Official Title PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life (PROMISE)

Purpose

The purpose of this study is to find out more about how health and exposures during pregnancy, such as having an infection, diet and growth may impact later risk of islet autoimmunity in the
child. We are also interested in finding out more about why having a father or sibling with type 1 diabetes increases risk of autoimmunity in the child than having a mother with type 1 diabetes.

Could this study be right for you?

Inclusion:

• Pregnant women:
  • who is between 8-24 weeks gestation with a singleton pregnancy
  • have had type 1 diabetes for at least 12 months, or the father of the baby or a full sibling of the baby has type 1 diabetes
  • is 18 years of age or older
  • is willing to have blood collected and to complete questionnaires about prenatal exposures once per trimester during their pregnancy (up to 3 visits) and up to 12 weeks after they deliver their baby
  • is willing to have their baby screened for genetic risk for type 1 diabetes, to complete online questionnaires, and to have their child followed for measurement of islet autoimmunity according to the determined risk for type 1 diabetes, through 5-7 years of age.
    • If low risk, two screenings: the first at 2 years of age and the second between 5-7 years of age
    • If high risk, five screenings: every six months through 2 years of age, and one between 5-7 years of age

The father of the baby will also be asked to complete one visit during pregnancy but it is not mandatory.

Exclusion:

• Multiple Gestation pregnancy
• Mother unable to consent due to intellectual impairment
• Fetus with known medical issue that would affect study participation
• Surrogate / gestational mothers who are not biologically related to offspring they are carrying

Age Range

18 years and up

Contact Information

Caitlin Rigsby

_OSUPROMISE_@osumc.edu

Official Title BUckeye Concussion Knowledge Survey (BUCKS)

Purpose

The purpose of this study is to examine health outcomes in former Ohio State University athletes who played a varsity sport during their time at OSU. The objective is to determine whether athletes who sustained a concussion have different health outcomes than those who did not sustain a concussion. Any former OSU varsity athlete can participate in a 20-minute online survey.

Could this study be right for you?

• Anyone who has played a varsity sport as an undergraduate student at OSU, and they have now graduated (i.e., OSU athlete alumni). There are no other restrictions in terms of age, sex/gender, type of sport, etc.

Age Range

18 years and up

Contact Information

Stacey Park

park.3367@osu.edu

614-292-3300

Official Title Safety, Tolerability, and Outcomes of Velpatasvir/SofosbuviR in Treatment of Chronic Hepatitis C Virus during Pregnancy (STORC), pregnant woman

Purpose

This study involves evaluating a medication for hepatitis C in pregnant women. 

If you are a pregnant woman with chronic hepatitis C and you join the study, you are consenting to enroll yourself and your baby after he/she is born.

Maternal participants will have 7 visits over approximately 7 months. Infant participants have four visits over approximately the first year of life.

Could this study be right for you?

(This is not a complete list)  

• Must be 18 - 45 years of age
• Chronic HCV infection of at least 6 months
• Singleton pregnancy at 20 + 0 to 30 + 0 weeks’ gestation
• Documented negative Hepatitis B testing for current infection (negative HBsAg test) prior to enrollment
• If living with HIV, must be on antiretroviral therapy

Exclusion Criteria (not a complete list)

• Plans to relocate away from the study site area in the next 16 months and unable/unwilling to return for study visits
• History of cirrhosis
• Known fetal chromosomal abnormality prior to enrollment

Age Range

18 - 45

Contact Information

Melanie Paglione

melanie.paglione@osumc.edu

614-685-5550

Official Title Assessing Responses to Exercise in the Heat in Trained Women

Purpose

The purpose of this research study is to conduct exercise in hot and neutral environments on women who are aerobically trained and resistance trained to characterize and compare responses across physiologic, perceptual, and neurocognitive domains. Our rationale for this investigation is that its completion would provide evidence as to how women of different fitness backgrounds respond to exercise in the heat and how that response is different from exercising in thermoneutral conditions to better describe how the female body tolerates exercise in the heat with implications for those in recreation, competitive sports, and occupation that expands to emergency and military services.

Could this study be right for you?

• Aerobically Trained: having a measured aerobic capacity in the 80th percentile according to age

• Resistance Trained: able to squat 120% and bench press 60% of their body weight.

• Unacclimatized: participants had not been consistently exposed to hot conditions (i.e., sauna, hot yoga, etc.) in the past 2 months.

Age Range

18 - 35

Contact Information

OSU - PAES Building

Barbara Sanchez

sanchez.1094@osu.edu

Official Title An Intervention Study about Primary Care Algorithms for Early Identification of Young Women with von Willebrand Disease

Purpose

Researchers at Nationwide Children’s Hospital are seeking volunteers to be a part of a study looking at how to best screen for bleeding disorders in young women.

Participants will be asked to complete questionnaires. If their survey answers suggest they have heavy menses or abnormal bleeding, they will also be asked to have a blood draw on the same day.

Could this study be right for you?

• Are 9 to 21 years old
• Have had your first menstrual cycle

Age Range

9 - 21

Contact Information

Adebimpe Adelaja

researchstudies@nationwidechildrens.org

614-355-1926

Official Title Performance and Cognitive Changes Across Menstrual Phase

Purpose

This study will look at the influence of the hormonal changes that occur between the early-follicular and mid-luteal phases of the menstrual cycle on neurocognitive performance before and after an intense resistance workout in premenopausal, moderately active females. Additionally, this study will be determining the accuracy and usefulness of using a menstrual cycle tracking phone application in predicting menstruation and ovulation

Your participation in the study will last between 2 and 3 months dependent on where in your current menstrual cycle you are upon enrollment in the study. There are 6 total visits across the 2 to 3 month study duration.

Could this study be right for you?

The eligibility criteria are as follows:

1. Be between the ages of 18 and 35
2. Participate in at least 3 hours of planned physical activity per week
3. Able to squat 100% of your body weight
4. Able to bench press 70% of your body weight
5. Using non-hormonal contraceptives

Age Range

18 and up

Contact Information

Barbara Sanchez

sanchez.1094@osu.edu

Official Title Exploring the Connectivity and Functional Organization of the Fetal and Infant Brain (pregnancy-3 yrs)

Purpose

The purpose of our study is to learn more about how biological sex may play a protective role in fetal and infant brain development in pregnancies both affected and unaffected by preeclampsia. 

We do this through at least two MRI visits, one during pregnancy and one 6 months after birth, as well as biometric data collected using Oura Rings, surveys, and cognitive and behavioral assessments. Together, these measures allow us to examine how preeclampsia and biological sex may influence brain development and early childhood development.

 

Could this study be right for you?

• Pregnant persons who are at least 25 weeks along
• Pregnant with no complications
• Pregnant with a hypertensive disorder
• Participants have no metal implanted in their body
• Have no serious health conditions or history of serious mental illness
• Do not suffer from a fear of enclosed spaces

Age Range

18 - 40 years

Contact Information

Emily Fennema

zlab@osu.edu

Official Title Mobile Health (mHealth), Breast Disease, and Lifestyle Modification: Developing a Grounded Theory

Purpose

The purpose of this study is to understand breast cancer survivors use of mobile health (mHealth) apps for lifestyle behavior change - eating a healthier diet, exercising more, dealing with stress, & stopping smoking. Interviews will last approximately 60 - 90 minutes.

Could this study be right for you?

• You have a diagnosis of breast disease or are a breast cancer survivor.
• You are age 18 or older
• You are a female

Age Range

18 and up

Contact Information

Marjorie Kelley

kelley.415@osu.edu

6145621449

Official Title Acute Inflammatory and Affective Responses to Varying Resistance Training Intensities in Postmenopausal Women.

Purpose

The primary aim of this study is to determine the effects of resistance exercise intensity on inflammatory markers and psychosocial response in postmenopausal women. Inflammation is part of your body’s immune response to various stimuli and is the body’s way of protecting itself from damage. It’s important to measure inflammation to determine the response to exercise. In this study, we aim to measure inflammation in the blood (what are called inflammatory markers) in response to three different resistance exercise intensities.

Could this study be right for you?

You may be eligible for this study if you are:

• Female, ages 40-75
• Postmenopausal (as diagnosed by a physician)
• Overweight (BMI >25 kg/m2)
• Physically capable to perform regular physical activity
• Recreationally trained (regular resistance exercise participation 2 times per week for the past 6 months)

Age Range

40 and up

Contact Information

Ciaran Fairman

fairman.13@osu.edu

614-292-0458