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Search Studies

Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

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Found 207 results. Displaying page 1 of 18.
  • White Matter Study

    Official Title Contribution of Glutamate Excess and Inflammation to Progressive White Matter Changes in Psychosis

    Purpose

    The purpose of this study is to assess the extent of white matter abnormalities, glutamate alterations, and inflammation in unmedicated patients with psychosis at different illness stages compared to healthy controls.

    Could this study be right for you?

    • No major medical conditions
    • No history of significant head trauma 
    • Not currently using medications for mental health purposes (anxiety, depression, other psychiatric diagnosis)
    • No metal implants that would present a risk to complete an MRI
    • No known pregnancy (if applicable)

    Age Range

    16 - 45 years
  • At home activity study examining children's early learning and development.

    Official Title Learning Interactions Made for Everyone (LIME)

    Purpose

    This study will examine activities of caregivers and their preschool aged child over a 12-week period. Caregivers will track learning activities with their child over the 12-weeks. Some participants will be asked to engage in additional learning activities with their child. Researchers will conduct assessments with the child before and after the 12-week program, as well as brief follow-ups 3-, 6-, and 12- months after completion. The total duration of participation in this study is up to 24 hours. The study will identify strategies in home-based learning activities and inform development of interventions to improve school readiness among children.

    Could this study be right for you?

    Child is minimally verbal in English.

    Caregiver understands enough English to understand intervention materials.

    Child does not have a severe intellectual disability.

    Caregiver and child reside in the greater Columbus area.

    Age Range

    42 - 57 months
  • Ketogenic Diet Intervention to Improve Response to Immunotherapy: KetoIO

    Official Title Phase I Study of the Safety and Feasibility of a Ketogenic Dietary Intervention to Improve Response to Immunotherapy

    Purpose

    This study will look at if a ketogenic diet (KD) can help treatment work better in patients with metastatic melanoma or metastatic kidney cancer. People who take part in the study will be randomly assigned to either continue eating their usual diet or trying the KD diet for 24 weeks. Participants will have blood and stool samples collected during the study. They will also test their sugar by doing daily glucose fingers sticks. Participants may be paid up to $200 for taking part in the study.

    Could this study be right for you?

    1. Patients with metastatic melanoma receiving first-line treatment with immunotherapy or Patients with metastatic renal cell cancer receiving first line treatment with immunotherapy.

    2. Willing to give three stool samples

    3. Willing to participate in a ketogenic diet (KD)

    Age Range

    18 years and up
  • Smartphone-based HIV-specific Smoking Cessation Study

    Official Title AMC-111 Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study

    Purpose

    This clinical trial evaluates the usefulness of using a smartphone-based HIV-specific smoking cessation intervention at the time of lung cancer screening in helping people living with HIV quit smoking. Positively Smoke Free - Mobile may help patients with HIV quit smoking.

     

    In this study, you will have lung cancer screening performed via a CT scan. You will also be enrolled into a self-guided smartphone-based HIV-specific smoking cessation intervention called “Positively Smoke Free - Mobile” lasting 42 days. After starting the intervention, you will be evaluated at 3, 6, and 12 months. 

    Could this study be right for you?

    Must have at least a 20 pack-year history of smoking (a way to measure how much a person has smoked over time, 1 pack-year is a pack per day for a year or 2 packs of cigarettes for half a year, etc.)

    Must have not had a CT scan in the past 12 months

    HIV positive, and must be receiving antiretroviral therapy and have a CD4 count of at least 200cells/uL within 6 months of enrolling in the study

    Able to understand and provide informed consent

    Possess a smart phone that can browse the web

    Not receiving any other smoking cessation interventions currently or within the prior 30 days

    Female volunteers cannot be pregnant, lactating, or breast-feeding

    Age Range

    45 - 80 years
  • Study to identify eligible patients with Parkinson's Disease for clinical trial in cell transplant of dopamine producing neurons

    Official Title A Screening Study Assessing Eligibility of Idiopathic Parkinson’s Disease Patients for Potential Future Intraputamenal Transplant Study with a Dopaminergic Precursor Product

    Purpose

    The purpose of this screening study is to identify eligible patients with Parkinson's Disease for a clinical trial in cell transplantation to a part of the brain called the putamen.  The cell transplantation will be of precursors of dopamine producing neurons (the precursors are intended to turn into mature neurons).  

    In the screening study patients will be evaluated for the following:

    • To characterize your Parkinson's Disease symptoms using information from clinical assessments, genetic tests, blood tests, and imaging of the brain.
    • Determine if you qualify for a future Phase 1b/2a transplant study to the putamen
    • To collect imaging information about dopamine function and brain function in Parkinson's Disease using 2 scans called a F-DOPA PET and a FDG PET
    • To study your blood and urine for biomarkers

    Could this study be right for you?

    Inclusion Criteria (summarized)

    1. Diagnosis of Idiopathic Parkinson’s Disease 
    2. Currently using anti-parkinsonian medications and experience some benefits from the medications.
    3. Both sides of your body experience symptoms of Parkinson's Disease
    4. Not currently pregnant or planning to get pregnant 
    5. Willing and able to avoid deep brain stimulation (DBS) during the course of the study and for at least 18 months after transplantation should the study participant be eligible for the interventional phase
    6. Willing and able to avoid treatment with continuous apomorphine IV infusions or Duodopa® during the course of the study

    Exclusion Criteria (summarized)

    1. Diagnosis of secondary or atypical parkinsonism.
    2. Previous infusion therapy or surgery for PD.
    3. Severe dyskinesia (mild to moderate levadopa induced dyskinesia is acceptable)
    4. Clinically significant hallucinations requiring antipsychotic use in the previous 6 months.
    5. Use of dopamine antagonists within 90 days of screening.
    6. Currently active major depression that is not well controlled
    7. History of any cancer (other than treated basal or squamous cell carcinoma) within past 3 years 
    8.  Current participation in another investigational clinical trial and/or receipt of any investigational medication within 90 days prior to screening.
    9. Known PD gene mutation or causative variant as informed by genetic testing.
    10. Unable to have a MRI

    Age Range

    45 - 75 years
  • DAANCE FOR CHEMOTHERAPY-INDUCED NEUROPATHY (DAANCE)

    Official Title Dance-Based Avenues to Advance Nonpharmacologic Treatment of Chemotherapy Effects (DAANCE): A Multi-Center Trial

    Purpose

    This study will teach tango dance to try to help with neuropathy symptoms. Tango dancing classes will take place for 2 times a week for 8 weeks. You will be asked about symptoms such as numbness, tingling, fatigue, pain, and balance. There is a 6 month follow up period where we will ask you to tell us about your symptoms via an app. 

    Could this study be right for you?

    1. Breast cancer survivors stage I-IV

    2. Exposure to chemotherapy with the last exposure being at least 3 months prior to study participation

    3. Must be ambulatory

     

    Age Range

    40 years and up
  • A Study to Evaluate Remibrutinib in Adults with Moderate to Severe Hidradenitis Suppurativa

    Official Title A randomized, double-blind, double-dummy, placebo-controlled, multicenter, Phase 3 study assessing the efficacy, safety, and tolerability of 2 doses of remibrutinib over a 68-week treatment period in adult patients with moderate to severe hidradenitis suppurativa

    Purpose

    This study is being done to see how well remibrutinib works for people who have hidradenitis suppurativa

     

    Could this study be right for you?

    - Subject must have a diagnosis of moderate to severe hidradenitis suppurativa (HS) for at least 6 months with lesions in 2 distinct areas

    - Subject must be in good general health with no history of tuberculosis, HIV, or hepatitis B or C

    - Subject must have no recent history (within 6 months) of significant medical conditions such as a heart attack or stroke

    - Subject must not be taking anticoagulant medication (ex. warfarin) or dual anti-platelet therapy (ex. acetylsalicylic acid + clopidogrel)

    Age Range

    18 years and up
  • Creating a Mobile Health Program for Teens with Congenital Heart Disease

    Official Title Creating a Mobile Health Program for Teens with Congenital Heart Disease

    Purpose

    The purpose of this study is to learn more about what teens with congenital heart disease want in a program that helps them learn more about living with congenital heart disease, dealing with stress, and staying away from e-cigarettes. The information from your participation may help us understand how we can improve the program and make it more interesting and appealing for teens.

    Could this study be right for you?

    • Have a diagnosis of a structural congenital heart defect
    • No cognitive impairments limiting ability to complete study interview/questionnaires
    • Proficient in English
    • Have access to a device that can connect to the internet
    • Not leaving the country at any point during study participation

    **This study is invite only. Study staff will contact you if you are invited to participate.**

    Age Range

    12 - 18 years
  • Study of a Wearable Device to Help People with Spinal Cord Injuries Regain Control of Hand Movements

    Official Title A User-Friendly, Non-Invasive Neuro-Orthosis That Restores Volitionally Controlled Grasp Functions for SCI Survivors with Tetraplegia

    Purpose

    This study is testing a new wearable device designed to help people with spinal cord injuries regain movement and control in their hands. The device uses electrical signals from the muscles to assist with hand movements. We are exploring whether using this device can improve hand function, support long-term recovery, and help track progress over time. The results will guide future development and testing to bring this technology into everyday rehabilitation and home use.

    This is a 20 week study where you will complete a 12-week rehabilitation training protocol (3x/week, 1-2 hours/session) with our study therapist.  Additionally, you will participate in six sessions where clinical assessments will be conducted to measure your arm/hand function.

     

    Could this study be right for you?

    • Cervical spinal cord injury sustained at least 1 year ago 
    • Unable to grasp and manipulate objects to allow independent performance of activities of daily living
    • Able to actively move your shoulder and elbow 
    • Not currently active in upper extremity rehabilitation

    Age Range

    22 years and up
  • Perceptions of Vaping Products

    Official Title Perceptions of Vaping Products Among Young Adults

    Purpose

    This study will examine how young adults perceive new vaping products.

    Participation involves taking part in a study at The Center for Tobacco Research. You will be asked to attend 3 study visits over the course of 3 weeks (1 visit/week for 3 weeks). You will be asked to bring your own preferred e-cigarette device to each study visit.

     

    Could this study be right for you?

    • Must be a current e-cigarette user
    • Must be willing to attend 3 in-person study visits

    Age Range

    21 - 34 years
  • The Ice E-Cigarette Study

    Official Title The ICE Study: Perceptions of E-Cigarettes and Synthetic Cooling Agents

    Purpose

    This study will examine the influence of synthetic cooling agents in e-cigarettes on vaping behavior and aims to find out how adding artificial cooling ingredients affects how people use a product and their exposure to harmful chemicals.

    Your participation in this study will last for 4 sessions, 1 session per week for 4 weeks.

     

     

    Could this study be right for you?

    • Must be a current e-cigarette user
    • Must be willing to attend four in-person study sessions

    Age Range

    21 - 29 years
  • Visual Search Strategy in Autistic Adults

    Official Title Visual Search Strategy in Neurodivergent Populations

    Purpose

    The NeuroLab is looking at differences in how Autistic and Neurotypical adults pay attention to their surrounding environment. Previous studies have found that autistic individuals are often better at focusing on visual cues—things they see in their environment—and this study wants to understand what causes that difference. To do so, participants will come in for 2-3 hours and complete computer games, paper and pencil games, and surveys. The goal is to learn how attention works for different people and why Autistic individuals might focus on visual cues differently.

    Could this study be right for you?

    • Have a medical diagnosis of Autism
    • Have normal or corrected color vision
    • Can communicate verbally

    Age Range

    18 - 40 years