Experiences, attitudes, and practices of firearms among women gun owners in New Jersey and Ohio

Official Title
Experiences, attitudes, and practices of firearms among women gun owners in New Jersey and Ohio
Purpose

The purpose of this study is to better understand experiences, attitudes, and practices of women gun owners in New Jersey and Ohio to ultimately improve understanding of factors that may influence suicide prevention strategies. 

Could this study be right for you?
  • Be at least 18 years old 
  • Identify as female 
  • Own at least one handgun 
  • Live in either New Jersey or Ohio 
  • Use an Internet-connected device with a webcam
Age Range
18 - 99

A Study Evaluating Treatment for Intrahepatic Cholestasis of Pregnancy (ICP) - A liver disorder that can develop in pregnancy

Official Title
A Phase 2a/2b Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Volixibat in Adult Women with Intrahepatic Cholestasis of Pregnancy and Elevated Serum Bile Acid Concentrations (OHANA)
Purpose

The purpose of this clinical research study is to learn more about the use of the study medicine, volixibat, for the treatment intrahepatic cholestasis of pregnancy (ICP).

Depending upon how many weeks pregnant you are when you are screened at the first study visit, study participation could last up to 27 weeks

Could this study be right for you?

Inclusion Criteria:
• Females aged 18 to 45 years old
• Viable pregnancy of 20 weeks 0 days above
• Diagnosis of intrahepatic cholestasis of pregnancy (ICP)
• Willing and able to not use of any of the following for the duration of the study: statins, rifampin, bile acid sequestrants (e.g., cholestyramine), peroxisome proliferator-activated receptor (PPAR) agonists/fibrate drugs (e.g., fenofibrate, bezafibrate), S-adenosyl methionine.

Exclusion Criteria:
• Presence of triplets or higher multiple gestation
• Breastfeeding
• Alcohol use disorder or substance abuse within 12 months
• Known diagnosis of HIV infection or HIV antibody positivity

Exclusion Criteria varies, please contact Study Coordinator for more information.

Age Range
18 and up

An Observational Study of Pregnant Individuals with Glucose Intolerance

Official Title
The use of continuous glucose monitors among pregnant individuals with various degrees of glucose intolerance: An observational cohort study
Purpose

The purpose of this study is to learn more about blood sugar levels in the third trimester among women with and without gestational diabetes.

You and your child will be in the study from the time of enrollment through hospital discharge after delivery.

Could this study be right for you?

Inclusion criteria:
• Women aged between 18 and 45 years old
• Women with a viable singleton or twin pregnancy between 24 0/7 and 31 6/7 weeks gestation
• Planning to deliver at OSU Wexner Medical Center

Exclusion Criteria:
• Known pregestational diabetes (type 1, type 2, MODY)
• Higher order pregnancy (three or more fetuses)
• Abnormal obstetrical ultrasound suspicious for major congenital abnormality
(Exclusion Criteria varies, please contact Study Coordinator for more information)

Age Range
18 and up

An Observation Study to Evaluate Retina Eye Picturing in Women with Preeclampsia

Official Title
Remote monitoring of retina vasculature in women with preeclampsia: novel biomarker for disease severity
Purpose

The overall goal is to evaluate whether pictures we take of the retina of the eye can be used to detect preeclampsia and its severity.

Your participation will be from your enrollment visit, until 2-4 months after delivery, which will be no more than 32 weeks.

Could this study be right for you?

Inclusion criteria for normal blood pressure healthy pregnant women:
• Women aged 18 years or older
• Pregnant females at enrollment being >= 24 0/7 of pregnancy
• Able and willing to provide consent and willing to conduct the postpartum follow-up
• Normal blood pressure at enrollment
Inclusion criteria for Preeclampsia Pregnancies with severe features:
• Women aged 18 years or older
• Pregnant female at enrollment between 24 0/7 and 33 6/7 of pregnancy
• Able and willing to provide consent and willing to conduct the postpartum follow-up
• All subjects must be Preeclampsia (dangerous high blood pressure in pregnancy) diagnosed.

Exclusion Criteria for both groups:
• Known chromosomal, genetic, major malformations, fetal demise.
• Past medical history of hypertension >5 years, pre-gestational diabetes, or know retinal disease
• Pregnant for twin, triplets or higher
• Participating in another intervention study that influences the outcomes in this study.

Age Range
18 and up

A Study Evaluating Ketorolac Dosing and Pain Management After C-section Delivery

Official Title
Dosing of Ketorolac Impacts post-cesarean paiN manaGement (KING): A Randomized Controlled Trial
Purpose

The purpose of this study is to compare the use of morphine milligram equivalents (MME) in the first 24 hours of post-op C-Section delivery in patients getting a single dose of 30 mg ketorolac injected through the vein vs. 60 mg ketorolac injected through the vein in the operating room after the end of surgery.

Participation in this study starts from enrollment until being discharged from the hospital.

Could this study be right for you?

INCLUSION:
• Pregnant women aged between 18 to 45 years old
• C-Section as the planned delivery process
• Regional anesthesia (Spinal, Epidural, Combined Spinal Epidural)
EXCLUSION:
• Known allergy or adverse reaction to NSAIDs, aspirin, or ketorolac
• Patients with peptic ulcer disease, preexisting kidney or liver disease
• Patients with bleeding problem
• Acute or chronic pain disorder
• General anesthesia
• Opioid use disorder
• Emergent Cesarean delivery
• Active asthma
• Patients weighing <50 kg

Age Range
18 and up

A Study about Non-Invasive Bioelectronic Treatment After C-Section Deliveries (ELECTRON)

Official Title
Non-invasive bioELEctroniC treatment foR pOst-cesareaN (ELECTRON)
Purpose

The overall goal of this study is to examine whether after a C-Section delivery, the use of non-invasive bioelectronic treatment (treating women with devices that balance electrical signaling in the nervous system) will help improve pain management and reduce inpatient postoperative opioid use.

Your participation in this study will last 6 weeks. You will be asked to complete a series of questions at the end of your enrollment.

Could this study be right for you?

Inclusion Criteria:
• Women aged 18 years or older
• English Speaking
• Cesarean (C-Section) delivery
• Recently given birth to singleton, or twin gestation
Exclusion Criteria:
• Combined vaginal/cesarean deliveries
• Fetal or neonatal death prior to randomization
• Inability to complete all three non-invasive bioelectronic treatment during inpatient stay as assessed by research staff
• Participation in another intervention study that influences the primary outcome in this trial

Age Range
18 and up

Performance and Cognitive Changes Across Menstrual Phase

Official Title
Performance and Cognitive Changes Across Menstrual Phase
Purpose

This study will look at the influence of the hormonal changes that occur between the early-follicular and mid-luteal phases of the menstrual cycle on neurocognitive performance before and after an intense resistance workout in premenopausal, moderately active females. Additionally, this study will be determining the accuracy and usefulness of using a menstrual cycle tracking phone application in predicting menstruation and ovulation

Your participation in the study will last between 2 and 3 months dependent on where in your current menstrual cycle you are upon enrollment in the study. There are 6 total visits across the 2 to 3 month study duration.

Could this study be right for you?

The eligibility criteria are as follows:

1. Be between the ages of 18 and 35
2. Participate in at least 3 hours of planned physical activity per week
3. Able to squat 100% of your body weight
4. Able to bench press 70% of your body weight
5. Using non-hormonal contraceptives

Age Range
18 and up

Keto Prescribed+: A Healthy Thinking and Eating Program

Official Title
Healthy Lifestyle Behaviors and Beliefs of African American Women
Purpose

Evaluate factors that influence African American women’s healthy lifestyle behaviors and beliefs. A descriptive study using anonymous survey data.

Could this study be right for you?

Adult African American/Black women

Age Range
18 and up

Hepatitis C Virus Immunity in Women and Children

Official Title
Hepatitis C Virus Immunity in Women and Children
Purpose

This is a study to find out how pregnancy affects a mother’s immune system. (The “immune system” is the part of the body that fights germs.) This study is also to find out why some babies who are exposed to infections during pregnancy get infected and others do not.

To do this project we need to study some women and babies who are infected with the hepatitis C virus and others who are not. This will allow us to compare their immune systems.

Could this study be right for you?

You may be eligible to participate if you are:

PREGNANCY COHORT eligibility criteria:
1) Pregnant (enrollment preferably during 1st or 2nd trimester, but may occur as late as the delivery hospitalization)
2) HCV-RNA positive (#150) or HCV-RNA negative (#50)
3) Willing and able to attend all study visits

Exclusion criteria for mothers:
1) Inability to provide informed consent
2) Incarceration

Inclusion criteria for infants:
1) Child born to study mother

Exclusion criteria for infants:
1) In custody of county children’s services (Enrolled infants who are temporarily in custody of children’s services will not have further study blood draws, but lab results from blood tests ordered by their pediatrician may be followed to monitor the outcome of their HCV exposure. Infants who are later placed back in the custody of their mother or relative may be re-enrolled.)

NON-PREGNANCY COHORT eligibility criteria:
1) Willing and able to attend all study visits

Exclusion criteria:
1) Currently pregnant
2) Inability to provide informed consent
3) Incarceration

COVID-19 Determinants of Disease Severity, Perinatal Transmission, and Immune Response to COVID-19 Vaccine

Official Title
COVID-19 Determinants of Disease Severity, Perinatal Transmission, and Immune Response to COVID-19 Vaccine
Purpose

To identify the factors that determine disease severity, immune development, and perinatal transmission in COVID-19 infections.

Could this study be right for you?

Inclusion criteria

Cohorts 1: Suspected/Infected Individuals (inpatient or outpatient)
1) All ages
2) Suspected or confirmed COVID-19 infection
3) Parents, guardians or patients over the age of 18 years of age must sign the informed consent; and children older than 9 years of age should sign assent, as required.

Cohort 2: Pregnant Women and/or their Infants*
1) Suspected or confirmed COVID-19 infection AND
2) Pregnant women in any stage of gestation, or within 14 days of a 20+ week gestation delivery; we may enroll mothers alone in situations where they choose for their newborn to not participate OR
3) Infants born to eligible mothers; in situations where the mother does not participate in the study, we may enroll infants born to infected women individually into this cohort

*Pregnant women without suspected or confirmed COVID-19 infection will also be enrolled as a healthy control group and will follow the same visit schedule.

Cohort 3 Vaccinated Children, Adults, Pregnant/Lactating Women and/or their Infants
• Pregnant/lactating women with intent to receive a COVID-19 vaccine; we may enroll mothers alone in situation where they choose for their newborn to not participate OR
• Infants born to eligible mothers; in situations where the mother chooses not to participate in the study, we may enroll their infant separately. OR
• Children/Adults of any age with intent to receive a COVID-19 vaccine

Cohort 4 Healthy Controls
• Anyone without an acute illness at the time of enrollment who agrees to participate in the study.

Exclusion criteria
a) Individuals who refuse participation in the study.