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IMPROVE-AD Trial: IMPRoving Outcomes in Vascular DisEase
Official Title IMPROVE-AD Trial: IMPRoving Outcomes in Vascular DisEase – Aortic DissectionPurpose
The goal of this study is to figure out the best way to treat type aortic dissection. An aortic dissection is a tear in the wall of the aorta. The aorta is a big blood vessel that carries blood from your heart to the rest of your body. Individuals with this problem usually get medicine or a special repair procedure. This procedure is called thoracic endovascular aortic repair (TEVAR). TEVAR is a procedure where a metal tube (called a stent), is inserted in the damaged part of the aorta. The study is being done to figure out which treatment works better. The results of the study may help to prevent future problems with the aorta or other health issues.
Could this study be right for you?
Inclusion:
- Age > 21 years
- Stanford type B aortic dissection not involving the aorta at or proximal to the innominate artery, without rupture and/or malperfusion (renal, mesenteric, or extremity)
- Acuity: within 48 hours – 6 weeks of index admission
Exclusion criteria:- Ongoing systemic infection
- Pregnant or planning to become pregnant in the next 3 months
- Life expectancy related to non-aortic conditions < 2 years
- Prior surgery for aortic dissection
Age Range
21 years and up -
AAA-SHAPE Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Expansion
Official Title AAA-SHAPE Pivotal Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of ExpansionPurpose
The purpose of this research is to determine if the IMPEDE-FX RapidFill System is safe and helps to shrink abdominal aortic aneurysm (AAA - a bulge or swelling due to weakening of the walls of the aorta, which is the main blood vessel that carries blood from your heart to other parts of your body) sacs after an endovascular stent graft (a fabric tube supported by metal wire stents that reinforces a weakened aorta) has been placed. The IMPEDE-FX RapidFill System used in this study is classified as investigational, which means it has not been approved by the Food and Drug Administration (FDA).
Could this study be right for you?
Inclusion:
- A candidate for elective EVAR of an infrarenal fusiform aortic aneurysm ≥5.5 cm in diameter in men and ≥ 5.0 cm in women
- Thrombus burden (percentage of the AAA sac occupied by thrombus) <50%, based on pre-procedure CTA
- Maximum Lumen diameter within the AAA sac of ≥40mm
- The predicted minimum number of IMPEDE-FX RapidFill Implants for the subject is ≤200
Exclusion:
- An inability to provide informed consent
- Enrolled in another clinical study that could interfere with the outcomes being studied in this trial
- Unable or unwilling to comply with study follow-up requirements
Inclusion and Exclusion Criteria varies, please contact Study Coordinator for more information.
Age Range
18 years and up -
Comparing How Different Racial and Ethnic Groups Raise Their Children
Official Title Testing Equivalence of Measures of Parental Socialization Beliefs and Behaviors Across Racial/Ethnic GroupsPurpose
This study aims to investigate the similarity and differences in parents' beliefs and practices across racial/ethnic backgrounds.
Could this study be right for you?
Eligibility Criteria includes:
- Must be proficient in written English
- You are parents of a child aged 3 to 10, who was born in the U.S.
Age Range
18 - 80 years -
Operating microscope versus traditional dental loupes - improving the view of dental surgery to save dental implants.
Official Title Operating Microscope versus Traditional Loupes during Regeneration Therapy for Peri-implantitis: A Randomized Controlled Trial with Ultrasonographic and Biomarkers EvaluationPurpose
The purpose of this study is to compare the one-year outcomes of treating peri-implantitis with periodontal surgical means between the use of an Operating Microscope and dental loupes.
This study includes the comparisons of the changes of inflammation of the gums, the bacteria present, and wound healing at the surgical site between the two methods. The hypothesis is that the use of the operating microscope, compared to dental loupes, is associated with better bacteria removal, quicker inflammatory resolution, and improved wound healing, which will contribute to better outcomes.
Could this study be right for you?
Inclusion criteria: Participant has at least one implant indicated for peri-implant regenerative treatment.
Exclusion criteria: Participant has known systemic conditions and medication interactions that can affect healing of the surgical site.
Age Range
18 - 99 years -
Bisexual Health and Relationships Project
Official Title Bisexual Health and Relationships ProjectPurpose
The purpose of this study is to better understand the health behaviors and health outcomes for married bisexual people.
Could this study be right for you?
Our study examines the health of married Bi+ (defined as bisexual, pansexual, queer, etc.) people. We are interviewing both Bi+ individuals and their partners over Zoom. We are specifically looking to speak with Bi+ men married to men and Bi+ people of color of any gender.
Age Range
35 - 65 years -
A Study for Veterans with Post-Traumatic Stress Disorder (PTSD)
Official Title Examining the safety and clinical efficacy of psilocybin therapy for Veterans with PTSD: An open label proof-of-concept trialPurpose
The study will demonstrate the safety and efficacy of psilocybin in treating post-traumatic stress disorder (PTSD) in veterans. Psilocybin-assisted therapy has shown great promise in treating anxiety symptoms that comprise post-traumatic stress disorder (PTSD). Current therapeutic treatments for PTSD are difficult to tolerate and limited in efficacy, especially in the US military veteran population. This study will examine the safety and efficacy of two psilocybin sessions, combined with psychotherapy, among military veterans with severe, treatment resistant PTSD.
Could this study be right for you?
Inclusion criteria:
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Be a United States military veteran
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21 to 64 years old
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Have at least a high-school level of education or equivalent (e.g. GED)
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Current diagnosis of PTSD
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Be medically stable as determined by screening for medical problems via a personal interview, a medical questionnaire, a physical examination, an electrocardiogram (ECG), and routine medical blood and urinalysis laboratory tests
Exclusion criteria:
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Women who are pregnant
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Cardiovascular conditions: coronary artery disease, stroke, angina, uncontrolled hypertension, a clinically significant ECG abnormality (e.g., atrial fibrilation), artificial heart valve, or TIA in the past year
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High blood pressure
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History of seizures or epilepsy
Exclusion Criteria varies, please contact Study Coordinator.
Age Range
21 - 64 years -
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Study Evaluating the Tears of the Eye
Official Title Lipid Composition of the Tear Film in Healthy Participants and Dry Eye Disease PatientsPurpose
The purpose of this study is to explore the lipid concentration of the tear film in healthy participants and those who have dry eye disease.
Could this study be right for you?
Inclusion criteria:
- At least 18 years of age (30 years of age for dry eye disease cohort).
- Good general health (defined by medication use that has not changed within the last month and the absence of medical conditions or treatments that are deemed confounding to the data as determined by the PI)
- Ability to give informed consent
- Willing to spend time for the study; approximately one hour for study assessments
- Either gender
Exclusion criteria:
- Use of any ocular prescription medication (such as but not limited to, glaucoma medications, anti-inflammatory eye drops and Restasis) used within 14 days of the screening visit or started prior to the measurement visit(s).
- Currently having punctal plugs inserted in lacrimal puncta
Inclusion and Exclusion Criteria varies, please contact Study Coordinator for more information.
Age Range
18 years and up -
A Study about How Essential Oil Inhalers and a Wearable TENS Unit Affect Nausea and Stress
Official Title AROMA-NT: Assessment of the Mechanisms of Action of Inhaled Essential Oils and Wearable TENS unit device on NauseaPurpose
The purpose of this research study is to understand how a combination of two aromatic inhalers containing a blend of essential oils and a wearable TENS unit affects nausea and stress in those suffering from chronic nausea and anxiety.
Could this study be right for you?
- Able to understand English
- Nausea going on for longer than 6 months
Age Range
18 - 80 years -
Preschooler's Language Use and Media (PLUM) Study
Official Title Preschooler's Language Use and Media (PLUM) StudyPurpose
This study is designed to investigate media’s role in language development during early childhood. The goal of the proposed work is to examine the relation between the quantity of children’s media use and their language development trajectories, as well as how characteristics of media use (i.e., parent-child joint engagement, interactive media features, and educational content) predict growth in language over time.
Could this study be right for you?
- Children 3 to 3.5 years of age (36 to 42 months).
Age Range
36 - 42 months -
Project Limb Rescue: A pilot study evaluating the feasibility of transcutaneous sensors for the detection of cancer-related lymphedema.
Official Title Project Limb Rescue: A pilot study evaluating the feasibility of transcutaneous sensors for the detection of cancer-related lymphedemaPurpose
The goal of this study is to use new, adhesive-based sensors (pads that stick on your skin) to detect lymphedema, and to develop a way for patients to check for lymphedema at home.
This study will assist in distinguishing participants with lymphedema in comparison to participants without lymphedema at rest by using a combination of photoplethysmography (PPG) and bioimpedance (BI). Photoplethysmography is an optical technique that can be used to detect blood volume changes in tissue. Bioimpedance evaluates how tissue responds to an externally applied electrical current.
Could this study be right for you?
- History of cancer related lymphedema, cancer in your arm, or the lymph nodes in the arm
- History of cancer therapy with surgery or radiation involving the axillary basin and upper arm that requires compression or pneumatic therapy
- Physically capable of performing a brief bike riding exercise for about seven minutes
- No metal implants
- Willingness to take off shoes and any metal jewelry
- Not currently pregnant
- Not currently incarcerated
Age Range
18 - 90 years