Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • A Study for those with Treatment Resistant Epilepsy & Anxiety

    Official Title
    An open-label clinical trial evaluating the ExAblate Model 4000 Type-1 focused ultrasound unilateral thalamotomy for patients with treatment-refractory focal onset epilepsy and comorbid anxiety
    Purpose

    The purpose of the study is to learn more about whether an ultrasound treatment for epilepsy and anxiety is safe and effective.

    Could this study be right for you?
    • Age: 18-65 years old
    • Treatment resistant Epilepsy (focal or partial-onset seizures)
    • ≥ 3 seizures/month
    • Moderate-to-severe Anxiety

     

     

    Age Range
    18 - 65 years
  • A Study Evaluating How Dietary Fat Affects Cognition

    Official Title
    Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study: Dietary Fat Quality and Cognitive Impairment
    Purpose

    The purpose of the EFFECT Study is to determine how dietary fats influence cognitive (mental) function in adults.

     

    During the 7-week study participants will

    • Consume one study food per day for a total of 3 weeks
    • Have their blood drawn
    • Have their body weight and shape measured
    • Complete cognitive tests
    • Fill out questionnaires
    • Complete diet and physical activity recalls
    Could this study be right for you?
    • Feel your memory or concentration is not as good as you'd like it to be
    • Are overweight
    • Do NOT have diabetes
    • Do NOT have dementia or Alzheimer's
    • Do NOT have food allergies 
    • Are NOT pregnant or nursing an infant
    Age Range
    40 - 75 years
  • Variations in Ketone Metabolism

    Official Title
    Strategies to Augment Ketosis- Variations in Ketone Metabolism
    Purpose

    This study is being done to see how individuals respond to a ketone ester (KE) across different age groups and health statuses. With the ketogenic diet becoming more popular, research on ketones (a molecule created when fat is broken down in the body) has grown as well. 

    These findings will be used to help develop future research studies and help others to pick the right doses of ketone supplement.

    Could this study be right for you?
    • Do NOT smoke or have diabetes, liver disease, kidney disease, cardiovascular disease, or any form of endocrine dysfunction 

    • Have NOT experienced >10% weight loss in the last 6 months 

    • Do NOT currently consume a low carbohydrate diet 

    • Do NOT consume alcohol more than 3 drinks/daily or 14 drinks/weekly 

    • Do NOT suffer from food allergies or gastrointestinal disorders 

    Age Range
    20 - 70 years
  • Sleep Restriction and Ketone Supplements

    Official Title
    Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction (STAK-Sleep)
    Purpose

    To examine if drinking a ketone supplement, twice a day, can improve brain, digital shooting, and physical performance during short-term sleep restriction (4 nights, 50% of normal sleep).

    Could this study be right for you?
    • Healthy
    • Age: 18 - 40 years old
    • BMI: 20-35 kg/m2
    • No diagnosed sleep disorders
    • Not consuming a ketogenic diet
    Age Range
    18 - 40 years
  • Emerging Adulthood and Parenthood Study

    Official Title
    Emerging Adulthood and Parenthood Study
    Purpose

    The Emerging Adulthood and Parenthood Study is a qualitative study designed to identify relevant factors and themes related the transitions to adulthood and parenthood in a sample of fathers. We will use qualitative, semi-structured interviews with parents to extract these themes and discuss important aspects about transitioning through life stages. After conducting these interviews, the identified themes will be utilized in the creation of questionnaire to measure the transition to parenthood. The goal of the study is to create a self-report questionnaire measure that captures the domains of emerging adulthood and emerging parenthood.

    We are currently looking to recruit fathers for our study. 

    Could this study be right for you?
    • Must have at least one biological child
    • Is/was one of the primary non-gestational caregivers (fathers) of that child
    • Speaks English as a first language
    Age Range
    18 - 65 years
  • Exogenous Ketone Study

    Official Title
    Strategies to Augment Ketosis: Optimization of Ketone Delivery Strategies (STAK: OK'd)
    Purpose

    This study is intended to evaluate the effects of different dosing measurements for different ketone products in healthy male adults. After giving consent to this study you will schedule 9 testing sessions about 3 days apart. During these sessions you will come into the Physical Activity and Education Services (PAES) building in the morning, having had no food that day and take a study product. Various tests will be administered after ingestion. You will have blood draws to tell us more about your metabolic response to the product.

    Could this study be right for you?
    • Have a BMI >18 kg/m2 or ≤29 kg/m2
    • Do NOT smoke or have diabetes, liver disease, kidney disease, cardiovascular disease, or any form of endocrine dysfunction
    • Do NOT currently consume a low carbohydrate diet

     

    Age Range
    20 - 30 years
  • A Study Investigating a Medicine to Improve Social Communication in Adolescents and Adults with Autism Spectrum Disorder (ASD).

    Official Title
    MapLight Study (IRIS Clinical Trial)
    Purpose

    The purpose of this study is to investigate a medication intended to improve social communication in adolescents and adults with ASD.

    Could this study be right for you?
    • Have an autism diagnosis or suspect you have an autism diagnosis
    • Have a caregiver or study partner willing to enroll in the study with you
    Age Range
    18 - 45 years
  • A Feasibility Study to Assess the Effect of a Ketogenic Diet as a Co-Therapy for Major Depressive Disorder

    Official Title
    Ketogenic Intervention in Depression (KIND)
    Purpose

    The overarching goal of this pilot study is to: (1) demonstrate that a well-formulated KD can be implemented in treatment program for major depression, and (2) test whether such a program results in reductions of symptoms of depression. 

    Could this study be right for you?

    Inclusion Criteria:

    • OSU students (age 18-30 years at the time of enrollment) with confirmed major depressive disorder as determined by SCID-5 diagnosis at baseline testing.
    • Currently engaged in counseling and or mediation treatment for depression
    • Available for a 12-week period and indicate willingness and ability to eat KD foods as prescribed

    Exclusion Criteria:

    • Disordered eating, as evidenced by meeting criteria for Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder, Other Specified Eating Disorder, Unspecified Eating Disorder, or Avoidant Restrictive Eating Disorder during the SCID-5 interview at baseline testing.
    • Substantial imminent risk of suicide as assessed during the SCID-5 interview.
    • Body mass index (BMI) < 20 kg/m2
    • Habitual consumption of a structured low-carbohydrate diet in the last 6-months

    Exclusion Criteria varies, please contact Study Coordinator.

     

    Age Range
    18 - 30 years
  • Pippa Fitness Pessary Device Effectiveness and Safety Study

    Official Title
    Pippa Fitness Pessary Device Effectiveness and Safety Study
    Purpose

    The purpose of this study is to demonstrate the effectiveness and safety of the Pippa Fitness Pessary (device) when self-administered and used in a home environment.
     

    Could this study be right for you?

    . Be a female 18 years or older
    · Live in or near Columbus, Ohio
    · Consistently leak during light exercise
    · Have no prior vaginal surgery

     

    Age Range
    18 years and up
  • Contact Lens Study

    Official Title
    Clinical Evaluation of Comfilcon A Contact Lenses
    Purpose

    The objective of this study is to confirm the clinical performance of two different lots of Biofinity contact lenses.  With different manufacturing lines making comfilcon A product, this study seeks to confirm the performance of Biofinity over one month of wear.

    Could this study be right for you?

    Inclusion:

    • Have had a self-reported oculo-visual examination in the last year.  
    • Are at least 18 years of age and has full legal capacity to give their informed consent.
    • Have read and understood the informed consent letter. 
    • Are willing and able to follow instructions and maintain the appointment schedule.
    • Have a contact lens spherical prescription between -0.50 D to -6.00 D (inclusive)
    • Are correctable to a visual acuity of 20/40 or better (in each eye) with their habitual vision correction or 20/20 best-corrected.
    • Have spectacle cylinder of ≤ 0.75 D in both eyes.
    • Is a habitual Biofinity (comfilcon A) wearer and worn a comfilcon A (Biofinity) lens for at least one month (minimum of 8 hours a day, 5 days per week)
    • Currently employ the use of a peroxide or multipurpose solution cleaning and disinfecting regimen in one of the following brand names:
      • Bausch and Lomb BioTrue Multi-Purpose Solution
      • Bausch and Lomb BioTrue Hydration Plus Multi-Purpose Solution
      • Bausch and Lomb ReNu Advanced Formulation Multi-Purpose Solution
      • Alcon Opti-Free Puremoist with Hydraglyde Multi-Purpose Solution
      • Alcon Opti-Free Replenish Multi-Purpose Solution
      • Alcon Clear Care Plus Hydrogen Peroxide Solution
      • Acuvue RevitaLens Multi-Purpose Solution
    • Have clear corneas and no active ocular disease.
    • Have not worn habitual lenses for at least 12 hours before the baseline/screening examination
    • Are willing to wear the study contact lenses for at least 8 hours per day, 5 days per week

    Exclusion

    • Have never worn contact lenses before.
    • Are currently wearing daily disposable contact lenses.
    • Have any systemic disease affecting ocular health.
    • Are using any systemic or topical medications that will affect ocular health.
    • Have any ocular pathology or abnormality that would affect the wearing of contact lenses.
    • Have any clinically significant lid or conjunctival abnormalities, active neovascularization or any central corneal scars.
    • Are aphakic.
    • Have undergone corneal refractive surgery.
    • Are participating in any other type of eye related clinical or research study.
    • Require a change in lens power from more than 1 diopter as dictated by over-refraction with their habitual lens prescription.
    Age Range
    18 years and up
  • Neurodevelopmental Effects of Youth Tackle Football

    Official Title
    Understanding the Neurodevelopmental Effects of Youth Tackle Football Participation
    Purpose

    In this study we are aiming to identify risk factors for higher exposure to football-related neurotrauma in youth tackle football players and to determine the effects of football-related neurotrauma exposure on neurodevelopment in children with no previous tackle football participation.

    For this specific posting, we are looking for boys ages 8-12 who are non-athletes or athletes who play non-contact sports to serve as control subjects for our fMRI study. 

    Could this study be right for you?

    We are looking for boys ages 8-12 who are either non-athletes or do not participate in any contact sports

    • Boys must have no metal implanted in the body
    • Have no prior history of head trauma
    • Have no serious health or mental health diagnoses
    • Must not have a fear of enclosed spaces
    Age Range
    8 - 12 years
  • Exploring the Development of the Infant and Fetal Brain

    Official Title
    Exploring the Connectivity and Functional Organization of the Infant Brain
    Purpose

    The purpose of the study is to investigate how the brain that we are each born with leads to our own unique behavior later in life, and the similarities and differences between maternal and child brains. We are studying infants prenatally and postnatally, following up with them as they grow and develop, and studying their mothers to understand how similar/different they are to their child.

    Could this study be right for you?
    • Infants under 3 years of age, and pregnant persons who are at least 20 weeks pregnant
    • All participants must have no metal implanted in the body
    • Have no significant health conditions or history of serious mental illness
    • Not suffer froma (fear of enclosed spaces)
    • Pregnancies must be without complication.
    Age Range
    Up to 40 years