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Pain Response & MRI Study in Autistic and Non-autistic Adults (ages 18-40)
Official Title Measurement and Mechanisms of Pain in Autistic AdultsPurpose
The purpose of this project is to study how pain may differ in adults with or without autism. Our goal is to study whether or not pain is experienced of felt differently in autistic adults compared to non-autistic adults.
Participants will be screened by phone. After meeting the initial screening criteria, the study visits will be scheduled.
In the first visit, you will be asked to take some paper and pencil tests, some surveys on a computer, and complete brief pain tasks. We may also ask that you bring a study partner with you, someone that knows you well.
In the second visit, you will complete a brief pain task, answer a few questions, and get an MRI of your brain. Each visit will not be more than 3 hours of your time in total. Your information will always be kept confidential.
Could this study be right for you?
- Not currently on any daily pain medications
- No history of traumatic brain injury (TBI)
Age Range
18 - 40 years -
Using Mobile Technology to Improve Body Composition Assessment and Track Physical Activity in Adults with Down Syndrome
Official Title Improving Body Composition Assessment and Physical Activity Monitoring in Adults with Down Syndrome using Mobile Technology
Purpose
The purpose of this study is to learn how well wearable technologies, such as smartwatches and activity trackers, can measure body composition and physical activity in adults with Down syndrome. Adults with Down syndrome are at a higher risk for obesity and related health conditions, and current methods used to measure body composition and activity can be difficult or uncomfortable. This study aims to identify simpler and more comfortable ways to collect this information.
If you choose to participate, you will be asked to attend one in-person study visit at a research laboratory. During this visit, you will complete a series of body measurements and light physical activity tasks. These include providing a small urine sample to check hydration, having your height, weight, and body composition measured using several methods (including a scan where you lie still for several minutes), and completing strength and walking tests. You will also wear multiple activity tracking devices on different parts of your body while completing short walking activities.
Your total time involved in this study will be one visit lasting approximately a few hours.
Could this study be right for you?
- Adult diagnosed with Down Syndrome
- Weight <350 lbs
- No condition that impacts body composition assessments (e.g., pacemaker)
- Not pregnant or planning to become pregnant
Age Range
18 - 60 years -
Research Study for Grave's Disease
Official Title A Phase 1, First-in-Human, Placebo-Controlled, Single and Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Intravenous and Subcutaneous Administration of MER511 in Adults With Graves’ DiseasePurpose
1. To find out how safe the study drug is and how well people with Graves’ disease can handle taking one or more doses.
2. To describe how the body absorbs, uses, and removes a single IV or subcutaneous dose, or several subcutaneous doses, of MER511 in people with Graves’ disease.
3. To check whether the body creates an immune response after a single IV or subcutaneous dose, or several subcutaneous doses, of MER511 in people with Graves’ disease.
Could this study be right for you?
1. Grave's disease diagnosis
2. Taking methimazole or propylthiouracil
3. Weigh at least 110 lbs
4. Women of childbearing potential must agree to use contraceptive methods and avoid egg donation during the study; Men with partners of childbearing potential must agree to use a condom or abstinence and avoid sperm donation during the study
Age Range
18 - 55 years -
Men’s Health, Friendships and Relationships
Official Title Men Talking: How Do Men Discuss Health, Friendships, and Relationships?Purpose
The purpose of this study is to gain a better understanding of men’s friendships, relationships, and health-information seeking.
The study consists of a 60–90-minute interview at a location of the participant’s choosing.
Thank you for your time and assistance!
Could this study be right for you?
- 18 years and older
- assigned male at birth
- live in Columbus Metro Area
Age Range
18 years and up -
Kicking the Habit: A Research Study Testing the Buckeye Quit Stick
Official Title A Pilot/Feasibility Study of the Buckeye Quit Stick: A Novel Resource for Successful Tobacco CessationPurpose
The Buckeye Quit Stick is part of a research study to learn whether people are willing to use a handheld stick as a tool for the hand-mouth routine of smoking. It focuses on the hand-to-mouth habit by providing something to hold and use instead of a cigarette. The main goal of this study is to see if patients that plan to quit smoking will use this device and evaluate their experiences with the Buckeye Quit Stick.
Participants will also continue to receive national guidelines for smoking cessation support from the James Comprehensive Cancer Center Smoking Cessation Clinic. A participant is considered to have completed the research study when they complete all study visits or at approximately 6 months.Could this study be right for you?
- Must be 21 years of age or older
- Patient of the OSU Thoracic Clinics
- Suspected or confirmed lung cancer diagnosis
- Current self-reported smoker
Age Range
21 years and up -
Chill Nic (Nicotine Pouch) Study
Official Title Examining the Role of Cooling Agents in Oral Nicotine PouchesPurpose
Adult cigarette smokers who live in Ohio are invited to participate in 5 study visits to understand how different nicotine pouches compare to one another as well as their usual brand of cigarette. Each visit lasts about 1 hour.
Participation involves visiting our lab, trying oral nicotine pouches, smoking your regular brand of cigarette, and filling out surveys.
Could this study be right for you?
- Must be a current cigarette user
- Must be 21 years old or older
- Must be willing to attend 5 study visits at OSU
Age Range
21 years and up -
TBI and other Acquired Brain Injuries Study
Official Title Resource Mapping for Families of Children with Brain InjuryPurpose
The purpose of this study is to assess the family needs of children with a brain injury. We want to explore your experiences getting care, the barriers, and facilitators your family has faced in navigating and accessing services after hospital discharge, and your ongoing unmet needs.
Could this study be right for you?
- You are a primary care giver of a child that sustained a brain injury
- Your child was hospitalized for an overnight stay as a result of their brain injury
- Your child was 18 or younger when their brain injury occurred
- You speak English
Age Range
19 years and up -
Testing Acolbifene vs Low Dose Tamoxifen to Prevent Breast Cancer
Official Title Phase IIA Trial of Acolbifene (20 mg) vs Low Dose Tamoxifen (5 mg) in Pre-menopausal Women at High Risk for Development of Breast CancerPurpose
This study wants to see if two medicines, acolbifene or a small dose of tamoxifen, can lower the chance of getting breast cancer in women who are at high risk before menopause.
Acolbifene and tamoxifen work by blocking estrogen, a hormone that can help cancer cells grow. By blocking estrogen, these medicines may lower the chance of breast cancer in women at high risk. The study lasts between 6 and 8 months.
If this study works, it could give us new ways to help prevent breast cancer.
Could this study be right for you?
- Pre-menopausal
- At increased risk of breast cancer, due to genetic mutation, family history, prior DCIS, LCIS, or atypical hyperplasia
- Seen in Stefanie Spielman Comprehensive Breast Cancer Center in Columbus, OH
Age Range
35 years and up -
Blocking Orexin Receptors to Help Treat Alcohol Addiction and Stress-Driven Drinking
Official Title OASIS - Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related DrinkingPurpose
This study will look at whether suvorexant can help treat alcohol use disorder, how it works, and who it works best for. Suvorexant is a medicine that blocks certain brain signals linked to wakefulness.
Your total participation time in this study will be approximately 9 weeks.
Could this study be right for you?
Inclusion Criteria:
- Age 18-65
- Participant is able to give informed consent
- Engage in heavy alcohol use defined as drinking ≥14 standard drinks per week if male and ≥7 standard drinks per week if female.
General - Exclusion Criteria
- Clinically significant medical or neurological condition (e.g., liver disease, narcolepsy, complex sleep behaviors, severe hepatic impairment, COPD, severe obstructive sleep apnea)
- Current or past DSM-5 diagnosis of mania, schizophrenia, psychosis
- Past suicide attempt within 3 years or presence of moderate suicidal ideation
- Engage in night-shift work
Age Range
18 - 65 years -
Improving Physical Ability and Cellular Senescence Elimination in HIV
Official Title Improving Physical Ability and Cellular Senescence Elimination in HIV (IPACE-HIV)Purpose
The purpose of this study is to evaluate the safety and tolerability of dasatinib and quercetin (D+Q) and efficacy of this regimen in improving physical function outcomes in people with HIV (PWH) who are frail or prefrail.
Could this study be right for you?
- People living with HIV ≥50 years diagnosed with HIV 10 or more years ago
- Currently on combination antiretroviral therapy
- Currently virologically suppressed
- Must meet FFP criteria & have 4-meter gait speed in the range of .5-1.2 m/sec
Age Range
50 years and up