• Diagnosed with stage I-IV colorectal cancer (ICD-10 C18, C19 and C20) OR Healthy.
• 18+ years of age at time of diagnosis.
• Able to communicate in English and provide consent.
• African American OR White.
• Not currently in cancer treatment.
• No current ostomy.
• No chronic bowel disorders (e.g., irritable bowel syndrome).
• No diagnosis of functional GI disorders.
• No food allergies or dietary restrictions.
• No use of probiotics or antibiotics within the past two months prior to fecal collection.
• No significant cognitive or developmental delay that precedes cancer diagnosis (e.g., down syndrome, autism spectrum disorder).

• Age ≥ 18 years old and ≤ 80 years old & willingness to be randomized to either diet.
• NYHA class I – III for at least 3 months.
• Ejection fraction ≥50% by biplane 2D, or 3D echo, or CMR
• Echo findings of abnormal or indeterminant diastolic function or RHC data:  At rest: mean pulmonary capillary wedge pressure (PCWP) > 15 mmHg.  pulmonary vascular resistance (PVR) < 3 Wood Units.
• Stable medical therapy for at least 3 months as determined by the treating physician (no new cardiac or diabetic medications within 3 months of enrollment or during enrollment and dosage should be stable for 1 month prior to enrollment).
• Dose of oral diuretics changes allowed but must be stable for 1 week prior to randomization.
• Body Mass Index (BMI) ≥ 25 and ≤ 50 or Type 2 Diabetes Mellitus or prediabetes (fasting glucose of 100 - 125 mg/dL or hemoglobin A1C 5.7-6.4%) or metabolic syndrome.
• Ability to participate in exercise treadmill testing.
• Ability to sign written consent.

Exclusions:

•  Women who are pregnant, current breast-feeding, or have intention to become pregnant while in the study.
•  Known allergy or sensitivity to gadolinium-based contrast agents.           
• Implanted pacemaker, cardioverter defibrillator, Cardiac resynchronization therapy, left ventricular assist devices.
• Other metallic implants/aneurysm clips that are contraindicated in MRI.           
• Claustrophobia
• History of severe kidney disease of eGFR<30 ml/kg/1.73m2.

Exclusion Criteria varies, please contact Study Coordinator. 

• Adults aged 18-65 years old
• Chronic spinal cord injury
• Level of injury between C4 and L2

• Are at least 25 pounds overweight
• Are a non-smoker
• No medications that affect blood sugar, blood pressure, or inflammation

• Free of MRI contradictions
• No dietary destrictions
• Normal vison
• Right handed

• Diagnosis of HTN treated with an antihypertensive medication or risk of HTN that includes obesity and high cholesterol
• Age 40 and older
• A caregiver rating of the PLWD of 2 or greater on the Alzheimer’s Dementia-8 scale
• Caregiver provides unpaid care to a PLWD at least 10 hours per week or assists with at least one instrumental activity of daily living
• Self-identifies as Black/African American
• English speaking
• Access to a telecommunications device such as the internet via desktop, laptop/tablet, smartphone, or telephone

Inclusion Criteria

• Ages 25-80
• Have nonalcoholic fatty liver disease or something similar

Exclusion Criteria Include

• Unable to have an MRI scan
• Pregnancy 

• Child has access to a computer or tablet device at home for virtual mentoring sessions/meetings
• Child suffers from overweight or obesity - does not need to be under the care of a health care professional for this condition
• Child and Parent able to participate read English at a 4th grade level. 
• Family not expected to move from rural Appalachia within the 18 months. 

Inclusion Criteria:
- Age 18 years and older
- Type 2 diabetes based on American Diabetes Association Criteria
- Hemoglobin A1c level > 7.5%
- Worried about running out of food before you have money to buy more

Exclusion Criteria:
- Pregnant

• Male or females aged 18 years or older
• Suffer from Chronic Digestive Symptoms
• Willing to meet virtually once per week for 1.5 hour group sessions