The purpose of this study is to compare the effectiveness of long-acting Nifedipine XL 60mg daily to 30mg twice daily among women admitted with hypertensive disorders of pregnancy and severe blood pressures. Participation for the duration of the study lasts 48 hours.
Inclusion Criteria: • Women aged 18-45 years old • Viable single or twin intrauterine pregnancy between 22 0/7 and 33 5/7 weeks gestation • Women with a hypertensive disorder of pregnancy and are undergoing expectant management (spontaneous labor) for a diagnosis of preeclampsia • Patient has already been started on 30mg Nifedipine XL by their primary OB provider and has been recommended to increase the daily dose to 60mg Exclusion Criteria: • Known allergy or poor reaction to Nifedipine or any medical condition where Nifedipine should not be used in ones treatment, such as galactose intolerance, severe GI stricture, and GI hypomotility disorder. • Participation in another trial without prior approval • Currently receiving a daily dose of Nifedipine XL of 60mg or greater • Continuation of alternate long-acting anti-hypertensive medication on admission • Triplet or higher order pregnancy (Exclusion Criteria still varies, please contact Study Coordinator for more information).
This study will look at the influence of the hormonal changes that occur between the early-follicular and mid-luteal phases of the menstrual cycle on neurocognitive performance before and after an intense resistance workout in premenopausal, moderately active females. Additionally, this study will be determining the accuracy and usefulness of using a menstrual cycle tracking phone application in predicting menstruation and ovulation
Your participation in the study will last between 2 and 3 months dependent on where in your current menstrual cycle you are upon enrollment in the study. There are 6 total visits across the 2 to 3 month study duration.
The eligibility criteria are as follows:
1. Be between the ages of 18 and 35
2. Participate in at least 3 hours of planned physical activity per week
3. Able to squat 100% of your body weight
4. Able to bench press 70% of your body weight
5. Using non-hormonal contraceptives
Evaluate factors that influence African American women’s healthy lifestyle behaviors and beliefs. A descriptive study using anonymous survey data.
Adult African American/Black women
This is a study to find out how pregnancy affects a mother’s immune system. (The “immune system” is the part of the body that fights germs.) This study is also to find out why some babies who are exposed to infections during pregnancy get infected and others do not.
To do this project we need to study some women and babies who are infected with the hepatitis C virus and others who are not. This will allow us to compare their immune systems.
You may be eligible to participate if you are:
PREGNANCY COHORT eligibility criteria:
1) Pregnant (enrollment preferably during 1st or 2nd trimester, but may occur as late as the delivery hospitalization)
2) HCV-RNA positive (#150) or HCV-RNA negative (#50)
3) Willing and able to attend all study visits
Exclusion criteria for mothers:
1) Inability to provide informed consent
Inclusion criteria for infants:
1) Child born to study mother
Exclusion criteria for infants:
1) In custody of county children’s services (Enrolled infants who are temporarily in custody of children’s services will not have further study blood draws, but lab results from blood tests ordered by their pediatrician may be followed to monitor the outcome of their HCV exposure. Infants who are later placed back in the custody of their mother or relative may be re-enrolled.)
NON-PREGNANCY COHORT eligibility criteria:
1) Willing and able to attend all study visits
1) Currently pregnant
2) Inability to provide informed consent
This study is designed to evaluate the safety and effectiveness of the Materna Prep Device in reducing pelvic muscle injuries during vaginal delivery.
You may be eligible for this study if you:
1. Are scheduled for vaginal birth.
2. Are pregnant with a single fetus.
3. Haven't given birth previously, or had a previous pregnancy terminated within 24 weeks gestation.
4. Are willing to comply with the protocol required follow-up visits.
5. Are able and willing to provide written informed consent prior to enrollment.
6. Are 18 years of age or older at time of consent.
You will be ineligible for this study if you:
1. Have a high likelihood of less than 1 hour of potential device dilation time after you arrive at the hospital.
2. Have a need for or is planning a Caesarean-section.
3. Begin labor with less than 36 weeks gestation.
4. Have a neurological disorder that could cause pelvic floor dysfunction, such as multiple sclerosis or spinal cord injury
5. Have a collagen-associated disorder that affects tissue elasticity, such as scleroderma or Ehlers-Danlos syndrome
6. Have a localized (genital tract) or systemic infection.
7. Have had prior surgical procedures to the vaginal anatomy which could lead to pelvic floor dysfunction, such as pelvic fractures or pelvic soft tissue injuries
8. Have any general health condition or systemic disease that may represent, in the opinion of the investigator, a potential increased risk associated with device use or pregnancy.
9. Have placenta previa or vasa previa.
10. Have a known significant chromosomal or structural fetal anomalies.
11. Have a category 2 and/or 3 fetal tracing that is unresolved.
The goal of this study is to learn more about problems with urine or stool control, prolapse (feeling or seeing a vaginal bulge), and pain with sex, all which can affect mothers after delivery when they are most busy with their newborn.
If you join this study, you will complete a series of online surveys over a period of 12 months. The surveys will ask about urine and stool control, pelvic issues, and sexual issues. Each survey will take about 5-10 minutes.
You may be eligible if upon reading this, you:
- Have given birth within the last 10 days at The Ohio State University Wexner Medical Center
- Are 18 years of age or older
- Recently had a full term vaginal delivery of one baby
- Able to speak and read English
The purpose of the T-Dot Study is to help researchers learn more about menstrual cycles in young women through the use of a mobile app that tracks blood flow, menstrual cramps, and quality of life as it relates to menstrual cycles. Participants will download an app to their phone and track their menstrual cycle for six months.
They will complete one in-person visit to enroll, and three email surveys over the course of the study. Participants will be given menstrual products to use throughout the study.
- 10-14 years of age
- Have had first menstrual cycle (period)
- Have regular access to the same smartphone
The purpose of this study is to understand how Continuous Positive Airway Pressure (CPAP)
for mild to moderate sleep apnea may affect hypertensive disorders of pregnancy and other
complications of pregnancy such as gestational diabetes.
1. No prior delivery at or after 20 weeks 0 days of gestation
2. Pregnancy with only one fetus
3. Gestational age at randomization between 14 weeks 0 days and 21 weeks 6 days
4. Diagnosis with mild to moderate OSA as defined by an AHI score ≥ 5 and <30
The purpose of this study is to understand breast cancer survivors use of mobile health (mHealth) apps for lifestyle behavior change - eating a healthier diet, exercising more, dealing with stress, & stopping smoking. Interviews will last approximately 60 - 90 minutes.
- You have a diagnosis of breast disease or are a breast cancer survivor.
- You are age 18 or older
- You are a female
The primary aim of this study is to determine the effects of resistance exercise intensity on inflammatory markers and psychosocial response in postmenopausal women. Inflammation is part of your body’s immune response to various stimuli and is the body’s way of protecting itself from damage. It’s important to measure inflammation to determine the response to exercise. In this study, we aim to measure inflammation in the blood (what are called inflammatory markers) in response to three different resistance exercise intensities.
You may be eligible for this study if you are:
• Female, ages 40-75
• Postmenopausal (as diagnosed by a physician)
• Overweight (BMI >25 kg/m2)
• Physically capable to perform regular physical activity
• Recreationally trained (regular resistance exercise participation 2 times per week for the past 6 months)