Targeting Aging with a Ketone Ester for Function in Frailty
Official Title
A randomized, double-blind, placebo-controlled, parallel group, pilot study to evaluate the effect of a ketone ester on muscle and immune function in older men and women who are at risk for strength and mobility decline
Purpose
The purpose of this study is to measure the effect of 20 weeks of Ketone Ester consumption on a composite score of vigor-frailty in older adults who are at risk for mobility and strength decline and to investigate the effect of 20 weeks of Ketone Ester consumption on additional physical function measures, cognitive and immune function, muscle metabolism, safety, tolerability, gut microbiome, and quality of life in older adults who are at risk for mobility and strength decline.
Could this study be right for you?
65 years of age or older
- living independently
- English speaking and able to understand study procedures and provide Informed Consent
- women must be post menopause
- ambulatory and able to pass the walk speed criteria at screening
- minimum body weight of 50kgs (110 lbs.) at time of screening
- able to fast and abstain from alcohol, cannabis products and not exercise for 10 hours prior to study visits
- maintain current diet, exercise, medication and supplement use
- must not have a known allergy, intolerance, or sensitivity to any soy or milk protein
- must not be under active surveillance or treatment for cancer
- has not followed a ketogenic diet or used any ketone products within 30 days of screening or at anytime during the study period
- does not work night shifts or shifts that do not allow for a consistent meal schedule during the day
- does not take any immunosuppressive medications, weight loss medications or supplements, chronic antibiotic usage or receiving chemotherapy
- must not adhere to any extreme dietary habits, including intermittent fasting, Atkins, vegan, high protein low carbohydrate
- must not be a heavy alcohol drinker (women 8 drinks or more per week; men 15 drinks or more per week)
- must not have uncontrolled elevated cholesterol upon results of screening laboratory results