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Impacts of Ketone Esters on Exercise and Heart Health in Type 2 Diabetics
Official Title Effects of Acute and Chronic Ketone Ester Consumption on Exercise Tolerance and Cardiac Function in Subjects with DiabetesPurpose
This placebo-controlled study is being done to evaluate the effects of a ketone ester drink on exercise performance and heart health in a group of subjects diagnosed with type 2 diabetes.
Could this study be right for you?
There are additional exclusion criteria, study staff will screen fully before enrollment.
Age Range
18 - 80 years -
Variations in Ketone Metabolism
Official Title Strategies to Augment Ketosis- Variations in Ketone MetabolismPurpose
This study is being done to see how individuals respond to a ketone ester (KE) across different age groups and health statuses. With the ketogenic diet becoming more popular, research on ketones (a molecule created when fat is broken down in the body) has grown as well.
These findings will be used to help develop future research studies and help others to pick the right doses of ketone supplement.
Could this study be right for you?
- Do NOT smoke or have diabetes, liver disease, kidney disease, cardiovascular disease, or any form of endocrine dysfunction
- Have NOT experienced >10% weight loss in the last 6 months
- Do NOT currently consume a low carbohydrate diet
- Do NOT consume alcohol more than 3 drinks/daily or 14 drinks/weekly
- Do NOT suffer from food allergies or gastrointestinal disorders
Age Range
20 - 70 years -
Sleep Restriction and Ketone Supplements
Official Title Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction (STAK-Sleep)Purpose
To examine if drinking a ketone supplement, twice a day, can improve brain, digital shooting, and physical performance during short-term sleep restriction (4 nights, 50% of normal sleep).
Could this study be right for you?
- Healthy
- Age: 18 - 40 years old
- BMI: 20-35 kg/m2
- No diagnosed sleep disorders
- Not consuming a ketogenic diet
Age Range
18 - 40 years -
Healthy Diet Study
Official Title A prospective randomized unblinded study of ketogenetic versus mixed diet on exercise tolerance in subjects with the metabolic phenotype of heart failure with preserved ejection fractionPurpose
The purpose of this study is to compare the effects of a well-formulated ketogenic diet with a low-fat diet on exercise tolerance in patients with diabetes or pre-diabetes or obesity; with shortness of breath or heart failure.
Could this study be right for you?
Inclusions:
- Age ≥ 18 years old and ≤ 80 years old & willingness to be randomized to either diet.
- NYHA class I – III for at least 3 months.
- Ejection fraction ≥40% by biplane 2D, or 3D echo, or CMR.
- Echo findings of abnormal or indeterminant diastolic function or RHC data: At rest: mean pulmonary capillary wedge pressure (PCWP) > 15 mmHg. Pulmonary vascular resistance (PVR) < 3 Wood Units.
- Stable medical therapy for at least 3 months as determined by the treating physician (no new cardiac or diabetic medications within 3 months of enrollment or during enrollment and dosage should be stable for 1 month prior to enrollment).
- Dose of oral diuretics changes allowed but must be stable for 1 week prior to randomization.
- Body Mass Index (BMI) ≥ 25 and ≤ 50 or Type 2 Diabetes Mellitus or prediabetes (fasting glucose of 100 - 125 mg/dL or hemoglobin A1C 5.7-6.4%) or metabolic syndrome.
- Ability to participate in exercise treadmill testing.
- Ability to sign written consent.
Exclusions:
- Women who are pregnant, current breast-feeding, or have intention to become pregnant while in the study.
- Known allergy or sensitivity to gadolinium-based contrast agents.
- Implanted pacemaker, cardioverter defibrillator, Cardiac resynchronization therapy, left ventricular assist devices.
- Other metallic implants/aneurysm clips that are contraindicated in MRI.
- Claustrophobia
- History of severe kidney disease of eGFR < 30 ml/kg/1.73m2.
Exclusion Criteria varies, please contact Study Coordinator.
Age Range
18 - 80 years -
A Study for Those With Type 2 Diabetes AND Who Are Experiencing Food Insecurity
Official Title Linking Education, Produce Provision, and Community Referrals to Improve Diabetes Care (LINK)Purpose
The purpose of this study is to improve hemoglobin A1c levels in patients with type 2 diabetes experiencing food insecurity. The study will examine the effects of a produce referral program alone and in combination with other interventions. Our research is designed to develop a deeper understanding of how to provide patients with type 2 diabetes that are experiencing food insecurity with the resources, skills, and education to manage their health and social needs.
Could this study be right for you?
Inclusion Criteria:
- Age 18 years and older
- Type 2 diabetes based on American Diabetes Association Criteria
- Hemoglobin A1c level > 7.5%
- Worried about running out of food before you have money to buy more
Exclusion Criteria:
- Pregnant
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Diet Quality of Low-Income Children 6-24 months old
Official Title An Examination of the Diet Quality of Low-Income Children 6-24 months oldPurpose
The purpose of the research is to determine the dietary patterns and calculate the dietary quality of children 6 to 24 months of age and enrolled in childcare centers, WIC, and other places that serve parents of young children; and to identify the most important cultural, social, and economic factors influencing the dietary and feeding patterns of these children. The total amount of time you will be asked to volunteer for this study is 2 hours and 10 minutes.
Could this study be right for you?
- Parent or caregiver of a child 6 to 24 months old
- Receiving WIC, SNAP, or similar benefits
- Live in Franklin County, Ohio
Age Range
18 and up -
A Study for Those with Chronic Pancreatitis - The PROCEED Study
Official Title Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies PROCEED Study)Purpose
This study is done for researchers to understand pancreatitis and learn how the disease progresses naturally over time.
From the results of this study, researchers hope to develop some lab tests to support early diagnosis of chronic pancreatitis and to also discover any genetic factors that may affect your chances of developing chronic pancreatitis. The results of this study may also provide information that will open opportunities for new drug discovery.
Could this study be right for you?
- You have a history of acute or chronic pancreatitis OR
- You have experienced pain in your abdomen that a doctor has suggested could be due to pancreatitis
- You are between the ages of 18 and 75
Age Range
18 and up -
A Study for Those with Chronic Pancreatitis
Official Title A PHASE 1, SINGLE DOSE PK AND SAFETY STUDY WITH NI-03 FOLLOWED BY A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PARALLEL-GROUP DOSE-RANGING STUDY TO EVALUATE THE SAFETY AND EFFICACY OF NI-03 COMPARED TO PLACEBO IN SUBJECTS WITH CHRONIC PANCREATITISPurpose
The purpose of this study is to learn if a study drug called NI-03 (also known as Camostat) can help people with chronic pancreatitis. We want to find out what effects, good or bad, the study drug has on the disease. It has been approved in Japan and has been available by prescription for the treatment of the acute pain associated with chronic pancreatitis. The study drug will not be approved for sale in the United States until tests from studies like this one show that it is safe and effective.
Could this study be right for you?
- You are between the ages of 18-80
- You have a diagnosis of chronic pancreatitis
- For males: documented surgical sterilization, sexual abstinence, or agreed upon means of contraception from screening until 28 days after final dose of study medication is required
- For females: documented surgical sterilization, sexual abstinence, postmenopausal status for at least 1 year, or agreed upon means of contraception from screening until 28 days after final dose of study medication is required
Age Range
18 and up -
The REGENERATE Study - A study to evaluate the effectiveness and safety of a medication (Obeticholic Acid) for those with NASH (nonalcoholic steatohepatitis)
Official Title A Phase 3, Double-Blind, Randomized, Long-Term, Placebo-Controlled, Multicenter Study Evaluating the Safety and Efficacy of Obeticholic Acid in Subjects with Nonalcoholic SteatohepatitisPurpose
This research study is for those who have nonalcoholic steatohepatitis (NASH) (meaning your liver is swollen and damaged because of a buildup of fat in your liver) and some liver fibrosis (which is damaged and scarred liver tissue). Because of your condition, you may be eligible for a research study on an investigational drug for your condition. The Regenerate Study will assess the safety and effectiveness of the investigational medication obeticholic acid (OCA) compared to placebo in delaying specific medical conditions or health related issues that can occur in patients with nonalcoholic steatohepatitis (NASH) (meaning your liver is swollen and damaged because of a buildup of fat in your liver) and some liver fibrosis (which is damaged and scarred liver tissue).
Could this study be right for you?
- Age 18 or older
- Diagnosed with Stage 2 or 3 NASH (nonalcoholic steatohepatitis--meaning your liver is swollen and damaged because of a buildup of fat in your liver) and some liver fibrosis (which is damaged and scarred liver tissue).
If you are eligible and decide to take part in this research study, you will need to complete 1 or 2 screening visits to see if you are eligible to participate in the study. Once the study doctor determines you can participate in the study, you will be asked to come back to the clinic 8 times (for the Month 0 [Day 1] Visit, the Month 1 Visit, the Month 3 Visit, and then every 3 months) for the first 18 months you are in the study and then 2 times per year (every 6 months) for each additional year you are in the study.
Age Range
18 and up