• Play and Learning Across a Year

    Official Title

    Play and Learning Across a Year

    Purpose

    The primary goal of this research is to learn how children and mothers interact at home and how that interaction and the home environment affect learning and development. (1) We will film you and your child playing and going about daily activities for an hour in your home (2) We will film the rooms in your home, create floor plans of the rooms and spaces that are accessible to your child, and record the noise level in your home (3) We may ask you questions about your child’s movement, language, emotion, health, toys and animals and media use in the home, and racial and ethnic background as well questions about family health, division of household labor, and education. (4) We may ask you and your child to play with a set of child-friendly toys for a few minutes. This single session study will last between 2 and 3 hours.

    Could this study be right for you?

    - healthy children less than 2 years old - children born full-term - only child living in household - primary language is English

  • Diet Quality in Children 3-5 Years Old from Low Income Households

    Official Title

    An Examination of the Diet Quality of Children Low Income Children from 3-5 Years of Age

    Purpose

    To determine dietary patterns and calculate dietary quality of young children enrolled in child care centers, WIC, and other places that serve parents and young children; and to identify the most significant cultural, social, and economic factors influencing the dietary and eating patterns of these children.

    The total amount of time you will be asked to volunteer for this study is 2 hours and 10 minutes.

    Could this study be right for you?

    - Parents and/or caregivers must be at least 18 years of age
    - Each household must qualify as low income status
    - Each parent/caregiver must be fluent in English
    - Each child must not have a medical condition requiring diet modifications
    - Each child must be 3-5 years old

    Age Range

    3 and up
  • Diet Quality in Children Birth to 6 Months Old from Low Income Households

    Official Title

    An Examination of the Diet Quality of Low-Income Children from Birth to 6 Months Old.

    Purpose

    The purpose of the research is to determine the dietary patterns and calculate the dietary quality of infants and enrolled in childcare centers, WIC, and other places that serve parents of young children; and to identify the most significant cultural, social, and economic factors influencing the dietary and feeding patterns of these children.

    The total amount of time you will be asked to volunteer for this study is 2 hours and 10 minutes.

    Could this study be right for you?

    - Parents or caregivers must be at least 18 years of age
    - Each parent/caregiver must be fluent in English
    - Each household must qualify as low income status based on the number of people in the household
    - Children must be within 0-6 months of age
    - Children must not have any medical condition requiring a modified diet

  • Evaluating Risk Factors and Behavior Change in Adolescents (16-19 years old)

    Official Title

    Trauma and Neurobiological Threat Reactivity as Risk Factors for Alcohol Abuse in Youth

    Purpose

    This research study will look at how brain and behavioral responses to emotional prompts relate to future behaviors. This research is being done to better understand risk factors and behavior change in adolescents. The total time that you will be involved in this study is 15 hours including 4 in-person visits and online follow-up forms every 3-months for 2 years.

    Could this study be right for you?

    Eligibility Criteria includes: - 16-19 years old - No history of alcohol use disorder - History of Interpersonal Trauma - Voluntarily consumed at least 1 prior alcoholic beverage (partial list of inclusion criteria) Exclusion Criteria - Currently pregnant (positive pregnancy test), or trying to become pregnant (women) - Lifetime history of any substance use disorder (partial list of exclusion criteria)

    Age Range

    16 and up
  • Frequency of Treatment in Children with Language Impairment

    Official Title

    Determining the Optimal Treatment Intensity for Children with Language Impairment

    Purpose

    The purpose of the study is to determine the amount of speech-language intervention children need to make improvements.

    We hope to identify the appropriate amount of intervention needed as well as the point at which adding more intervention is no longer beneficial.

    Participation in this study will last for approximately 10 weeks with one 2 hour session before the book reading intervention, one 2 hour session after the book reading intervention and a 6-month follow up.

    Could this study be right for you?

    Inclusion Criteria:

    • Your child is between the ages of 5 and 6 years 11 months old
    • Has received a primary diagnosis of a Language Impairment with vocabulary deficits
    • Receives Speech and Language services through their school
    • Primarily communicates in English

    Age Range

    5 and up
  • A study for children with nearsightedness

    Official Title

    The Chaperone Study: A multi-center, double-masked, randomized, placebo-controlled, phase III study of the safety and efficacy of atropine 0.1% and 0.01% ophthalmic solutions administered with a microdose dispenser for the reduction of pediatric myopia progression

    Purpose

    Is your child nearsighted?

    Nearsightedness, or myopia, is a condition that results in blurry vision when looking at distant objects.

    Myopia happens when the eyeball grows too long or the cornea (the clear front cover of the eye) is too curved.
    As a result, light entering the eye is not focused correctly. While glasses and contact lenses can help a person with myopia see clearly, they do not address the underlying stretching of the eye.

    Myopia detected in young children tends to increase through the school years . As myopia progresses, it can increase the risk of retinal detachment, cataracts, myopia maculopathy and even blindness. To date, FDA has not approved any drug therapies for reducing myopia progression.

    This is why researchers are working to develop new medications and technologies that may help children and teens with this condition. The CHAPERONE Study is a research study testing the safety and effectiveness of microdosed atropine eye solution to see if it slows the progression of myopia in children.

    Could this study be right for you?

    - Is your child between 3-12 years old?
    - Does your child need glasses to see distant objects?
    - Is your child able to go to periodic visits at the study clinic to check his/her vision and overall eye health over a 4-year period (11 scheduled visits will be required)?
    - Are you available to speak with study staff by phone periodically between your child’s clinic visits to review your child’s experience using study medication?

    This study is not for children who have:
    - Used atropine or other myopia drug therapies
    - Had prior eye surgery
    - A systemic disease or condition that can affect their vision

    Age Range

    3 and up
  • A Study of Milestones to Advance Language Learning

    Official Title

    SMALL Talk: Study of Milestones to Advance Language Learning

    Purpose

    The goal of this study is to identify early risk for developmental language disorder (DLD) among young, low-income children, and to determine how caregiver and child chronic stress and interaction quality interact to disrupt language growth among these children. The long-term objective is to identify pathways through which early family situations and the conditions of poverty disrupt early language paths among low-income children and contribute to heightened rates of DLD.

    Could this study be right for you?

    Inclusion criteria are: - have a child that is 9 months or younger - child resides in a low-income household, using some sort of government assistance or using the 200% threshold from the Department of Health and Human Services based on annual household income and number of persons in home Exclusion criteria: - Children who are multiple births, preterm (<35 weeks), and have profound or severe disabilities will be excluded, with the latter including congenital blindness, deafness, Down syndrome and other frank neurological deficits.

  • A Study to Evaluate Upadacitinib Along with Topical Corticosteroids on Teens and Adults with Atopic Dermatitis (eczema)

    Official Title

    M16-047: A Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Combination with Topical Corticosteroids on Adolescent and Adult Subjects with Moderate to Severe Atopic Dermatitis

    Purpose

    The purpose of this study is to compare the effectiveness and safety of Upadacitinib (ABT-494) to placebo (pill without any active substance that looks like upadacitinib) in combination with topical corticosteroids for adolescents (12-17 years of age) and adults (18-75 years of age with moderate to severe atopic dermatitis (AD).

    Could this study be right for you?

    - Adolescent subjects must weigh more than 40 kg (88 lb) - Subject must be in good general health (other than Atopic Dermatitis) - Subject must have chronic Atopic Dermatitis (AD) with onset of symptoms at least 3 years before first dose of study medication - Subject must have documented history of inadequate response to topical corticosteroids (TCS), topical calcineurin inhibitor (TCI), or systemic treatment for AD within 6 months prior to first dose of study medication - Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study and for 30 days after last dose of the study drug. - No history of drug or alcohol abuse in the 6 months prior to receiving the first dose of study medication

    Age Range

    12 and up
  • A Study to Evaluate Relationship Dynamics in Families of Children with ADHD and Their Opposite-Sex Siblings

    Official Title

    Relationship Dynamics in Families of Children with ADHD and Their Opposite-Sex Siblings

    Purpose

    This study is being done to better understand relationship dynamics between children with ADHD, their siblings, and their parents. Our goal is to better understand how differences in family dynamics affect children with ADHD. Participants will be asked to fill out several self-report questionnaires and engage in a family conflict task. During several tasks, participants will have various physiological measures (e.g., heart rate, breathing rate, etc.) taken using electrodes placed on their body. Results of this study will be used to develop other studies and to inform future treatment and prevention programs.

    Could this study be right for you?

    We are recruiting children between 8 and 10 years old with an opposite sex sibling. In order to participate, families must meet the following criteria:
    • Mothers must be willing to participate,
    • They must have a child between ages 8 and 10, and
    • That child must have a sibling of the opposite sex that is within 2 years of their age

    Age Range

    6 and up
  • A Medication study for Children with Major Depressive Disorder (Ages 7 -17)

    Official Title

    A Double-blind, Placebo- and Active-controlled Evaluation of the Safety and Efficacy of Levomilnacipran ER in Pediatric Patients 7-17 Years With Major Depressive Disorder

    Purpose

    The purpose of this research study is to evaluate the drug Levomilnacipran extended-release to see how well the drug works, observe the side effects, and how well tolerated it is compared to placebo in pediatric patients with major depressive disorder.

    Could this study be right for you?

    Your child may be eligible if:
    • be between 7 and 17 years of age
    • give their assent (a simplified version of this consent form that your child will sign)
    • have a diagnosis of Major Depressive Disorder
    • meet all of the additional relevant inclusion criteria
    • understand the study instructions, and be willing and able to follow these instructions

    Exclusion Criteria:
    • Your child will not be able to take part in the study if she is pregnant, nursing, or planning a pregnancy
    • Your child will not be able to take part in this study if he/she takes any illegal substances

    Age Range

    7 and up