• Study Evaluating the Tears of the Eye

    Official Title

    Lipid Composition of the Tear Film in Healthy Participants and Dry Eye Disease Patients

    Purpose

    The purpose of this study is to explore the lipid concentration of the tear film in healthy participants and those who have dry eye disease. 

    Could this study be right for you?

    Inclusion criteria:

    • At least 18 years of age (30 years of age for dry eye disease cohort).
    • Good general health (defined by medication use that has not changed within the last month and the absence of medical conditions or treatments that are deemed confounding to the data as determined by the PI)
    • Ability to give informed consent
    • Willing to spend time for the study; approximately one hour for study assessments
    • Either gender

    Exclusion criteria:

    • Use of any ocular prescription medication (such as but not limited to, glaucoma medications, anti-inflammatory eye drops and Restasis) used within 14 days of the screening visit or started prior to the measurement visit(s).   
    • Currently having punctal plugs inserted in lacrimal puncta

    Inclusion and Exclusion Criteria varies, please contact Study Coordinator for more information. 

    Age Range

    18 years and up
  • Research Study on Light Sensitivity after Head Injury

    Official Title

    Effect of Fixation Training with Colored Light Targets on Traumatic Brain Injury-Associated Photophobia

    Purpose

    Researchers at The Ohio State University College of Optometry are seeking individuals with a recent history of head trauma who are experiencing light sensitivity. The goal of this study is to determine if daily 20 minute fixation training sessions using a colored (red or blue) light target affects symptoms of light sensitivity, or alters other measurements of the eyes and vision including pupil response.  

    This study will involve attending five 1-2 hour study visits, occurring every 1.5 months for 6 months. Study visits will include answering questions about eye and health history, completing surveys, reading letters on an eye chart, having the pupils measured in response to flashes of light, measuring the side vision, measuring eye alignment and in some cases focusing ability. Outside of the study visits, participants will also complete daily 20 minute fixation training sessions for 6 months using a colored (red or blue) light target, completed at home between study visits.

    Could this study be right for you?

    • Must be 18 to 80 years old
    • Experienced a head injury 3 or more months ago
    • Current symptoms of light sensitivity
    • Be healthy and have good eye health 

    Age Range

    18 - 80 years
  • Determining the Best Glasses Prescription for Children with Down Syndrome

    Official Title

    Dilated Wavefront versus Non-Dilated Wavefront for Metric-Optimized Refraction Procedure for Individuals with Down Syndrome

    Purpose

    The purpose of this study is to examine whether we can use an instrument that measures how the eye focuses light to determine the best glasses prescription.

    Could this study be right for you?

    • Children with Down syndrome age 5 to 17 years
    • Able to do vision tests by naming or matching shapes or letters
    • Able to look at lights for short periods of time
    • No nystagmus (uncontrolled eye movements when trying to look at things)
    • Safe to dilate the eyes - we will screen medical history, eye health, and allergies to determine this
    • No scars on the front of the eye
    • No cataracts
    • No eye diseases like glaucoma or retinal problems

    Age Range

    5 - 17 years
  • A Study about Eye Teaming, Focusing Ability and Quality of Life

    Official Title

    Development of Patient-Reported Outcome Measures for Children with Concussion-Related and Non-Concussion-Related Non-Strabismic Binocular Vision, Accommodative and Visual Tracking Problems: Phase 1

    Purpose

    The purpose of this study is to assist in development of a new quality of life survey that can be used to learn more about how eye teaming, focusing ability and eye movement problems affect a child’s life.

    Could this study be right for you?

    • Children experiencing eye teaming, focusing, and eye movement problems (with recent concussion or non-concussed)
    • Children with amblyopia (lazy eye) are excluded

    Age Range

    8 - 17 years
  • A Randomized Trial to Evaluate Sequential vs Simultaneous Spectacles plus Patching for Amblyopia in Children 3 to <13 Years Old

    Official Title

    AMBLYOPIA TREATMENT STUDY (ATS22): A Randomized Trial to Evaluate Sequential vs Simultaneous Spectacles plus Patching for Amblyopia in Children 3 to <13 Years Old

    Purpose

    The purpose of this study is to evaluate if treating amblyopia (lazy eye) with glasses and patching at the same time improves vision as well as treating amblyopia first with glasses and then with patching, if needed.

    Could this study be right for you?

    • Visual acuity in the amblyopic eye between 20/40 and 20/200
    • No previous treatment for amblyopia, including glasses or contact lenses
    • Amblyopia (lazy eye) in one eye

    Age Range

    3 - 12
  • Tear Film in Children Study

    Official Title

    Tear Film and Corneal Profile of Pediatric Contact Lens Wearers

    Purpose

    The goal of this study is to describe the risks associated with overnight orthokeratology contact lens wear in children by identifying corneal and tear film changes. The study aims to describe and compare the tear film components in a pediatric sample wearing orthokeratology contact lenses (used to change the shape of the cornea), soft contact lenses, or glasses. Additionally, the study aims to compare the corneal thickness profile in a pediatric sample wearing orthokeratology contact lenses, soft contact lenses, or glasses. 

    This study requires one visit only. The overall timeline from subject recruitment to study completion is dependent upon subject and examiner availability and scheduling. As long as no changes occur to subject eligibility between initial recruitment and the study visit, there is some flexibility with timing.

     

    Could this study be right for you?

    • Near-sighted prescription between -1.00D and -6.00D
    • Current correction with glasses, soft contact lenses, or overnight orthokeratology contact lenses
    • Has been wearing current correction for 6 months or longer
    • Good eye and overall health

    Age Range

    7 - 17
  • A Study About the Development of Learning in African-American/Black Children

    Official Title

    Ontogenesis of Categorization; Linking development, mechanisms, and biology

    Purpose

    The purpose of this study is to investigate the early development of attention, learning, and memory during childhood. Participation in this study includes 4, 90-minute-long visits to the lab per year. During these visits, your child will play 2-3 fun, computerized games. These games are designed to assess various aspects of their cognitive ability. 

    The duration of the study will last 4 years.

    Could this study be right for you?

    Eligibility Criteria: 

    • African-American/Black children who are 4 years old 

    Age Range

    4 - 4
  • A Study to Examine Atropine for the Reduction of Nearsightedness (The CHAPERONE Study)

    Official Title

    Microdosed Atropine for the Reduction of Pediatric Myopia Progression (The CHAPERONE Study)

    Purpose

    The purpose of this study to test the safety and effectiveness of atropine 0.1% and atropine 0.01% eye solutions. These drugs are being tested to see if they slow the worsening of nearsightedness. Children who participate in this study will be asked to use their assigned study medication every night and willing to attend visits at The Ohio State University of Optometry 1 month after starting treatment. These visits will continue for 6 months until the duration of the study ends. This study will take place over a 4-year time period.

    Could this study be right for you?

    · Children aged 3 to < 13 years old. · No previous use of medications related to myopia control. · Glasses and/or contact lens prescription between -1.00 and -6.00 diopters. Interested guardians who believe their child may be eligible should contact study coordinators to further determine eligibility

    Age Range

    3 and up
  • Reviewing and Evaluating Resources Related to Dizziness and Home Based Therapies

    Official Title

    Usability & Acceptability of a Patient-Oriented Educational Resource for Dizziness

    Purpose

    The purpose of this study is to look at a web-based tool on the topic of dizziness so that we can create resources for teaching patients about causes of dizziness and home-based therapies. We are recruiting patients with dizziness and/or general volunteers to review the web-based tool and then provide feedback which will then be used to help update requirements for the educational tool. This study will take about 20-30 minutes of your time to review a website and complete a survey. If you decide to also participate in the discussion, it will take about 20-30 more minutes.

    Could this study be right for you?

    - Participants must be 18 years or older - able to speak and read English at an eighth-grade level or above - be willing and able to participate

    Age Range

    18 and up
  • A study for children with nearsightedness

    Official Title

    The Chaperone Study: A multi-center, double-masked, randomized, placebo-controlled, phase III study of the safety and efficacy of atropine 0.1% and 0.01% ophthalmic solutions administered with a microdose dispenser for the reduction of pediatric myopia progression

    Purpose

    Is your child nearsighted?

    Nearsightedness, or myopia, is a condition that results in blurry vision when looking at distant objects.

    Myopia happens when the eyeball grows too long or the cornea (the clear front cover of the eye) is too curved.
    As a result, light entering the eye is not focused correctly. While glasses and contact lenses can help a person with myopia see clearly, they do not address the underlying stretching of the eye.

    Myopia detected in young children tends to increase through the school years . As myopia progresses, it can increase the risk of retinal detachment, cataracts, myopia maculopathy and even blindness. To date, FDA has not approved any drug therapies for reducing myopia progression.

    This is why researchers are working to develop new medications and technologies that may help children and teens with this condition. The CHAPERONE Study is a research study testing the safety and effectiveness of microdosed atropine eye solution to see if it slows the progression of myopia in children.

    Could this study be right for you?

    - Is your child between 3-12 years old?
    - Does your child need glasses to see distant objects?
    - Is your child able to go to periodic visits at the study clinic to check his/her vision and overall eye health over a 4-year period (11 scheduled visits will be required)?
    - Are you available to speak with study staff by phone periodically between your child’s clinic visits to review your child’s experience using study medication?

    This study is not for children who have:
    - Used atropine or other myopia drug therapies
    - Had prior eye surgery
    - A systemic disease or condition that can affect their vision

    Age Range

    3 and up