Cardiovascular

Official Title

A prospective randomized unblinded study of ketogenetic versus mixed diet on exercise tolerance in subjects with the metabolic phenotype of heart failure with preserved ejection fraction

Purpose

The purpose of this study is to compare the effects of a well-formulated ketogenic diet with a low-fat diet on exercise tolerance in patients with heart failure and diabetes or pre-diabetes or metabolic syndrome.

 

Could this study be right for you?

• Age ≥ 18 years old and ≤ 80 years old & willingness to be randomized to either diet.
• NYHA class I – III for at least 3 months.
• Ejection fraction ≥50% by biplane 2D, or 3D echo, or CMR
• Echo findings of abnormal or indeterminant diastolic function or RHC data:  At rest: mean pulmonary capillary wedge pressure (PCWP) > 15 mmHg.  pulmonary vascular resistance (PVR) < 3 Wood Units.
• Stable medical therapy for at least 3 months as determined by the treating physician (no new cardiac or diabetic medications within 3 months of enrollment or during enrollment and dosage should be stable for 1 month prior to enrollment).
• Dose of oral diuretics changes allowed but must be stable for 1 week prior to randomization.
• Body Mass Index (BMI) ≥ 25 and ≤ 50 or Type 2 Diabetes Mellitus or prediabetes (fasting glucose of 100 - 125 mg/dL or hemoglobin A1C 5.7-6.4%) or metabolic syndrome.
• Ability to participate in exercise treadmill testing.
• Ability to sign written consent.

Exclusions:

•  Women who are pregnant, current breast-feeding, or have intention to become pregnant while in the study.
•  Known allergy or sensitivity to gadolinium-based contrast agents.           
• Implanted pacemaker, cardioverter defibrillator, Cardiac resynchronization therapy, left ventricular assist devices.
• Other metallic implants/aneurysm clips that are contraindicated in MRI.           
• Claustrophobia
• History of severe kidney disease of eGFR<30 ml/kg/1.73m2.

 

Exclusion Criteria varies, please contact Study Coordinator. 

Age Range

18 - 80 years

Official Title

PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults

Purpose

The purpose of PREVENTABLE is to learn if taking a statin could help older adults live well for longer by preventing dementia, disability, or heart disease. The duration of the study will last 5 years. 

Could this study be right for you?

Inclusion Criteria:

• Community-dwelling adults
• Age ≥75 years
• English or Spanish as primary language

 

Exclusion Criteria:

• Clinically evident cardiovascular disease defined as prior myocardial Infarction (MI), prior stroke, prior revascularization procedure, or a secondary prevention indication for a statin (clinician determined)
• Hospitalization for a primary diagnosis of heart failure in the prior 12 months (Note: History of heart failure in the absence of recent hospitalization or clinically evident cardiovascular disease is not an exclusion)
• Dementia (clinically evident or previously diagnosed)
• Dependence in any Katz Basic Activities of Daily Living [ADL] (with the exception of urinary or bowel continence)
• Severe hearing impairment (preventing phone follow up)
• Unable to talk (preventing phone follow up)

Exclusion Criteria varies, please contact Study Coordinator for more information. 

Age Range

75 years and up

Official Title

A Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled, 24-week Phase 3 Study with an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab in Patients with Hypereosinophilic Syndrome (HES)

Purpose

The purpose of this study is to see if benralizumab (biologic drug), given as injections under the skin, can help control your Hypereosinophilic Syndrome (HES) better if it is added to available standard of care HES medications which you may be currently taking. 

HES (Hypereosinophilic Syndrome) is a disease characterized by high levels of eosinophils (a particular type of white blood cell) in your blood and a build-up of eosinophils in some organs and tissues (like skin, heart, lungs, intestines or others) causing their dysfunction.

The duration of the study will last 18 months.

Could this study be right for you?

 

• Eosinophil (a type of white blood cells) count ≥ 1000 cells/μL at screening
• Documented diagnosis of Hypereosinophilic Syndrome (HES)
• History of persistent eosinophilia >1500 cells/μL (at least 2 examinations, interval ≥1 month)
• End organ manifestations attributable to the eosinophilia

Inclusion and Exclusion Criteria varies, please contact Study Coordinator for more information.

Age Range

18 years and up

Official Title

Effect of Glucose Fluctuations on Atrial Fibrillation Burden among Patients with Diabetes Mellitus and Paroxysmal Atrial Fibrillation or Recent Atrial Fibrillation Ablation

Purpose

The purpose of this study is to examine the effects of glucose levels on atrial fibrillation episodes in people with diabetes and history of atrial fibrillation.

The duration of the study lasts 6 months. 

Could this study be right for you?

• Participants diagnosed with type 2 diabetes mellitus
• Body mass index between 25 and 45 kg/m2
• Insulin use at least 10 units per day or more than 1 glucose lowering medication with a hemoglobin A1c greater than 7%
• ICM placement
• Paroxysmal atrial fibrillation (irregular heartbeat that goes back to normal after a week) or atrial fibrillation ablation (procedure to treat irregular heartbeat) within 30 days

Age Range

40 - 79 years

Official Title

BUckeye Concussion Knowledge Survey (BUCKS)

Purpose

The purpose of this study is to examine health outcomes in former Ohio State University athletes who played a varsity sport during their time at OSU. The objective is to determine whether athletes who sustained a concussion have different health outcomes than those who did not sustain a concussion. Any former OSU varsity athlete can participate in a 20-minute online survey.

Could this study be right for you?

• Anyone who has played a varsity sport as an undergraduate student at OSU, and they have now graduated (i.e., OSU athlete alumni). There are no other restrictions in terms of age, sex/gender, type of sport, etc.

Age Range

18 years and up

Official Title

Addressing the double jeopardy of stress and hypertension among African American female caregivers of persons living with Alzheimer’s disease and related dementias (R21)

Purpose

The purpose of this study is to determine the feasibility of a group delivered intervention for stress and blood pressure in African American women caregivers.

Could this study be right for you?

• Diagnosis of HTN treated with an antihypertensive medication or risk of HTN that includes obesity and high cholesterol
• Age 40 and older
• A caregiver rating of the PLWD of 2 or greater on the Alzheimer’s Dementia-8 scale
• Caregiver provides unpaid care to a PLWD at least 10 hours per week or assists with at least one instrumental activity of daily living
• Self-identifies as Black/African American
• English speaking
• Access to a telecommunications device such as the internet via desktop, laptop/tablet, smartphone, or telephone

Age Range

40 and up

Official Title

Cardiovascular Effects of Acute Ketone Ester Ingestion in Healthy Adults

Purpose

This study is intended to evaluate the effects of a drink supplement on heart function and health in healthy adults after consuming a ketone ester (KE) supplement drink compared to a placebo drink.

You will undergo an MRI exam for this study. You will also receive six blood draws in total, from an IV catheter set at the beginning of the study. 

The duration of this study will comprise a single visit and will last no longer than 4 hours. 

Could this study be right for you?

Inclusion:

• Able to comply with study requirements as well as pre-test requirements
• BMI between 18 and 30 kg/m2
• Body weight > 150lbs

Exclusion:

Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including:

• Pregnancy 
• Allergies to components in the test products, including milk protein, and not lactose intolerant
• History of alcoholism (previous 2 years)
• Taking prescriptive medications or over-the-counter (OTC) medications (other than those taken as nutritional supplements for non-therapeutic indications)
• Current smoker
• Contraindications to MRI including cardiac pacemaker or defibrillator, brain aneurysm clips, neuro-stimulator, the presence of any magnetic metal in the body or claustrophobia

Exclusion Criteria varies, please contact Study Coordinator for more information. 

Age Range

18 - 65

Official Title

Mobile Health App as a Cardiotoxicity Symptom Logging Tool: Feasibility Pilot Study

Purpose

To evaluate the cardio-oncology patient population’s experience with using smart-phone technology as a part of self-management with their care through features such as symptom logging and education. Eligible patients will be asked to participate in a 30-minute virtual interview and/or a 60-minute virtual design or usability session to discuss their thoughts on a mobile app for cardio-oncology patients.

Could this study be right for you?

- English-speaking - Prior cancer diagnosis - Currently undergoing a cancer regimen that includes a targeted, biologic, radiation, and/or immune-based therapy (ex. TKIs and/or ICIs). - No pregnant females - No prisoners

Age Range

18 and up

Official Title

Measurement of Mitochondrial Dysfunction Using Phosphorus Magnetic Resonance Spectroscopy in Diabetic Patients Undergoing an Exercise Regimen

Purpose

We are looking at parts of the cells in our bodies (called mitochondria). Mitochondria give our cells energy and help them stay healthy. People with diabetes have mitochondria which do not work as well as the mitochondria in people without diabetes.

In this study, we want to see if exercise (cardiac rehabilitation) will cause your mitochondria to work better. Using a magnetic resonance imaging (MRI) machine, we can measure how much your cardiac rehabilitation has helped your mitochondria. We will be looking at your leg muscle and the mitochondria in those cells.

In this study, we hope to show that we can help those with diabetes by making their mitochondria work better using things like exercise. We will be looking for people who are beginning cardiac rehabilitation, some with and some without diabetes.

Could this study be right for you?

- 18 yrs and older
- Have been referred for cardiac rehabilitation
- Are able to have an MRI (study coordinator can screen you for this)

Age Range

18 and up