Cardiovascular Effects of Ketone Ester Ingestion
This study is intended to evaluate the effects of a drink supplement on heart function and health in healthy adults after consuming a ketone ester (KE) supplement drink compared to a placebo drink.
You will undergo an MRI exam for this study. You will also receive six blood draws in total, from an IV catheter set at the beginning of the study.
The duration of this study will comprise a single visit and will last no longer than 4 hours.
Inclusion:
- Able to comply with study requirements as well as pre-test requirements
- BMI between 18 and 30 kg/m2
- Body weight > 150lbs
Exclusion:
Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including:
- Pregnancy
- Allergies to components in the test products, including milk protein, and not lactose intolerant
- History of alcoholism (previous 2 years)
- Taking prescriptive medications or over-the-counter (OTC) medications (other than those taken as nutritional supplements for non-therapeutic indications)
- Current smoker
- Contraindications to MRI including cardiac pacemaker or defibrillator, brain aneurysm clips, neuro-stimulator, the presence of any magnetic metal in the body or claustrophobia
Exclusion Criteria varies, please contact Study Coordinator for more information.
A Study to Evaluate E-Cigarette Nicotine Form, Concentration, and Flavor Among Youth
The purpose of this study is to examine the influence of nicotine form, concentration, and e-liquid flavor on youth vaping as well as the heart and lung effects associated with this behavior. You will be asked to attend 9 vaping sessions at The Ohio State University.
Your participation in this study will last up to 6 months.
• Male or females aged 21-25 years old
• Current E-Cigarette user
• Able to attend 9 vaping sessions at The Ohio State University
A Study to Examine Atropine for the Reduction of Nearsightedness (The CHAPERONE Study)
The purpose of this study to test the safety and effectiveness of atropine 0.1% and atropine 0.01% eye solutions. These drugs are being tested to see if they slow the worsening of nearsightedness.
Children who participate in this study will be asked to use their assigned study medication every night and willing to attend visits at The Ohio State University of Optometry 1 month after starting treatment. These visits will continue for 6 months until the duration of the study ends.
This study will take place over a 4-year time period.
· Children aged 3 to < 13 years old.
· No previous use of medications related to myopia control.
· Glasses and/or contact lens prescription between -1.00 and -6.00 diopters.
Interested guardians who believe their child may be eligible should contact study coordinators to further determine eligibility
A Study Evaluating How Heart Disease Affects School Readiness in Children
The purpose of the p-SCHOLAR study is to learn about how congenital heart disease (CHD) might be related to school readiness and development in young children.
This is a single-study visit that will last approximately 3 hours and take place at Nationwide Children's Hospital.
During the 3-hour study visit, we will measure the child's thinking skills, knowledge of letters and numbers, and their behavior. We will also ask the caregiver to complete a set of surveys and a short interview about the child.
If the child is enrolled in a preschool or another educational program, their teacher will have the opportunity to participate in the study as well.
- Legal guardians and their child aged 4 or 5 years old
- Children who have not yet started kindergarten
- Children with no history of congenital heart defects (CHD), traumatic brain injury (TBI), or genetic conditions known to affect cognition
- Children with no severe hearing or vision impairments
- Children born full term (gestational age ≥ 37 weeks)
- Children and caregivers fluent in English
Fertility and Contraception Among African Immigrants in the United States
The purpose of the study is to learn about how African immigrants make decisions about childbearing, both individually and as a couple, the role of modern contraception in helping them achieve their fertility desires and the effect of migration on their childbearing desires.
- Nigerian immigrant men and women of reproductive age (18-45 years) and,
- Are in a relationship (dating, engaged or married)
A Study Evaluating Cognition, Insulin Resistance and Omega-3s (RACIR O-3) in Breast Cancer Survivors
We are studying the relationships between cognitive function, insulin resistance, and omega-3 fatty acids in the blood and from the diet among breast cancer survivors and women without a history of cancer diagnoses. We hope to learn more about how to potentially protect breast cancer patients from uncomfortable mental changes during and after treatment for breast cancer, such as “chemo brain”.
This is a completely remote study, meaning all study tasks can be completed from the comfort of home. Enrolled participants will complete several online surveys and questionnaires, a Zoom video call for additional assessments, and will be sent materials to complete finger-stick blood sample collections from the comfort of home over a period of 3-4 weeks.
The information we gain from this research study will help us design a future clinical trial to test if dietary interventions can help reduce or prevent cognitive changes like chemo brain in breast cancer patients.
- Accepts healthy volunteers - YES
- Females
- Age 45-75 years
- Post-menopausal (at least 12 months no menses)
- Stage I-III Breast Cancer diagnosis
- 1-4 years post initial breast cancer diagnosis
- No diagnosis of diabetes
- English speaking
COVID-19 Determinants of Disease Severity, Perinatal Transmission, and Immune Response to COVID-19 Vaccine
To identify the factors that determine disease severity, immune development, and perinatal transmission in COVID-19 infections.
Inclusion criteria
Cohorts 1: Suspected/Infected Individuals (inpatient or outpatient)
1) All ages
2) Suspected or confirmed COVID-19 infection
3) Parents, guardians or patients over the age of 18 years of age must sign the informed consent; and children older than 9 years of age should sign assent, as required.
Cohort 2: Pregnant Women and/or their Infants*
1) Suspected or confirmed COVID-19 infection AND
2) Pregnant women in any stage of gestation, or within 14 days of a 20+ week gestation delivery; we may enroll mothers alone in situations where they choose for their newborn to not participate OR
3) Infants born to eligible mothers; in situations where the mother does not participate in the study, we may enroll infants born to infected women individually into this cohort
*Pregnant women without suspected or confirmed COVID-19 infection will also be enrolled as a healthy control group and will follow the same visit schedule.
Cohort 3 Vaccinated Children, Adults, Pregnant/Lactating Women and/or their Infants
• Pregnant/lactating women with intent to receive a COVID-19 vaccine; we may enroll mothers alone in situation where they choose for their newborn to not participate OR
• Infants born to eligible mothers; in situations where the mother chooses not to participate in the study, we may enroll their infant separately. OR
• Children/Adults of any age with intent to receive a COVID-19 vaccine
Cohort 4 Healthy Controls
• Anyone without an acute illness at the time of enrollment who agrees to participate in the study.
Exclusion criteria
a) Individuals who refuse participation in the study.
A Study Evaluating Brain Development and Behavior in Children
The purpose of the study is to investigate how the brain develops and how it leads to our own unique behavior later on in life. We are studying children as they start school and learn new skills, and following up with them as they grow.
Children will perform computer based tasks such as seeing colorful faces, objects, and scenes, watching or listening to stimuli and making a response (e.g., button or verbal response), or move areas of his/her body (e.g., tapping his/her fingers) while we monitor their brain activity using functional Magnetic Resonance Imaging (fMRI). We may also monitor the participant’s eye position with a special eye-tracking camera so that we can assess where the participants are looking during the tasks.
The total length of the study will be between 3 and 5 hours, including up to 3 hours outside the MRI scanner and 2 hours in the scanner. Because the purpose of this study is to track development in each individual across time, we will ask you if you would like to participate in subsequent scan sessions as your child gets older.
- Children ages 3-15 years of age
- Born at greater than 37 weeks or to term
- no family history of mental illness
- No alcohol or drug use
- normal vision and hearing
- Native English speakers
Adult Eye Tracking Study
The purpose of this study is to better understand learning, memory and attention development from childhood to adulthood using eye-tracking techniques.
This study will include one lab visit which will take place on Ohio State's main campus and will last approximately 40-60 minutes.
Eligibility Criteria:
- Must be 18 and 35 years of age
- Have normal or corrected to normal vision
A Study Evaluationg Decision-making for Young Adults, Older Adults, and Adults with Early Alzheimer’s Disease and Mild Cognitive Impairment
The goal of this study is to develop models to better understand decision-making for young adults, older adults, and adults with early Alzheimer’s disease and Mild Cognitive Impairment.
This study involves making simple decisions (such as “are there more blue dots or more yellow dots?”) on a computer. Healthy volunteers will also complete basic tasks such as solving puzzles, questionnaires involving numbers, and will be asked to provide basic demographic and health information.
You may be eligible for this study if:
- You are ages 18-25 OR
- You are age 60-90 and have NOT been diagnosed with a memory disorder OR
- You are age 60-90 and HAVE been diagnosed with either Mild Cognitive Impairment OR mild Alzheimer's disease
- You are a native English speaker
- You are able to see a computer screen and use hands on keyboard/screen