Official Title An Examination of the Diet Quality of Low-Income Children 6-24 months old

Purpose

The purpose of the research is to determine the dietary patterns and calculate the dietary quality of children 6 to 24 months of age and enrolled in childcare centers, WIC, and other places that serve parents of young children; and to identify the most important cultural, social, and economic factors influencing the dietary and feeding patterns of these children. The total amount of time you will be asked to volunteer for this study is 2 hours and 10 minutes.

Could this study be right for you?

• Parent or caregiver of a child 6 to 24 months old
• Receiving WIC, SNAP, or similar benefits
• Live in Franklin County, Ohio

Age Range

18 and up

Official Title An Examination of the Diet Quality of Children Low Income Children from 3-5 Years of Age

Purpose

To determine dietary patterns and calculate dietary quality of young children enrolled in child care centers, WIC, and other places that serve parents and young children; and to identify the most significant cultural, social, and economic factors influencing the dietary and eating patterns of these children.

The total amount of time you will be asked to volunteer for this study is 2 hours and 10 minutes.

Could this study be right for you?

• Parents and/or caregivers must be at least 18 years of age
• Each household must qualify as low income status
• Each parent/caregiver must be fluent in English
• Each child must not have a medical condition requiring diet modifications
• Each child must be 3-5 years old

Age Range

3 and up

Official Title An Examination of the Diet Quality of Low-Income Children from Birth to 6 Months Old.

Purpose

The purpose of the research is to determine the dietary patterns and calculate the dietary quality of infants and enrolled in childcare centers, WIC, and other places that serve parents of young children; and to identify the most significant cultural, social, and economic factors influencing the dietary and feeding patterns of these children.

The total amount of time you will be asked to volunteer for this study is 2 hours and 10 minutes.

Could this study be right for you?

• Parents or caregivers must be at least 18 years of age
• Each parent/caregiver must be fluent in English
• Each household must qualify as low income status based on the number of people in the household
• Children must be within 0-6 months of age
• Children must not have any medical condition requiring a modified diet

Official Title The Chaperone Study: A multi-center, double-masked, randomized, placebo-controlled, phase III study of the safety and efficacy of atropine 0.1% and 0.01% ophthalmic solutions administered with a microdose dispenser for the reduction of pediatric myopia progression

Purpose

Is your child nearsighted?

Nearsightedness, or myopia, is a condition that results in blurry vision when looking at distant objects.

Myopia happens when the eyeball grows too long or the cornea (the clear front cover of the eye) is too curved.
As a result, light entering the eye is not focused correctly. While glasses and contact lenses can help a person with myopia see clearly, they do not address the underlying stretching of the eye.

Myopia detected in young children tends to increase through the school years . As myopia progresses, it can increase the risk of retinal detachment, cataracts, myopia maculopathy and even blindness. To date, FDA has not approved any drug therapies for reducing myopia progression.

This is why researchers are working to develop new medications and technologies that may help children and teens with this condition. The CHAPERONE Study is a research study testing the safety and effectiveness of microdosed atropine eye solution to see if it slows the progression of myopia in children.

Could this study be right for you?

• Is your child between 3-12 years old?
• Does your child need glasses to see distant objects?
• Is your child able to go to periodic visits at the study clinic to check his/her vision and overall eye health over a 4-year period (11 scheduled visits will be required)?
• Are you available to speak with study staff by phone periodically between your child’s clinic visits to review your child’s experience using study medication?

This study is not for children who have:

• Used atropine or other myopia drug therapies
• Had prior eye surgery
• A systemic disease or condition that can affect their vision

Age Range

3 and up

Official Title SMALL Talk: Study of Milestones to Advance Language Learning

Purpose

The goal of this study is to identify early risk for developmental language disorder (DLD) among young, low-income children, and to determine how caregiver and child chronic stress and interaction quality interact to disrupt language growth among these children. The long-term objective is to identify pathways through which early family situations and the conditions of poverty disrupt early language paths among low-income children and contribute to heightened rates of DLD.

Could this study be right for you?

Inclusion criteria are:

• have a child that is 9 months or younger
• child resides in a low-income household, using some sort of government assistance or using the 200% threshold from the Department of Health and Human Services based on annual household income and number of persons in home

Exclusion criteria:

• Children who are multiple births, preterm (<35 weeks), and have profound or severe disabilities will be excluded, with the latter including congenital blindness, deafness, Down syndrome, and other frank neurological deficits.

Official Title Relationship Dynamics in Families of Children with ADHD and Their Opposite-Sex Siblings

Purpose

This study is being done to better understand relationship dynamics between children with ADHD, their siblings, and their parents. Our goal is to better understand how differences in family dynamics affect children with ADHD. Participants will be asked to fill out several self-report questionnaires and engage in a family conflict task. During several tasks, participants will have various physiological measures (e.g., heart rate, breathing rate, etc.) taken using electrodes placed on their body. Results of this study will be used to develop other studies and to inform future treatment and prevention programs.

Could this study be right for you?

We are recruiting children between 8 and 10 years old with an opposite sex sibling. In order to participate, families must meet the following criteria:

• Mothers must be willing to participate
• They must have a child between ages 8 and 10
• That child must have a sibling of the opposite sex that is within 2 years of their age

Age Range

6 and up

Official Title Immune Response in Adolescents

Purpose

Our goal in this study is to learn more about the immune system in adolescence and early adulthood. We are looking to enroll healthy children ages 12-18 years old.

Enrollment in the study will require 1 visit to Nationwide Children’s Hospital involving a blood draw and 2 nasal swabs.
The visit will take approximately 1- 1 ½ hour(s). We ask that the family brings a copy of the child’s immunization record to the visit.

Could this study be right for you?

Children will need to meet the following criteria to be in the study:

Inclusion Criteria:

• Parents/Legal guardian able and willing to sign informed consent and the child is willing to sign assent form for participation. All forms are in English.
• Healthy children, age 12-18 years old

Exclusion Criteria:

• Any chronic or congenital conditions that may potentially affect immune responses
• Cough, congestion, fever, rhinorrhea, rash and any other symptoms indicative of infection within the 2 weeks prior to enrollment sampling
• HIV, AIDS or other immunodeficiencies or any other condition that may affect their immune system
• Use of systemic steroids within 2 weeks prior to enrollment
• Immunization(s) within the last 30 days

Age Range

12 and up

Official Title CHILDHOOD ATROPINE FOR MYOPIA PROGRESSION (CHAMP): A 3-ARM RANDOMIZED, DOUBLE-MASKED, PLACEBO-CONTROLLED, PHASE 3 STUDY OF ATROPINE SULFATE OPHTHALMIC SOLUTION 0.01% AND 0.02%

Purpose

The purpose of the study is to determine if a daily eye drop will help slow the progression of nearsightedness in children.

Could this study be right for you?

Your child may be eligible for this study if he/she is:

• Ages 3-17
• Nearsighted

Participants will complete visits for follow-up (every 6 months) and to pick up study eye drops (every 3 months).

Please have your child’s current eye glasses prescription available when you call.

Age Range

3 and up

Official Title Development of Parent-Child Interactions

Purpose

This study will examine how a child’s hearing loss may affect the dynamics of parent-child interactions. The study will observe how normal-hearing and hearing-impaired child learn novel words during videotaped parent-child interactions.

Individual study visits may last 30-45 minutes, and there may be multiple study visits per year.

Could this study be right for you?

• Families with children 9 months to 6 years of age
• Children who do and do not have hearing loss may be eligible to participate in this study

Official Title Daily and Weekly Rehabilitation Delivery for Young Children with Cerebral Palsy ("DRIVE")

Purpose

The purpose of this study is to find out how to best distribute physical therapy sessions for your children with significant motor delays.

Participants will receive 40 hours of physical therapy. Participants will be randomly assigned to one of the three treatment groups: intensive, moderate or weekly.

Could this study be right for you?

• Children ages 6 months to 24 months of age
• Has a diagnosis of cerebral palsy or an acquired brain injury prior to age of 24 months.
• Has persistent delays in motor skills
• Ability to participate in outpatient physical therapy and attend visits consistently

The intensive group will receive physical therapy 2 hours per day, 5 days per week for 4 weeks followed by a 16 week break from outpatient physical therapy. The intermediate group will receive physical therapy 2 hours per day, 3 days per week for 6.6 weeks followed by a 13 week break from outpatient physical therapy. The weekly group will receive physical therapy for 2 hours per day, 1 day per week for 20 weeks.