Search Studies
Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.
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Comparing Tongue Strength and Endurance Before and After Eating a Meal
Official Title Impact of Meal Consumption on Lingual EndurancePurpose
The purpose of this study is to understand how eating a meal can affect muscle fatigue in the tongue in individuals with swallowing difficulties due to a neurological disorder or history of a stroke.
If you choose to participate, you will:
- Complete questionnaires about your swallowing and overall health.
- Participate in measurements of your tongue strength using a small, soft bulb placed in your mouth.
- Eat a standard meal of chicken, masked potatoes and green beans.
- Remeasure your tongue and grip strength after the meal
This study is completed in 1 session that lasts approximately 90 minutes.
Could this study be right for you?
- 18 years of age or older
- Report at least some signs/symptoms of difficulty swallowing (dysphagia)
- Have a diagnosed neurological disorder
- English speaking
- Able to eat a standardized meal of chicken, green beans and mashed potatoes
- Adequate dexterity to self-administer foods and drink via fork and cup
Age Range
18 - 100 years -
Pain Response & MRI Study in Autistic and Non-autistic Adults (ages 18-40)
Official Title Measurement and Mechanisms of Pain in Autistic AdultsPurpose
The purpose of this project is to study how pain may differ in adults with or without autism. Our goal is to study whether or not pain is experienced of felt differently in autistic adults compared to non-autistic adults.
Participants will be screened by phone. After meeting the initial screening criteria, the study visits will be scheduled.
In the first visit, you will be asked to take some paper and pencil tests, some surveys on a computer, and complete brief pain tasks. We may also ask that you bring a study partner with you, someone that knows you well.
In the second visit, you will complete a brief pain task, answer a few questions, and get an MRI of your brain. Each visit will not be more than 3 hours of your time in total. Your information will always be kept confidential.
Could this study be right for you?
- Not currently on any daily pain medications
- No history of traumatic brain injury (TBI)
Age Range
18 - 40 years -
Food and Fitness with Medicine
Official Title Food and Fitness with MedicinePurpose
We are conducting a new study to explore whether a supportive program that combines healthy eating, enjoyable physical activity, and practical resources can improve health in postmenopausal women living with heart, kidney, or metabolic conditions who are using weight‑management medications. As more women use these medications, researchers want to understand how they can be paired with supportive lifestyle changes like nourishing food and enjoyable movement to improve overall health.
As more women turn to these medications, there is an important need to understand how they work best alongside real‑world lifestyle supports. This study aims to answer that question.
Depending on your group, you may also take part in activities such as personalized nutrition counseling, cooking demonstrations, groceries or vouchers, structured fitness, and optional online or at‑home resources. The goal of this research is to understand what truly helps people build and maintain healthy habits over time. By participating, you can contribute to research that will help guide future care and improve health programs for women like you.
Could this study be right for you?
Eligibility criteria:
- Post-menopausal
- Have at least one of the following conditions: hypertension, type 2 diabetes, high triglycerides, metabolic syndrome, moderate CKD
- Plan to start a GLP-1 medication or have started a GLP-1 medication within the last 6 weeks
Age Range
45 - 79 years -
The Effects of Carbohydrates in Half-Ironman and Full-Ironman Triathletes Habitually Consuming a High Carbohydrate Diet
Official Title The Performance and Metabolic Effects of Carbohydrate Dosing Strategies (10g, 60g, 90g/hr) During Endurance Cycling in Triathletes Habitually Consuming a High Carbohydrate Diet, Including ¹³C-Breath Analysis of Exogenous Carbohydrate OxidationPurpose
This study will look at how different amounts of carbohydrates—10g, 60g, or 90g per hour—affect the energy and performance of male triathletes during long bike rides. By using endurance tests and a simple breath test, we will track a specific type of carbon (13C) found in cycling drinks to see how the body burns fuel while exercising.
Ultimately, the goal is to create clear, science-based rules to help athletes know exactly how much they should drink during cycling to perform their best during training and races.
This study includes one familiarization where we measure your aerobic fitness, and 4 experimental visits where we test various carbohydrate solutions (0, 10, 60, 90g per hour) during cycling time-to-exhaustion and then a 20-km time-trial.
Could this study be right for you?
- Healthy men aged 18-50
- Have completed a half-Ironman in under 6 hours or a full Ironman in under 13 hours,
- Cycle >100 miles per week,
- Have 2+ years of consistent triathlon training
Age Range
18 - 50 years -
Using Mobile Technology to Improve Body Composition Assessment and Track Physical Activity in Adults with Down Syndrome
Official Title Improving Body Composition Assessment and Physical Activity Monitoring in Adults with Down Syndrome using Mobile Technology
Purpose
The purpose of this study is to learn how well wearable technologies, such as smartwatches and activity trackers, can measure body composition and physical activity in adults with Down syndrome. Adults with Down syndrome are at a higher risk for obesity and related health conditions, and current methods used to measure body composition and activity can be difficult or uncomfortable. This study aims to identify simpler and more comfortable ways to collect this information.
If you choose to participate, you will be asked to attend one in-person study visit at a research laboratory. During this visit, you will complete a series of body measurements and light physical activity tasks. These include providing a small urine sample to check hydration, having your height, weight, and body composition measured using several methods (including a scan where you lie still for several minutes), and completing strength and walking tests. You will also wear multiple activity tracking devices on different parts of your body while completing short walking activities.
Your total time involved in this study will be one visit lasting approximately a few hours.
Could this study be right for you?
- Adult diagnosed with Down Syndrome
- Weight <350 lbs
- No condition that impacts body composition assessments (e.g., pacemaker)
- Not pregnant or planning to become pregnant
Age Range
18 - 60 years -
Contact Lens Study in Adults Over the Age of 40
Official Title Study Presbyopic Wear Experience with TOTAL30 Multifocal Lenses compared to Single Vision Lenses and Reading GlassesPurpose
For this study, we are seeking adults over 40 to participate in a contact lens study to compare distance contact lenses used with reading glasses to multifocal contact lenses that correct vision at all distances. Participants will be asked to wear study-provided lenses for 8 weeks. Vision and eye health will be check at each visit, and participants will complete surveys using their smart device.
Participants will be in the study for approximately 8 weeks. The first visit will take the longest, 2 hours, and each subsequent visit should take no longer than 1 hour. You will be contacted 6 months and 1 year after study completion to take a survey.
Could this study be right for you?
- Adults with contact lens experience.
- Ability to attend 5 visits over the course of 8 weeks.
- Satisfy all other study eligibility and exclusion criteria.
Age Range
40 years and up -
Evaluating the Efficacy of a Psychedelic Investigational Drug for Patients who are Struggling with Symptoms of Depression and Anxiety due to Cancer or Other Life-Changing Medical Illness
Official Title A Randomized, Double-Blind, Parallel-Group, Dose-Controlled Study Evaluating the Safety and Efficacy of RE104 for Injection in the Treatment of Adjustment Disorder in Patients with Cancer and Other Medical IllnessesPurpose
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms or depressive symptoms mixed with anxiety symptoms in participants with Adjustment Disorder due to cancer or other illnesses such as Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Parkinson's Disease (PD) or Idiopathic Pulmonary Fibrosis (IPF) as compared to active-placebo.
Could this study be right for you?
- Depression due to cancer, Parkinson’s, ALS, MS, or IPF
- Currently depressed
- Projected life expectancy of ≥6 months.
Age Range
18 - 80 years -
Evaluating the Safety and Efficacy of Icalcaprant in the Treatment of Subjects with Major Depressive Disorder (MDD)
Official Title A Phase 2, Multicenter, 6-Week, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Icalcaprant in Subjects with Major Depressive DisorderPurpose
Major depressive disorder (MDD; depression) is a mood disorder that causes a continued feeling of sadness and loss of interest. It is a common and serious illness that can cause both emotional and physical symptoms such as feelings of sadness, irritability, not being able to focus on activities, tiredness, changes in eating habits, and aches and pains.
This study will assess the changes in disease activity and adverse events of oral Icalcaprant in adult participants with major depressive disorder who are currently experiencing a major depressive episode (MDE).
Could this study be right for you?
- Diagnosed with MDD
- Current major depressive episode
- Willing to discontinue antidepressant treatments
Age Range
18 - 65 years -
Evaluating the Efficacy and Safety of Icalcaprant in Subjects with Bipolar Depression
Official Title A Phase 2, Multicenter, 6-Week, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Icalcaprant in Subjects with Bipolar DepressionPurpose
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population.This study will assess how safe and effective Icalcaprant is in treating adult participants with bipolar I or II disorder.
Could this study be right for you?
- Diagnosed with Bipolar Disorder I or II
- Currently in a depressive episode
- Currently receiving treatment of a mood stabilizer
Age Range
18 - 65 years -
Generalized Anxiety Disorder Study for Those Who Have Had an Inadequate Response to Antidepressants
Official Title A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Fixed-Dose Study to Evaluate the Efficacy, Safety, and Tolerability of ABBV-932 as an Adjunct to Antidepressant Therapies in the Treatment of Subjects With Generalized Anxiety Disorder Who Have Had an Inadequate Response to Antidepressant TherapiesPurpose
Generalized anxiety disorder (GAD) is usually treated with antidepressant therapy (ADT); however, sometimes ADTs alone are not enough to adequately treat GAD. The purpose of this study is to assess how safe and effective ABBV-932 is when added to the antidepressant therapies in adult participants with GAD who have had an inadequate response ADTs.
Could this study be right for you?
- Adults 18-65
- Diagnosed with GAD
- No depressive episodes in at least 6 months
- Currently receiving treatment of either paroxetine, escitalopram, duloxetine, or venlafaxine ER
Age Range
18 - 65 years -
Research Study for Grave's Disease
Official Title A Phase 1, First-in-Human, Placebo-Controlled, Single and Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Intravenous and Subcutaneous Administration of MER511 in Adults With Graves’ DiseasePurpose
1. To find out how safe the study drug is and how well people with Graves’ disease can handle taking one or more doses.
2. To describe how the body absorbs, uses, and removes a single IV or subcutaneous dose, or several subcutaneous doses, of MER511 in people with Graves’ disease.
3. To check whether the body creates an immune response after a single IV or subcutaneous dose, or several subcutaneous doses, of MER511 in people with Graves’ disease.
Could this study be right for you?
1. Grave's disease diagnosis
2. Taking methimazole or propylthiouracil
3. Weigh at least 110 lbs
4. Women of childbearing potential must agree to use contraceptive methods and avoid egg donation during the study; Men with partners of childbearing potential must agree to use a condom or abstinence and avoid sperm donation during the study
Age Range
18 - 55 years -
Men’s Health, Friendships and Relationships
Official Title Men Talking: How Do Men Discuss Health, Friendships, and Relationships?Purpose
The purpose of this study is to gain a better understanding of men’s friendships, relationships, and health-information seeking.
The study consists of a 60–90-minute interview at a location of the participant’s choosing.
Thank you for your time and assistance!
Could this study be right for you?
- 18 years and older
- assigned male at birth
- live in Columbus Metro Area
Age Range
18 years and up