undergoing surgery with Dr Jonathan Barlow or Dr Julie Bishop (will be asked to enroll once the clinical decision has been made to proceed with surgery)
    - 18 to 89 years old
    - Able to provide consent

    Age Range
    18 and up
  • Rotator Cuff Study--For Those Who Require Surgical Treatment for Full Thickness Massive Tear

    Official Title
    A prospective, single blinded, multi-center, randomized, controlled, pivotal study to assess the safety and effectiveness of the InSpace™ device for treatment of full thickness Massive Rotator Cuff Tears

    This research study will evaluate a new device, InSpace, for use with a full thickness massive tear of rotator cuff (the group of connective tissues in the shoulder). The device is designed to allow smooth gliding of the bones in the shoulder during motion, which may allow rehabilitation exercises with less pain. The research study is being conducted to see whether the InSpace device is safe and effective for shoulder problems due to a full thickness massive rotator cuff tear.

    Could this study be right for you?

    1) Is male or female ≥ forty (40) years of age
    2) Positive diagnostic imaging by MRI within 9 months of enrollment of the index shoulder indicating a full thickness MRCT: measuring ≥ 5 cm in diameter (Cofield classification) and involving ≥ two tendons
    3) Functional deltoid muscle and preserved passive range of motion on physical examination
    4) Failed non-operative treatment of at least 4 months from the initial treatment to include one or all of the following: Oral analgesics, Anti-inflammatory medication (e.g., ibuprofen, naproxen), Corticosteroid injection(s), Physical therapy, Activity modification, or Rest (sling used)
    5) Must be able to read and understand the approved Informed Consent Form (written and oral)
    6) Must be in general good health (as determined by the Investigator) based on screening assessments and medical history
    7) Must be independent, ambulatory, and can comply with all post-operative evaluations and visits.

    Other details will be shared by the study coordinator.

    Age Range
    40 and up
  • Study to Assess the Efficacy and Safety of Adjunctive NBI-1065845 in Adults with Major Depressive Disorder (MDD) (SAVITRI)

    Official Title
    Study to Assess the Efficacy and Safety of Adjunctive NBI-1065845 in Adults with Major Depressive Disorder (MDD) (SAVITRI)

    The purpose of this study is to evaluate the effectiveness and safety of NBI-1065845 compared with placebo. In addition to the study drug, participants will continue their normal antidepressant medications. The main goal of this study is to examine the improving symptoms of depression.

    The duration of the study will last 14 weeks, including up to 4 weeks of screening, 8 weeks of study drug dosing, and a follow-up period of 2 weeks.

    Could this study be right for you?

    • Aged 18-65 years old
    • Have a diagnosis of Major Depressive Disorder (MDD)
    • Currently depressed
    • Poor response to antidepressant treatment

    Age Range
    18 and up
  • Studying the Effect of Using Virtual Reality with Spinal Cord Stimulation to Manage Pain

    Official Title
    Investigating mechanisms underlying spinal cord stimulation efficacy using virtual reality and full body illusion

    This study is being to see if using virtual reality (VR) along with spinal cord stimulation can help better manage pain. Research has shown that using this type of “leg illumination” virtual reality reduces pain. We hope to further this research by identifying which sensory pathway (part of the nervous system that makes one aware of what one feels) causes pain to decrease. If the Virtual Realty acts through a different sensory pathway than a spinal cord stimulator, those with pain may have some additional pain relief.
    This study will require 2 study visits; one will last approximately 1 hour, and the other visit will last about 5 hours throughout the day.

    Could this study be right for you?

    Inclusion Criteria:
    1. Age 18–and older at the time of enrollment
    2. Individuals who are experiencing lower extremity pain e.g. neuropathy, Complex Regional Pain Syndromes (CRPS) type-1, neuropathic leg pain following Failed Back Surgery (FBS) etc.
    3. Those who have an implanted epidural Spinal Cord Stimulator (SCS)
    4. The SCS implantation for at least three months prior to enrollment

    Age Range
    18 and up
  • The ARCADIA Study -- A medication study for prevention of recurrent ischemic stroke

    Official Title
    AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke (ARCADIA)

    The purpose of this research study is to compare the effects (good and bad) of apixaban with the effects (good and bad) of aspirin in patients with unexplained strokes and atrial cardiopathy to see which is better at prevention of future strokes.

    Could this study be right for you?

    - You are at least 45 years old
    - Clinical diagnosis of ischemic stroke* of unknown cause (ESUS or cryptogenic) in the last 120 days
    - Underwent an echocardiogram as part of your stroke work up
    - No history of atrial fibrillation (irregular heartbeat)
    - No known allergy or intolerance to aspirin or apixaban

    *An “ischemic” stroke is an injury to the brain caused by a blocked blood vessel supplying the brain.

    Age Range
    45 and up
  • The Brain Exercise Study

    Official Title
    Strategies for the Development of Social Cognitive Training for Impulsive Aggression (Brain Exercise Study or BES).

    The purpose of this study is to see if brain exercise done on the computer can reduce aggression in those with “anger issues”.

    The study is a six-week clinical trial using selected brain exercises versus other computer-based exercises.

    Could this study be right for you?

    - Medically healthy man or woman
    - You are between 21 and 55 years of age
    - With a current history of “anger issues”
    - You have regular access to a computer and a smart phone

    Age Range
    21 and up
  • The EASE Study

    Official Title

    This study is designed to evaluate the safety and effectiveness of the Materna Prep Device in reducing pelvic muscle injuries during vaginal delivery.

    Could this study be right for you?

    You may be eligible for this study if you:
    1. Are scheduled for vaginal birth.
    2. Are pregnant with a single fetus.
    3. Haven't given birth previously, or had a previous pregnancy terminated within 24 weeks gestation.
    4. Are willing to comply with the protocol required follow-up visits.
    5. Are able and willing to provide written informed consent prior to enrollment.
    6. Are 18 years of age or older at time of consent.

    You will be ineligible for this study if you:
    1. Have a high likelihood of less than 1 hour of potential device dilation time after you arrive at the hospital.
    2. Have a need for or is planning a Caesarean-section.
    3. Begin labor with less than 36 weeks gestation.
    4. Have a neurological disorder that could cause pelvic floor dysfunction, such as multiple sclerosis or spinal cord injury
    5. Have a collagen-associated disorder that affects tissue elasticity, such as scleroderma or Ehlers-Danlos syndrome
    6. Have a localized (genital tract) or systemic infection.
    7. Have had prior surgical procedures to the vaginal anatomy which could lead to pelvic floor dysfunction, such as pelvic fractures or pelvic soft tissue injuries
    8. Have any general health condition or systemic disease that may represent, in the opinion of the investigator, a potential increased risk associated with device use or pregnancy.
    9. Have placenta previa or vasa previa.
    10. Have a known significant chromosomal or structural fetal anomalies.
    11. Have a category 2 and/or 3 fetal tracing that is unresolved.

    Age Range
    18 and up
  • The Emerging Adulthood Health Project

    Official Title
    The Emerging Adulthood Health Project

    Researchers at The Ohio State University are looking for teens and young adults to participate in an online research study aimed at better understanding people’s health behaviors and attitudes.

    Participation involves a 10-15 minute baseline survey and three 5-10 minute follow-up surveys. Links to these surveys would be emailed to you.

    Could this study be right for you?

    - You are a teen or young adult
    - Have access to smart device or computer with internet to be able to complete surveys