A Study on the immune response to TdaP vaccine during pregnancy

Official Title: Characterization of cellular immune responses to pertussis vaccination during pregnancy


The primary objective of this study is to characterize the cellular immune responses of women immunized with either wPV or aPV during childhood who receive a TdaP booster during the 3rd trimester of pregnancy.

Eligibility criteria:

You may be eligible for this study if you:
- Are 18 years of age or older
- Pregnant with a single fetus
- Women with confirmed wPV or aPV immunization with be given prioritization. If unknown, you will be placed in group 1 or 2 based on birth year (pre-1997 (wPV) or post-1997 (aPV))
- Prior pregnancy immunization history will be noted if available
-Non-pregnant volunteers in the same age ranges and known immunization history will be recruited as controls for groups 3 and 4.

You will be ineligible if you:
- Have hypertension, gestational diabetes, type 1 or 2 diabetes, connective tissue diseases (autoimmune disorders), anemia, chronic steroid treatment, cancer, HIV, and/or allergy to TdaP vaccine, and who are prisoners, are uncertain of their vaccine status, or who have had multiple gestations.

Contact Information

Anna Bartholomew, MPH, BSN, RN, CCRP