A Study of Milestones to Advance Language Learning
The goal of this study is to identify early risk for developmental language disorder (DLD) among young, low-income children, and to determine how caregiver and child chronic stress and interaction quality interact to disrupt language growth among these children. The long-term objective is to identify pathways through which early family situations and the conditions of poverty disrupt early language paths among low-income children and contribute to heightened rates of DLD.
Inclusion criteria are: - have a child that is 9 months or younger - child resides in a low-income household, using some sort of government assistance or using the 200% threshold from the Department of Health and Human Services based on annual household income and number of persons in home Exclusion criteria: - Children who are multiple births, preterm (<35 weeks), and have profound or severe disabilities will be excluded, with the latter including congenital blindness, deafness, Down syndrome and other frank neurological deficits.
A Study to Evaluate Upadacitinib Along with Topical Corticosteroids on Teens and Adults with Atopic Dermatitis (eczema)
The purpose of this study is to compare the effectiveness and safety of Upadacitinib (ABT-494) to placebo (pill without any active substance that looks like upadacitinib) in combination with topical corticosteroids for adolescents (12-17 years of age) and adults (18-75 years of age with moderate to severe atopic dermatitis (AD).
- Adolescent subjects must weigh more than 40 kg (88 lb) - Subject must be in good general health (other than Atopic Dermatitis) - Subject must have chronic Atopic Dermatitis (AD) with onset of symptoms at least 3 years before first dose of study medication - Subject must have documented history of inadequate response to topical corticosteroids (TCS), topical calcineurin inhibitor (TCI), or systemic treatment for AD within 6 months prior to first dose of study medication - Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study and for 30 days after last dose of the study drug. - No history of drug or alcohol abuse in the 6 months prior to receiving the first dose of study medication
A Study to Evaluate Relationship Dynamics in Families of Children with ADHD and Their Opposite-Sex Siblings
This study is being done to better understand relationship dynamics between children with ADHD, their siblings, and their parents. Our goal is to better understand how differences in family dynamics affect children with ADHD. Participants will be asked to fill out several self-report questionnaires and engage in a family conflict task. During several tasks, participants will have various physiological measures (e.g., heart rate, breathing rate, etc.) taken using electrodes placed on their body. Results of this study will be used to develop other studies and to inform future treatment and prevention programs.
We are recruiting children between 8 and 10 years old with an opposite sex sibling. In order to participate, families must meet the following criteria:
• Mothers must be willing to participate,
• They must have a child between ages 8 and 10, and
• That child must have a sibling of the opposite sex that is within 2 years of their age
A Medication study for Children with Major Depressive Disorder (Ages 7 -17)
The purpose of this research study is to evaluate the drug Levomilnacipran extended-release to see how well the drug works, observe the side effects, and how well tolerated it is compared to placebo in pediatric patients with major depressive disorder.
Your child may be eligible if:
• be between 7 and 17 years of age
• give their assent (a simplified version of this consent form that your child will sign)
• have a diagnosis of Major Depressive Disorder
• meet all of the additional relevant inclusion criteria
• understand the study instructions, and be willing and able to follow these instructions
Exclusion Criteria:
• Your child will not be able to take part in the study if she is pregnant, nursing, or planning a pregnancy
• Your child will not be able to take part in this study if he/she takes any illegal substances
Immune Response in Adolescents
Our goal in this study is to learn more about the immune system in adolescence and early adulthood. We are looking to enroll healthy children ages 12-18 years old.
Enrollment in the study will require 1 visit to Nationwide Children’s Hospital involving a blood draw and 2 nasal swabs.
The visit will take approximately 1- 1 ½ hour(s). We ask that the family brings a copy of the child’s immunization record to the visit.
Children will need to meet the following criteria to be in the study:
Inclusion Criteria:
· Parents/Legal guardian able and willing to sign informed consent and the child is willing to sign assent form for participation. All forms are in English.
· Healthy children, age 12-18 years old
Exclusion Criteria:
· Any chronic or congenital conditions that may potentially affect immune responses
· Cough, congestion, fever, rhinorrhea, rash and any other symptoms indicative of infection within the 2 weeks prior to enrollment sampling
· HIV, AIDS or other immunodeficiencies or any other condition that may affect their immune system
· Use of systemic steroids within 2 weeks prior to enrollment
· Immunization(s) within the last 30 days
A Study about Tools to Assess Mental Health for Youth with Intellectual Disabilities and Their Caregivers
This study will help researchers to learn more about mental health for youth with intellectual disabilities. The purpose of our study is to develop a diagnostic interview to assess mental health issues in youths with Intellectual Disabilities. The instrument would address a significant need and allow for more accurate estimation of mental disorders in the Intellectual Disabilities population.
We are recruiting youths with Intellectual Disabilities aged 14-21, and their caregivers as well. Each participant would take part in one individual session of approximately 60-90 minutes (with breaks) at the Ohio State University Nisonger Center. Youths will be asked to respond to a set of interview questions about mental health, including providing feedback on a set of illustrations related to the interview questions about emotions, feelings, and behaviors. Parents or caregivers will be asked to provide feedback on the interview questions asked of youth.
You may be eligible to participate in the study if you are:
--14 to 21 years old AND have been diagnosed with an Intellectual Disability
Youths will be asked to respond to a set of interview questions about mental health, including providing feedback on a set of illustrations related to the interview questions about emotions, feelings, and behaviors. Parents or caregivers will be asked to provide feedback on the interview questions asked of youth.
Nearsightedness in Children--A Study to Determine if Daily Eye Drops Can Slow the Progression
The purpose of the study is to determine if a daily eye drop will help slow the progression of nearsightedness in children.
Your child may be eligible for this study if he/she is:
*Ages 3- 17
*Nearsighted
Participants will complete visits for follow-up (every 6 months) and to pick up study eye drops (every 3 months).
Please have your child’s current eye glasses prescription available when you call.
Parent-Infant Eye Tracking Study for Children With and Without Hearing Loss
This study will examine how a child’s hearing loss may affect the dynamics of parent-child interactions. The study will observe how normal-hearing and hearing-impaired child learn novel words during videotaped parent-child interactions.
Individual study visits may last 30-45 minutes, and there may be multiple study visits per year.
- Families with children 9 months to 6 years of age
- Children who do and do not have hearing loss may be eligible to participate in this study
Physical Therapy Study for Young Children (6 months to 24 months) with Motor Delays
The purpose of this study is to find out how to best distribute physical therapy sessions for your children with significant motor delays.
Participants will receive 40 hours of physical therapy. Participants will be randomly assigned to one of the three treatment groups: intensive, moderate or weekly.
- Children ages 6 months to 24 months of age
- Has a diagnosis of cerebral palsy or an acquired brain injury prior to age of 24 months.
- Has persistent delays in motor skills
- Ability to participate in outpatient physical therapy and attend visits consistently
The intensive group will receive physical therapy 2 hours per day, 5 days per week for 4 weeks followed by a 16 week break from outpatient physical therapy. The intermediate group will receive physical therapy 2 hours per day, 3 days per week for 6.6 weeks followed by a 13 week break from outpatient physical therapy. The weekly group will receive physical therapy for 2 hours per day, 1 day per week for 20 weeks
Media Use and Youth--For Those 12-17 Years of Age
Researchers want to learn how teens use technology like TV, the internet, video games, and music. The study examines children’s use of media on a daily basis over two weeks.
Your child and one parent will meet with researchers two times on campus. Your child will answer some questions during those meetings. The first meeting will be for about 2 hours and the second meeting will be for about 30 minutes. Over a two week period between those meetings, the child will report daily on activities using a tablet supplied by the study.
- Ages 12-17 accompanied by one parent or guardian