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How Do Ketone Supplements Affect Brain Function in Healthy Adults
Official Title Effects of Acute Ketone Supplementation on the Brain (KETO-BRAIN)Purpose
This study looks at how ketone drinks affect the brain in healthy adults. Ketones are natural substances your body makes when it breaks down fat for energy. Scientists think ketones might help protect the brain and improve how it works.
We want to learn if drinking a ketone supplement changes blood flow to the brain and affects brain chemicals that help with thinking and memory. This information could help us understand if ketone drinks might be helpful for brain health as people age.
If you join this study, you will:
- Come to the research center 3 times over about 1-2 weeks
- Drink either a ketone supplement or a comparison drink (you will not know which one)
- Have brain scans using an MRI machine (like a large medical camera)
- Take simple thinking tests on a computer
- Have finger stick blood tests to measure ketone and sugar levels
You will first come in for a consent visit that take about 1 hour. Then, you will return for two more visits that will take about 3 hours each. You will drink a special beverage twice a day for two days before each scan visit. The study uses MRI scans to safely take pictures of your brain without radiation. We will measure blood flow in your brain and certain brain chemicals before and after you drink the supplement.
This research may help scientists better understand how ketones work in the brain. This could lead to new ways to support brain health in the future.
Could this study be right for you?
Who Can Join:
- Body Mass Index (BMI) between 18.5 and 30
- Able to skip eating overnight before study visits
- Not following a keto diet
Who Cannot Join:
- People who do not speak English
- Currently using ketone supplements or following a keto diet
- Pregnant or breastfeeding
- Allergic to milk protein or lactose intolerant
- History of high blood pressure
- History of alcohol problems in the past 2 years
- History of illegal drug use
- Head injury that caused loss of consciousness
- Brain or nerve disease diagnosis
- Taking medications for mental health conditions
- Current smokers
- Anyone with metal in their body or other reasons they cannot have an MRI scan
Age Range
45 - 65 years -
Low Dose Tamoxifen with or without Omega-3 Fatty Acids for Breast Cancer Risk Reduction
Official Title Phase 2 Study of Low Dose Tamoxifen +/- High Dose Omega-3 Fatty Acids in Overweight Postmenopausal Women at Increased Risk for Breast CancerPurpose
This study wants to measure the effects of low dose tamoxifen and omega-3 fatty acids (may also be known as fish oil) on a woman's risk of developing breast cancer.
In this study, half of the participants will be asked to take low dose tamoxifen and the other half low dose tamoxifen with omega-3 fatty acids for about six months. Everyone taking part in the study will be watched carefully for any side effects, which may or may not happen. Tissue and blood collection will be a part of the study participation.
This study is looking for volunteers with an above average risk of developing breast cancer. We will enroll up to 66 participants at institutions across the country. The study lasts about eight months.
Could this study be right for you?
- Postmenopausal
- At increased risk of breast cancer, due to genetic mutation, family history, prior DCIS, LCIS, or atypical hyperplasia
- Overweight or obese (BMI ≥ 25 kg/m2)
- Do not have breast implants
- Seen in Stefanie Spielman Comprehensive Breast Cancer Center in Columbus, OH
Age Range
45 - 65 years -
Help Co-design a New Emotion Mapping Tool to Improve Patient-Provider Communication
Official Title Co-designing a Emotion Mapping Tool to Enhance Patient-Provider CommunicationPurpose
The objective of this research is to co-design with former inpatients to gradually refine and reimagine an emotion mapping toolkit through co-design workshops hosted at The Ohio State University (OSU) campus.
This research will ultimately inform future work aimed at enhancing patient engagement, emotional empowerment, and satisfaction through improved communication practices and the creation of actionable emotional data in healthcare settings.Your time involved with this study will be approximately 1 hour.
Could this study be right for you?
- Former inpatient who had been hospitalized for 3 or more days within the last 6 months
- Able to attend in-person workshop at The Ohio State University Columbus Campus
Age Range
18 years and up -
Vitamin C and Gut Health in adults with obesity
Official Title Anti-inflammatory Activities of Vitamin C Supplementation on the Gut Barrier Function in Adults with ObesityPurpose
This study is testing whether taking vitamin C can improve gut health and reduce inflammation in adults with obesity. We want to learn if vitamin C helps strengthen the gut lining (“gut barrier”), improve digestion, and support overall health.
Could this study be right for you?
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Body weight: Have overweight or obesity (BMI 30 or higher)
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Location: Able to come to The Ohio State University campus in Columbus, Ohio for study visits
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Diet: Willing to follow a low vitamin C diet during the study
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Health status: Generally healthy, without major chronic diseases other than obesity
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Other: Non-smoker, not pregnant or breastfeeding, not currently taking high-dose vitamin C supplements
Age Range
18 - 55 years -
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Targeting Aging with a Ketone Ester for Function in Frailty
Official Title A randomized, double-blind, placebo-controlled, parallel group, pilot study to evaluate the effect of a ketone ester on muscle and immune function in older men and women who are at risk for strength and mobility declinePurpose
The purpose of this study is to measure the effect of 20 weeks of Ketone Ester consumption on a composite score of vigor-frailty in older adults who are at risk for mobility and strength decline and to investigate the effect of 20 weeks of Ketone Ester consumption on additional physical function measures, cognitive and immune function, muscle metabolism, safety, tolerability, gut microbiome, and quality of life in older adults who are at risk for mobility and strength decline.
Could this study be right for you?
65 years of age or older
- living independently
- English speaking and able to understand study procedures and provide Informed Consent
- women must be post menopause
- ambulatory and able to pass the walk speed criteria at screening
- minimum body weight of 50kgs (110 lbs.) at time of screening
- able to fast and abstain from alcohol, cannabis products and not exercise for 10 hours prior to study visits
- maintain current diet, exercise, medication and supplement use
- must not have a known allergy, intolerance, or sensitivity to any soy or milk protein
- must not be under active surveillance or treatment for cancer
- has not followed a ketogenic diet or used any ketone products within 30 days of screening or at anytime during the study period
- does not work night shifts or shifts that do not allow for a consistent meal schedule during the day
- does not take any immunosuppressive medications, weight loss medications or supplements, chronic antibiotic usage or receiving chemotherapy
- must not adhere to any extreme dietary habits, including intermittent fasting, Atkins, vegan, high protein low carbohydrate
- must not be a heavy alcohol drinker (women 8 drinks or more per week; men 15 drinks or more per week)
- must not have uncontrolled elevated cholesterol upon results of screening laboratory results
Age Range
65 - 99 years -
A Study Evaluating How Dietary Oils Effect Muscle Function and Strength
Official Title The Foods and Oils to Repair Correct and Enhance Strength (FORCES) Study: Determining the effect of dietary oils on muscle function, strength and massPurpose
The purpose of the FORCES Study is to determine how dietary oils effect muscle function, strength and mass in older adults who feel their muscle function and strength has declined with age.
During this 27-week study participants will
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Consume ~2.5 tsp of oil each day through foods
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Complete muscle function and strength testing
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Have their blood drawn
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Have their body weight and composition measured
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Have an MRI scan of your legs, if able
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Fill out questionnaires
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Collect a small amount of muscle tissue from the leg (muscle biopsy
Could this study be right for you?
Feel your muscle function, strength or mass as decreased with age
Do NOT have food allergies
Are not taking any weight loss medications or following a weight loss program
Age Range
65 - 80 years -
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Ketogenic Diet Intervention to Improve Response to Immunotherapy: KetoIO
Official Title Phase I Study of the Safety and Feasibility of a Ketogenic Dietary Intervention to Improve Response to ImmunotherapyPurpose
This study will look at if a ketogenic diet (KD) can help treatment work better in patients with metastatic melanoma or metastatic kidney cancer. People who take part in the study will be randomly assigned to either continue eating their usual diet or trying the KD diet for 24 weeks. Participants will have blood and stool samples collected during the study. They will also test their sugar by doing daily glucose fingers sticks. Participants may be paid up to $200 for taking part in the study.
Could this study be right for you?
- Patients with metastatic melanoma receiving first-line treatment with immunotherapy or Patients with metastatic renal cell cancer receiving first line treatment with immunotherapy.
- Willing to give three stool samples
- Willing to participate in a ketogenic diet (KD)
Age Range
18 years and up -
The Perceptions of Gen Zs Regarding the Dietary Guidelines for Americans (DGA)
Official Title The Knowledge and Perceptions of Gen Zs Regarding the Dietary Guidelines for AmericansPurpose
- Use ideas from Social Cognitive Theory to describe Gen Zs regarding the Dietary Guidelines for Americans (DGA) 2020 to 2025
- Explain what Gen Z knows and believes regarding the MyPlate recommendations for healthy eating related to:
- Filling half their plate with fruit and vegetables
- Filling one-quarter of their plate with lean protein, and varying the sources of protein
- Filling one-quarter of their plate with grains, making half of the grains whole grains
- To describe the associations between demographic variables (ethnicity, education, household income, and home environment) and Gen Zs perceptions and knowledge of the DGA
Could this study be right for you?
18 to 28 years old
Live in the US
English speaker
Have access to a device that supports Zoom
Age Range
18 - 28 years -
Impacts of Ketone Esters on Exercise and Heart Health in Type 2 Diabetics
Official Title Effects of Acute and Chronic Ketone Ester Consumption on Exercise Tolerance and Cardiac Function in Subjects with DiabetesPurpose
This placebo-controlled study is being done to evaluate the effects of a ketone ester drink on exercise performance and heart health in a group of subjects diagnosed with type 2 diabetes.
Could this study be right for you?
There are additional exclusion criteria, study staff will screen fully before enrollment.
Age Range
18 - 80 years -
Diabetic Foot Ulcer Study
Official Title Concurrent optical and magnetic stimulation (COMS) for treatment of refractory diabetic foot ulcer; a prospective randomized, sham-controlled, double-blinded, pivotal clinical trialPurpose
The purpose of this study is to evaluate the safety and effectiveness of the treatment with the COMS One device in subjects with refractory diabetic foot ulcers (DFUs).
The duration of this study will last up to 28 weeks.
Could this study be right for you?
Inclusion
- Male and females aged 22 to 90 years old
- Able to understand and sign the informed consent form (ICF) and comply with requirements set in the protocol including trial visits, trial treatment and dressing regimens and compliance with required offloading device (if applicable)
- Type 1 or Type 2 diabetes mellitus
Exclusion
- Known pregnancy or lactating
- Active skin cancer, a history of skin cancer or any other localized cancer, precancerous lesions or large moles in the areas to be treated
Inclusion and Exclusion Criteria varies, please contact Study Coordinator for more information.
Age Range
22 - 90 years