The purpose of this study is to lower the rate of type 2 diabetes in rural Appalachia youth due to obesity and/or being overweight. Our long-term goal is to improve the health of underserved, high-risk youth.
This study will test the effectiveness of the Mentored Planning to be Active + Family on physical activity outcomes and health outcomes among rural Appalachian middle school aged youth suffering from either overweight or obesity.
We have local high school-aged teen mentors work closely with middle school youth to increase social support, self-efficacy, and self-regulation skills to sustain physical activity and improve health before the children enter high school.
The peer mentoring is followed by a 6-month family reinforcement program.
Some parents will provide child assessment data of perceived child physical activity behaviors and child health.
- Child has access to a computer or tablet device at home for virtual mentoring sessions/meetings
- Child suffers from overweight or obesity - does not need to be under the care of a health care professional for this condition
- Child and Parent able to participate read English at a 4th grade level.
- Family not expected to move from rural Appalachia within the 18 months.
The purpose of this study is to investigate the early development of attention, learning, and memory.
The duration of the study will last over 4 years.
Participation in this study includes 4, 90-minute-long visits to the lab per year. During these 90-minute-long visits, your child will play 2-3 computerized games, designed to assess different aspects of their cognitive ability.
Children aged 4 years old only; children must be 4 years old at their initial visit to participate.
The purpose of this study is to understand the best ways to help students return to school after brain injury of any severity. This is important to study because finding the best ways to help students go back to school right after brain injury, and over time, can help improve student success and recovery.
Your participation in the study would take place when you/your child begins the study and then at 3 months, 6 months, 12 months, 2 years (if applicable) and 3 years (if applicable) after the study starts.
• Students aged 5 to 18 years old
• In kindergarten through 12th grade
• Must Speak English
• Traumatic Brain Injury (TBI) of any severity
• Parent/caregiver is willing to share medical and academic information with the research team (all study activities are virtual/remote)
The purpose of this study to test the safety and effectiveness of atropine 0.1% and atropine 0.01% eye solutions. These drugs are being tested to see if they slow the worsening of nearsightedness.
Children who participate in this study will be asked to use their assigned study medication every night and willing to attend visits at The Ohio State University of Optometry 1 month after starting treatment. These visits will continue for 6 months until the duration of the study ends.
This study will take place over a 4-year time period.
· Children aged 3 to < 13 years old.
· No previous use of medications related to myopia control.
· Glasses and/or contact lens prescription between -1.00 and -6.00 diopters.
Interested guardians who believe their child may be eligible should contact study coordinators to further determine eligibility
The purpose of the p-SCHOLAR study is to learn about how congenital heart disease (CHD) might be related to school readiness and development in young children.
This is a single-study visit that will last approximately 3 hours and take place at Nationwide Children's Hospital.
During the 3-hour study visit, we will measure the child's thinking skills, knowledge of letters and numbers, and their behavior. We will also ask the caregiver to complete a set of surveys and a short interview about the child.
If the child is enrolled in a preschool or another educational program, their teacher will have the opportunity to participate in the study as well.
- Legal guardians and their child aged 4 or 5 years old
- Children who have not yet started kindergarten
- Children with no history of congenital heart defects (CHD), traumatic brain injury (TBI), or genetic conditions known to affect cognition
- Children with no severe hearing or vision impairments
- Children born full term (gestational age ≥ 37 weeks)
- Children and caregivers fluent in English
The purpose of this study is to get a better understanding and improve measurement of sleep problems in children with Autism Spectrum Disorder (ASD).
Total time involved in study will be approximately 5 hours
- Parents of children with ASD, and
- Children with ASD ages 3-12, with mild, medium or major sleep problems either currently or in the past
- Children on medication can participate if the medicine dose is stable for at least one month
The purpose of the study is to investigate the early development of attention, learning and memory; this is a multi-year study.
All sessions will take approximately 60-120 minutes to complete. This study will be conducted in our lab, and mandated OSU COVID safety protocol will be followed.
- Children who are 4 years old
- Have normal or corrected to normal vision
The purpose of this study is to understand how children sort new information using simple memory exercises with animated computer games.
All sessions will take approximately 25-45 minutes to complete. Participating children will play memory games on our touchscreens and computers. For on-campus sessions, mandated OSU COVID safety precautions will be followed.
- Children ages 4-9 years old
Children who suffered a stroke before or shortly after being born that was caused by blockage of blood flow in an artery, it often results in the child showing some weakness on one side of their body.
With this study, we want to find out if a type of therapy may help children who have weakness on one side of their body due to perinatal arterial ischemic stroke, learn how to better use their weaker arm.
All children will be in the study for about 13 - 15 months. Some children may be in the study for a longer period, depending on which treatment they receive during Phase 1 of the study. The I-ACQUIRE therapy involves fun learning and play, self-help activities, and manipulating interesting toys and objects.
- Your child must be between the ages of 8 and 36 months old when beginning this study
- Your child must have suffered an a perinatal arterial ischemic stroke
- Upper limb weakness
- Parents must be able to participate at least 1x/week for therapy and 40-60 minutes/day at home
This is a study to find out how pregnancy affects a mother’s immune system. (The “immune system” is the part of the body that fights germs.) This study is also to find out why some babies who are exposed to infections during pregnancy get infected and others do not.
To do this project we need to study some women and babies who are infected with the hepatitis C virus and others who are not. This will allow us to compare their immune systems.
You may be eligible to participate if you are:
PREGNANCY COHORT eligibility criteria:
1) Pregnant (enrollment preferably during 1st or 2nd trimester, but may occur as late as the delivery hospitalization)
2) HCV-RNA positive (#150) or HCV-RNA negative (#50)
3) Willing and able to attend all study visits
Exclusion criteria for mothers:
1) Inability to provide informed consent
Inclusion criteria for infants:
1) Child born to study mother
Exclusion criteria for infants:
1) In custody of county children’s services (Enrolled infants who are temporarily in custody of children’s services will not have further study blood draws, but lab results from blood tests ordered by their pediatrician may be followed to monitor the outcome of their HCV exposure. Infants who are later placed back in the custody of their mother or relative may be re-enrolled.)
NON-PREGNANCY COHORT eligibility criteria:
1) Willing and able to attend all study visits
1) Currently pregnant
2) Inability to provide informed consent