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Research Study for Grave's Disease
Official Title A Phase 1, First-in-Human, Placebo-Controlled, Single and Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Intravenous and Subcutaneous Administration of MER511 in Adults With Graves’ DiseasePurpose
1. To find out how safe the study drug is and how well people with Graves’ disease can handle taking one or more doses.
2. To describe how the body absorbs, uses, and removes a single IV or subcutaneous dose, or several subcutaneous doses, of MER511 in people with Graves’ disease.
3. To check whether the body creates an immune response after a single IV or subcutaneous dose, or several subcutaneous doses, of MER511 in people with Graves’ disease.
Could this study be right for you?
1. Grave's disease diagnosis
2. Taking methimazole or propylthiouracil
3. Weigh at least 110 lbs
4. Women of childbearing potential must agree to use contraceptive methods and avoid egg donation during the study; Men with partners of childbearing potential must agree to use a condom or abstinence and avoid sperm donation during the study
Age Range
18 - 55 years -
Men’s Health, Friendships and Relationships
Official Title Men Talking: How Do Men Discuss Health, Friendships, and Relationships?Purpose
The purpose of this study is to gain a better understanding of men’s friendships, relationships, and health-information seeking.
The study consists of a 60–90-minute interview at a location of the participant’s choosing.
Thank you for your time and assistance!
Could this study be right for you?
- 18 years and older
- assigned male at birth
- live in Columbus Metro Area
Age Range
18 years and up -
Kicking the Habit: A Research Study Testing the Buckeye Quit Stick
Official Title A Pilot/Feasibility Study of the Buckeye Quit Stick: A Novel Resource for Successful Tobacco CessationPurpose
The Buckeye Quit Stick is part of a research study to learn whether people are willing to use a handheld stick as a tool for the hand-mouth routine of smoking. It focuses on the hand-to-mouth habit by providing something to hold and use instead of a cigarette. The main goal of this study is to see if patients that plan to quit smoking will use this device and evaluate their experiences with the Buckeye Quit Stick.
Participants will also continue to receive national guidelines for smoking cessation support from the James Comprehensive Cancer Center Smoking Cessation Clinic. A participant is considered to have completed the research study when they complete all study visits or at approximately 6 months.Could this study be right for you?
- Must be 21 years of age or older
- Patient of the OSU Thoracic Clinics
- Suspected or confirmed lung cancer diagnosis
- Current self-reported smoker
Age Range
21 years and up -
Chill Nic (Nicotine Pouch) Study
Official Title Examining the Role of Cooling Agents in Oral Nicotine PouchesPurpose
Adult cigarette smokers who live in Ohio are invited to participate in 5 study visits to understand how different nicotine pouches compare to one another as well as their usual brand of cigarette. Each visit lasts about 1 hour.
Participation involves visiting our lab, trying oral nicotine pouches, smoking your regular brand of cigarette, and filling out surveys.
Could this study be right for you?
- Must be a current cigarette user
- Must be 21 years old or older
- Must be willing to attend 5 study visits at OSU
Age Range
21 years and up -
Participate in an Eight-week Online Mind-body Research Intervention for Brain Health
Official Title Internet-based Mind-Body Training (iMBT) for Brain HealthPurpose
The Clinical Neuroscience Laboratory is looking for male volunteers (ages 50 years and older) with cognitive concerns to participate in an online eight-week mind-body research intervention for promoting brain health.
Participation will involve web-based, phone-based, and in-person assessment sessions. Assessment sessions will include a blood draw, neuropsychological assessments, MRI scan, and Fitbit tracking followed by the eight-week online internet-based mind-body intervention where participants are invited to complete one 2.5 hour session per week at their own pace.
Could this study be right for you?
- At least 50 years old and concerned about your memory or attention?
- Fluent in English?
- Do you have access to WiFi at home?
- Never diagnosed with mild cognitive impairment or dementia?
- Live in the Greater Columbus Metropolitan area?
- Willing to commit to a virtual research intervention and in-person assessments?
Age Range
50 years and up -
TBI and other Acquired Brain Injuries Study
Official Title Resource Mapping for Families of Children with Brain InjuryPurpose
The purpose of this study is to assess the family needs of children with a brain injury. We want to explore your experiences getting care, the barriers, and facilitators your family has faced in navigating and accessing services after hospital discharge, and your ongoing unmet needs.
Could this study be right for you?
- You are a primary care giver of a child that sustained a brain injury
- Your child was hospitalized for an overnight stay as a result of their brain injury
- Your child was 18 or younger when their brain injury occurred
- You speak English
Age Range
19 years and up -
Testing Acolbifene vs Low Dose Tamoxifen to Prevent Breast Cancer
Official Title Phase IIA Trial of Acolbifene (20 mg) vs Low Dose Tamoxifen (5 mg) in Pre-menopausal Women at High Risk for Development of Breast CancerPurpose
This study wants to see if two medicines, acolbifene or a small dose of tamoxifen, can lower the chance of getting breast cancer in women who are at high risk before menopause.
Acolbifene and tamoxifen work by blocking estrogen, a hormone that can help cancer cells grow. By blocking estrogen, these medicines may lower the chance of breast cancer in women at high risk. The study lasts between 6 and 8 months.
If this study works, it could give us new ways to help prevent breast cancer.
Could this study be right for you?
- Pre-menopausal
- At increased risk of breast cancer, due to genetic mutation, family history, prior DCIS, LCIS, or atypical hyperplasia
- Seen in Stefanie Spielman Comprehensive Breast Cancer Center in Columbus, OH
Age Range
35 years and up -
Blocking Orexin Receptors to Help Treat Alcohol Addiction and Stress-Driven Drinking
Official Title OASIS - Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related DrinkingPurpose
This study will look at whether suvorexant can help treat alcohol use disorder, how it works, and who it works best for. Suvorexant is a medicine that blocks certain brain signals linked to wakefulness.
Your total participation time in this study will be approximately 9 weeks.
Could this study be right for you?
Inclusion Criteria:
- Age 18-65
- Participant is able to give informed consent
- Engage in heavy alcohol use defined as drinking ≥14 standard drinks per week if male and ≥7 standard drinks per week if female.
General - Exclusion Criteria
- Clinically significant medical or neurological condition (e.g., liver disease, narcolepsy, complex sleep behaviors, severe hepatic impairment, COPD, severe obstructive sleep apnea)
- Current or past DSM-5 diagnosis of mania, schizophrenia, psychosis
- Past suicide attempt within 3 years or presence of moderate suicidal ideation
- Engage in night-shift work
Age Range
18 - 65 years -
Help Co-design a New Emotion Mapping Tool to Improve Patient-Provider Communication
Official Title Co-designing a Emotion Mapping Tool to Enhance Patient-Provider CommunicationPurpose
The objective of this research is to co-design with former inpatients to gradually refine and reimagine an emotion mapping toolkit through co-design workshops hosted at The Ohio State University (OSU) campus.
This research will ultimately inform future work aimed at enhancing patient engagement, emotional empowerment, and satisfaction through improved communication practices and the creation of actionable emotional data in healthcare settings.Your time involved with this study will be approximately 1 hour.
Could this study be right for you?
- Former inpatient who had been hospitalized for 3 or more days within the last 6 months
- Able to attend in-person workshop at The Ohio State University Columbus Campus
Age Range
18 years and up -
Improving Physical Ability and Cellular Senescence Elimination in HIV
Official Title Improving Physical Ability and Cellular Senescence Elimination in HIV (IPACE-HIV)Purpose
The purpose of this study is to evaluate the safety and tolerability of dasatinib and quercetin (D+Q) and efficacy of this regimen in improving physical function outcomes in people with HIV (PWH) who are frail or prefrail.
Could this study be right for you?
- People living with HIV ≥50 years diagnosed with HIV 10 or more years ago
- Currently on combination antiretroviral therapy
- Currently virologically suppressed
- Must meet FFP criteria & have 4-meter gait speed in the range of .5-1.2 m/sec
Age Range
50 years and up