Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.
Study Categories
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A Study to Investigate Where Franklin County Residents Overdose and What Supports They Need
Official Title Where Do Franklin County Residents Overdose and What Supports Do They Need?Purpose
The purpose of this study is to identify places where Franklin County residents have had an opioid-related overdose (e.g. home, workplace, coffee shop, grocery story). We also want to identify what resources people want to see in these places (e.g. NaloxBoxes, vending machines, a motion monitoring device) to help people stay safe.
Could this study be right for you?
- Male and females aged 18 years or older
- Resident of Franklin County
- Experienced at least one overdose in Franklin County, OH between January 2021 and December 2022
- You suspected your overdose was opioid-related or someone gave you Narcan
- Willing to discuss your overdose experience in a one-on-one interview
- Have access to a private room and an Internet connection, or able to travel to a local public library for the interview
Age Range
18 and up -
Clinical Trial Testing if an FDA Approved Medication Changes Stress Responses
Official Title Orexin Receptor Antagonists as Modulators of Threat Sensitivity in individuals with Alcohol Use DisorderPurpose
The purpose of this study is to see if BELSOMRA, an FDA approved medication that is prescribed to treat insomnia, changes the body’s response to stress. Participation in the study includes 3 or 5 in-person lab visits (depending on randomization), which include EEG and MRI. Nearly all visits are 1.5 hours long, with the exception of one that is 4-5 hours in duration. Visits are flexible and scheduled at your convenience. Participants take the medication (or placebo) for 4 weeks, during which participation is only composed of virtual surveys via a smartphone app.
The total length of participation in the study is 1.5-2 months depending on scheduling/availability.
Could this study be right for you?
Eligibility Criteria:
- 18-65 years old
- Generally medically and physically healthy
- Regular alcohol use
Exclusion Criteria:
- Diagnosis of bipolar disorder, schizophrenia, mania, or psychosis
- Currently pregnant or trying to become pregnant (female)
- Presence of ferrous-containing metal in the body
- Inability to tolerate enclosed spaces
Exclusion Criteria varies, please contact Study Coordinator for more information.
Age Range
18 - 65 -
A Study About the Development of Learning in African-American/Black Children
Official Title Ontogenesis of Categorization; Linking development, mechanisms, and biologyPurpose
The purpose of this study is to investigate the early development of attention, learning, and memory during childhood. Participation in this study includes 4, 90-minute-long visits to the lab per year. During these visits, your child will play 2-3 fun, computerized games. These games are designed to assess various aspects of their cognitive ability.
The duration of the study will last 4 years.
Could this study be right for you?
Eligibility Criteria:
- African-American/Black children who are 4 years old
Age Range
4 - 4 -
A Study About Gene Therapy for Early Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI)
Official Title A Phase I Study to Assess the Safety, Tolerability and Preliminary Efficacy of AAV2-BDNF [Adeno-Associated Virus (AAV)-based, Vector-Mediated Delivery of Human Brain Derived Neurotrophic Factor] in Subjects with Early Alzheimer’s Disease and Mild Cognitive ImpairmentPurpose
The primary aim of this study is to determine whether administration of the nervous system growth factor "Brain-Deruved Neurotrophic Factor" (BDNF) to eligible patients with Alzheimer's disease and Mild Cognitive Impairment is safe and tolerable. This study will be used to determine whether BDNF administration reduces neuronal loss and rebuilds synapses in the brain of patients with Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI).
Could this study be right for you?
- Male and Females aged 50 years or older
- Diagnosis of dementia due to Alzheimer's Disease/Diagnosis of Mild Cognitive Impairment (MCI) due to Alzheimer’s Disease
- A caregiver is available who has frequent contact with the subject, agrees to observe for adverse events, and will accompany the subject to all clinic visits for the duration of the protocol
- CT or MRI scans within 24 months prior to screening without evidence of an infection, infarction, or other focal
Inclusion Criteria varies, please contact Study Coordinator for more information.
The below Exclusion Criteria apply to both the AD and MCI groups.
- Any significant neurological disease other than suspected incipient disease
- History of schizophrenia
- History of systemic cancer within the past 18 months (non-metastatic skin cancers are acceptable).
- Any significant systemic illness or unstable medical conditions which could lead to difficulty complying with the protocol
- Use of any investigational drugs within thirty days or five half-lives, whichever is longer, prior to screening.
Exclusion Criteria varies, please contact Study Coordinator for more information.
Age Range
50 and up -
Biomarkers for Evaluating Spine Treatments
Official Title A Study About Biomarkers for Evaluating Spine TreatmentsPurpose
The purpose of this research study is to study four treatments for chronic low-back pain to learn whether or not certain treatments work better for people with certain characteristics.
The study’s main goal is to find a way to match treatments to low-back pain patients based on their characteristics and how they responded to treatments they have used before.
Could this study be right for you?
Inclusion Criteria:
To be eligible, an individual must meet all of the following inclusion criteria:
- Ability to read and understand English
- Provision of signed and dated informed consent form(s)
- Willing and able to receive study-related messages and survey links via email
- Willing and able to receive study-related phone calls
- Age 18 years old or older
- Low-back pain for at least 3 months and occurring on at least half the days in the past 6 months
- Contraindicated to no more than one of the study interventions at the time of eligibility assessment(s)
- Eligible to receive at least three of the four study interventions and willing to receive any intervention for which they are eligible
- A PEG score 4 or higher at two time points: 1) screening prior to the Run-in period and 2) screening prior to baseline (Visit 0)
- Willing and able to undergo required phenotyping
- Regular reliable access to an internet-enabled device such as a smart phone, tablet, or laptop computer
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Meet Run-in period engagement eligibility criteria:
- Completion of two Run-in study information modules prior to period 1 randomization (Visit 0)
- Response to at least 5 emails prior to period 1 randomization (Visit 0)
- Low-back pain more severe than pain in other parts of the body
- Available to complete the full study protocol (approximately 9 months)
Exclusion Criteria:
An individual who meets any of the following criteria will be excluded from participation in this study:
- Pregnant at the time of Visit 0 (Baseline)
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Affirmative participant response to any of the following conditions:
- Progressive neurodegenerative disease
- History of discitis osteomyelitis (spine infection) or spine tumor
- History of ankylosing spondylitis, rheumatoid arthritis, polymyalgia rheumatica, psoriatic arthritis, or lupus
- History of cauda equina syndrome or spinal radiculopathy with functional motor deficit (strength <4/5 on manual motor testing)
- Diagnosis of any vertebral fracture in the last 6 months
- Osteoporosis requiring pharmacologic treatment other than vitamin D, calcium supplements, or bisphosphonates.
- History of any bone-related cancer or cancer that metastasized to the bone
- Currently in treatment for any non-skin cancer or plan to start non-skin cancer treatment in the next 12 months
- History of any non-skin cancer treatment in the last 24 months
- Visual or hearing difficulties that would preclude participation
- Uncontrolled drug/alcohol addiction
- Individuals actively pursuing disability or workers compensation or involved in active personal injury-related litigation
- Currently participating in another interventional pain study
- Any condition that, in the opinion of the investigator, would preclude the patient from being able to safely participate in in the trial
Age Range
18 and up -
Young Women’s Health Study
Official Title An Intervention Study about Primary Care Algorithms for Early Identification of Young Women with von Willebrand DiseasePurpose
Researchers at Nationwide Children’s Hospital are seeking volunteers to be a part of a study looking at how to best screen for bleeding disorders in young women.
Participants will be asked to undergo a finger prick blood test and complete questionnaires. If their survey answers suggest they have heavy menses or abnormal bleeding, they will also be asked to have a blood draw on the same day.
Could this study be right for you?
- Are 9 to 21 years old
- Have had your first menstrual cycle
Age Range
9 - 21 -
A Study to Examine if a Foot Stool can Make it Easier for People with Constipation to have a Bowel Movement (FASED Study)
Official Title FASED (Footstool in Alleviating Symptoms of Evacuation Disorder)Purpose
The purpose of this research study is to see if using a footstool can make it easier to have bowel movements in patients who suffer from chronic constipation. The participants will be given a free footstool to use. They will be asked to keep a record of their bowel symptoms and answer some surveys about their symptoms on a phone or computer.
You will be in the study for approximately 12 weeks. This includes 2 weeks before you start using the footstool, followed by 8 weeks where you will be using the footstool and up to 2 weeks to complete your initial and final surveys.
Could this study be right for you?
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At least 18 years old
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Able to understand English
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Symptoms such as feeling incompletely empty after a bowel movement, needing to strain a lot when having a bowel movement or needing to use maneuvers such as rocking one's body back and forth or using their finger to remove stool.
Age Range
18 - 99 -
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Mentoring to be Active: Peer Mentoring for Rural Appalachian Children to Reduce Overweight and Obesity
Official Title Mentoring to be Active: Peer Mentoring for Rural Appalachian Children to Reduce Overweight and ObesityPurpose
The purpose of this study is to lower the rate of type 2 diabetes in rural Appalachia youth due to obesity and/or being overweight. Our long-term goal is to improve the health of underserved, high-risk youth.
This study will test the effectiveness of the Mentored Planning to be Active + Family on physical activity outcomes and health outcomes among rural Appalachian middle school aged youth suffering from either overweight or obesity.
We have local high school-aged teen mentors work closely with middle school youth to increase social support, self-efficacy, and self-regulation skills to sustain physical activity and improve health before the children enter high school.
The peer mentoring is followed by a 6-month family reinforcement program.
Some parents will provide child assessment data of perceived child physical activity behaviors and child health.
Could this study be right for you?
- Child has access to a computer or tablet device at home for virtual mentoring sessions/meetings
- Child suffers from overweight or obesity - does not need to be under the care of a health care professional for this condition
- Child and Parent able to participate read English at a 4th grade level.
- Family not expected to move from rural Appalachia within the 18 months.
Age Range
12 - 13 -
"What do physicians know about intellectual disability?" Getting information to design better medical training
Official Title "What do physicians know about intellectual disability?" Getting information to design better medical trainingPurpose
The purpose of this study is to explore the physicians’ knowledge of intellectual disabilities (ID) and their medical training and practice. The information resulting from this study will help to design adequate interventions and training programs for medical students and physicians aimed to improve their ID knowledge and the health care services provided to patients with ID. This is an observational cross-sectional study of physicians in the US using an anonymous online survey. The entire survey has 156 items and will require 15-20 minutes to complete.
Could this study be right for you?
- You are an American medical resident, an attending physician, or a medical educator in any type of medical specialization, and - You have or do not have experience with patients with intellectual disabilities
Age Range
24 and up -
A Distracted Driving Study for iPhone and Android Phone Users-- Ages 18 - 20
Official Title Distracted Driving Study--A phone app to reduce cell phone usage among young driversPurpose
This is a study is being done to find out if a phone app reduces calling and texting while driving among young drivers.
Could this study be right for you?
- 18-20 years old
- Use an iPhone or Android smartphone
- Have a full driver’s license that allows unsupervised driving at all times
- Have a car that they are exclusive access to (primary driver, do not share the car)
- Car is insured for liability during crashes
- Driver uses the car more than 2 days a week on average
- Are a US citizenAge Range
18 and up -
A Medication study for Children with Major Depressive Disorder (Ages 7 -17)
Official Title A Double-blind, Placebo- and Active-controlled Evaluation of the Safety and Efficacy of Levomilnacipran ER in Pediatric Patients 7-17 Years With Major Depressive DisorderPurpose
The purpose of this research study is to evaluate the drug Levomilnacipran extended-release to see how well the drug works, observe the side effects, and how well tolerated it is compared to placebo in pediatric patients with major depressive disorder.
Could this study be right for you?
Your child may be eligible if:
• be between 7 and 17 years of age
• give their assent (a simplified version of this consent form that your child will sign)
• have a diagnosis of Major Depressive Disorder
• meet all of the additional relevant inclusion criteria
• understand the study instructions, and be willing and able to follow these instructionsExclusion Criteria:
• Your child will not be able to take part in the study if she is pregnant, nursing, or planning a pregnancy
• Your child will not be able to take part in this study if he/she takes any illegal substancesAge Range
7 and up -
A Medication Study for Individuals with Alport Syndrome (AS) and Primary Steroid-Resistant Focal Segmental (FSGS)
Official Title A multicenter, randomized, double-blind, parallel group, placebo-controlled study to assess safety, tolerability, pharmacokinetics and pharmacodynamics of BI 764198 administered orally once daily for 12 weeks in patients with focal segmental glomerulosclerosis.Purpose
The overall objective is to investigate to investigate how safe, how well tolerated, and how effective R3R01 is in treating uncontrolled proteinuria in patients with Alport syndrome and steroid-resistant Focal Segmental Glomerulosclerosis. All eligible participants will be enrolled to receive R3R01 over a treatment period of 12 weeks. The study will consist of 3 periods, including a screening period of 3 weeks, a treatment period of 12 weeks, and a follow up of period of 12 weeks.
Could this study be right for you?
You may be eligible to participate if: • You are aged 18 years or older • Female patients and female partners of male patients willing to not become pregnant for the duration of the study • Have not had an organ transplant and/or on a organ transplant list • Have high protein in urine Alport Syndrome (AS) specific: • Have X-linked AS and autosomal recessive AS • Confirmed diagnosis of AS be genetic testing or kidney biopsy • Do not have another kidney disease FSGS specific: • Not older than 75 years of age • Primary Focal segmental glomerulosclerosis (FSGS) (not caused by other condition) that is confirmed by kidney biopsy or documentation of genetic mutation • Steroid-resistance: previous steroid treatment without remission
Age Range
18 and up