A Feasibility Study to Assess the Effect of a Ketogenic Diet as a Co-Therapy for Major Depressive Disorder

Official Title

Ketogenic Intervention in Depression (KIND)


The overarching goal of this pilot study is to: (1) demonstrate that a well-formulated KD can be implemented in treatment program for major depression, and (2) test whether such a program results in reductions of symptoms of depression. 

Could this study be right for you?

Inclusion Criteria:

  • OSU students (age 18-30 years at the time of enrollment) with confirmed major depressive disorder as determined by SCID-5 diagnosis at baseline testing.
  • Currently engaged in counseling and or mediation treatment for depression
  • Available for a 12-week period and indicate willingness and ability to eat KD foods as prescribed

Exclusion Criteria:

  • Disordered eating, as evidenced by meeting criteria for Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder, Other Specified Eating Disorder, Unspecified Eating Disorder, or Avoidant Restrictive Eating Disorder during the SCID-5 interview at baseline testing.
  • Substantial imminent risk of suicide as assessed during the SCID-5 interview.
  • Body mass index (BMI) < 20 kg/m2
  • Habitual consumption of a structured low-carbohydrate diet in the last 6-months

Exclusion Criteria varies, please contact Study Coordinator.


Age Range

18 - 30 years