A Study Evaluating How Dietary Fat Affects Cognition

Official Title
Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study: Dietary Fat Quality and Cognitive Impairment

The purpose of the EFFECT Study is to determine how dietary fats influence cognitive (mental) function in adults.


During the 7-week study participants will

  • Consume one study food per day for a total of 3 weeks
  • Have their blood drawn
  • Have their body weight and shape measured
  • Complete cognitive tests
  • Fill out questionnaires
  • Complete diet and physical activity recalls
Could this study be right for you?
  • Feel your memory or concentration is not as good as you'd like it to be
  • Are overweight
  • Do NOT have diabetes
  • Do NOT have dementia or Alzheimer's
  • Do NOT have food allergies 
  • Are NOT pregnant or nursing an infant
Age Range
40 - 75 years

Variations in Ketone Metabolism

Official Title
Strategies to Augment Ketosis- Variations in Ketone Metabolism

This study is being done to see how individuals respond to a ketone ester (KE) across different age groups and health statuses. With the ketogenic diet becoming more popular, research on ketones (a molecule created when fat is broken down in the body) has grown as well. 

These findings will be used to help develop future research studies and help others to pick the right doses of ketone supplement.

Could this study be right for you?
  • Do NOT smoke or have diabetes, liver disease, kidney disease, cardiovascular disease, or any form of endocrine dysfunction 

  • Have NOT experienced >10% weight loss in the last 6 months 

  • Do NOT currently consume a low carbohydrate diet 

  • Do NOT consume alcohol more than 3 drinks/daily or 14 drinks/weekly 

  • Do NOT suffer from food allergies or gastrointestinal disorders 

Age Range
20 - 70 years

Sleep Restriction and Ketone Supplements

Official Title
Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction (STAK-Sleep)

To examine if drinking a ketone supplement, twice a day, can improve brain, digital shooting, and physical performance during short-term sleep restriction (4 nights, 50% of normal sleep).

Could this study be right for you?
  • Healthy
  • Age: 18 - 40 years old
  • BMI: 20-35 kg/m2
  • No diagnosed sleep disorders
  • Not consuming a ketogenic diet
Age Range
18 - 40 years

Exogenous Ketone Study

Official Title
Strategies to Augment Ketosis: Optimization of Ketone Delivery Strategies (STAK: OK'd)

This study is intended to evaluate the effects of different dosing measurements for different ketone products in healthy male adults. After giving consent to this study you will schedule 9 testing sessions about 3 days apart. During these sessions you will come into the Physical Activity and Education Services (PAES) building in the morning, having had no food that day and take a study product. Various tests will be administered after ingestion. You will have blood draws to tell us more about your metabolic response to the product.

Could this study be right for you?
  • Have a BMI >18 kg/m2 or ≤29 kg/m2
  • Do NOT smoke or have diabetes, liver disease, kidney disease, cardiovascular disease, or any form of endocrine dysfunction
  • Do NOT currently consume a low carbohydrate diet


Age Range
20 - 30 years

Investigating Symptoms & Stool Gut Bacteria between African Americans and Caucasian Americans

Official Title
Associations between Race, Gut Microbiota-Metabolites, and Long-Term Symptom Toxicity in African Americans and Caucasian Americans Colorectal Cancer Survivors

The purpose of this study is to learn about the associations of symptoms such as fatigue, depression, and gastrointestinal distress including constipation, abdominal pain, and diarrhea with stool microbiomes and metabolites in patients with colorectal cancer. We will compare the associations of symptoms with microbiomes among colorectal cancer patients and healthy patients. You will be asked to complete several surveys that ask questions about your dietary habits, your health history, your social demographics, and your symptoms. You will also be asked to collect a stool sample with an at-home stool sample collection kit that will be provided to you.

Could this study be right for you?
  • Diagnosed with stage I-IV colorectal cancer (ICD-10 C18, C19 and C20) OR Healthy.
  • 18+ years of age at time of diagnosis.
  • Able to communicate in English and provide consent.
  • African American OR White.
  • Not currently in cancer treatment.
  • No current ostomy.
  • No chronic bowel disorders (e.g., irritable bowel syndrome).
  • No diagnosis of functional GI disorders.
  • No food allergies or dietary restrictions.
  • No use of probiotics or antibiotics within the past two months prior to fecal collection.
  • No significant cognitive or developmental delay that precedes cancer diagnosis (e.g., down syndrome, autism spectrum disorder).
Age Range
18 years and up

Healthy Diet Study

Official Title
A prospective randomized unblinded study of ketogenetic versus mixed diet on exercise tolerance in subjects with the metabolic phenotype of heart failure with preserved ejection fraction

The purpose of this study is to compare the effects of a well-formulated ketogenic diet with a low-fat diet on exercise tolerance in patients with heart failure and diabetes or pre-diabetes or metabolic syndrome.


Could this study be right for you?
  • Age ≥ 18 years old and ≤ 80 years old & willingness to be randomized to either diet.
  • NYHA class I – III for at least 3 months.
  • Ejection fraction ≥50% by biplane 2D, or 3D echo, or CMR
  • Echo findings of abnormal or indeterminant diastolic function or RHC data:  At rest: mean pulmonary capillary wedge pressure (PCWP) > 15 mmHg.  pulmonary vascular resistance (PVR) < 3 Wood Units.
  • Stable medical therapy for at least 3 months as determined by the treating physician (no new cardiac or diabetic medications within 3 months of enrollment or during enrollment and dosage should be stable for 1 month prior to enrollment).
  • Dose of oral diuretics changes allowed but must be stable for 1 week prior to randomization.
  • Body Mass Index (BMI) ≥ 25 and ≤ 50 or Type 2 Diabetes Mellitus or prediabetes (fasting glucose of 100 - 125 mg/dL or hemoglobin A1C 5.7-6.4%) or metabolic syndrome.
  • Ability to participate in exercise treadmill testing.
  • Ability to sign written consent.


  •  Women who are pregnant, current breast-feeding, or have intention to become pregnant while in the study.
  •  Known allergy or sensitivity to gadolinium-based contrast agents.           
  • Implanted pacemaker, cardioverter defibrillator, Cardiac resynchronization therapy, left ventricular assist devices.
  • Other metallic implants/aneurysm clips that are contraindicated in MRI.           
  • Claustrophobia
  • History of severe kidney disease of eGFR<30 ml/kg/1.73m2.


Exclusion Criteria varies, please contact Study Coordinator. 

Age Range
18 - 80 years

Impact of A Low Glycemic Index Diet on Blood Pressure and Blood Sugar in Individuals with Spinal Cord Injury

Official Title
Two Birds with One Stone: Impact of A Low Glycemic Index Diet on Postprandial Hypotension and Glucose Metabolism in Individuals with Spinal Cord Injury (FIP)

The purpose of this study is to examine the effect of a short-term low glycemic index diet on blood pressure and blood sugar control after eating.

Could this study be right for you?
  • Adults aged 18-65 years old
  • Chronic spinal cord injury
  • Level of injury between C4 and L2
Age Range
18 - 65 years

A Study about Brain Imaging on Forming Impressions of Food

Official Title
Decoding Social Perceptions in Naturalistic Contexts

The purpose of this study is to examine impressions on foods. This study involves looking at brain activity while you perform simple tasks (judging images of different foods). 

The duration of this study will last 3 hours. 

Could this study be right for you?
  • Free of MRI contradictions
  • No dietary destrictions
  • Normal vison
  • Right handed
Age Range
18 - 35 years

Blood Pressure Health for Black/African American Women Caregivers

Official Title
Addressing the double jeopardy of stress and hypertension among African American female caregivers of persons living with Alzheimer’s disease and related dementias (R21)

The purpose of this study is to determine the feasibility of a group delivered intervention for stress and blood pressure in African American women caregivers.

Could this study be right for you?
  • Diagnosis of HTN treated with an antihypertensive medication or risk of HTN that includes obesity and high cholesterol
  • Age 40 and older
  • A caregiver rating of the PLWD of 2 or greater on the Alzheimer’s Dementia-8 scale
  • Caregiver provides unpaid care to a PLWD at least 10 hours per week or assists with at least one instrumental activity of daily living
  • Self-identifies as Black/African American
  • English speaking
  • Access to a telecommunications device such as the internet via desktop, laptop/tablet, smartphone, or telephone
Age Range
40 and up

Mentoring to be Active: Peer Mentoring for Rural Appalachian Children to Reduce Overweight and Obesity

Official Title
Mentoring to be Active: Peer Mentoring for Rural Appalachian Children to Reduce Overweight and Obesity

The purpose of this study is to lower the rate of type 2 diabetes in rural Appalachia youth due to obesity and/or being overweight. Our long-term goal is to improve the health of underserved, high-risk youth.

This study will test the effectiveness of the Mentored Planning to be Active + Family on physical activity outcomes and health outcomes among rural Appalachian middle school aged youth suffering from either overweight or obesity.

We have local high school-aged teen mentors work closely with middle school youth to increase social support, self-efficacy, and self-regulation skills to sustain physical activity and improve health before the children enter high school.

The peer mentoring is followed by a 6-month family reinforcement program.

Some parents will provide child assessment data of perceived child physical activity behaviors and child health.


Could this study be right for you?
  • Child has access to a computer or tablet device at home for virtual mentoring sessions/meetings
  • Child suffers from overweight or obesity - does not need to be under the care of a health care professional for this condition
  • Child and Parent able to participate read English at a 4th grade level. 
  • Family not expected to move from rural Appalachia within the 18 months. 
Age Range
12 - 13