Official Title A Phase 2/3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy, Safety and Tolerability of BHV-7000 in Subjects with Refractory Focal Onset Epilepsy

Purpose

This research is being done to see the effectiveness and safety of a new drug called BHV-7000 as a possible treatment for focal seizures for patients who are taking anti-seizure medications (ASMs) and still experiencing seizures. Refractory focal epilepsy is when someone continues to have focal seizures despite treatment with ASMs or other treatments.

People who take part in this study will be randomly assigned to either study medication or a placebo, will participate for up to 5 months, and the study includes up to 7 in-person visits.

Could this study be right for you?

1. Experiencing at least 4 or more observable focal seizures per month

2. Taking at least 1 and up to 3 anti-seizure medications

3. Do not have a history of cluster/repetitive seizures (which you were not able to individually count) in the past 6 months

4. Between the ages of 18 to 75

Age Range

18 - 75 years

Official Title A Randomized, Double-blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

Purpose

In this research study a study drug named XEN1101 is being tested for the treatment of seizures. The main purpose of this study is to determine if XEN1101 can reduce the seizure frequency and if it is safe to use.  People who take part in this study will be randomly assigned to either study medication or a placebo, will participate for up to 5 months, and includes up to 7 in-person visits.

Could this study be right for you?

1. Experiencing at least 3 PGTCS in an 8-week period

2. Have tried at least 2 anti-seizure medications without success

3. Do not have a history of cluster/repetitive seizures (which you were not able to individually count) in the past 12 months

4. 18 years old and up

Age Range

18 years and up

Official Title Sex Differences in Alcohol Use: Neural and Hormonal Influences

Purpose

The goal of the study is to gain a better understanding of how hormonal fluctuation across the female menstrual cycle impact brain activity and associated drinking behaviors.

Participation includes:
•    One orientation session (2 hours)
•    Three brain imaging (fMRI)/alcohol and saline administration sessions (7 hours each)
•    Six follow-up online surveys (30 mins each)
•    Two follow-up sessions (1 hour each)

The total time commitment of the study is 28 hours over the course of 21 months.

Could this study be right for you?

1. Age: 21–26 years old (must bring proof of age to Orientation, e.g., driver’s license or passport)
2. In good health, as confirmed by responses to the Screening Interview
3. No contraindications for fMRI (e.g., no metal in the body, as confirmed by MRI screening form)
4. Reports typical weekly alcohol consumption 
5. No current or past treatment for a drug or alcohol use disorder
6. Not currently pregnant, breastfeeding, or planning to become in the next 3 months (women only)
7. Regular menstrual cycles (women only)
8. No use  of hormonal contraception or plans to begin use within the next 3 months (women only)

Age Range

21 - 26 years

Official Title Identification of novel signatures of proximal changes in the severity of suicide risk states

Purpose

This study will examine how people experience mental health symptoms, distress, and suicidal thoughts in their daily lives, to identify signs that indicate that someone's suicide risk is getting worse or improving. We will recruit people who are at different levels of suicide risk.

You will be asked to complete a survey about your life experiences, mental health symptoms, suicide thoughts, and coping strategies. You will also be asked to complete short surveys on your phones several times a day for 28 days to understand how suicide risk changes over time, and you will be provided with mental health resources you can access if in crisis.

Could this study be right for you?

1. aged 18+
2. the ability to speak, read, and understand English well enough to participate in study procedures 
3. comfort with smartphone technology
4. are currently a U.S. resident
5. participants must endorse suicidal ideation in the past week
6. and/or endorse an suicide attempt, aborted attempt, or interrupted attempt within the past month

Age Range

18 - 100 years

Official Title Pain Sensitivity and Endogenous Pain Modulation in Autistic Adults (R21)

Purpose

The purpose of this project is to study how pain may differ in adults with or without autism. Our goal is to study whether or not pain is experienced of felt differently in autistic adults compared to non-autistic adults.

Participants will be screened by phone. After meeting the initial screening criteria, the study visit will be scheduled. Participants can expect one study visit lasting 2-3 hours with time built in for breaks.

Could this study be right for you?

• Not currently on any daily pain medications

Age Range

30 - 70 years

Official Title Examining the efficacy of a soft soy pretzel intervention in altering chronic inflammation and immune profiles in obese individuals

Purpose

The objective of this study is to evaluate if soy isoflavones, delivered via soft soy pretzels (SSP), can be an effective, feasible intervention for chronic inflammation.

 

All study visits will be at The Ohio State University Medical Center and the study will last 8 weeks and involve 7 clinic visits.

Could this study be right for you?

You may be eligible if you:

• Are a male between 18 and 49 years old
• Have a body mass index (BMI) less than 25 or greater than or equal to 30
• Are not allergic to soy or soy-containing products
• Are not actively trying to lose weight

Exclusion criteria: 

• Current or prior history of Type 2 diabetes mellitus as defined by ICD-10-CM E11
• Current or prior history of cancer (excluding non-melanoma skin cancers)
• History of blood clotting disorders or adverse events relating to blood draws
• Use of antibiotic regime lasting longer than one week within the last six months
• Strict veganism (no consumption of animal, fish, or egg products)
• Heavy alcohol consumption (defined as consumption of >14 drinks/week on average)
• Current or prior history of any condition that causes altered immunity such as chronic inflammatory disease, autoimmune disorders, cancer, anemia, and blood dyscrasias
• Regular usage of inflammation lowering medications which include but not limited to nonsteroidal anti-inflammatory drugs such as aspirin, ibuprofen, and naproxen, or anti-pyretic medications such as acetaminophen

 

Age Range

18 - 49 years

Official Title Linking Age, Balance, Vestibular Function, and Falls

Purpose

The purpose of this study is to learn how aging in different sensory systems, including the vestibular system (that portion of the inner ear that measures both motion and orientation of the head), influences maintaining balance while standing and walking, and contributes to fall risk. 

Could this study be right for you?

• Must be able to stand
• No leg or foot amputations
• No lower limb braces
• Not currently feeling dizzy/lightheaded
• Not currently pregnant by self-report
  • Due to potentially nauseogenic nature of some motions and to protect fetus and mother, pregnant women will also be excluded from this study
• Weight <= 275 pounds
• No past or current history of:
  • Severe head trauma or traumatic brain injury
  • Any vestibular disorder (e.g., Meniere’s Disease, Vestibular Migraine, Unresolved BPPV/BPPN, Vestibular hypofunction, except that due to aging, PPPD) as assessed using clinical diagnostic tests described in proposal
  • History of seizures
  • Neurologic illness or conditions known to impact vestibular or balance function(e.g., stroke, neurodegenerative disorders, demyelinating illness)
  • Major psychiatric (e.g., panic disorder, psychosis, etc.) disorder
  • Any of the following eye diseases or conditions: amblyopia (or “lazy eye”) or history of amblyopia, diagnosis of age-related macular degeneration, retina dystrophy, glaucoma, cataracts, or any other eye condition that limits vision to worse than 20/40
  • Recent (<6 months) orthopedic injuries of the lower extremities (e.g., plantar fasciitis, ankle, knee or hip injury, back strain/herniated disc, …).
  • Upper extremity injuries requiring current sling immobilization
  • Recent surgery
  • Any other severe health problem (heart disease, pulmonary disease, cancer, etc.).
  • Vision in both eyes must be better than 20/40 with best correction
  • Outer and/or middle ear pathologies
  • Otologic pathologies or diagnoses (e.g. Meniere’s disease, otosclerosis, conductive or mixed hearing losses)
• Must be able to walk unassisted for 30 minutes
• No current use of ambulatory assistive devices
• Normal hearing bilaterally, air conduction pure-tone thresholds ≤ 25 dB HL at all octave frequencies between 250 and 8000 Hz
• Bilaterally, symmetric sensorineural hearing loss with four-frequency pure-tone average (500, 1000, 2000, 4000) less than 71 dB HL
• If interested, please go to go.osu.edu/vestibular to be screened for eligibility

Age Range

18 - 89 years

Official Title Fostering Agricultural Relationships and Meaning - Thriving on Kinship (FARM-TOK)

Purpose

The purpose of this study is to understand how well and how accepted a phone-based intervention for loneliness works for people in rural or farming/agricultural areas. The goal of this intervention is to reduce loneliness and improve mental well-being. 

Could this study be right for you?

Inclusion criteria 

• Understand English
• Reside in an agricultural area in Ohio 
• Experiencing loneliness or social isolation 

Exclusion Criteria 

• Limited mental competency/not able to give informed consent 
• Non-English Speaking 
• Diagnosis of neurological disorder or Bipolar I
• Current psychotic diagnosis
• Suicidal or homicidal intent indicating need for hospitalization or treatment (as determined by clinical interviewer)

Age Range

18 years and up

Official Title The Foods and Oils to Repair Correct and Enhance Strength (FORCES) Study: Determining the effect of dietary oils on muscle function, strength and mass

Purpose

The purpose of the FORCES Study is to determine how dietary oils effect muscle function, strength and mass in older adults who feel their muscle function and strength has declined with age.

During this 27-week study participants will

•  Consume ~2.5 tsp of oil each day through foods

• Complete muscle function and strength testing

• Have their blood drawn

• Have their body weight and composition measured

• Have an MRI scan of your legs, if able

• Fill out questionnaires

• Collect a small amount of muscle tissue from the leg (muscle biopsy

Could this study be right for you?

Feel your muscle function, strength or mass as decreased with age

Do NOT have food allergies 

Are not taking any weight loss medications or following a weight loss program

Age Range

65 - 80 years

Official Title Contribution of Glutamate Excess and Inflammation to Progressive White Matter Changes in Psychosis

Purpose

The purpose of this study is to assess the extent of white matter abnormalities, glutamate alterations, and inflammation in unmedicated patients with psychosis at different illness stages compared to healthy controls.

Could this study be right for you?

• No major medical conditions
• No history of significant head trauma 
• Not currently using medications for mental health purposes (anxiety, depression, other psychiatric diagnosis)
• No metal implants that would present a risk to complete an MRI
• No known pregnancy (if applicable)

Age Range

16 - 45 years

Official Title Learning Interactions Made for Everyone (LIME)

Purpose

This study will examine activities of caregivers and their preschool aged child over a 12-week period. Caregivers will track learning activities with their child over the 12-weeks. Some participants will be asked to engage in additional learning activities with their child. Researchers will conduct assessments with the child before and after the 12-week program, as well as brief follow-ups 3-, 6-, and 12- months after completion. The total duration of participation in this study is up to 24 hours. The study will identify strategies in home-based learning activities and inform development of interventions to improve school readiness among children.

Could this study be right for you?

Child is minimally verbal in English.

Caregiver understands enough English to understand intervention materials.

Child does not have a severe intellectual disability.

Caregiver and child reside in the greater Columbus area.

Age Range

42 - 57 months

Official Title Phase I Study of the Safety and Feasibility of a Ketogenic Dietary Intervention to Improve Response to Immunotherapy

Purpose

This study will look at if a ketogenic diet (KD) can help treatment work better in patients with metastatic melanoma or metastatic kidney cancer. People who take part in the study will be randomly assigned to either continue eating their usual diet or trying the KD diet for 24 weeks. Participants will have blood and stool samples collected during the study. They will also test their sugar by doing daily glucose fingers sticks. Participants may be paid up to $200 for taking part in the study.

Could this study be right for you?

1. Patients with metastatic melanoma receiving first-line treatment with immunotherapy or Patients with metastatic renal cell cancer receiving first line treatment with immunotherapy.
2. Willing to give three stool samples
3. Willing to participate in a ketogenic diet (KD)

Age Range

18 years and up