A Study to Examine Atropine for the Reduction of Nearsightedness (The CHAPERONE Study)

Official Title
Microdosed Atropine for the Reduction of Pediatric Myopia Progression (The CHAPERONE Study)
Purpose

The purpose of this study to test the safety and effectiveness of atropine 0.1% and atropine 0.01% eye solutions. These drugs are being tested to see if they slow the worsening of nearsightedness.

Children who participate in this study will be asked to use their assigned study medication every night and willing to attend visits at The Ohio State University of Optometry 1 month after starting treatment. These visits will continue for 6 months until the duration of the study ends.

This study will take place over a 4-year time period.

Could this study be right for you?

· Children aged 3 to < 13 years old.

· No previous use of medications related to myopia control.

· Glasses and/or contact lens prescription between -1.00 and -6.00 diopters.

Interested guardians who believe their child may be eligible should contact study coordinators to further determine eligibility

Age Range
3 and up

A Study on Where a Pitched Ball Will Arrive

Official Title
Threshold Values of Cues to Predict the Vertical Height of Approaching Objects
Purpose

The ability to predict where a moving target will arrive is important in sports and activities such as driving. The purpose of this study is to better understand how we use our vision to make these decisions. The study might help us to develop training exercises to improve these predictions. The study will require one session that will last approximately one hour.

A pitching machine will be used to pitch tennis balls toward you. You will be asked to judge the height of those pitched balls as they arrive. You will be wearing special shutter glasses that will block your vision at different times after the ball leaves the pitching machine. Nets will be in place so that no ball is able to hit you.

The study requires one visit and will last approximately one hour.

Could this study be right for you?

- You must have played organized baseball or softball at the high school level or above within the past 10 years
- Must have good vision in both eyes (20/20) with or without glasses or contact lenses
- Participants must have good depth perception and good eye alignment - no lazy eye or crossed or turned eyes
- Must be 18 - 40 years of age

Age Range
18 and up

A study for children with nearsightedness

Official Title
The Chaperone Study: A multi-center, double-masked, randomized, placebo-controlled, phase III study of the safety and efficacy of atropine 0.1% and 0.01% ophthalmic solutions administered with a microdose dispenser for the reduction of pediatric myopia progression
Purpose

Is your child nearsighted?

Nearsightedness, or myopia, is a condition that results in blurry vision when looking at distant objects.

Myopia happens when the eyeball grows too long or the cornea (the clear front cover of the eye) is too curved.
As a result, light entering the eye is not focused correctly. While glasses and contact lenses can help a person with myopia see clearly, they do not address the underlying stretching of the eye.

Myopia detected in young children tends to increase through the school years . As myopia progresses, it can increase the risk of retinal detachment, cataracts, myopia maculopathy and even blindness. To date, FDA has not approved any drug therapies for reducing myopia progression.

This is why researchers are working to develop new medications and technologies that may help children and teens with this condition. The CHAPERONE Study is a research study testing the safety and effectiveness of microdosed atropine eye solution to see if it slows the progression of myopia in children.

Could this study be right for you?

- Is your child between 3-12 years old?
- Does your child need glasses to see distant objects?
- Is your child able to go to periodic visits at the study clinic to check his/her vision and overall eye health over a 4-year period (11 scheduled visits will be required)?
- Are you available to speak with study staff by phone periodically between your child’s clinic visits to review your child’s experience using study medication?

This study is not for children who have:
- Used atropine or other myopia drug therapies
- Had prior eye surgery
- A systemic disease or condition that can affect their vision

Age Range
3 and up

A TBI (Traumatic Brain Injury) and Vision Study

Official Title
TBI and Vision Study
Purpose

The goal of this study is to determine whether measurements of the pupil’s reaction to light are associated with the presence of vision problems which are commonly observed after head trauma.

This study will compare how the pupil reacts to a flash of light (like a camera flash) in those with and without vision problems after TBI to see if this measure could be a widely available screener for vision problems.

If you are eligible and participate, you will be asked to read letters and follow targets with your eyes. You will also have your pupil reflexes measured with a short flash of light (similar to a camera flash).

Could this study be right for you?

- Be at least 7 years of age
- Have a history of head trauma, such as concussion

Age Range
7 and up

Nearsightedness in Children--A Study to Determine if Daily Eye Drops Can Slow the Progression

Official Title
CHILDHOOD ATROPINE FOR MYOPIA PROGRESSION (CHAMP): A 3-ARM RANDOMIZED, DOUBLE-MASKED, PLACEBO-CONTROLLED, PHASE 3 STUDY OF ATROPINE SULFATE OPHTHALMIC SOLUTION 0.01% AND 0.02%
Purpose

The purpose of the study is to determine if a daily eye drop will help slow the progression of nearsightedness in children.

Could this study be right for you?

Your child may be eligible for this study if he/she is:
*Ages 3- 17
*Nearsighted

Participants will complete visits for follow-up (every 6 months) and to pick up study eye drops (every 3 months).

Please have your child’s current eye glasses prescription available when you call.

Age Range
3 and up