Official Title Modeling Cognition and Aging

Purpose

The goal of this study is to develop models to better understand decision-making for young adults, older adults, and adults with early Alzheimer’s disease and Mild Cognitive Impairment. This study involves making simple decisions (such as “are there more blue dots or more yellow dots?”) on a computer. Healthy volunteers will also complete basic tasks such as solving puzzles, questionnaires involving numbers, and will be asked to provide basic demographic and health information.

Could this study be right for you?

You may be eligible for this study if:

• You are ages 18-25 OR
• You are age 60-90 and have NOT been diagnosed with a memory disorder OR
• You are age 60-90 and HAVE been diagnosed with either Mild Cognitive Impairment OR mild Alzheimer's disease
• You are a native English speaker
• You are able to see a computer screen and use hands on keyboard/screen

Age Range

18 and up

Official Title Booster Seats Interview

Purpose

To explore how parents make the decision on transitioning their children from booster seats to seat belts; what factors may influence parents’ decision on the transition.

Could this study be right for you?

Inclusion criteria:

• At least 18 years of age
• A parent or legal guardian who is responsible for transporting their child routinely
• Have a child who stopped using booster seats within 1 year prior to the interview date, and the child who made the transition must be the first child of the parent
• Drive with a child at least once per week
• In good general health
• Fluent in English

Age Range

20 and up

Official Title Development and Testing of Ferumoxytol-enhanced MRI Protocol in Healthy Subjects

Purpose

This study is being done to develop a Magnetic resonance imaging (MRI) test that provides better-quality whole-heart pictures. MRI is a non-invasive machine that collects detailed pictures inside your body. Healthy volunteers will be tested in the MRI scanner while being given a dose of a medicine called Ferumoxytol into an IV (intravenous catheter) that will be placed in your arm or hand. Ferumoxytol is a medicine usually used in patients with iron deficiencies and has recently been used as an alternative to other MRI contrast agents and has successfully been applied in adult and pediatric patient populations.

Could this study be right for you?

Inclusion:

• Males and females ages 18 years and older
• No history of cardiovascular disease

Exclusion:

• Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including:
• Reactions to MRI including metallic foreign body, orbital metal, cerebral aneurysm clip, pacemaker, defibrillator, coronary artery stent, neurostimulator, any other medical metallic implant
• History of cardiovascular disease or uncontrolled high blood pressure
• Claustrophobia
• Inability to lie flat for up to 1 hour
• Weight exceeding 300 pounds
• Pregnancy

Age Range

18 and up

Official Title Decision-Making Abilities and Testamentary Capacity Among Older Adults

Purpose

The overall goal of this research is to examine factors such as social resources, personality characteristics, and neurocognitive functioning in relation to decision-making abilities testamentary capacity among healthy older adults.

Another purpose of this research study is to evaluate the impact of Problem-Solving Treatment-Primary Care (PST-PC), a cognitive-behavioral therapeutic approach, on decision making among healthy older adults. PST-PC involves a seven-step model, in which participants identify problems to be solved, discuss and evaluate different resolutions to reach desired goals; create action plans to accomplish determined goals; and evaluate their effectiveness in resolving designated problems.

We will compare the effectiveness of PST-PC on individuals who will not receive any intervention.

A no treatment control group of older adult participants will also be recruited to compare the effectiveness of PST-PC to individuals who do not receive the intervention. This no treatment control group will composed of participants who do not receive the PST-PC sessions.

Could this study be right for you?

Inclusion Criteria:

• adults aged 65 and older
• Must be independently-living and community-dwelling
• Participants must be willing to undergo a health interview to rule out outstanding medical and psychiatric conditions
• Adequate sensory abilities

Exclusion Criteria:

• A history of psychiatric illness necessitating inpatient treatment
• Participants with self-reported depression and/or anxiety exceeding mild levels of clinical severity

Age Range

65 and up

Official Title The influence of receiving real-time visual feedback on breathing during treadmill running to exhaustion

Purpose

The purpose of this research is to assess if receiving real-time visual feedback on your breathing pattern during a run has any influence on time to exhaustion.

The feedback will be provided through animations on a screen placed in front of the treadmill that open and close as the chest and abdomen expand and contract. Research has shown that you want the chest and abdomen to expand and contract at the same time to achieve the most efficient breathing possible, meaning you will want the animations to open and close at the same time.

The ultimate objective is to see if this feedback allowed the participant to last longer until reaching their exhaustion point.

Could this study be right for you?

• Healthy adults who run 5 to 20 miles per week
• Have NOT been injured while running in the past six months
• Have NOT been medically diagnosed with breathing deficiencies
• must be age 18 or older

Those who are interested in participating will be directed to complete a survey, found at go.osu.edu/RunningAndBreathing, to ensure that they meet the previously mentioned criteria.

Age Range

18 and up

Official Title Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy for Tremor Surgery

Purpose

The goal of this study is to understand if there are any changes to the connections between the cells in the brain before and after the ultrasound surgery for the treatment of Essential Tremor. This will be done by comparing patients who have had ultrasound surgery and Essential Tremor with healthy individuals. This study may help us to better target the tremor region in the brain during the ultrasound surgery.

Could this study be right for you?

• You must be between the ages of 40 and 85
• Willing to have MRI imaging of the brain

Age Range

40 and up

Official Title Healthy New Albany: Breast Cancer Project

Purpose

Determine the feasibility of delivering a community-based, lifestyle weight management intervention in producing meaningful improvements in weight loss and relevant clinical and patient-reported outcomes in Breast Cancer survivors.

Could this study be right for you?

• Female breast cancer survivor within 60 months after cessation of active treatment.
• Overweight/Obese (BMI > 25).
• Ability to understand and willing to sign a written informed consent.
• Willing and physically able to participate in physical activity.
• Obtain physician consent via primary care physician and/or treating oncologist.

Age Range

30 and up

Official Title Transcranial Direct Current Stimulation Therapy for Sleepiness Related to Shift Work Disorder (tDCS-SWORD)

Purpose

This research study aims to determine the effects of a noninvasive form of brain stimulation on alertness for night shift workers.

Could this study be right for you?

• You are age 18 to 65
• You are currently working the night shift at least 3x/week
• You are suffering from sleepiness at work
• You do not have significant heart and lung problems
• You work within the Columbus, OH area

Age Range

18 and up

Official Title Adipocyte-T Cell Interactions Modulate Adipose Inflammation and Insulin Sensitivity Following Weight Gain

Purpose

The purpose of this research study is to better understand the role of fat tissue, how cells in fat tissue communicate, and determine what signals specific cells use to cause inflammation and insulin resistance during weight gain. This may help researchers better understand the process that happens in Type 2 Diabetes. As a result, through the course of six--nine weeks, participants will be asked to gain at least 10% of their starting body weight. A dietitian will meet with participants to give advice to help with meeting the study weight gain goals, as well as provide additional meal vouchers and supplemental shakes as needed. Following the study, participants will receive guidance how to lose the weight they've gained if they would like to do that.

Could this study be right for you?

You may be eligible if you:

• Are 18-60 years of age
• Are lean; Have a BMI 18-24.9 kg/m2 (*see link below for calculating your BMI -- Body Mass Index)
• Have healthy levels of cholesterol and triglycerides (These will be tested at screening)
• Are a non-smoker
• Are non-diabetic
• Are free of chronic illness
• Are not pregnant or breastfeeding

*Calculate your BMI

Exclusion Criteria:

• Fasting triglycerides > 150 mg/dL or nonfasting triglycerides ˃ 250 mg/dl
• LDL-Cholesterol level > 150 mg/dL
• Presence of significant anemia (hemoglobin <10.0 gm/dL)
• Currently or planning to take blood thinners
• Current smokers
• Have taken steroids or anti-inflammatory meds for >6 months in the last 6 months
• >10% body weight loss within 3 months of enrollment
• *Other exclusions may apply

Age Range

18 and up

Official Title Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies PROCEED Study)

Purpose

This study is done for researchers to understand pancreatitis and learn how the disease progresses naturally over time.

From the results of this study, researchers hope to develop some lab tests to support early diagnosis of chronic pancreatitis and to also discover any genetic factors that may affect your chances of developing chronic pancreatitis. The results of this study may also provide information that will open opportunities for new drug discovery.

Could this study be right for you?

• You have a history of acute or chronic pancreatitis OR
• You have experienced pain in your abdomen that a doctor has suggested could be due to pancreatitis
• You are between the ages of 18 and 75

Age Range

18 and up