Search Studies
Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.
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The OSU Sleep Study - An Online Parent Training Research Study for Insomnia/Sleep Problems in Young Children with Autism Spectrum Disorder
Official Title A Parent-Mediated Telehealth Intervention for Insomnia in Young Autistic ChildrenPurpose
Insomnia is a common problem for young children with autism spectrum disorder (ASD) and their families. The purpose of this study is to compare the benefits of sleep parent training (SPT) program to a structured parent education program (SPE) for insomnia improvement in young children with autism spectrum disorder.
Could this study be right for you?
You may be eligible if your child:
1. Has a diagnosis of Autism Spectrum Disorder
2. Has significant Sleep Disturbance
3. Is free of a significant health problem
4. Is on stable medication
Age Range
3 - 7 years -
The ADAPT-GH Study
Official Title Adaptation of the Dietary Approaches to Stop Hypertension (DASH) Eating Pattern to Improve Cardiovascular, Kidney, and Metabolic Health in Ghanaian Adults: The ADAPT-GH StudyPurpose
This study will develop and test a culturally adapted meal plan consistent with the DASH eating pattern to improve blood pressure and heart health among Ghanaian adults with elevated BP.
We hypothesize that adapting a traditional DASH eating pattern to fit the preferences of first-generation Ghanaian immigrant adults, and using a meal plan schedule, shopping list, nutrition education, and remote patient monitoring, will produce improvements in blood pressure and heart health when compared to the traditional DASH eating pattern.
Participants in this study will be involved in one of two parts.
The first part of the study involves group discussion. Using co-design sessions, we will collect information on the nutrition-related experiences, dietary preferences, challenges and facilitators of culture-aligned healthy eating in 15 Ghanaian adults to improve their blood pressure and heart health. We will use the information from these sessions to construct a DASH meal plan that is culturally adapted for the Ghanaian diet. Participation in this part of the study will last a total of 4 weeks, and includes 1 virtual session, with 3 following sessions either virtually or in-person at OSU Wexner Medical Center approved locations. Participants will receive a $25 Kroger gift card for each session attended.
To participate in this part of the study, you must be:
- A first-generation or second-generation Ghanaian Immigrant
- 18 years or older
- Residing in or near Columbus, Ohio
- English speaking
The second part of the study will use a randomized controlled trial to randomly assign 40 adults with elevated blood pressure or hypertension to one of two arms: the culturally adapted DASH meal plan arm or the traditional DASH meal plan arm. Participation in this part of the study will last a total of 20 weeks, and includes 3 in-person lab visits and a follow up, following a meal plan with associated shopping list, taking part in at home blood pressure and weight monitoring, and watching educational nutrition videos. Participants will receive a $25 Kroger gift card for each lab visit attended.
To participate in this part of the study, you must be:
- A first-generation or second-generation Ghanaian Immigrant
- 18 years or older
- Residing in or near Columbus, Ohio
- English speaking
Participants involved in the first part of the study may choose whether they would like to participate in the second part.
Could this study be right for you?
First-Generation or Second-Generation Ghanaian Immigrant
Residing in or near Columbus, Ohio
History of High Blood Pressure/Hypertension
English Speaking
Possesses a Smartphone with Bluetooth Capabilities
Age Range
18 years and up -
Emotional Regulation among Distressed Young Adults
Official Title Emotion Regulation Training to Reduce Cardiovascular Disease Risk Among Distressed Young Adults: A Single-Session DesignPurpose
This study looks at how learning to manage emotions can improve your mental and physical health.
You will meet with a research team member for an interview about your mental health. If you qualify, we will take a few drops of blood from a finger prick and check your heart rate and blood pressure. You will also learn some emotional regulation skills for handling tough emotions and fill out surveys about yourself. For two weeks after, you'll answer short surveys on your phone five times a day. Then you'll come back for one more short visit.
Could this study be right for you?
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Have a depressive or anxiety disorder
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Are not currently receiving mental health counseling
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Read and understand English
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Are willing to have a finger prick for a blood sample
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Free from immune-related or heart-related diseases
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Own or have access to a smartphone
Age Range
18 - 39 years -
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Anxiety and Inflammation in Adults
Official Title Inflammation in adults with anxiety disordersPurpose
This study looks at how anxiety can affect your immune health.
You will meet with a research team member for an interview about your mental health. If you qualify, we will take a few drops of blood from a finger prick. Then you will fill out some surveys about yourself and your mental health.
Study visits will last approximately 2 hours. Once the 2-hour visit is complete, you will be released from the study. There will be no long-term follow-up after completion of research related procedures.
Could this study be right for you?
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Have an anxiety disorder (social anxiety disorder, specific phobia, panic disorder, agoraphobia, generalized anxiety disorder).
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Are 18 years or older
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Read and understand English
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Free from immune-related diseases
Age Range
18 years and up -
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Effectiveness of Pairing a Keto Diet with Psychotherapy for PTSD
Official Title Enhancing PTSD Recovery with Metabolic-Augmented PsychotherapyPurpose
To test whether a personalized ketogenic program in combination with cognitive processing therapy (CPT) can improve symptoms of post-traumatic stress disorder (PTSD).
The study will involve 11 weeks of a personalized ketogenic program guided by a dietician, 10 sessions of CPT, interviews, questionnaires, and wearing sensors to track your stress, sleep, glucose, and ketones.
Could this study be right for you?
- 18 years or older
- Able to attend in-person visits to OSU once per week for 12 weeks
- Meet diagnostic criteria for PTSD (prior diagnosis is NOT required, all individuals will be evaluated by the study team)
Age Range
18 years and up -
Exercise MRI Study
Official Title Exercise Stress CMR to Identify Myocardial DysfunctionPurpose
The purpose of this study is to compare heart MRI images taken at rest and during exercise to look for signs of heart problems.
Could this study be right for you?
Researchers are studying a new cardiac MRI exercise test that may help doctors better diagnose heart muscle disease (cardiomyopathy).
You may be eligible if you:
Are a healthy adult volunteer
Have shortness of breath at rest or during activity
Had an abnormal heart imaging test but do not have symptoms
What Will Happen?
Participants will complete one exercise cardiac MRI scan as part of this research study.Age Range
18 - 80 years -
Single-Dose Investigational Drug Study for Depression and Anxiety
Official Title A Randomized, Double-Blind, Placebo-Controlled Mechanistic Study to Assess a Single Oral Dose of CYB003 in Participants with Major Depressive Disorder (MDD) and Moderate to Severe AnxietyPurpose
The aim of this study is to determine the effects of one administration of the psychedelic compound CYB003 on depression and anxiety symptoms as well as its effects on brain function.
Could this study be right for you?
1. Currently have depression with moderate to severe anxiety
2. Are currently taking an antidepressant and your symptoms have not improved enough
3. Have been on the same antidepressant dose for about 1 month
Age Range
21 - 65 years -
EEG Research Study
Official Title Neural Biomarkers of Sensory Symptoms in AutismPurpose
This research aims to understand how sensory issues, particularly related to hearing, impact children on the autism spectrum. Using a tool called EEG, we study how their brains respond to sounds. Previous research with adults on the spectrum showed that their brains react more slowly to sounds, affecting their ability to pay attention. This protocol investigates if a similar pattern exists in children with autism.
Could this study be right for you?
We are searching for healthy neurotypical boys aged 8-12.
Age Range
8 - 12 years -
Menthol Study
Official Title Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse LiabilityPurpose
Adults age 21+ are invited to participate in 5 study visits to understand how different menthol cigarettes compare to one another as well as their usual brand of menthol cigarettes.
Participation includes:
· Five study visits at OSU (four visits, ~3 hours each; one final visit, 2 hours) over the course of three weeks, where you'll smoke your usual brand and study cigarette products and complete surveys
· Two weeks of daily phone surveys (~7 minutes per day)
Could this study be right for you?
- currently smoke menthol cigarettes daily
- willing to abstain from nicotine, tobacco and cannabis products for 12 hours before each study visit
- own a smartphone and are willing to complete daily assessments
- able to read, speak and understand English
Age Range
21 years and up -
A Study about how virtual Yoga sessions affect symptoms and quality of life in patients with diabetic gastroparesis
Official Title The Effect of Virtual Yoga Intervention on Symptom Severity and Quality of Life in Patients with Diabetic GastroparesisPurpose
The purpose of this research study is to understand how virtual Yoga sessions conducted 4 days a week for 12 weeks affect digestive symptoms and quality of life in those suffering from gastroparesis due to diabetes mellitus.
Could this study be right for you?
- Able to understand English
- Must have been diagnosed with gastroparesis
- Must have type 1 or type 2 diabetes mellitusAge Range
18 - 65 years -
Clinical Trial Involving Monthly Injections for Osteogenesis Imperfecta (OI)
Official Title A Phase 2, Multi-center, Randomized, Double-blind, Placebo-controlled, Dose-ranging Study to Evaluate the Safety and Efficacy of AGA2115 in Adults with Type I, III, or IV Osteogenesis Imperfecta (OI)Purpose
The reason for this study is to see if the investigational drug, called AGA2115, can help increase bone mineral density in people with osteogenesis imperfecta. AGA2115 or a placebo drug will be given at the clinic once a month subcutaneously. During this study, changes in bone biomarkers, number of bone fractures, and quality of life, will be measured to see if AGA2115 can help people with osteogenesis imperfecta. This study will also look at how the body absorbs, breaks down and gets rid of AGA2115 (called pharmacokinetics), if AGA2115 affects any markers of bone metabolism in the body, if the body’s natural defense system (the immune system) tries to make antibodies to AGA2115 (called immunogenicity) and how well people feel while taking AGA2115, including any side effects they may have.
You will be asked to complete the following: perform monthly injections, take Vitamin D and Calcium supplements, perform ECGs and DEXA scans, provide blood samples, perform grip strength tests, do hearing tests (called Audiometry and Tympanometry), complete questionnaires, undergo a one-time bone biopsy, and see the study doctor.
If you do not have genetic confirmation of osteogenesis imperfecta, we may be able to test for it through the study.
The study will last 27 months.
Could this study be right for you?
The most important eligibility criteria include the following. This is not an expansive list.
- Genetic confirmation of Osteogenesis Imperfecta Type I, III, or IV diagnosis
- DXA scan assessing L1-L4 region
- BMD T-score <= -1.0 at lumber spine OR total hip OR femoral neck
- Cannot be taking IV or oral bisphosphonate with the past 6 months
Age Range
18 - 75 years -
Heart2Heart Research Study
Official Title Creating a Mobile Health Program for Teens with Congenital Heart Disease (“Heart2Heart Research Study”)Purpose
The study aims to understand what teens with congenital heart disease want and need in mobile health program that helps them learn about their heart health and overall wellness.
Could this study be right for you?
Enrollment is by invitation only. The study team will contact you if you are eligible to participate.
Age Range
12 - 18 years