A Study to Examine Sex Differences in Pain Reports and Brain Activation in Older Adults with Alzheimer's Disease

Official Title
Sex Differences in Pain Reports and Brain Activation in Older Adults with Alzheimer's Disease
Purpose

The purpose of this study is to examine how men and women with and without dementia might perceive and respond to pain or discomfort.

Participants may complete various questionnaires by phone or video conferencing once a week for up to 8 weeks with an optional MRI screening.

Could this study be right for you?

• Men and women aged 60 years or older
• Dementia or memory issues

Participants and their caregiver (if applicable) may complete only 1 day of the study, or they may complete as many as they would like for up to 8 days total.

Age Range
60 and up

A Study about Pain Sensitivity and Unpleasantness in People with Alzheimer's Disease and Cancer

Official Title
Pain Sensitivity and Unpleasantness in People with Alzheimer's Disease and Cancer
Purpose

The purpose of this study is to examine how men and women with dementia and/or cancer might process and respond to pain or discomfort.

Participants may complete various questionnaires by phone or video conferencing once a week for up to 7 weeks with one optional in-person session.

Could this study be right for you?

• Men and women aged 60 years or older
• Dementia or memory issues
• Cancer (any type excluding brain cancer)
• Dementia or memory issues and cancer (any type excluding brain cancer)

Age Range
60 and up

Fertility and Contraception Among African Immigrants in the United States

Official Title
Fertility Desires and Demand for Modern Contraception Among African Immigrants in the United States
Purpose

The purpose of the study is to learn about how African immigrants make decisions about childbearing, both individually and as a couple, the role of modern contraception in helping them achieve their fertility desires and the effect of migration on their childbearing desires.

Could this study be right for you?

- Nigerian immigrant men and women of reproductive age (18-45 years) and,
- Are in a relationship (dating, engaged or married)

Age Range
18 and up

A study on language impairment following a stroke

Official Title
Laying the Groundwork for Personalized Medicine in Aphasia Therapy: Genetic and Cognitive Predictors of Restorative Treatment Response
Purpose

This NIH-funded project will investigate patient-specific factors that may influence response to therapy for language impairment after stroke, or aphasia. Results from this work will assist with better estimation of prognosis for stroke survivors with aphasia, which could empower patients and families to make more informed health care decisions about how to pursue the most appropriate rehabilitation services based on their unique characteristics, such as genetics, cognitive skills, and brain structure after stroke.

Could this study be right for you?

Participants must meet the following criteria:
- Native English speaker
- Able to have an MRI
- Had only one stroke (in the left hemisphere of the brain)

Age Range
18 and up

Keto Prescribed+: A Healthy Thinking and Eating Program

Official Title
Healthy Lifestyle Behaviors and Beliefs of African American Women
Purpose

Evaluate factors that influence African American women’s healthy lifestyle behaviors and beliefs. A descriptive study using anonymous survey data.

Could this study be right for you?

Adult African American/Black women

Age Range
18 and up

Intervention to Improve Teen Driving

Official Title
A Hybrid Effectiveness-Implementation Trial to Improve Safe Driving among Teen Drivers with Traffic Violations
Purpose

The purpose of this study is to test the effects of an in-vehicle driving feedback technology, with and without parent training, on parent-teen communications as well as teens' risky driving behaviors, unsafe driving behaviors, and subsequent traffic violations.

Could this study be right for you?

In order to be eligible:
- You must be 16 -18 years of age
- Need a valid State of Ohio driver's license (no learner's permit)
- Proof of car insurance
- Must drive more than one hour per week

Age Range
16 and up

Studying the Effects Nitrous Oxide (Laughing Gas) Has on Aggression

Official Title
Nitrous Oxide and Cortico-Limbic Function in Aggression (Laughing Gas Study or LGS).
Purpose

The purpose of this study is to see how laughing gas (nitrous oxide) changes brain activity in study participants with and without “anger issues”. Brain activity is measured by Magnetic Resonance Imaging.

The length of time you will be involved in this study will be 4-8 weeks.

Could this study be right for you?

- You are a medically healthy man or woman
- You are between the ages of 21 and 55 years of age
- Do not abuse alcohol or other drugs
- With a current history of “anger issues”
- Able to complete study sessions during the week

Age Range
21 and up

Adjusting to Life After COVID-19

Official Title
Adjusting to Life After COVID-19
Purpose

This study looks at what is helping people adjust to the changes caused by the COVID-19 pandemic so that we may understand what could help people adapt to crises in the future. This information could benefit with the understanding and improvement of treatments for conditions such as depression and anxiety.

The study will examine the experience of psychological symptoms, adaptability, and coping over time.

Could this study be right for you?

You may eligible for this study if you are:
• 18 years of age or older
• Currently unemployed or laid off
• Be considered high risk if infected with COVID-19 (e.g., being 65 or older or having an underlying health condition).
• Have NOT had a positive COVID-19 test result
• Do NOT have an immunity to COVID-19

Age Range
18 and up

A Study to Evaluate Baricitinib in Adults with Severe or Very Severe Alopecia Areata

Official Title
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Operationally Seamless, Adaptive Phase 2/3 Study to Evaluate the Efficacy and Safety of Baricitinib in Adult Patients with Severe or Very Severe Alopecia Areata (JAHO)
Purpose

The main reason for you to take part in this study is not to treat you for your condition but to help in answering the following research questions:
• Whether baricitinib is better than placebo in the treatment of patients with severe alopecia areata (AA)
• The safety of baricitinib and any side effects you may have when you take it.

Could this study be right for you?

- Are at least 18 years and ≤60 years for males (≤70 years of age for females) at
the time of informed consent

- Are able to read, understand, and give documented (electronic or paper
signature) informed consent

- Current AA episode of more than 6 months’ duration and hair loss
encompassing ≥50% of the scalp

- No spontaneous improvement over the past 6 months

Age Range
18 and up

An Intervention Study for Subjects with Palmoplantar Pustulosis

Official Title
ANB019-003: A Phase II, Randomized, Placebo-controlled, Double-blind, Multiple Dose Study to Evaluate the Efficacy and Safety of ANB019 in Subjects with Palmoplantar Pustulosis
Purpose

This study is being done to assess the effects of the experimental study drug (ANB019) in patients with PPP.

Could this study be right for you?

- Must have a clinical diagnosis of PPP for at least 6 months prior to screening
- Must have active pustules on palms and/or soles of feet
- BMI must be within the range of 18-36 kg/m2
- Subjects must be in otherwise good health
- Must not have any suspected autoimmune disorder or immune deficiency
- No major surgeries in the past 4 weeks
- No history of malignancy in the past 5 years
- No history of drug, alcohol, or other substance abuse

Age Range
18 and up