A Study for Patients with Hypereosinophilic Syndrome (HES)
The purpose of this study is to see if benralizumab (biologic drug), given as injections under the skin, can help control your Hypereosinophilic Syndrome (HES) better if it is added to available standard of care HES medications which you may be currently taking.
HES (Hypereosinophilic Syndrome) is a disease characterized by high levels of eosinophils (a particular type of white blood cell) in your blood and a build-up of eosinophils in some organs and tissues (like skin, heart, lungs, intestines or others) causing their dysfunction.
The duration of the study will last 18 months.
- Eosinophil (a type of white blood cells) count ≥ 1000 cells/μL at screening
- Documented diagnosis of Hypereosinophilic Syndrome (HES)
- History of persistent eosinophilia >1500 cells/μL (at least 2 examinations, interval ≥1 month)
- End organ manifestations attributable to the eosinophilia
Inclusion and Exclusion Criteria varies, please contact Study Coordinator for more information.
Development of a Non-Invasive Medical Device to Measure Troponin
Clinicians use heart proteins to help them detect when there are heart problems (for example, heart attacks). Currently heart proteins can only be measured with blood work. The purpose of this research is to measure heart proteins using a non-invasive device.
The duration of this study will last one hour.
- Participant is willing to provide a blood sample
- Participant must complete a brief eligibility survey
A Study for Participants with Type 2 Diabetes Mellitus and Atrial Fibrillation
The purpose of this study is to examine the effects of glucose levels on atrial fibrillation episodes in people with diabetes and history of atrial fibrillation.
The duration of the study lasts 6 months.
- Participants diagnosed with type 2 diabetes mellitus
- Body mass index between 25 and 45 kg/m2
- Insulin use at least 10 units per day or more than 1 glucose lowering medication with a hemoglobin A1c greater than 7%
- ICM placement
- Paroxysmal atrial fibrillation (irregular heartbeat that goes back to normal after a week) or atrial fibrillation ablation (procedure to treat irregular heartbeat) within 30 days
Buckeye Concussion Knowledge Survey (BUCKS)
The purpose of this study is to examine health outcomes in former Ohio State University athletes who played a varsity sport during their time at OSU. The objective is to determine whether athletes who sustained a concussion have different health outcomes than those who did not sustain a concussion. Any former OSU varsity athlete can participate in a 20-minute online survey.
- Anyone who has played a varsity sport as an undergraduate student at OSU, and they have now graduated (i.e., OSU athlete alumni). There are no other restrictions in terms of age, sex/gender, type of sport, etc.
Blood Pressure Health for Black/African American Women Caregivers
The purpose of this study is to determine the feasibility of a group delivered intervention for stress and blood pressure in African American women caregivers.
- Diagnosis of HTN treated with an antihypertensive medication or risk of HTN that includes obesity and high cholesterol
- Age 40 and older
- A caregiver rating of the PLWD of 2 or greater on the Alzheimer’s Dementia-8 scale
- Caregiver provides unpaid care to a PLWD at least 10 hours per week or assists with at least one instrumental activity of daily living
- Self-identifies as Black/African American
- English speaking
- Access to a telecommunications device such as the internet via desktop, laptop/tablet, smartphone, or telephone
Cardiovascular Effects of Ketone Ester Ingestion
This study is intended to evaluate the effects of a drink supplement on heart function and health in healthy adults after consuming a ketone ester (KE) supplement drink compared to a placebo drink.
You will undergo an MRI exam for this study. You will also receive six blood draws in total, from an IV catheter set at the beginning of the study.
The duration of this study will comprise a single visit and will last no longer than 4 hours.
Inclusion:
- Able to comply with study requirements as well as pre-test requirements
- BMI between 18 and 30 kg/m2
- Body weight > 150lbs
Exclusion:
Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including:
- Pregnancy
- Allergies to components in the test products, including milk protein, and not lactose intolerant
- History of alcoholism (previous 2 years)
- Taking prescriptive medications or over-the-counter (OTC) medications (other than those taken as nutritional supplements for non-therapeutic indications)
- Current smoker
- Contraindications to MRI including cardiac pacemaker or defibrillator, brain aneurysm clips, neuro-stimulator, the presence of any magnetic metal in the body or claustrophobia
Exclusion Criteria varies, please contact Study Coordinator for more information.
Evaluating a Mobile Health App for Cardio-Oncology Patients
To evaluate the cardio-oncology patient population’s experience with using smart-phone technology as a part of self-management with their care through features such as symptom logging and education. Eligible patients will be asked to participate in a 30-minute virtual interview and/or a 60-minute virtual design or usability session to discuss their thoughts on a mobile app for cardio-oncology patients.
- English-speaking - Prior cancer diagnosis - Currently undergoing a cancer regimen that includes a targeted, biologic, radiation, and/or immune-based therapy (ex. TKIs and/or ICIs). - No pregnant females - No prisoners
A Study for Those Going Through Cardiac Rehabilitation--Measurement of Mitochondrial Dysfunction in Those with and without Diabetes
We are looking at parts of the cells in our bodies (called mitochondria). Mitochondria give our cells energy and help them stay healthy. People with diabetes have mitochondria which do not work as well as the mitochondria in people without diabetes.
In this study, we want to see if exercise (cardiac rehabilitation) will cause your mitochondria to work better. Using a magnetic resonance imaging (MRI) machine, we can measure how much your cardiac rehabilitation has helped your mitochondria. We will be looking at your leg muscle and the mitochondria in those cells.
In this study, we hope to show that we can help those with diabetes by making their mitochondria work better using things like exercise. We will be looking for people who are beginning cardiac rehabilitation, some with and some without diabetes.
- 18 yrs and older
- Have been referred for cardiac rehabilitation
- Are able to have an MRI (study coordinator can screen you for this)