Clinical Trial Testing if an FDA Approved Medication Changes Stress Responses

Official Title Orexin Receptor Antagonists as Modulators of Threat Sensitivity in individuals with Alcohol Use Disorder

Purpose

The purpose of this study is to see if BELSOMRA, an FDA approved medication that is prescribed to treat insomnia, changes the body’s response to stress. Participation in the study includes 3 or 5 in-person lab visits (depending on randomization), which include EEG and MRI. Nearly all visits are 1.5 hours long, with the exception of one that is 4-5 hours in duration. Visits are flexible and scheduled at your convenience. Participants take the medication (or placebo) for 4 weeks, during which participation is only composed of virtual surveys via a smartphone app.

The total length of participation in the study is 1.5-2 months depending on scheduling/availability.

Could this study be right for you?

Eligibility Criteria:

  • 18-65 years old
  • Generally medically and physically healthy
  • Regular alcohol use

Exclusion Criteria:

  • Diagnosis of bipolar disorder, schizophrenia, mania, or psychosis
  • Currently pregnant or trying to become pregnant (female)
  • Presence of ferrous-containing metal in the body
  • Inability to tolerate enclosed spaces

Exclusion Criteria varies, please contact Study Coordinator for more information.

Age Range

18 - 65