Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.
Study Categories
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A Study to Evaluate the Effectiveness and Safety of NBI-1065846 (TERPIS)
Official Title Study to Evaluate the Efficacy and Safety of Once-Weekly Oral NBI-1065846 in the Treatment of Anhedonia in MDD (TERPSIS)Purpose
To evaluate the efficacy and safety of study drug NBI-1065846, used as adjunctive treatment to oral antidepressant medication(s), compared with a placebo when treating symptoms of anhedonia.
Could this study be right for you?
• Aged 18-65 years old • Diagnosis of MDD • Currently on stable dose of at least one antidepressant • Experiencing anhedonia (low interest, decreased enjoyment)
Age Range
18 and up -
A Study to Evaluate the Safety and Effectiveness of a Dietary Supplement Used in Treating COVID-19
Official Title Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of a Plant Polyphenol for COVID-19Purpose
The purpose of this trial is to determine whether a commercially available dietary supplement may decrease the severity of patients with early COVID-19
Could this study be right for you?
Inclusion Criteria:
- Outpatients who test positive for infection with SARS-CoV-2
- Age 45 years and older
- Experiencing COVID 19 symptoms for 7 days or less,
OR 72 hours of new respiratory symptoms
- Patient must have access to the internet or a smartphone to complete surveys
- English-speaking patientsAge Range
45 and up -
A Study to Evaluate the Safety of REL-1017, A Study Drug Used to Treat Major Depressive Disorder (MDD)
Official Title Safety of REL-1017 for Major Depressive Disorder (RELIANCE-OLS)Purpose
This is a 1-year open-label study to access the safety of REL-1017, a study medication, once daily as a workable treatment of Major Depressive Disorder. Study participants will continue to take their current antidepressant therapy in addition to the study drug for the duration of the treatment period.
This study will last 13 months and you will come to the study site at least 15 times over this period. This will include 1 final visit about 1 month after you stop taking the study drug.
Could this study be right for you?
• Aged 18-65 years old
• Diagnosed with Major Depressive Disorder (MDD)
• Currently depressed
• Taking or having taken between 1 and 3 antidepressants for the current episode of depressionAge Range
18 and up -
A Study to Evaluate Upadacitinib Along with Topical Corticosteroids on Teens and Adults with Atopic Dermatitis (eczema)
Official Title M16-047: A Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Combination with Topical Corticosteroids on Adolescent and Adult Subjects with Moderate to Severe Atopic DermatitisPurpose
The purpose of this study is to compare the effectiveness and safety of Upadacitinib (ABT-494) to placebo (pill without any active substance that looks like upadacitinib) in combination with topical corticosteroids for adolescents (12-17 years of age) and adults (18-75 years of age with moderate to severe atopic dermatitis (AD).
Could this study be right for you?
- Adolescent subjects must weigh more than 40 kg (88 lb) - Subject must be in good general health (other than Atopic Dermatitis) - Subject must have chronic Atopic Dermatitis (AD) with onset of symptoms at least 3 years before first dose of study medication - Subject must have documented history of inadequate response to topical corticosteroids (TCS), topical calcineurin inhibitor (TCI), or systemic treatment for AD within 6 months prior to first dose of study medication - Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study and for 30 days after last dose of the study drug. - No history of drug or alcohol abuse in the 6 months prior to receiving the first dose of study medication
Age Range
12 and up -
A Study to Examine Atropine for the Reduction of Nearsightedness (The CHAPERONE Study)
Official Title Microdosed Atropine for the Reduction of Pediatric Myopia Progression (The CHAPERONE Study)Purpose
The purpose of this study to test the safety and effectiveness of atropine 0.1% and atropine 0.01% eye solutions. These drugs are being tested to see if they slow the worsening of nearsightedness. Children who participate in this study will be asked to use their assigned study medication every night and willing to attend visits at The Ohio State University of Optometry 1 month after starting treatment. These visits will continue for 6 months until the duration of the study ends. This study will take place over a 4-year time period.
Could this study be right for you?
· Children aged 3 to < 13 years old. · No previous use of medications related to myopia control. · Glasses and/or contact lens prescription between -1.00 and -6.00 diopters. Interested guardians who believe their child may be eligible should contact study coordinators to further determine eligibility
Age Range
3 and up -
A Study to Examine How Art Reduces Stress in People Who Suffer from Chronic Digestive Issues (ART-GUT study)
Official Title Art to promote Reduction in stress, Truncate severity of Gastrointestinal symptoms Understand its role in Therapy (ART-GUT study)Purpose
The purpose of this study is to evaluate whether group-art sessions can reduce stress, improve sleep quality, improve quality of life and decrease severity of digestive symptoms in participants who suffer from chronic digestive issues. Participants will meet virtually once per week for 1.5 hour sessions, via Zoom, and will be provided with art supplies.
The start date will be determined by the date the 1st session starts for a given group. Thus participants can be in the study for up to 14 weeks.
Could this study be right for you?
• Male or females aged 18 years or older
• Suffer from Chronic Digestive Symptoms
• Willing to meet virtually once per week for 1.5 hour group sessionsAge Range
18 and up -
A Study to Examine Sex Differences in Pain Reports and Brain Activation in Older Adults with Alzheimer's Disease
Official Title Sex Differences in Pain Reports and Brain Activation in Older Adults with Alzheimer's DiseasePurpose
The purpose of this study is to examine how men and women with and without dementia might perceive and respond to pain or discomfort.
Participants may complete various questionnaires by phone or video conferencing once a week for up to 8 weeks with an optional MRI screening.
Could this study be right for you?
• Men and women aged 60 years or older
• Dementia or memory issuesParticipants and their caregiver (if applicable) may complete only 1 day of the study, or they may complete as many as they would like for up to 8 days total.
Age Range
60 and up -
A Study to Examine the Early Development of Attention, Learning, and Memory During Childhood
Official Title A multi-year study of learning during childhoodPurpose
The purpose of this study is to investigate the early development of attention, learning, and memory.
The duration of the study will last over 4 years.
Participation in this study includes 4, 90-minute-long visits to the lab per year. During these 90-minute-long visits, your child will play 2-3 computerized games, designed to assess different aspects of their cognitive ability.
Could this study be right for you?
Children aged 4 years old only; children must be 4 years old at their initial visit to participate.
Age Range
4 and up -
A Study to Examine the Effects of Movies on Children's Behavior
Official Title Media Violence and Gun ViolencePurpose
Researchers want to examine the effects of movies on children aged 8 - 12 years. If your child joins this study, they will watch a 1-minute safety video at home and answer a short survey. At-home activities should take less than 20 minutes. Next, they will come to OSU campus for the lab part (parking is paid, mask wearing is required) with a same aged peer or sibling. There they will watch a movie clip for 20 minutes (rated PG) and afterwards be placed in a room containing toys and games that they can play with for another 20 minutes. The children will be videotaped so we can see what they do. Participation in the lab portion will take 50 – 60 minutes.
Could this study be right for you?
- Participants in the study will be children aged 8 - 12 years old - In order to participate in this study, your child must bring another child 8 - 12 years old. If you don't have two children within this age range, your child can bring a friend or relative.
Age Range
8 and up -
A Study to Help Improve Symptoms of Gastroparesis (BREATHE)
Official Title Breathing Reduces Enteric symptoms and Anxiety promoting Therapeutic Healing Experience (BREATHE) – A Randomized Clinical Trial in Patients with Symptoms of GastroparesisPurpose
The purpose of this research study is to see if practicing mindful breathing daily can reduce stress, improve sleep
and possibly improve symptoms in patients with Gastroparesis.Gastroparesis is a condition characterized by symptoms such as nausea, vomiting, feeling excessively full after eating a little bit, bloating and abdominal pain. One or more of these symptoms can be present in a given patient.
Your participation throughout the study will last 6 weeks.
Could this study be right for you?
• At least 18 years of age
• Able to read and understand English
• Has symptoms of gastroparesis for at least 6 months (gastric emptying study is NOT required for inclusion)Age Range
18 and up -
A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression
Official Title A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With DepressionPurpose
This study is being done to see if the study drug, called BI 1358894, compared to a drug called quetiapine, may help people with Major Depressive Disorder (MDD) who do not progress when taking an antidepressant medication alone. This study will help to gain information for providing better or new possible treatments for people in the future.
This study will take place over a period of 13 weeks and have about 8 visits to the study center and 2 that will be done by phone.
Could this study be right for you?
• Aged 18-65 years old
• Diagnosed with Major Depressive Disorder (MDD)
• Currently depressed
• Taking an antidepressantAge Range
18 and up -
A Study to Understand How Medications Can Affect Prediabetes in African Americans
Official Title The Role of the Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose Metabolism among African Americans: Pilot StudyPurpose
The purpose of this study is to find out if taking one medication Diovan (valsartan) or a combination of two medications (valsartan and sacubatril) in one pill called Entresto, will improve prediabetes in Blacks /African Americans over the course of 6 months. We will also look for changes in blood pressure and blood vessel stiffness throughout the course of the study in order to better understand how these medications may impact prediabetes.
Could this study be right for you?
Inclusion Criteria: - African American aged 18-65 years old - History of impaired fasting glucose - Impaired glucose tolerance - A1c 5.7-6.4% or other risk factors for diabetes Exclusion Criteria: - Type 2 diabetes - Systolic blood pressure greater than 150/100 or medications to lower your blood pressure - Systolic blood pressure less than 100/60 - Steroid use - Hyperkalemia (high potassium levels)
Age Range
18 and up