Search Studies
Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.
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The Teen Period Study (T-DOT): Understanding Patterns of Menstruation and Risk Factors for Iron Deficiency After a Girl’s First Period
Official Title The Teen Period (T-Dot) cohort: a longitudinal study to understand patterns of menstruation and risk factors for iron deficiency in the early postmenarchal yearsPurpose
The purpose of this research is to determine normal menstrual patterns, as well as the risk factors for iron deficiency (not enough iron in the blood).
Participants will:
- Track their menstrual patterns using the Teen Period (T-Dot) app over 2 years
- Complete online (virtual) study visits every six months
- Have four blood draws to test iron levels at the beginning of the study, then at 8 months, 16 months and 24 months. Blood draws will be done in the participant’s home.
Could this study be right for you?
Inclusion Criteria
Post-menarchal adolescents 9-15 years of age who:
1) experienced menarche (first menstrual period) <6 months prior to study enrollment;
2) have consistent access to a mobile app capable device (smart phone or tablet); and
3) provide informed consent from parent/legal guardian and assent from participant.Exclusion Criteria
Participants will be excluded for any of the following reasons:
4) Unable to speak English
5) Self-reported use or intended use of hormonal contraception
6) Self-reported presence of chronic disease known to impact menses (bleeding disorder, thyroid disease, eating disorder, or receiving chemotherapy)
7) Self-reported presence of chronic disease highly associated with iron deficiency (inflammatory bowel disease, celiac disease, bleeding disorders, or chronic kidney disease)
Age Range
9 - 15 years -
DONUT Study
Official Title Delaying the Onset of Nearsightedness Until Treatment StudyPurpose
This study is being done to determine whether low-concentration atropine eye drops can delay the onset of nearsightedness (the inability to see clearly far away) in children who are likely to become nearsighted.
Could this study be right for you?
- Children ages 6-11 years
- Children who are not yet nearsighted
- Additional screening questions will be asked by phone or email
Age Range
6 - 11 years -
A Study of Psilocybin-Assisted Therapy for Adults with Posttraumatic Stress Disorder (PTSD)
Official Title A Randomized Mechanistic Study of Effect of Psilocybin Combined with Mindfulness-based Therapy vs Support on Posttraumatic Stress Disorder (PTSD)Purpose
This study will look at the effects of psilocybin-assisted therapy on brain function and mental health. If eligible, you will be asked to complete brain scans (fMRI, EEG), blood tests, and surveys about your mental health before and after you receive a dose of psilocybin. In addition, you will participate in virtual and in-person therapy sessions.
Could this study be right for you?
General Inclusion Criteria:
- Been diagnosed with Posttraumatic Stress Disorder (PTSD) and experiencing active symptoms
- Experiencing active depression symptoms
General Exclusion Criteria:
- Diagnosis of cardiovascular disease, hypertension, or arrhythmia
- Current or past diagnosis of schizophrenia spectrum or other psychotic disorders
- Clinically significant medical or neurological condition
- History of substance use disorder within the past 12 months
Age Range
21 - 65 years -
Comparing Tongue Strength and Endurance Before and After Eating a Meal
Official Title Impact of Meal Consumption on Lingual EndurancePurpose
The purpose of this study is to understand how eating a meal can affect muscle fatigue in the tongue in individuals with swallowing difficulties due to a neurological disorder or history of a stroke.
If you choose to participate, you will:
- Complete questionnaires about your swallowing and overall health.
- Participate in measurements of your tongue strength using a small, soft bulb placed in your mouth.
- Eat a standard meal of chicken, masked potatoes and green beans.
- Remeasure your tongue and grip strength after the meal
This study is completed in 1 session that lasts approximately 90 minutes.
Could this study be right for you?
- 18 years of age or older
- Report at least some signs/symptoms of difficulty swallowing (dysphagia)
- Have a diagnosed neurological disorder
- English speaking
- Able to eat a standardized meal of chicken, green beans and mashed potatoes
- Adequate dexterity to self-administer foods and drink via fork and cup
Age Range
18 - 100 years -
Pain Response & MRI Study in Autistic and Non-autistic Adults (ages 18-40)
Official Title Measurement and Mechanisms of Pain in Autistic AdultsPurpose
The purpose of this project is to study how pain may differ in adults with or without autism. Our goal is to study whether or not pain is experienced of felt differently in autistic adults compared to non-autistic adults.
Participants will be screened by phone. After meeting the initial screening criteria, the study visits will be scheduled.
In the first visit, you will be asked to take some paper and pencil tests, some surveys on a computer, and complete brief pain tasks. We may also ask that you bring a study partner with you, someone that knows you well.
In the second visit, you will complete a brief pain task, answer a few questions, and get an MRI of your brain. Each visit will not be more than 3 hours of your time in total. Your information will always be kept confidential.
Could this study be right for you?
- Not currently on any daily pain medications
- No history of traumatic brain injury (TBI)
Age Range
18 - 40 years -
Food and Fitness with Medicine
Official Title Food and Fitness with MedicinePurpose
We are conducting a new study to explore whether a supportive program that combines healthy eating, enjoyable physical activity, and practical resources can improve health in postmenopausal women living with heart, kidney, or metabolic conditions who are using weight‑management medications. As more women use these medications, researchers want to understand how they can be paired with supportive lifestyle changes like nourishing food and enjoyable movement to improve overall health.
As more women turn to these medications, there is an important need to understand how they work best alongside real‑world lifestyle supports. This study aims to answer that question.
Depending on your group, you may also take part in activities such as personalized nutrition counseling, cooking demonstrations, groceries or vouchers, structured fitness, and optional online or at‑home resources. The goal of this research is to understand what truly helps people build and maintain healthy habits over time. By participating, you can contribute to research that will help guide future care and improve health programs for women like you.
Could this study be right for you?
Eligibility criteria:
- Post-menopausal
- Have at least one of the following conditions: hypertension, type 2 diabetes, high triglycerides, metabolic syndrome, moderate CKD
- Plan to start a GLP-1 medication or have started a GLP-1 medication within the last 6 weeks
Age Range
45 - 79 years -
The Effects of Carbohydrates in Half-Ironman and Full-Ironman Triathletes Habitually Consuming a High Carbohydrate Diet
Official Title The Performance and Metabolic Effects of Carbohydrate Dosing Strategies (10g, 60g, 90g/hr) During Endurance Cycling in Triathletes Habitually Consuming a High Carbohydrate Diet, Including ¹³C-Breath Analysis of Exogenous Carbohydrate OxidationPurpose
This study will look at how different amounts of carbohydrates—10g, 60g, or 90g per hour—affect the energy and performance of male triathletes during long bike rides. By using endurance tests and a simple breath test, we will track a specific type of carbon (13C) found in cycling drinks to see how the body burns fuel while exercising.
Ultimately, the goal is to create clear, science-based rules to help athletes know exactly how much they should drink during cycling to perform their best during training and races.
This study includes one familiarization where we measure your aerobic fitness, and 4 experimental visits where we test various carbohydrate solutions (0, 10, 60, 90g per hour) during cycling time-to-exhaustion and then a 20-km time-trial.
Could this study be right for you?
- Healthy men aged 18-50
- Have completed a half-Ironman in under 6 hours or a full Ironman in under 13 hours,
- Cycle >100 miles per week,
- Have 2+ years of consistent triathlon training
Age Range
18 - 50 years -
Using Mobile Technology to Improve Body Composition Assessment and Track Physical Activity in Adults with Down Syndrome
Official Title Improving Body Composition Assessment and Physical Activity Monitoring in Adults with Down Syndrome using Mobile Technology
Purpose
The purpose of this study is to learn how well wearable technologies, such as smartwatches and activity trackers, can measure body composition and physical activity in adults with Down syndrome. Adults with Down syndrome are at a higher risk for obesity and related health conditions, and current methods used to measure body composition and activity can be difficult or uncomfortable. This study aims to identify simpler and more comfortable ways to collect this information.
If you choose to participate, you will be asked to attend one in-person study visit at a research laboratory. During this visit, you will complete a series of body measurements and light physical activity tasks. These include providing a small urine sample to check hydration, having your height, weight, and body composition measured using several methods (including a scan where you lie still for several minutes), and completing strength and walking tests. You will also wear multiple activity tracking devices on different parts of your body while completing short walking activities.
Your total time involved in this study will be one visit lasting approximately a few hours.
Could this study be right for you?
- Adult diagnosed with Down Syndrome
- Weight <350 lbs
- No condition that impacts body composition assessments (e.g., pacemaker)
- Not pregnant or planning to become pregnant
Age Range
18 - 60 years -
Contact Lens Study in Adults Over the Age of 40
Official Title Study Presbyopic Wear Experience with TOTAL30 Multifocal Lenses compared to Single Vision Lenses and Reading GlassesPurpose
For this study, we are seeking adults over 40 to participate in a contact lens study to compare distance contact lenses used with reading glasses to multifocal contact lenses that correct vision at all distances. Participants will be asked to wear study-provided lenses for 8 weeks. Vision and eye health will be check at each visit, and participants will complete surveys using their smart device.
Participants will be in the study for approximately 8 weeks. The first visit will take the longest, 2 hours, and each subsequent visit should take no longer than 1 hour. You will be contacted 6 months and 1 year after study completion to take a survey.
Could this study be right for you?
- Adults with contact lens experience.
- Ability to attend 5 visits over the course of 8 weeks.
- Satisfy all other study eligibility and exclusion criteria.
Age Range
40 years and up -
Evaluating the Efficacy of a Psychedelic Investigational Drug for Patients who are Struggling with Symptoms of Depression and Anxiety due to Cancer or Other Life-Changing Medical Illness
Official Title A Randomized, Double-Blind, Parallel-Group, Dose-Controlled Study Evaluating the Safety and Efficacy of RE104 for Injection in the Treatment of Adjustment Disorder in Patients with Cancer and Other Medical IllnessesPurpose
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms or depressive symptoms mixed with anxiety symptoms in participants with Adjustment Disorder due to cancer or other illnesses such as Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Parkinson's Disease (PD) or Idiopathic Pulmonary Fibrosis (IPF) as compared to active-placebo.
Could this study be right for you?
- Depression due to cancer, Parkinson’s, ALS, MS, or IPF
- Currently depressed
- Projected life expectancy of ≥6 months.
Age Range
18 - 80 years -
Evaluating the Safety and Efficacy of Icalcaprant in the Treatment of Subjects with Major Depressive Disorder (MDD)
Official Title A Phase 2, Multicenter, 6-Week, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Icalcaprant in Subjects with Major Depressive DisorderPurpose
Major depressive disorder (MDD; depression) is a mood disorder that causes a continued feeling of sadness and loss of interest. It is a common and serious illness that can cause both emotional and physical symptoms such as feelings of sadness, irritability, not being able to focus on activities, tiredness, changes in eating habits, and aches and pains.
This study will assess the changes in disease activity and adverse events of oral Icalcaprant in adult participants with major depressive disorder who are currently experiencing a major depressive episode (MDE).
Could this study be right for you?
- Diagnosed with MDD
- Current major depressive episode
- Willing to discontinue antidepressant treatments
Age Range
18 - 65 years -
Evaluating the Efficacy and Safety of Icalcaprant in Subjects with Bipolar Depression
Official Title A Phase 2, Multicenter, 6-Week, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Icalcaprant in Subjects with Bipolar DepressionPurpose
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population.This study will assess how safe and effective Icalcaprant is in treating adult participants with bipolar I or II disorder.
Could this study be right for you?
- Diagnosed with Bipolar Disorder I or II
- Currently in a depressive episode
- Currently receiving treatment of a mood stabilizer
Age Range
18 - 65 years