Radiotracer Imaging of Lower Extremity Skeletal Muscle Perfusion in Patients with Peripheral Arterial Disease (PAD)
Purpose
The purpose of the study is to evaluate the usefulness of a new imaging method that measures blood flow to the calves and feet.
A group of patients with a history of peripheral artery disease (PAD) will have blood flow to their legs and/or feet evaluated using a nuclear imaging technique called positron emission tomography (PET). A separate group of patients with PAD who are scheduled to undergo a revascularization procedure on their leg (such as balloon angioplasty, stent placement, or bypass surgery) will undergo PET imaging before and after their surgical intervention to evaluate how the intervention improved blood flow to their leg.
In addition to patients with PAD undergoing imaging studies, we will also recruit and image healthy volunteers to establish a normal healthy database of blood flow values for our new imaging method.
Patients with PAD will be evaluated for up to 18 months after their imaging study visit to evaluate how their blood flow values are related to their clinical outcomes, such as rates of diabetic wound healing and amputation. Outcomes will be monitored through medical chart review and through follow-up visits at OSU-affiliated clinics.
Could this study be right for you?
We are interested in recruiting healthy volunteers with no known history of cardiovascular disease or diabetes mellitus.
OR
Patients with previously diagnosed peripheral artery disease.