Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • Adults Helping Adults With Immune Diseases

    Official Title
    Creation of a pediatric healthy control repository for clinical diagnostic immunology test development and validation
    Purpose

    A test for healthy adults from 19 - 75 years old to develop normal values for interpretation of immunological tests in adults with disorders of the immune system.

    Voluntary participation involves blood draw at Nationwide Children's hospital. Qualified participants would be eligible to provide a sample every 2 months (not more than 6 times per year).

    Could this study be right for you?

    If you are:

    - An adult 19 years of age or older
    - Healthy with no significant medical diagnoses
    - Have no chronic conditions that can affect results of immunological studies
    - Not any medication known to alter immune status or function
    - Have not undergone recent surgery, chemotherapy, radiation or transplantation
    - Non-smoker
    - Body mass index (BMI) in healthy range
    - No infections within last 2 months

    Age Range
    19 and up
  • An Intervention Study for Subjects with Palmoplantar Pustulosis

    Official Title
    ANB019-003: A Phase II, Randomized, Placebo-controlled, Double-blind, Multiple Dose Study to Evaluate the Efficacy and Safety of ANB019 in Subjects with Palmoplantar Pustulosis
    Purpose

    This study is being done to assess the effects of the experimental study drug (ANB019) in patients with PPP.

    Could this study be right for you?

    - Must have a clinical diagnosis of PPP for at least 6 months prior to screening
    - Must have active pustules on palms and/or soles of feet
    - BMI must be within the range of 18-36 kg/m2
    - Subjects must be in otherwise good health
    - Must not have any suspected autoimmune disorder or immune deficiency
    - No major surgeries in the past 4 weeks
    - No history of malignancy in the past 5 years
    - No history of drug, alcohol, or other substance abuse

    Age Range
    18 and up
  • An Intervention Study to Evaluate a Medication (MIJ821) Used to Treat Major Depressive Disorder

    Official Title
    Study of Efficacy and Safety of MIJ821 in Addition to Comprehensive Standard of Care on the Rapid Reduction of Symptoms of Major Depressive Disorder in Subjects Who Have Suicidal Ideation With Intent
    Purpose

    The purpose of the study is to determine if the investigational study drug will rapidly reduce depression associated with thoughts of harming oneself when given in addition to standard antidepressant medication.

    Your participation in this study will last for a minimum of 14 weeks and maximum of 58 weeks.

    Could this study be right for you?

    • Aged 18-65 years old
    • Diagnosed with major depressive disorder (MDD) with a current major depressive episode
    • Having current suicidal ideation with intent
    • Already in the hospital or agree to be hospitalized voluntarily for the required period of time

    Age Range
    18 and up
  • An Intervention Study to Examine the Effects of Knee Brace Stiffness on Muscle Control following Total Knee Replacement

    Official Title
    Effects of Knee Brace Stiffness on Muscle Control following Total Knee Replacement
    Purpose

    The purpose of this study is to determine the effects of various knee braces on how you walk.

    Participation in this study consists of 1 session lasting 2-3 hours. During testing, you will walk on a treadmill during several trials, each lasting 2-5 minutes. While walking, you will wear a knee brace, motion capture markers, and muscle activation sensors.

    Could this study be right for you?

    Knee Replacement participants:

    · Men and women aged 45-89 years old

    · Can walk for 45 minutes without stopping

    · Received a TKR (total knee replacement) in the last 2 years

    Healthy participants:

    · Men and women aged 45-89 years old

    · Can walk for 45 minutes without stopping

    · No history of lower limb surgery

    Exclusion criteria:

    · Lower extremity surgeries (other than knee replacement);

    · Spine pain

    · Scoliosis

    · Known pregnancy

    Exclusion criteria varies, please contact Study Coordinator for more information.

    Age Range
    45 and up
  • An Observation Study to Evaluate Retina Eye Picturing in Women with Preeclampsia

    Official Title
    Remote monitoring of retina vasculature in women with preeclampsia: novel biomarker for disease severity
    Purpose

    The overall goal is to evaluate whether pictures we take of the retina of the eye can be used to detect preeclampsia and its severity.

    Your participation will be from your enrollment visit, until 2-4 months after delivery, which will be no more than 32 weeks.

    Could this study be right for you?

    Inclusion criteria for normal blood pressure healthy pregnant women:
    • Women aged 18 years or older
    • Pregnant females at enrollment being >= 24 0/7 of pregnancy
    • Able and willing to provide consent and willing to conduct the postpartum follow-up
    • Normal blood pressure at enrollment
    Inclusion criteria for Preeclampsia Pregnancies with severe features:
    • Women aged 18 years or older
    • Pregnant female at enrollment between 24 0/7 and 33 6/7 of pregnancy
    • Able and willing to provide consent and willing to conduct the postpartum follow-up
    • All subjects must be Preeclampsia (dangerous high blood pressure in pregnancy) diagnosed.

    Exclusion Criteria for both groups:
    • Known chromosomal, genetic, major malformations, fetal demise.
    • Past medical history of hypertension >5 years, pre-gestational diabetes, or know retinal disease
    • Pregnant for twin, triplets or higher
    • Participating in another intervention study that influences the outcomes in this study.

    Age Range
    18 and up
  • An Observation Study to Examine the Effectiveness of Nifedipine

    Official Title
    Frequency and dosing of Long Acting Anti-Hypertensive Agent in Women with Pre-eclampsia with severe features undergoing expectant management: A Randomized Controlled Trial
    Purpose

    The purpose of this study is to compare the effectiveness of long-acting Nifedipine XL 60mg daily to 30mg twice daily among women admitted with hypertensive disorders of pregnancy and severe blood pressures.

    Participation for the duration of the study lasts 48 hours.

    Could this study be right for you?

    Inclusion Criteria:
    • Women aged 18-45 years old
    • Viable single or twin intrauterine pregnancy between 22 0/7 and 33 5/7 weeks gestation
    • Women with a hypertensive disorder of pregnancy and are undergoing expectant management (spontaneous labor) for a diagnosis of preeclampsia
    • Patient has already been started on 30mg Nifedipine XL by their primary OB provider and has been recommended to increase the daily dose to 60mg

    Exclusion Criteria:
    • Known allergy or poor reaction to Nifedipine or any medical condition where Nifedipine should not be used in ones treatment, such as galactose intolerance, severe GI stricture, and GI hypomotility disorder.
    • Participation in another trial without prior approval
    • Currently receiving a daily dose of Nifedipine XL of 60mg or greater
    • Continuation of alternate long-acting anti-hypertensive medication on admission
    • Triplet or higher order pregnancy
    (Exclusion Criteria still varies, please contact Study Coordinator for more information).

    Age Range
    18 and up
  • An Observational Study of Pregnant Individuals with Glucose Intolerance

    Official Title
    The use of continuous glucose monitors among pregnant individuals with various degrees of glucose intolerance: An observational cohort study
    Purpose

    The purpose of this study is to learn more about blood sugar levels in the third trimester among women with and without gestational diabetes.

    You and your child will be in the study from the time of enrollment through hospital discharge after delivery.

    Could this study be right for you?

    Inclusion criteria:
    • Women aged between 18 and 45 years old
    • Women with a viable singleton or twin pregnancy between 24 0/7 and 31 6/7 weeks gestation
    • Planning to deliver at OSU Wexner Medical Center

    Exclusion Criteria:
    • Known pregestational diabetes (type 1, type 2, MODY)
    • Higher order pregnancy (three or more fetuses)
    • Abnormal obstetrical ultrasound suspicious for major congenital abnormality
    (Exclusion Criteria varies, please contact Study Coordinator for more information)

    Age Range
    18 and up
  • An Observational Study to Evaluate Lung Health in Young Adults

    Official Title
    [American Lung Association (ALA)] Lung Health Cohort (LHC) Study
    Purpose

    The purpose of this study is to examine why some people have better lung function than others as young adults during the period of peak lung health (ages 25 to 35 years old). The long-term goal of this study is to come up with ideas about how to promote the best possible lung function in young adults.

    Participation in this study will be 4.5 years.

    Could this study be right for you?

    Inclusion Criteria:
    • Men and women aged 25-35 years old at time of examination
    • Able to read and understand English or Spanish
    • Have a social security number

    Exclusion Criteria:
    • Severe asthma or other chronic lung disease
    • Diagnosed cardiovascular disease
    • History of cancer other than non-melanoma skin cancer
    • Currently pregnant

    Age Range
    25 and up
  • An Observational Study to Examine School Transition after Traumatic Brain Injury

    Official Title
    STATBI: School Transitions after Traumatic Brain Injury
    Purpose

    The purpose of this study is to understand the best ways to help students return to school after brain injury of any severity. This is important to study because finding the best ways to help students go back to school right after brain injury, and over time, can help improve student success and recovery.

    Your participation in the study would take place when you/your child begins the study and then at 3 months, 6 months, 12 months, 2 years (if applicable) and 3 years (if applicable) after the study starts.

    Could this study be right for you?

    • Students aged 5 to 18 years old
    • In kindergarten through 12th grade
    • Must Speak English
    • Traumatic Brain Injury (TBI) of any severity
    • Parent/caregiver is willing to share medical and academic information with the research team (all study activities are virtual/remote)

    Age Range
    5 and up
  • Child Categorization Study

    Official Title
    The Ontogenesis of Categorization (Children age 4)
    Purpose

    The purpose of the study is to investigate the early development of attention, learning and memory; this is a multi-year study.

    All sessions will take approximately 60-120 minutes to complete. This study will be conducted in our lab, and mandated OSU COVID safety protocol will be followed.

    Could this study be right for you?

    - Children who are 4 years old
    - Have normal or corrected to normal vision

    Age Range
    4 and up
  • Child Memory Study

    Official Title
    Cognitive Development (Children 4-9 yrs old)
    Purpose

    The purpose of this study is to understand how children sort new information using simple memory exercises with animated computer games.

    All sessions will take approximately 25-45 minutes to complete. Participating children will play memory games on our touchscreens and computers. For on-campus sessions, mandated OSU COVID safety precautions will be followed.

    Could this study be right for you?

    - Children ages 4-9 years old

    Age Range
    4 and up
  • Children Helping Children With Immune Diseases

    Official Title
    Creation of a pediatric healthy control repository for clinical diagnostic immunology test development and validation
    Purpose

    This study uses healthy children from newborns to 18 years old to help understand immune disorders. This study will compare healthy children and teens to children and teens with disorders of the immune system.

    Volunteers will visit Nationwide Children's Hospital (NCH) for a blood draw either one time or not more than once every three months.

    Could this study be right for you?

    If your child is:

    - Newborn to 18 years of age
    - Healthy with no significant medical diagnoses
    - Has no chronic medical conditions that can affect results of immunological studies
    - Is not on any medication known to alter immune status or function
    - Has not undergone recent surgery, chemotherapy, radiation or transplantation
    - Has had no infections within the last 2 months