Search Studies
Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.
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The IQOS Study
Official Title The Abuse Liability of IQOS Heated Tobacco Products Among Adults Who SmokePurpose
The purpose of this study is to examine the way adults who smoke would use an IQOS heated tobacco product compared to their own preferred brand of cigarette.
You will be asked to participate in 2 study visits over the course of 3 days minimum (Each visit will be separated by at least 48 hours).
Could this study be right for you?
- Adults ages 21 - 65
- Currently smoke cigarettes
Age Range
21 - 65 years -
Evaluation of Deep Brain Stimulation (DBS) in Participants with Major Depression Disorder for safety and benefit.
Official Title A prospective, double-blind, randomized, multi-center, clinical investigation. Patients will be randomized to a treatment (active DBS) or control group (delayed-stimulation DBS)Purpose
The purpose of this research study is to evaluate whether adding stimulation of the subcallosal cingulate white matter (or SCCwm), using the investigational Abbott’s Infinity™ Deep Brain Stimulation (DBS) system, as a primary treatment of Major Depressive Disorder (MDD) is safe and beneficial.
Could this study be right for you?
- Diagnosed with MDD
- Current major depressive episode
- Willing to discontinue antidepressant treatments
- Otherwise medically stable
Age Range
22 - 70 years -
Rheumatology Blood and Tissue Collection Study
Official Title The Ohio State University Rheumatology and Immunology BiorepositoryPurpose
The purpose of this study is to collect samples from patients with rheumatic conditions and store them for use in future research studies which will enable a greater understanding of the conditions and how to better treat them.
Could this study be right for you?
Eligibility Criteria:
- 18 or older
- Ability to provide informed consent
- Willingness to participate in a research study
- Patients with autoimmune diseases or other rheumatic or degenerative disorders, or healthy controls.
Exclusion Criteria:
- Inability to provide informed consent
- Self-reported history of fainting during a blood draw
- Incarceration
Age Range
18 years and up -
Mindfulness-Based Group Medical Visits on Stress, Microbiome, and Quality of Life in Women Experiencing Perimenopause and Menopause
Official Title A Pilot Study to Evaluate the Effects of Lifestyle Medicine and Mindfulness-Based Group Medical Visits on Stress, Microbiome, and Quality of Life in Women Experiecing Perimenopause and MenopausePurpose
The purpose of this pilot study is to evaluate the effectiveness of eight monthly group medical visits that incorporate individual physical assessments, focused education on the foundational elements of Lifestyle Medicine relative to health and well-being, mindfulness practices, and community-building discussions with women experiencing perimenopause or menopause. Individual outcomes, obtained pre-intervention, post-intervention, and four months post-intervention, will include measures of physiological stress, inflammation, microbiome, body mass index (BMI), systolic and diastolic blood pressure, and self-reported perceptions of physical, mental, and social health.
Could this study be right for you?
- Biological female.
- Age 40 to 60.
- Irregular menstruation for 3 months and experiencing perimenopause or menopause as determined by reporting at least one symptom on the Menopause Quality of Life Questionnaire (MENQOL).
- Ability to attend group medical visits monthly, in-person for 8 months, at The Ohio State University Center for Integrative Health as well as the baseline and end of study visit
- Ability to participate in the Mindfulness in Motion (MIM) study activities.
- Ability and willingness to download MyCap, the smartphone app that securely links participant study responses to the REDCap study project.
- WiFi connectivity or LTE to allow use of MyCap when not at OSU study site
Age Range
40 - 60 years -
Hypoparathyroidism-Focused Clinical Trial
Official Title A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Followed by an Open-Label Extension to Evaluate the Safety and Efficacy of Canvuparatide (MBX 2109) in Adult Patients with HypoparathyroidismPurpose
The purpose of this study is to find out how well canvuparatide works and how safe it is when given as an injection once a week to adults with HypoPT. Canvuparatide is designed to replace parathyroid hormone (PTH), which helps control calcium levels in the body. The goal of this study is to see if participants taking canvuparatide can stop using active vitamin D and reduce the amount of calcium supplements they need while still maintaining normal calcium levels in the blood. In this study, you will get either canvuparatide or placebo for the first 26 weeks of this study. A placebo looks like the study drug but does not contain any active ingredient. Researchers use a placebo to see if a study drug works better or is safer than the current standard of care for hypoparathyroidism.
Could this study be right for you?
Eligibility Criteria of Interest
- Documented diagnosis of post-surgical, chronic, genetic, idiopathic, or autoimmune hypoparathyroidism for atleast 12 months
- Taking calcium supplementation
- NO oral or intravenous bisphosphonates within 12 months
- No active cancer within the past 2 years (5 years for parathyroid carcinoma) or receiving current cancer treatment
- Cannot have previously participated in clinical study with canvuparatide (MBX 2109)
- Willing to participate in weekly injections
Age Range
18 years and up -
Assessing Breathing and Swallowing Coordination in People With Swallowing Problems After Stroke
Official Title Respiratory-Swallow Coordination for Chronic Dysphagia Following Cortical Ischemic StrokePurpose
To identify factors that contribute to swallowing problems following a stroke.
Participants will:
- Complete a swallowing questionnaire.
- Use tools that measure tongue strength and grip strength.
- Complete a simple breathing test by blowing into a small device.
- Complete an x-ray video swallowing test.
- Complete surveys about how swallowing affects their quality of life.
Time Commitment:
- One in-person session lasting approximately two hours.
Could this study be right for you?
- Greater than 6 months from a single stroke with no other neurological diagnosis
- Currently experiencing or reporting difficulty swallowing
- Consuming some degree of food intake; not fully reliant on a feeding tube
Age Range
18 - 100 years -
Understanding Stress and Alcohol Use in College-Aged Women
Official Title Examining the Role of Sensitivity to Uncertain Threat and Alcohol Response in Risk for AUD following Sexual Assault in College WomenPurpose
The purpose of this study is to better understand how stress relates to alcohol use in biological females aged 21-29.
Participation in the study includes three in-person visits and the completion of daily phone surveys across 21 days while wearing a biosensor, which is similar to a Fitbit or smart watch. The first lab visit includes screening and orientation with blood draw, EKG, and sensory tasks. The second and third lab visits include sensory tasks and intravenous alcohol or placebo (a saline solution) administration. Participation in the study occurs over a period of 7 weeks.
Could this study be right for you?
Inclusion Criteria:
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Biological female
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21-29 years old
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At least a high school education
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Fluency in English
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Drink alcohol regularly
(partial list of inclusion criteria)
Exclusion Criteria:
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Current pregnancy
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Lifetime history of psychosis
(partial list of exclusion criteria)
Age Range
21 - 29 years -
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Study of Pain Sensitivity and Responses to Alcohol
Official Title Pain Sensitivity, Alcohol-Induced Analgesia, and Heavy Drinking in Individuals with Opioid Use DisorderPurpose
The purpose of this study is to better understand how pain and related emotions change during sobriety and after drinking alcohol.
The length of the study is approximately 4 weeks and will include three on-campus lab visits at Ohio State's Medical Campus. The first lab visit includes screening and orientation with blood draw, EKG, and sensory tasks. The second and third lab visits include sensory tasks and intravenous alcohol or placebo (a saline solution) administration. The total time commitment of the study is approximately 17 hours.
Could this study be right for you?
Inclusion Criteria:
For this study, we are looking for people ages 21–65 who meet one of the following:
- Drink alcohol regularly
- Drink alcohol regularly and use opioids
- Occasionally drink alcohol and use opioids
(partial list of inclusion criteria)
Exclusion Criteria:
- Sensitivity to alcohol
- Current pregnancy
- Current or past diagnosis of mania or psychosis
(partial list of exclusion criteria)
Age Range
21 - 65 years -
Children's Hobbies, Interests, and Media Use
Official Title Children's Hobbies, Interests, and Media UsePurpose
Purpose
Researchers at The Ohio State University are studying children's hobbies, interests, and YouTube viewing. We hope to learn more about the types of videos children watch and how those videos relate to their hobbies and interests.What will I do?
If you have a child ages 3-8 who watches YouTube using a supervised kid account (or if you are willing to create one), you will complete two online surveys over about one month. At the end of the study, you will download and securely provide your child's YouTube viewing history to the research team. Detailed instructions will be provided.How long will participation take?
Participation lasts about one month. The study includes two surveys (about 20 minutes each) and a final viewing-history submission (about 10 minutes).Could this study be right for you?
- Parent or guardian of a child ages 3-8
- Child watches YouTube
- Child has a supervised kid account or parent is willing to create one
- Willing to provide the child's YouTube viewing history at the end of the study
Age Range
18 years and up -
Online Caregiver Focus Group Study
Official Title Development of Internet-Based Mind-Body Trainings for Spousal Caregivers of Persons Living with Dementia (Caregiver iMBT)Purpose
The main goal of this study is to better understand the experiences of caregivers. We are interested in the mental and physical health of spousal caregivers of persons living with dementia. We will learn about caregiver experiences using online focus groups, which are discussions where a group of people get together to talk about a particular topic. The information we learn from the focus groups will be used to adapt existing internet-based mind-body interventions to promote caregiver wellbeing.
Study participation will typically take place over 3 to 4 months. The total time commitment will be up to 6 hours, involving a brief eligibility screening, two 2-hour focus group sessions, and online questionnaires lasting up to 1 hour.
Could this study be right for you?
- You provide weekly care for your spouse who has a formal diagnosis of dementia
- You do not have any of the following: Alzheimer's disease, vascular dementia, Parkinson's disease, Lewy body disease, fronto-temporal lobar degeneration
- You are a fluent English speaker
- You have access to the internet and an at-home computer with a working microphone and video camera
- You have adequate hearing for focus group participation
- You live in the state of Ohio
Age Range
50 years and up -
Testing the Impact of COVID-19 on Taste and Smell
Official Title Short-term and long-term impact of COVID-19 on multiple sensory systemsPurpose
Aim 1. To learn about how COVID-19 impacts the senses
We will study how COVID-19 influences basic senses including smell, taste, and balance. We will also administer health questionnaires and cognitive tests to determine how a past COVID-19 infection may influence current health.
Aim 2. To learn about how sensory problems may change and recover over time
We track people with COVID-19 and other infections over time to determine if sensory related symptoms improve. This includes three total follow up visits after the initial assessment.
Our overall goal is to better understand how COVID-19 influences sensory systems over time.
Could this study be right for you?
- Have had COVID-19 or an upper respiratory infection (such as the common cold or flu) within the last 8 weeks, OR
- Had COVID-19 or an upper respiratory infection >8 weeks ago with ongoing sensory symptoms (smell, taste, hearing or balancing problems, dizziness).
Age Range
18 - 99 years -
Understanding the Link Between Chronic Pain and Suicide Risk
Official Title Modifiable Mechanisms Linking Chronic Pain to Suicide RiskPurpose
The purpose of this study is to better understand how certain thoughts, feelings, and responses to pain may be related to thoughts of suicide in people with chronic pain.
Participants will complete an online screening session that will involve a short interview and questionnaires which will take approximately 3.5 hours and a 2.5-hour in-person lab visit that will include EMG and EEG and a pain pressure test. After, participants will be asked to complete daily app-based questionnaires on their phone for 21 days.
Could this study be right for you?
- Currently experiencing chronic pain
- Have recently felt that life is not worth living or that you would be better off dead
Age Range
18 - 65 years