Official Title A randomized, double-blind, placebo-controlled, parallel group, pilot study to evaluate the effect of a ketone ester on muscle and immune function in older men and women who are at risk for strength and mobility decline

Purpose

The purpose of this study is to measure the effect of 20 weeks of Ketone Ester consumption on a composite score of vigor-frailty in older adults who are at risk for mobility and strength decline and to investigate the effect of 20 weeks of Ketone Ester consumption on additional physical function measures, cognitive and immune function, muscle metabolism, safety, tolerability, gut microbiome, and quality of life in older adults who are at risk for mobility and strength decline. 

Could this study be right for you?

65 years of age or older

• living independently
• English speaking and able to understand study procedures and provide Informed Consent
• women must be post menopause
• ambulatory and able to pass the walk speed criteria at screening            
• minimum body weight of 50kgs (110 lbs.) at time of screening
• able to fast and abstain from alcohol, cannabis products and not exercise for 10 hours prior to study visits
• maintain current diet, exercise, medication and supplement use
• must not have a known allergy, intolerance, or sensitivity to any soy or milk protein
• must not be under active surveillance or treatment for cancer
• has not followed a ketogenic diet or used any ketone products within 30 days of screening or at anytime during the study period
• does not work night shifts or shifts that do not allow for a consistent meal schedule during the day
• does not take any immunosuppressive medications,  weight loss medications or supplements, chronic antibiotic usage or receiving chemotherapy
• must not adhere to any extreme dietary habits, including intermittent fasting, Atkins, vegan, high protein low carbohydrate
• must not be a heavy alcohol drinker (women 8 drinks or more per week; men 15 drinks or more per week)
• must not have uncontrolled elevated cholesterol upon results of screening laboratory results

Age Range

65 - 99 years

Official Title Identification of novel signatures of proximal changes in the severity of suicide risk states

Purpose

This study will examine how people experience mental health symptoms, distress, and suicidal thoughts in their daily lives, to identify signs that indicate that someone's suicide risk is getting worse or improving. We will recruit people who are at different levels of suicide risk.

You will be asked to complete a survey about your life experiences, mental health symptoms, suicide thoughts, and coping strategies. You will also be asked to complete short surveys on your phones several times a day for 28 days to understand how suicide risk changes over time, and you will be provided with mental health resources you can access if in crisis.

Could this study be right for you?

1. aged 18+
2. the ability to speak, read, and understand English well enough to participate in study procedures 
3. comfort with smartphone technology
4. are currently a U.S. resident
5. participants must endorse suicidal ideation in the past week
6. and/or endorse an suicide attempt, aborted attempt, or interrupted attempt within the past month

Age Range

18 - 100 years

Official Title Dance-Based Avenues to Advance Nonpharmacologic Treatment of Chemotherapy Effects (DAANCE): A Multi-Center Trial

Purpose

This study will teach tango dance to try to help with neuropathy symptoms. Tango dancing classes will take place for 2 times a week for 8 weeks. You will be asked about symptoms such as numbness, tingling, fatigue, pain, and balance. There is a 6 month follow up period where we will ask you to tell us about your symptoms via an app. 

Could this study be right for you?

1. Breast cancer survivors stage I-IV
2. Exposure to chemotherapy with the last exposure being at least 3 months prior to study participation
3. Must be ambulatory

 

Age Range

40 years and up

Official Title Creating a Mobile Health Program for Teens with Congenital Heart Disease

Purpose

The purpose of this study is to learn more about what teens with congenital heart disease want in a program that helps them learn more about living with congenital heart disease, dealing with stress, and staying away from e-cigarettes. The information from your participation may help us understand how we can improve the program and make it more interesting and appealing for teens.

Could this study be right for you?

• Have a diagnosis of a structural congenital heart defect
• No cognitive impairments limiting ability to complete study interview/questionnaires
• Proficient in English
• Have access to a device that can connect to the internet
• Not leaving the country at any point during study participation

**This study is invite only. Study staff will contact you if you are invited to participate.**

Age Range

12 - 18 years

Official Title AN OBSERVATIONAL, LONG-TERM SAFETY STUDY OF TZIELD® (TEPLIZUMAB-MZWV) IN PATIENTS WITH STAGE 2 TYPE 1 DIABETES

Purpose

The objective of the study is to test the safety and efficacy of TZIELD over the course of 10 years in patients with Stage 2, Type 1 Diabetes, as well as the prevention of Stage 3, Type 1 Diabetes. 

Could this study be right for you?

Inclusion Criteria:

TZIELD-Exposed Cohort
1. Patients in the US diagnosed with Stage 2 T1D who are planned to initiate TZIELD treatment according to the currently approved label or who have initiated TZIELD treatment within 6 months prior to enrollment:
− Day 1: 65 μg/m²
− Day 2: 125 μg/m²
− Day 3: 250 μg/m²
− Day 4: 500 μg/m²
− Days 5 through 14: 1,030 μg/m² per day
− Cumulative dose is approximately 11,240 μg/m²

2. Appropriate written informed consent/assent as applicable for the age of the patient

TZIELD-Unexposed Cohort
1. Patients in the US diagnosed with Stage 2 T1D but who are not treated with TZIELD
2. Appropriate written informed consent/assent as applicable for the age of the patient

Exclusion Criteria:
1. Patients who initiated TZIELD treatment more than 6 months prior to enrollment
2. Patients who had participated in a previous clinical trial for TZIELD
3. Patients in an ongoing clinical trial of an investigational product or who had ended participation within 6 months prior to study enrollment; patients participating in other observational studies may be enrolled.

Age Range

18 - 70 years

Official Title An Examination of Culturally Responsive, Inclusive, and Socially Just Practices Parent Feedback

Purpose

The research study will examine parents’ - or a child’s primary caregiver - perspectives on an online professional development (PD) training for teachers, targeting early care and education (ECE) teachers’ use of culturally responsive, inclusive, and socially just practices. Parents of young children will be recruited to review the online PD course and complete surveys about the course. A subset of participants will participate in a focus group to share their feedback on the course.

Could this study be right for you?

Parent or caregiver to a child who:

• Is between 3 and 5 years old
• Is identified as Black/African American
• Attends a center-based early care and education program (pre-kindergarten, Head Start, child care, preschool, etc.)

Age Range

17 - 99 years

Official Title Sexual and gender diverse young adults' preferences for nicotine and tobacco product attributes

Purpose

We are inviting LGBTQ+ folks to share their opinions about product features (e.g., flavors, nicotine levels) and other factors (e.g., stress, social media, marketing) that make people want to try or continue to use tobacco products.

Could this study be right for you?

• Able to speak English fluently
• Identify as LGBTQ+
• Used nicotine/tobacco products in the past 30-days (cigarettes, cigars, cigarillos, e-cigarettes, etc.)
• Reside in the U.S.

Age Range

18 - 34 years

Official Title A prospective randomized unblinded study of ketogenetic versus mixed diet on exercise tolerance in subjects with the metabolic phenotype of heart failure with preserved ejection fraction

Purpose

The purpose of this study is to compare the effects of a well-formulated ketogenic diet with a low-fat diet on exercise tolerance in patients with diabetes or pre-diabetes or obesity; with shortness of breath or heart failure.

Could this study be right for you?

Inclusions:

• Age ≥ 18 years old and ≤ 80 years old & willingness to be randomized to either diet.
• NYHA class I – III for at least 3 months.
• Ejection fraction ≥40% by biplane 2D, or 3D echo, or CMR.
• Echo findings of abnormal or indeterminant diastolic function or RHC data: At rest: mean pulmonary capillary wedge pressure (PCWP) > 15 mmHg. Pulmonary vascular resistance (PVR) < 3 Wood Units.
• Stable medical therapy for at least 3 months as determined by the treating physician (no new cardiac or diabetic medications within 3 months of enrollment or during enrollment and dosage should be stable for 1 month prior to enrollment).
• Dose of oral diuretics changes allowed but must be stable for 1 week prior to randomization.
• Body Mass Index (BMI) ≥ 25 and ≤ 50 or Type 2 Diabetes Mellitus or prediabetes (fasting glucose of 100 - 125 mg/dL or hemoglobin A1C 5.7-6.4%) or metabolic syndrome.
• Ability to participate in exercise treadmill testing.
• Ability to sign written consent.

Exclusions:

• Women who are pregnant, current breast-feeding, or have intention to become pregnant while in the study.
• Known allergy or sensitivity to gadolinium-based contrast agents.
• Implanted pacemaker, cardioverter defibrillator, Cardiac resynchronization therapy, left ventricular assist devices.
• Other metallic implants/aneurysm clips that are contraindicated in MRI.
• Claustrophobia
• History of severe kidney disease of eGFR < 30 ml/kg/1.73m2.

Exclusion Criteria varies, please contact Study Coordinator.

Age Range

18 - 80 years

Official Title PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults

Purpose

The purpose of PREVENTABLE is to learn if taking a statin could help older adults live well for longer by preventing dementia, disability, or heart disease. The duration of the study will last 5 years. 

Could this study be right for you?

Inclusion Criteria:

• Community-dwelling adults
• Age ≥75 years
• English or Spanish as primary language

 

Exclusion Criteria:

• Clinically evident cardiovascular disease defined as prior myocardial Infarction (MI), prior stroke, prior revascularization procedure, or a secondary prevention indication for a statin (clinician determined)
• Hospitalization for a primary diagnosis of heart failure in the prior 12 months (Note: History of heart failure in the absence of recent hospitalization or clinically evident cardiovascular disease is not an exclusion)
• Dementia (clinically evident or previously diagnosed)
• Dependence in any Katz Basic Activities of Daily Living [ADL] (with the exception of urinary or bowel continence)
• Severe hearing impairment (preventing phone follow up)
• Unable to talk (preventing phone follow up)

Exclusion Criteria varies, please contact Study Coordinator for more information. 

Age Range

75 years and up

Official Title Uncertainty and Firearms: Obtaining Secure Storage (UFOS)

Purpose

The purpose of this study is to examine whether fear of uncertainty plays a role in home safety practices among firearm owners who are currently or have recently served in the U.S. military.

Could this study be right for you?

• Currently serving in any Branch or Component of the U.S. military, or were discharged from the U.S. military within the past 90 days
• 18 years or older
• Own at least one firearm located in your home or vehicle
• Are able to speak and understand the English language
• Have an Apple or Android smartphone

Age Range

18 - 99 years