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Exercise MRI Study
Official Title Exercise Stress CMR to Identify Myocardial DysfunctionPurpose
The purpose of this study is to compare heart MRI images taken at rest and during exercise to look for signs of heart problems.
Could this study be right for you?
Researchers are studying a new cardiac MRI exercise test that may help doctors better diagnose heart muscle disease (cardiomyopathy).
You may be eligible if you:
Are a healthy adult volunteer
Have shortness of breath at rest or during activity
Had an abnormal heart imaging test but do not have symptoms
What Will Happen?
Participants will complete one exercise cardiac MRI scan as part of this research study.Age Range
18 - 80 years -
Heart2Heart Research Study
Official Title Creating a Mobile Health Program for Teens with Congenital Heart Disease (“Heart2Heart Research Study”)Purpose
The study aims to understand what teens with congenital heart disease want and need in mobile health program that helps them learn about their heart health and overall wellness.
Could this study be right for you?
Enrollment is by invitation only. The study team will contact you if you are eligible to participate.
Age Range
12 - 18 years -
Food and Fitness with Medicine
Official Title Food and Fitness with MedicinePurpose
We are conducting a new study to explore whether a supportive program that combines healthy eating, enjoyable physical activity, and practical resources can improve health in postmenopausal women living with heart, kidney, or metabolic conditions who are using weight‑management medications. As more women use these medications, researchers want to understand how they can be paired with supportive lifestyle changes like nourishing food and enjoyable movement to improve overall health.
As more women turn to these medications, there is an important need to understand how they work best alongside real‑world lifestyle supports. This study aims to answer that question.
Depending on your group, you may also take part in activities such as personalized nutrition counseling, cooking demonstrations, groceries or vouchers, structured fitness, and optional online or at‑home resources. The goal of this research is to understand what truly helps people build and maintain healthy habits over time. By participating, you can contribute to research that will help guide future care and improve health programs for women like you.
Could this study be right for you?
Eligibility criteria:
- Post-menopausal
- Have at least one of the following conditions: hypertension, type 2 diabetes, high triglycerides, metabolic syndrome, moderate CKD
- Plan to start a GLP-1 medication or have started a GLP-1 medication within the last 6 weeks
Age Range
45 - 79 years -
Smartphone-based HIV-specific Smoking Cessation Study
Official Title AMC-111 Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility StudyPurpose
This clinical trial evaluates the usefulness of using a smartphone-based HIV-specific smoking cessation intervention at the time of lung cancer screening in helping people living with HIV quit smoking. Positively Smoke Free - Mobile may help patients with HIV quit smoking.
In this study, you will have lung cancer screening performed via a CT scan. You will also be enrolled into a self-guided smartphone-based HIV-specific smoking cessation intervention called “Positively Smoke Free - Mobile” lasting 42 days. After starting the intervention, you will be evaluated at 3, 6, and 12 months.
Could this study be right for you?
Must have at least a 20 pack-year history of smoking (a way to measure how much a person has smoked over time, 1 pack-year is a pack per day for a year or 2 packs of cigarettes for half a year, etc.)
Must have not had a CT scan in the past 12 months
HIV positive, and must be receiving antiretroviral therapy and have a CD4 count of at least 200cells/uL within 6 months of enrolling in the study
Able to understand and provide informed consent
Possess a smart phone that can browse the web
Not receiving any other smoking cessation interventions currently or within the prior 30 days
Female volunteers cannot be pregnant, lactating, or breast-feeding
Age Range
45 - 80 years -
Impacts of Ketone Esters on Exercise and Heart Health in Type 2 Diabetics
Official Title Effects of Acute and Chronic Ketone Ester Consumption on Exercise Tolerance and Cardiac Function in Subjects with DiabetesPurpose
This placebo-controlled study is being done to evaluate the effects of a ketone ester drink on exercise performance and heart health in a group of subjects diagnosed with type 2 diabetes.
Could this study be right for you?
There are additional exclusion criteria, study staff will screen fully before enrollment.
Age Range
18 - 80 years -
Radiotracer Imaging of Lower Extremity Skeletal Muscle Perfusion in Patients with Peripheral Arterial Disease (PAD)
Official Title Radiotracer Imaging of Lower Extremity Skeletal Muscle Perfusion in Patients with Peripheral Arterial DiseasePurpose
The purpose of this study is to look at a new method to evaluate blood flow to the calves and feet.
Peripheral Artery Disease (PAD) patient outcomes will be evaluated for up to 12 months after their revascularization procedure to assess how early changes in SPECT-derived foot perfusion relate to rates of diabetic wound healing and limb salvage. Outcomes will be specifically evaluated at 3, 6, 9, and 12 months after revascularization at the time of their follow-up clinic visits to the OSU Comprehensive Wound Center at OSU Hospital East. Primary outcomes of interest will be 1) changes in wound size and healing, 2) minor or major amputations of the lower extremity, and 3) any subsequent interventional procedures, such as balloon angioplasty, stenting, or surgical bypass.
Could this study be right for you?
Heathly Volunteers with out previous cardiovascular disease
Or
PAD
Age Range
18 years and up -
IMPROVE-AD Trial: IMPRoving Outcomes in Vascular DisEase
Official Title IMPROVE-AD Trial: IMPRoving Outcomes in Vascular DisEase – Aortic DissectionPurpose
The goal of this study is to figure out the best way to treat type aortic dissection. An aortic dissection is a tear in the wall of the aorta. The aorta is a big blood vessel that carries blood from your heart to the rest of your body. Individuals with this problem usually get medicine or a special repair procedure. This procedure is called thoracic endovascular aortic repair (TEVAR). TEVAR is a procedure where a metal tube (called a stent), is inserted in the damaged part of the aorta. The study is being done to figure out which treatment works better. The results of the study may help to prevent future problems with the aorta or other health issues.
Could this study be right for you?
Inclusion:
- Age > 21 years
- Stanford type B aortic dissection not involving the aorta at or proximal to the innominate artery, without rupture and/or malperfusion (renal, mesenteric, or extremity)
- Acuity: within 48 hours – 6 weeks of index admission
Exclusion criteria:
- Ongoing systemic infection
- Pregnant or planning to become pregnant in the next 3 months
- Life expectancy related to non-aortic conditions < 2 years
- Prior surgery for aortic dissection
Age Range
21 years and up -
AAA-SHAPE Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Expansion
Official Title AAA-SHAPE Pivotal Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of ExpansionPurpose
The purpose of this research is to determine if the IMPEDE-FX RapidFill System is safe and helps to shrink abdominal aortic aneurysm (AAA - a bulge or swelling due to weakening of the walls of the aorta, which is the main blood vessel that carries blood from your heart to other parts of your body) sacs after an endovascular stent graft (a fabric tube supported by metal wire stents that reinforces a weakened aorta) has been placed. The IMPEDE-FX RapidFill System used in this study is classified as investigational, which means it has not been approved by the Food and Drug Administration (FDA).
Could this study be right for you?
Inclusion:
- A candidate for elective EVAR of an infrarenal fusiform aortic aneurysm ≥5.5 cm in diameter in men and ≥ 5.0 cm in women
- Thrombus burden (percentage of the AAA sac occupied by thrombus) <50%, based on pre-procedure CTA
- Maximum Lumen diameter within the AAA sac of ≥40mm
- The predicted minimum number of IMPEDE-FX RapidFill Implants for the subject is ≤200
Exclusion:
- An inability to provide informed consent
- Enrolled in another clinical study that could interfere with the outcomes being studied in this trial
- Unable or unwilling to comply with study follow-up requirements
Inclusion and Exclusion Criteria varies, please contact Study Coordinator for more information.
Age Range
18 years and up -
MOMI Study
Official Title The mom and infant outcomes (MOMI) study: A trial of perinatal outpatient delivery systemsPurpose
To improve our ability to provide the best possible care to every mom and infant, we are testing two different models of primary care during the first year after childbirth.
Could this study be right for you?
- You may qualify if you’re currently pregnant – AND – you’ve ever had high blood pressure, diabetes, depression, or anxiety, including during pregnancy.
If you participate, you’ll be randomly assigned to an Ohio State location that delivers one of two models of care. Providers at all locations can help you manage your health, but the models differ in several ways.
- You’ll complete three study visits with surveys, several measurements, and blood and hair sampling. We’ll collect cord blood and review medical records.
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Long-term Follow-up of Adults Who Experience an out of Hospital Cardiac Arrest
Official Title Patterns Of Survivors’ Recovery Trajectories in the ICECAP trial POST-ICECAPPurpose
The purpose of this study is to describe the physical, neuropsychological outcomes of adults who have experienced an outside of hospital cardiac arrest; and examine any associations between those outcomes and any clinical and/or rehabilitative interventions and/or social determinants of health.
Could this study be right for you?
- Experienced a coma after resuscitation from a cardiac arrest
- Received targeted/controlled body temperature management
- Survived to at least 1 month after experiencing a outside of hospital cardiac arrest
Age Range
18 years and up