Official Title

A Double-Blind, Placebo-Controlled Study of Cariprazine as an Adjunct to Antidepressants in the Treatment of Patients with Major Depressive Disorder Who Have had an Inadequate Response to Antidepressants Alone

Purpose

The purpose of this study is to look into the safety and efficacy of cariprazine as an add-on medication in the treatment of major depressive disorder.

Could this study be right for you?

Inclusion criteria:
- Between the ages of 18 and 61
- Currently taking an antidepressant
- Currently experiencing symptoms of depression

Age Range

18 and up

Official Title

Decision-Making Abilities and Testamentary Capacity Among Older Adults

Purpose

The overall goal of this research is to examine factors such as social resources, personality characteristics, and neurocognitive functioning in relation to decision-making abilities testamentary capacity among healthy older adults.

Another purpose of this research study is to evaluate the impact of Problem-Solving Treatment-Primary Care (PST-PC), a cognitive-behavioral therapeutic approach, on decision making among healthy older adults. PST-PC involves a seven-step model, in which participants identify problems to be solved, discuss and evaluate different resolutions to reach desired goals; create action plans to accomplish determined goals; and evaluate their effectiveness in resolving designated problems.

We will compare the effectiveness of PST-PC on individuals who will not receive any intervention.

A no treatment control group of older adult participants will also be recruited to compare the effectiveness of PST-PC to individuals who do not receive the intervention. This no treatment control group will composed of participants who do not receive the PST-PC sessions.

Could this study be right for you?

Inclusion Criteria:
-adults aged 65 and older
- Must be independently-living and community-dwelling
- Participants must be willing to undergo a health interview to rule out outstanding medical and psychiatric conditions
- Adequate sensory abilities

Exclusion Criteria:

- A history of psychiatric illness necessitating inpatient treatment
- Participants with self-reported depression and/or anxiety exceeding mild levels of clinical severity

Age Range

65 and up

Official Title

Mindfulness-based cognitive therapy for comorbid depression and type 2 diabetes

Purpose

The aim of this study is to improve mood and diabetes-related outcomes for those with type 2 diabetes mellitus (T2DM) AND symptoms of depression. The present study will examine the effect of mindfulness-based cognitive therapy (MBCT) on symptoms of depression and diabetes.

Your participation in this study will last 8 weeks.

Could this study be right for you?

You may qualify if:
• You are between the ages 18-75
• You have type 2 diabetes
• You are feeling symptoms of depression

Age Range

18 and up

Official Title

A Double-blind, Placebo- and Active-controlled Evaluation of the Safety and Efficacy of Levomilnacipran ER in Pediatric Patients 7-17 Years With Major Depressive Disorder

Purpose

The purpose of this research study is to evaluate the drug Levomilnacipran extended-release to see how well the drug works, observe the side effects, and how well tolerated it is compared to placebo in pediatric patients with major depressive disorder.

Could this study be right for you?

Your child may be eligible if:
• be between 7 and 17 years of age
• give their assent (a simplified version of this consent form that your child will sign)
• have a diagnosis of Major Depressive Disorder
• meet all of the additional relevant inclusion criteria
• understand the study instructions, and be willing and able to follow these instructions

Exclusion Criteria:
• Your child will not be able to take part in the study if she is pregnant, nursing, or planning a pregnancy
• Your child will not be able to take part in this study if he/she takes any illegal substances

Age Range

7 and up

Official Title

A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating the Efficacy, Safety, and Pharmacokinetics of SAGE-547 Injection in the Treatment of Adult Female Subjects with Severe or Moderate Post-partum Depression

Purpose

The purpose of this study is to evaluate the safety and effectiveness of an investigational medication in women with moderate to severe postpartum depression. The investigational medication is called SAGE-547 (allopregnanolone) . An investigational medication is one that is not yet approved by the United States Food and Drug Administration (FDA).

Could this study be right for you?

- Ages 18-45
- Currently depressed
- Less than 6 months postpartum

We will ask you to complete 4 study visits, including a Screening visit, a 3-day and night stay at the study center, and 2 follow-up visits.

Age Range

18 and up