Cardiovascular Effects of Ketone Ester Ingestion

Official Title
Cardiovascular Effects of Acute Ketone Ester Ingestion in Healthy Adults
Purpose

This study is intended to evaluate the effects of a drink supplement on heart function and health in healthy adults after consuming a ketone ester (KE) supplement drink compared to a placebo drink.

You will undergo an MRI exam for this study. You will also receive six blood draws in total, from an IV catheter set at the beginning of the study. 

The duration of this study will comprise a single visit and will last no longer than 4 hours. 

Could this study be right for you?

Inclusion:

  • Able to comply with study requirements as well as pre-test requirements
  • BMI between 18 and 30 kg/m2
  • Body weight > 150lbs

Exclusion:

Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including:

  • Pregnancy 
  • Allergies to components in the test products, including milk protein, and not lactose intolerant
  • History of alcoholism (previous 2 years)
  • Taking prescriptive medications or over-the-counter (OTC) medications (other than those taken as nutritional supplements for non-therapeutic indications)
  • Current smoker
  • Contraindications to MRI including cardiac pacemaker or defibrillator, brain aneurysm clips, neuro-stimulator, the presence of any magnetic metal in the body or claustrophobia

Exclusion Criteria varies, please contact Study Coordinator for more information. 

Age Range
18 - 65

A Study for Those Going Through Cardiac Rehabilitation--Measurement of Mitochondrial Dysfunction in Those with and without Diabetes

Official Title
Measurement of Mitochondrial Dysfunction Using Phosphorus Magnetic Resonance Spectroscopy in Diabetic Patients Undergoing an Exercise Regimen
Purpose

We are looking at parts of the cells in our bodies (called mitochondria). Mitochondria give our cells energy and help them stay healthy. People with diabetes have mitochondria which do not work as well as the mitochondria in people without diabetes.

In this study, we want to see if exercise (cardiac rehabilitation) will cause your mitochondria to work better. Using a magnetic resonance imaging (MRI) machine, we can measure how much your cardiac rehabilitation has helped your mitochondria. We will be looking at your leg muscle and the mitochondria in those cells.

In this study, we hope to show that we can help those with diabetes by making their mitochondria work better using things like exercise. We will be looking for people who are beginning cardiac rehabilitation, some with and some without diabetes.

Could this study be right for you?

- 18 yrs and older
- Have been referred for cardiac rehabilitation
- Are able to have an MRI (study coordinator can screen you for this)

Age Range
18 and up