Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • A Study Evaluating How Dietary Oils Affect Fat in the Liver

    Official Title
    Weight, Energy, Lipids, and the Liver (WELL) Study: A randomized controlled trial to understand how dietary fat quality affects fat in the liver
    Purpose

    The purpose of the WELL study is to examine how consuming dietary oils in foods like spreads, bread, cookies, muffins, and brownies everyday influences liver fat.  

    The study will measure liver fat using and MRI before and after consuming 3 of the study foods per day for 16 weeks.  The study will also examine how consuming the study foods each day influences fat in the abdomen and in the blood.  The total study duration is 18 weeks.

    Could this study be right for you?

    Inclusion Criteria

    • Ages 25-80
    • Have nonalcoholic fatty liver disease or something similar

    Exclusion Criteria Include

    • Unable to have an MRI scan
    • Pregnancy 
  • A Study to Investigate Where Franklin County Residents Overdose and What Supports They Need

    Official Title
    Where Do Franklin County Residents Overdose and What Supports Do They Need?
    Purpose

    The purpose of this study is to identify places where Franklin County residents have had an opioid-related overdose (e.g. home, workplace, coffee shop, grocery story). We also want to identify what resources people want to see in these places (e.g. NaloxBoxes, vending machines, a motion monitoring device) to help people stay safe.

    Could this study be right for you?
    • Male and females aged 18 years or older
    • Resident of Franklin County
    • Experienced at least one overdose in Franklin County, OH between January 2021 and December 2022
    • You suspected your overdose was opioid-related or someone gave you Narcan
    • Willing to discuss your overdose experience in a one-on-one interview
    • Have access to a private room and an Internet connection, or able to travel to a local public library for the interview
    Age Range
    18 and up
  • Stress Reactivity Study

    Official Title
    Orexin Receptor Antagonists as Modulators of Threat Sensitivity in individuals with Alcohol Use Disorder
    Purpose

    The purpose of this study is to see if BELSOMRA, an FDA approved medication that is prescribed to treat insomnia, changes the body’s response to stress.

    Could this study be right for you?

    Eligibility Criteria:

    • 18-65 years old
    • Generally medically and physically healthy
    • Regular alcohol use

    Exclusion Criteria:

    • Diagnosis of bipolar disorder, schizophrenia, mania, or psychosis
    • Currently pregnant or trying to become pregnant (female)
    • Presence of ferrous-containing metal in the body
    • Inability to tolerate enclosed spaces
       

    Exclusion Criteria varies, please contact Study Coordinator for more information.

    Age Range
    18 - 65
  • A Study About the Development of Learning in African-American/Black Children

    Official Title
    Ontogenesis of Categorization; Linking development, mechanisms, and biology
    Purpose

    The purpose of this study is to investigate the early development of attention, learning, and memory during childhood. Participation in this study includes 4, 90-minute-long visits to the lab per year. During these visits, your child will play 2-3 fun, computerized games. These games are designed to assess various aspects of their cognitive ability. 

    The duration of the study will last 4 years.

    Could this study be right for you?

    Eligibility Criteria: 

    • African-American/Black children who are 4 years old 
    Age Range
    4 - 4
  • A Study About Gene Therapy for Early Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI)

    Official Title
    A Phase I Study to Assess the Safety, Tolerability and Preliminary Efficacy of AAV2-BDNF [Adeno-Associated Virus (AAV)-based, Vector-Mediated Delivery of Human Brain Derived Neurotrophic Factor] in Subjects with Early Alzheimer’s Disease and Mild Cognitive Impairment
    Purpose

    The primary aim of this study is to determine whether administration of the nervous system growth factor "Brain-Deruved Neurotrophic Factor" (BDNF) to eligible patients with Alzheimer's disease and Mild Cognitive Impairment is safe and tolerable. This study will be used to determine whether BDNF administration reduces neuronal loss and rebuilds synapses in the brain of patients with Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI). 

    Could this study be right for you?
    • Male and Females aged 50 years or older
    • Diagnosis of dementia due to Alzheimer's Disease/Diagnosis of Mild Cognitive Impairment (MCI) due to Alzheimer’s Disease
    • A caregiver is available who has frequent contact with the subject, agrees to observe for adverse events, and will accompany the subject to all clinic visits for the duration of the protocol
    • CT or MRI scans within 24 months prior to screening without evidence of an infection, infarction, or other focal 

    Inclusion Criteria varies, please contact Study Coordinator for more information.

    The below Exclusion Criteria apply to both the AD and MCI groups.

    • Any significant neurological disease other than suspected incipient disease
    • History of schizophrenia 
    • History of systemic cancer within the past 18 months (non-metastatic skin cancers are acceptable).
    • Any significant systemic illness or unstable medical conditions which could lead to difficulty complying with the protocol
    • Use of any investigational drugs within thirty days or five half-lives, whichever is longer, prior to screening.

    Exclusion Criteria varies, please contact Study Coordinator for more information. 

    Age Range
    50 and up
  • Biomarkers for Evaluating Spine Treatments

    Official Title
    A Study About Biomarkers for Evaluating Spine Treatments
    Purpose

    The purpose of this research study is to study four treatments for chronic low-back pain to learn whether or not certain treatments work better for people with certain characteristics.

    The study’s main goal is to find a way to match treatments to low-back pain patients based on their characteristics and how they responded to treatments they have used before.
     

    Could this study be right for you?

    Inclusion Criteria:

    To be eligible, an individual must meet all of the following inclusion criteria:

    • Ability to read and understand English
    • Provision of signed and dated informed consent form(s)
    • Willing and able to receive study-related messages and survey links via email
    • Willing and able to receive study-related phone calls
    • Age 18 years old or older
    • Low-back pain for at least 3 months and occurring on at least half the days in the past 6 months
    • Contraindicated to no more than one of the study interventions at the time of eligibility assessment(s)
    • Eligible to receive at least three of the four study interventions and willing to receive any intervention for which they are eligible
    • A PEG score 4 or higher at two time points: 1) screening prior to the Run-in period and 2) screening prior to baseline (Visit 0)
    • Willing and able to undergo required phenotyping
    • Regular reliable access to an internet-enabled device such as a smart phone, tablet, or laptop computer
    • Meet Run-in period engagement eligibility criteria:

      • Completion of two Run-in study information modules prior to period 1 randomization (Visit 0)
      • Response to at least 5 emails prior to period 1 randomization (Visit 0)
    • Low-back pain more severe than pain in other parts of the body
    • Available to complete the full study protocol (approximately 9 months)

    Exclusion Criteria:

    An individual who meets any of the following criteria will be excluded from participation in this study:

    • Pregnant at the time of Visit 0 (Baseline)
    • Affirmative participant response to any of the following conditions:

      • Progressive neurodegenerative disease
      • History of discitis osteomyelitis (spine infection) or spine tumor
      • History of ankylosing spondylitis, rheumatoid arthritis, polymyalgia rheumatica, psoriatic arthritis, or lupus
      • History of cauda equina syndrome or spinal radiculopathy with functional motor deficit (strength <4/5 on manual motor testing)
      • Diagnosis of any vertebral fracture in the last 6 months
      • Osteoporosis requiring pharmacologic treatment other than vitamin D, calcium supplements, or bisphosphonates.
      • History of any bone-related cancer or cancer that metastasized to the bone
      • Currently in treatment for any non-skin cancer or plan to start non-skin cancer treatment in the next 12 months
      • History of any non-skin cancer treatment in the last 24 months
      • Visual or hearing difficulties that would preclude participation
      • Uncontrolled drug/alcohol addiction
      • Individuals actively pursuing disability or workers compensation or involved in active personal injury-related litigation
      • Currently participating in another interventional pain study
    • Any condition that, in the opinion of the investigator, would preclude the patient from being able to safely participate in in the trial
    Age Range
    18 and up
  • An Intervention Study about Primary Care Algorithms for Early Identification of Young Women with von Willebrand Disease

    Official Title
    Primary Care Algorithms for Early Identification of Young Women with von Willebrand Disease
    Purpose

    Researchers at Nationwide Children’s Hospital are seeking volunteers to be a part of a study looking at how to best screen for bleeding disorders in young women.

    Participants will be asked to undergo a finger prick blood test and complete questionnaires. If their survey answers suggest they have heavy menses, they will also be asked to have a blood draw on the same day.

    Could this study be right for you?
    • Are 10 to 20 years old
    • Have had your first menstrual cycle
    Age Range
    10 - 20
  • A Study to Examine if a Foot Stool can Make it Easier for People with Constipation to have a Bowel Movement (FASED Study)

    Official Title
    FASED (Footstool in Alleviating Symptoms of Evacuation Disorder)
    Purpose

    The purpose of this research study is to see if using a footstool can make it easier to have bowel movements in patients who suffer from chronic constipation. The participants will be given a free footstool to use. They will be asked to keep a record of their bowel symptoms and answer some surveys about their symptoms on a phone or computer. 

    You will be in the study for approximately 12 weeks. This includes 2 weeks before you start using the footstool, followed by 8 weeks where you will be using the footstool and up to 2 weeks to complete your initial and final surveys. 

    Could this study be right for you?
    • At least 18 years old 

    • Able to understand English 

    • Symptoms such as feeling incompletely empty after a bowel movement, needing to strain a lot when having a bowel movement or needing to use maneuvers such as rocking one's body back and forth or using their finger to remove stool. 

     

    Age Range
    18 - 99
  • Sleep and Blood Sugar in People with Alzheimer's Disease

    Official Title
    Sleep Actigraphy and Continuous Glucose Monitoring in People with Alzheimer’s Disease
    Purpose

    The purpose of this study is to learn about sleep and blood sugar (glucose) levels in people living with Alzheimer’s disease (AD). Another purpose of the study is to see how people with AD and their caregivers/family members feel about wearing small devices to measure sleep and blood sugar.

    The duration of this study is 10 days. 

     

    Could this study be right for you?
    • 60 years or older, with Alzheimer’s disease,
    • Has a caregiver 18 years or older,
    • Willing to wear a watch-like device,
    • Willing to wear a small sensor on the skin
    Age Range
    18 and up
  • Experiences, attitudes, and practices of firearms among women gun owners in New Jersey and Ohio

    Official Title
    Experiences, attitudes, and practices of firearms among women gun owners in New Jersey and Ohio
    Purpose

    The purpose of this study is to better understand experiences, attitudes, and practices of women gun owners in New Jersey and Ohio to ultimately improve understanding of factors that may influence suicide prevention strategies. 

    Could this study be right for you?
    • Be at least 18 years old 
    • Identify as female 
    • Own at least one handgun 
    • Live in either New Jersey or Ohio 
    • Use an Internet-connected device with a webcam
    Age Range
    18 - 99
  • Mentoring to be Active: Peer Mentoring for Rural Appalachian Children to Reduce Overweight and Obesity

    Official Title
    Mentoring to be Active: Peer Mentoring for Rural Appalachian Children to Reduce Overweight and Obesity
    Purpose

    The purpose of this study is to lower the rate of type 2 diabetes in rural Appalachia youth due to obesity and/or being overweight. Our long-term goal is to improve the health of underserved, high-risk youth.

    This study will test the effectiveness of the Mentored Planning to be Active + Family on physical activity outcomes and health outcomes among rural Appalachian middle school aged youth suffering from either overweight or obesity.

    We have local high school-aged teen mentors work closely with middle school youth to increase social support, self-efficacy, and self-regulation skills to sustain physical activity and improve health before the children enter high school.

    The peer mentoring is followed by a 6-month family reinforcement program.

    Some parents will provide child assessment data of perceived child physical activity behaviors and child health.

     

    Could this study be right for you?
    • Child has access to a computer or tablet device at home for virtual mentoring sessions/meetings
    • Child suffers from overweight or obesity - does not need to be under the care of a health care professional for this condition
    • Child and Parent able to participate read English at a 4th grade level. 
    • Family not expected to move from rural Appalachia within the 18 months. 
    Age Range
    12 - 13
  • Cardiovascular Effects of Ketone Ester Ingestion

    Official Title
    Cardiovascular Effects of Acute Ketone Ester Ingestion in Healthy Adults
    Purpose

    This study is intended to evaluate the effects of a drink supplement on heart function and health in healthy adults after consuming a ketone ester (KE) supplement drink compared to a placebo drink.

    You will undergo an MRI exam for this study. You will also receive six blood draws in total, from an IV catheter set at the beginning of the study. 

    The duration of this study will comprise a single visit and will last no longer than 4 hours. 

    Could this study be right for you?

    Inclusion:

    • Able to comply with study requirements as well as pre-test requirements
    • BMI between 18 and 30 kg/m2
    • Body weight > 150lbs

    Exclusion:

    Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including:

    • Pregnancy 
    • Allergies to components in the test products, including milk protein, and not lactose intolerant
    • History of alcoholism (previous 2 years)
    • Taking prescriptive medications or over-the-counter (OTC) medications (other than those taken as nutritional supplements for non-therapeutic indications)
    • Current smoker
    • Contraindications to MRI including cardiac pacemaker or defibrillator, brain aneurysm clips, neuro-stimulator, the presence of any magnetic metal in the body or claustrophobia

    Exclusion Criteria varies, please contact Study Coordinator for more information. 

    Age Range
    18 - 65