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Emotional Regulation among Distressed Young Adults
Official Title Emotion Regulation Training to Reduce Cardiovascular Disease Risk Among Distressed Young Adults: A Single-Session DesignPurpose
This study looks at how learning to manage emotions can improve your mental and physical health.
You will meet with a research team member for an interview about your mental health. If you qualify, we will take a few drops of blood from a finger prick and check your heart rate and blood pressure. You will also learn some emotional regulation skills for handling tough emotions and fill out surveys about yourself. For two weeks after, you'll answer short surveys on your phone five times a day. Then you'll come back for one more short visit.
Could this study be right for you?
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Have a depressive or anxiety disorder
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Are not currently receiving mental health counseling
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Read and understand English
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Are willing to have a finger prick for a blood sample
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Free from immune-related or heart-related diseases
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Own or have access to a smartphone
Age Range
18 - 39 years -
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Anxiety and Inflammation in Adults
Official Title Inflammation in adults with anxiety disordersPurpose
This study looks at how anxiety can affect your immune health.
You will meet with a research team member for an interview about your mental health. If you qualify, we will take a few drops of blood from a finger prick. Then you will fill out some surveys about yourself and your mental health.
Study visits will last approximately 2 hours. Once the 2-hour visit is complete, you will be released from the study. There will be no long-term follow-up after completion of research related procedures.
Could this study be right for you?
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Have an anxiety disorder (social anxiety disorder, specific phobia, panic disorder, agoraphobia, generalized anxiety disorder).
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Are 18 years or older
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Read and understand English
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Free from immune-related diseases
Age Range
18 years and up -
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Effectiveness of Pairing a Keto Diet with Psychotherapy for PTSD
Official Title Enhancing PTSD Recovery with Metabolic-Augmented PsychotherapyPurpose
To test whether a personalized ketogenic program in combination with cognitive processing therapy (CPT) can improve symptoms of post-traumatic stress disorder (PTSD).
The study will involve 11 weeks of a personalized ketogenic program guided by a dietician, 10 sessions of CPT, interviews, questionnaires, and wearing sensors to track your stress, sleep, glucose, and ketones.
Could this study be right for you?
- 18 years or older
- Able to attend in-person visits to OSU once per week for 12 weeks
- Meet diagnostic criteria for PTSD (prior diagnosis is NOT required, all individuals will be evaluated by the study team)
Age Range
18 years and up -
Single-Dose Investigational Drug Study for Depression and Anxiety
Official Title A Randomized, Double-Blind, Placebo-Controlled Mechanistic Study to Assess a Single Oral Dose of CYB003 in Participants with Major Depressive Disorder (MDD) and Moderate to Severe AnxietyPurpose
The aim of this study is to determine the effects of one administration of the psychedelic compound CYB003 on depression and anxiety symptoms as well as its effects on brain function.
Could this study be right for you?
1. Currently have depression with moderate to severe anxiety
2. Are currently taking an antidepressant and your symptoms have not improved enough
3. Have been on the same antidepressant dose for about 1 month
Age Range
21 - 65 years -
A Study about how virtual Yoga sessions affect symptoms and quality of life in patients with diabetic gastroparesis
Official Title The Effect of Virtual Yoga Intervention on Symptom Severity and Quality of Life in Patients with Diabetic GastroparesisPurpose
The purpose of this research study is to understand how virtual Yoga sessions conducted 4 days a week for 12 weeks affect digestive symptoms and quality of life in those suffering from gastroparesis due to diabetes mellitus.
Could this study be right for you?
- Able to understand English
- Must have been diagnosed with gastroparesis
- Must have type 1 or type 2 diabetes mellitusAge Range
18 - 65 years -
A Study of Psilocybin-Assisted Therapy for Adults with Posttraumatic Stress Disorder (PTSD)
Official Title A Randomized Mechanistic Study of Effect of Psilocybin Combined with Mindfulness-based Therapy vs Support on Posttraumatic Stress Disorder (PTSD)Purpose
This study will look at the effects of psilocybin-assisted therapy on brain function and mental health. If eligible, you will be asked to complete brain scans (fMRI, EEG), blood tests, and surveys about your mental health before and after you receive a dose of psilocybin. In addition, you will participate in virtual and in-person therapy sessions.
Could this study be right for you?
General Inclusion Criteria:
- Been diagnosed with Posttraumatic Stress Disorder (PTSD) and experiencing active symptoms
- Experiencing active depression symptoms
General Exclusion Criteria:
- Diagnosis of cardiovascular disease, hypertension, or arrhythmia
- Current or past diagnosis of schizophrenia spectrum or other psychotic disorders
- Clinically significant medical or neurological condition
- History of substance use disorder within the past 12 months
Age Range
21 - 65 years -
Pain Response & MRI Study in Autistic and Non-autistic Adults (ages 18-40)
Official Title Measurement and Mechanisms of Pain in Autistic AdultsPurpose
The purpose of this project is to study how pain may differ in adults with or without autism. Our goal is to study whether or not pain is experienced of felt differently in autistic adults compared to non-autistic adults.
Participants will be screened by phone. After meeting the initial screening criteria, the study visits will be scheduled.
In the first visit, you will be asked to take some paper and pencil tests, some surveys on a computer, and complete brief pain tasks. We may also ask that you bring a study partner with you, someone that knows you well.
In the second visit, you will complete a brief pain task, answer a few questions, and get an MRI of your brain. Each visit will not be more than 3 hours of your time in total. Your information will always be kept confidential.
Could this study be right for you?
- Not currently on any daily pain medications
- No history of traumatic brain injury (TBI)
Age Range
18 - 40 years -
Evaluating the Efficacy of a Psychedelic Investigational Drug for Patients who are Struggling with Symptoms of Depression and Anxiety due to Cancer or Other Life-Changing Medical Illness
Official Title A Randomized, Double-Blind, Parallel-Group, Dose-Controlled Study Evaluating the Safety and Efficacy of RE104 for Injection in the Treatment of Adjustment Disorder in Patients with Cancer and Other Medical IllnessesPurpose
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms or depressive symptoms mixed with anxiety symptoms in participants with Adjustment Disorder due to cancer or other illnesses such as Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Parkinson's Disease (PD) or Idiopathic Pulmonary Fibrosis (IPF) as compared to active-placebo.
Could this study be right for you?
- Depression due to cancer, Parkinson’s, ALS, MS, or IPF
- Currently depressed
- Projected life expectancy of ≥6 months.
Age Range
18 - 80 years -
Evaluating the Safety and Efficacy of Icalcaprant in the Treatment of Subjects with Major Depressive Disorder (MDD)
Official Title A Phase 2, Multicenter, 6-Week, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Icalcaprant in Subjects with Major Depressive DisorderPurpose
Major depressive disorder (MDD; depression) is a mood disorder that causes a continued feeling of sadness and loss of interest. It is a common and serious illness that can cause both emotional and physical symptoms such as feelings of sadness, irritability, not being able to focus on activities, tiredness, changes in eating habits, and aches and pains.
This study will assess the changes in disease activity and adverse events of oral Icalcaprant in adult participants with major depressive disorder who are currently experiencing a major depressive episode (MDE).
Could this study be right for you?
- Diagnosed with MDD
- Current major depressive episode
- Willing to discontinue antidepressant treatments
Age Range
18 - 65 years -
Evaluating the Efficacy and Safety of Icalcaprant in Subjects with Bipolar Depression
Official Title A Phase 2, Multicenter, 6-Week, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Icalcaprant in Subjects with Bipolar DepressionPurpose
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population.This study will assess how safe and effective Icalcaprant is in treating adult participants with bipolar I or II disorder.
Could this study be right for you?
- Diagnosed with Bipolar Disorder I or II
- Currently in a depressive episode
- Currently receiving treatment of a mood stabilizer
Age Range
18 - 65 years