Hepatitis C Virus Immunity in Women and Children
This is a study to find out how pregnancy affects a mother’s immune system. (The “immune system” is the part of the body that fights germs.) This study is also to find out why some babies who are exposed to infections during pregnancy get infected and others do not.
To do this project we need to study some women and babies who are infected with the hepatitis C virus and others who are not. This will allow us to compare their immune systems.
You may be eligible to participate if you are:
PREGNANCY COHORT eligibility criteria:
1) Pregnant (enrollment preferably during 1st or 2nd trimester, but may occur as late as the delivery hospitalization)
2) HCV-RNA positive (#150) or HCV-RNA negative (#50)
3) Willing and able to attend all study visits
Exclusion criteria for mothers:
1) Inability to provide informed consent
2) Incarceration
Inclusion criteria for infants:
1) Child born to study mother
Exclusion criteria for infants:
1) In custody of county children’s services (Enrolled infants who are temporarily in custody of children’s services will not have further study blood draws, but lab results from blood tests ordered by their pediatrician may be followed to monitor the outcome of their HCV exposure. Infants who are later placed back in the custody of their mother or relative may be re-enrolled.)
NON-PREGNANCY COHORT eligibility criteria:
1) Willing and able to attend all study visits
Exclusion criteria:
1) Currently pregnant
2) Inability to provide informed consent
3) Incarceration
A Study to Examine the Effects of Movies on Children's Behavior
Researchers want to examine the effects of movies on children aged 8 - 12 years. If your child joins this study, they will watch a 1-minute safety video at home and answer a short survey. At-home activities should take less than 20 minutes. Next, they will come to OSU campus for the lab part (parking is paid, mask wearing is required) with a same aged peer or sibling. There they will watch a movie clip for 20 minutes (rated PG) and afterwards be placed in a room containing toys and games that they can play with for another 20 minutes. The children will be videotaped so we can see what they do. Participation in the lab portion will take 50 – 60 minutes.
- Participants in the study will be children aged 8 - 12 years old - In order to participate in this study, your child must bring another child 8 - 12 years old. If you don't have two children within this age range, your child can bring a friend or relative.
Diet Quality of Low-Income Children 6-24 months old
The purpose of the research is to determine the dietary patterns and calculate the dietary quality of children 6 to 24 months of age and enrolled in childcare centers, WIC, and other places that serve parents of young children; and to identify the most important cultural, social, and economic factors influencing the dietary and feeding patterns of these children. The total amount of time you will be asked to volunteer for this study is 2 hours and 10 minutes.
- Parent or caregiver of a child 6 to 24 months old - Receiving WIC, SNAP, or similar benefits - Live in Franklin County, Ohio
Play and Learning Across a Year
The primary goal of this research is to learn how children and mothers interact at home and how that interaction and the home environment affect learning and development. (1) We will film you and your child playing and going about daily activities for an hour in your home (2) We will film the rooms in your home, create floor plans of the rooms and spaces that are accessible to your child, and record the noise level in your home (3) We may ask you questions about your child’s movement, language, emotion, health, toys and animals and media use in the home, and racial and ethnic background as well questions about family health, division of household labor, and education. (4) We may ask you and your child to play with a set of child-friendly toys for a few minutes. This single session study will last between 2 and 3 hours.
- healthy children less than 2 years old - children born full-term - only child living in household - primary language is English
Diet Quality in Children 3-5 Years Old from Low Income Households
To determine dietary patterns and calculate dietary quality of young children enrolled in child care centers, WIC, and other places that serve parents and young children; and to identify the most significant cultural, social, and economic factors influencing the dietary and eating patterns of these children.
The total amount of time you will be asked to volunteer for this study is 2 hours and 10 minutes.
- Parents and/or caregivers must be at least 18 years of age
- Each household must qualify as low income status
- Each parent/caregiver must be fluent in English
- Each child must not have a medical condition requiring diet modifications
- Each child must be 3-5 years old
Diet Quality in Children Birth to 6 Months Old from Low Income Households
The purpose of the research is to determine the dietary patterns and calculate the dietary quality of infants and enrolled in childcare centers, WIC, and other places that serve parents of young children; and to identify the most significant cultural, social, and economic factors influencing the dietary and feeding patterns of these children.
The total amount of time you will be asked to volunteer for this study is 2 hours and 10 minutes.
- Parents or caregivers must be at least 18 years of age
- Each parent/caregiver must be fluent in English
- Each household must qualify as low income status based on the number of people in the household
- Children must be within 0-6 months of age
- Children must not have any medical condition requiring a modified diet
Evaluating Risk Factors and Behavior Change in Adolescents (16-19 years old)
This research study will look at how brain and behavioral responses to emotional prompts relate to future behaviors. This research is being done to better understand risk factors and behavior change in adolescents. The total time that you will be involved in this study is 15 hours including 4 in-person visits and online follow-up forms every 3-months for 2 years.
Eligibility Criteria includes: - 16-19 years old - No history of alcohol use disorder - History of Interpersonal Trauma - Voluntarily consumed at least 1 prior alcoholic beverage (partial list of inclusion criteria) Exclusion Criteria - Currently pregnant (positive pregnancy test), or trying to become pregnant (women) - Lifetime history of any substance use disorder (partial list of exclusion criteria)
Exploring the Connectivity and Functional Organization of the Infant Brain (0-3 yrs)
The purpose of the study is to investigate how the brain that we are each born with leads to our own unique behavior later on in life. We are studying infants from as close to birth as possible and following up with them as they grow. You will be selected as a possible volunteer for this study if your completed pre-screening form indicates your child has no conditions that would prevent having a magnetic resonance imaging (MRI) procedure. The total length of the study will be between 2 and 3 hours, including up to 1 hour outside the MRI scanner and 2 hours in the scanner. We are conducting 10 phases of this study as your child gets older; Because the purpose of this study is to track development in each individual across time, we will ask you if you would like to participate in subsequent scan sessions as your child gets older or if your child cannot complete a scan at the current time.
-Children who are 0-3 years of age, - at least early-term (>37 weeks) at birth, -no family history of mental illness, - no alcohol or drug abuse, - normal vision and hearing, - no current developmental delays
Frequency of Treatment in Children with Language Impairment
The purpose of the study is to determine the amount of speech-language intervention children need to make improvements.
We hope to identify the appropriate amount of intervention needed as well as the point at which adding more intervention is no longer beneficial.
Participation in this study will last for approximately 10 weeks with one 2 hour session before the book reading intervention, one 2 hour session after the book reading intervention and a 6-month follow up.
Inclusion Criteria:
• Your child is between the ages of 5 and 6 years 11 months old
• Has received a primary diagnosis of a Language Impairment with vocabulary deficits
• Receives Speech and Language services through their school
• Primarily communicates in English
A study for children with nearsightedness
Is your child nearsighted?
Nearsightedness, or myopia, is a condition that results in blurry vision when looking at distant objects.
Myopia happens when the eyeball grows too long or the cornea (the clear front cover of the eye) is too curved.
As a result, light entering the eye is not focused correctly. While glasses and contact lenses can help a person with myopia see clearly, they do not address the underlying stretching of the eye.
Myopia detected in young children tends to increase through the school years . As myopia progresses, it can increase the risk of retinal detachment, cataracts, myopia maculopathy and even blindness. To date, FDA has not approved any drug therapies for reducing myopia progression.
This is why researchers are working to develop new medications and technologies that may help children and teens with this condition. The CHAPERONE Study is a research study testing the safety and effectiveness of microdosed atropine eye solution to see if it slows the progression of myopia in children.
- Is your child between 3-12 years old?
- Does your child need glasses to see distant objects?
- Is your child able to go to periodic visits at the study clinic to check his/her vision and overall eye health over a 4-year period (11 scheduled visits will be required)?
- Are you available to speak with study staff by phone periodically between your child’s clinic visits to review your child’s experience using study medication?
This study is not for children who have:
- Used atropine or other myopia drug therapies
- Had prior eye surgery
- A systemic disease or condition that can affect their vision