• Immune Response in Adolescents

    Official Title

    Immune Response in Adolescents

    Purpose

    Our goal in this study is to learn more about the immune system in adolescence and early adulthood. We are looking to enroll healthy children ages 12-18 years old.

    Enrollment in the study will require 1 visit to Nationwide Children’s Hospital involving a blood draw and 2 nasal swabs.
    The visit will take approximately 1- 1 ½ hour(s). We ask that the family brings a copy of the child’s immunization record to the visit.

    Could this study be right for you?

    Children will need to meet the following criteria to be in the study:

    Inclusion Criteria:
    · Parents/Legal guardian able and willing to sign informed consent and the child is willing to sign assent form for participation. All forms are in English.
    · Healthy children, age 12-18 years old

    Exclusion Criteria:
    · Any chronic or congenital conditions that may potentially affect immune responses
    · Cough, congestion, fever, rhinorrhea, rash and any other symptoms indicative of infection within the 2 weeks prior to enrollment sampling
    · HIV, AIDS or other immunodeficiencies or any other condition that may affect their immune system
    · Use of systemic steroids within 2 weeks prior to enrollment
    · Immunization(s) within the last 30 days

    Age Range

    12 and up
  • Nearsightedness in Children--A Study to Determine if Daily Eye Drops Can Slow the Progression

    Official Title

    CHILDHOOD ATROPINE FOR MYOPIA PROGRESSION (CHAMP): A 3-ARM RANDOMIZED, DOUBLE-MASKED, PLACEBO-CONTROLLED, PHASE 3 STUDY OF ATROPINE SULFATE OPHTHALMIC SOLUTION 0.01% AND 0.02%

    Purpose

    The purpose of the study is to determine if a daily eye drop will help slow the progression of nearsightedness in children.

    Could this study be right for you?

    Your child may be eligible for this study if he/she is:
    *Ages 3- 17
    *Nearsighted

    Participants will complete visits for follow-up (every 6 months) and to pick up study eye drops (every 3 months).

    Please have your child’s current eye glasses prescription available when you call.

    Age Range

    3 and up
  • Parent-Infant Eye Tracking Study for Children With and Without Hearing Loss

    Official Title

    Development of Parent-Child Interactions

    Purpose

    This study will examine how a child’s hearing loss may affect the dynamics of parent-child interactions. The study will observe how normal-hearing and hearing-impaired child learn novel words during videotaped parent-child interactions.

    Individual study visits may last 30-45 minutes, and there may be multiple study visits per year.

    Could this study be right for you?

    - Families with children 9 months to 6 years of age
    - Children who do and do not have hearing loss may be eligible to participate in this study

  • Physical Therapy Study for Young Children (6 months to 24 months) with Motor Delays

    Official Title

    Daily and Weekly Rehabilitation Delivery for Young Children with Cerebral Palsy ("DRIVE")

    Purpose

    The purpose of this study is to find out how to best distribute physical therapy sessions for your children with significant motor delays.

    Participants will receive 40 hours of physical therapy. Participants will be randomly assigned to one of the three treatment groups: intensive, moderate or weekly.

    Could this study be right for you?

    - Children ages 6 months to 24 months of age
    - Has a diagnosis of cerebral palsy or an acquired brain injury prior to age of 24 months.
    - Has persistent delays in motor skills
    - Ability to participate in outpatient physical therapy and attend visits consistently

    The intensive group will receive physical therapy 2 hours per day, 5 days per week for 4 weeks followed by a 16 week break from outpatient physical therapy. The intermediate group will receive physical therapy 2 hours per day, 3 days per week for 6.6 weeks followed by a 13 week break from outpatient physical therapy. The weekly group will receive physical therapy for 2 hours per day, 1 day per week for 20 weeks

  • Media Use and Youth--For Those 12-17 Years of Age

    Official Title

    Media Use and Youth--For Those 12-17 Years of Age

    Purpose

    Researchers want to learn how teens use technology like TV, the internet, video games, and music. The study examines children’s use of media on a daily basis over two weeks.

    Your child and one parent will meet with researchers two times on campus. Your child will answer some questions during those meetings. The first meeting will be for about 2 hours and the second meeting will be for about 30 minutes. Over a two week period between those meetings, the child will report daily on activities using a tablet supplied by the study.

    Could this study be right for you?

    - Ages 12-17 accompanied by one parent or guardian

    Age Range

    12 and up
  • A Study to Better Understand Fainting--The ENCHANT Study--seeking healthy 12-20 year olds

    Official Title

    Electrographic and Neurohormonal Characteristics of Adolescent Nausea during Tilt Table Testing, The ENCHANT Study

    Purpose

    Researchers are looking for healthy young volunteers in order to understand what happens when someone faints. They want to know about changes in children and teenagers who frequently faint, and compare those who faint to healthy people who do not normally faint.

    Researchers want to learn more about what happens to the brain and the stomach when people faint. The electroencephalogram or EEG measures brainwaves. The electrogastrogram or EGG records stomach electrical activity. The goal of this study is to measure how gastric electricity changes during fainting. They will use the EEG to confirm that fainting happened. Researchers will compare results of those who are healthy to patients who faint.

    Some individuals with fainting or frequent lightheadedness can have excessive nausea. This is'orthostatic nausea', which means nausea with standing. The purpose of this study is to measure hormones from the blood and electrical changes in the stomach during tilt-table testing in patients and healthy controls. Researchers hope to identify the physiologic changes that lead to orthostatic nausea.

    Could this study be right for you?

    - Ages 12-20
    - No prior fainting or frequent dizziness/lightheadedness
    - No prior anxiety or depression
    - No medicines that can affect dizziness/lightheadedness
    - No difficulties with nausea or abdominal pain
    - Normal weight-

    Age Range

    12 and up
  • Child Attitudes and Behaviors Study

    Official Title

    Child Attitudes and Behaviors Study

    Purpose

    The purpose of this study is to examine the effects of parental presence on child task performance (puzzles, drawing, etc.).

    Could this study be right for you?

    - children between the ages of 8--12 AND his/her parent or guardian

    Age Range

    8 and up
  • Biomarkers of Sickle Cell Lung Disease -BOLD

    Official Title

    Biomarkers of Sickle Cell Lung Disease -BOLD

    Purpose

    This is a study to determine risk factors for developing lung disease in children with sickle cell disease (SCD). Specifically we are researching factors that lead to the development of Acute Chest Syndrome, a pneumonia-like illness that affects many children with SCD.

    Could this study be right for you?

    --Diagnosis of Sickle Cell Disease (SCD)
    --under the age of 19

  • Oral Bacteria Transmission from Mother to Child (Seeking Mothers with Adopted Children)

    Official Title

    Contribution of Genetics to Oral Bacterial Transmission from Mothers to Babies: a Study of Biologic and Adoptive Mother-Child Dyads

    Purpose

    The purpose of this study is to determine how young children get normal mouth bacteria and how it might be passed from mother to child. Researchers want to compare the adoptive mother-child pairs with biologic mother-child pairs to see how closely the bacteria of each set of mothers match those of their children.

    Could this study be right for you?

    You are eligible for this study if:
    - You are a mother with a child who was adopted at birth and is now between the ages of 3 months and 6 years

    Age Range

    1 and up