Blocking Orexin Receptors to Help Treat Alcohol Addiction and Stress-Driven Drinking

Mental Health
Other
Official Title OASIS - Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related Drinking

Purpose

This study will look at whether suvorexant can help treat alcohol use disorder, how it works, and who it works best for. Suvorexant is a medicine that blocks certain brain signals linked to wakefulness.

 

Your total participation time in this study will be approximately 9 weeks.

Could this study be right for you?

Inclusion Criteria: 

  1. Age 18-65
  2. Participant is able to give informed consent 
  3. Engage in heavy alcohol use defined as drinking ≥14 standard drinks per week if male and ≥7 standard drinks per week if female. 

General - Exclusion Criteria

  1. Clinically significant medical or neurological condition (e.g., liver disease, narcolepsy, complex sleep behaviors, severe hepatic impairment, COPD, severe obstructive sleep apnea) 
  2. Current or past DSM-5 diagnosis of mania, schizophrenia, psychosis 
  3. Past suicide attempt within 3 years or presence of moderate suicidal ideation
  4. Engage in night-shift work 

 

 

Age Range

18 - 65 years