Official Title A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single Escalating Doses of LH-001 in Healthy Subjects

Purpose

The purpose of this study is to evaluate the safety and tolerability of an investigational new drug in healthy participants aged 18-60 years.

Could this study be right for you?

• In good health and BMI (ratio of body weight to height) between 18-26 kg/m2
• Willing to participate in various research assessments including blood collection, urine collection, electrocardiogram, and vital signs
• Willing to stay overnight (~30 hours) in the OSU Hospital Clinical Research Center
• If sexually active, willing to utilize highly effective birth control during the study period
• Not currently pregnant or breast-feeding
• No significant medical condition involving any major organs (heart, lung, liver, brain, or endocrine)
• No any of the following: cancer, alcohol or substance abuse, spleen problems, or drug hypersensitivity
• No history of or undergoing treatment for: major psychiatric illness, seizures, or autoimmune disease
• Not currently taking immunosuppressive drugs
• No active Hepatitis B, Hepatitis C, or HIV

Age Range

18 - 60 years

Official Title The mom and infant outcomes (MOMI) study: A trial of perinatal outpatient delivery systems

Purpose

​To improve our ability to provide the best possible care to every mom and infant, we are testing two different models of primary care during the first year after childbirth.

Could this study be right for you?

• You may qualify if you’re currently pregnant – AND – you’ve ever had high blood pressure, diabetes, depression, or anxiety, including during pregnancy.

If you participate, you’ll be randomly assigned to an Ohio State location that delivers one of two models of care. Providers at all locations can help you manage your health, but the models differ in several ways.

• You’ll complete three study visits with surveys, several measurements, and blood and hair sampling. We’ll collect cord blood and review medical records.

Official Title Longitudinal Changes in Eye Shape in Young Adults Treated with Low-Dose Atropine and Soft Multifocal Contact Lenses

Purpose

The purpose of this study is to understand how the myopia control treatments (multifocal contact lenses and low-dose atropine) affect the shape of the eye over one year.

Could this study be right for you?

• Nearsighted
• Current contact lens wearer
• No significant ocular disease
• Willingness to be randomized to one of three groups: no intervention, MiSight contact lenses (multifocal contact lenses, instead of current lenses), or daily low-dose atropine eyedrops
• Willingness to attend a study visit every three months for one year (5 total visits)
• Meet other study eligibility criteria

Age Range

21 - 30 years

Official Title Bisexual Health and Relationships Project

Purpose

The purpose of this study is to better understand the health behaviors and health outcomes for married bisexual people. 

Could this study be right for you?

Our study examines the health of married Bi+ (defined as bisexual, pansexual, queer, etc.) people. We are interviewing both Bi+ individuals and their partners over Zoom. We are specifically looking to speak with:

• Bi+ men married to men
• Bi+ people of color of any gender

Age Range

35 - 65 years

Official Title Booster Seat Features that Influence Pediatric Posture and Comfort During Extended Time Periods: On-Road Assessment

Purpose

This study will help identify how booster seats influence children’s comfort during car rides and their behaviors. Car seat footrests will also be used to see how children engage with them. Data will be collected during car rides in the caregiver’s personal vehicle. 

Could this study be right for you?

Child is currently riding in a booster seat during travel in the car

Age Range

5 - 12 years

Official Title Project Limb Rescue: A pilot study evaluating the feasibility of transcutaneous sensors for the detection of cancer-related lymphedema.

Purpose

The goal of the study is to test the success of using two types of sensors at rest after a bike exercise on volunteers with and without lymphedema, to look for differences in their readings. This part of the study will be testing persons who do not have lymphedema.

 

Could this study be right for you?

• No history of cancer related to lymphedema, cancer in your arm, or the lymph nodes in the arm
• Able to complete a brief biking exercise for about seven minutes
• No metal implants
• Willingness to take off shoes and any metal jewelry
• Not currently pregnant
• Not currently incarcerated

Your participation will involve completing an online or over the phone screening.

This visit will take approximately 2.5 hours.

Age Range

18 - 90 years

Official Title Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction (STAK-Sleep)

Purpose

To examine if drinking a ketone supplement, twice a day, can improve brain, digital shooting, and physical performance during short-term sleep restriction (4 nights, 50% of normal sleep).

Could this study be right for you?

• Healthy
• Age: 18 - 40 years old
• BMI: 20-35 kg/m2
• No diagnosed sleep disorders
• Not consuming a ketogenic diet

Age Range

18 - 40 years

Official Title Strategies to Augment Ketosis: Optimization of Ketone Delivery Strategies (STAK: OK'd)

Purpose

This study is intended to evaluate the effects of different dosing measurements for different ketone products in healthy male adults. After giving consent to this study you will schedule 9 testing sessions about 3 days apart. During these sessions you will come into the Physical Activity and Education Services (PAES) building in the morning, having had no food that day and take a study product. Various tests will be administered after ingestion. You will have blood draws to tell us more about your metabolic response to the product.

Could this study be right for you?

• Have a BMI >18 kg/m2 or ≤29 kg/m2
• Do NOT smoke or have diabetes, liver disease, kidney disease, cardiovascular disease, or any form of endocrine dysfunction
• Do NOT currently consume a low carbohydrate diet

Age Range

20 - 30 years

Official Title Understanding the Neurodevelopmental Effects of Youth Tackle Football Participation

Purpose

In this study we are aiming to identify risk factors for higher exposure to football-related neurotrauma in youth tackle football players and to determine the effects of football-related neurotrauma exposure on neurodevelopment in children with no previous tackle football participation.

For this specific posting, we are looking for boys ages 8-12 who are non-athletes or athletes who play non-contact sports to serve as control subjects for our fMRI study. 

Could this study be right for you?

We are looking for boys ages 8-12 who are either non-athletes or do not participate in any contact sports.

• Boys must have no metal implanted in the body
• Have no prior history of head trauma
• Have no serious health or mental health diagnoses
• Must not have a fear of enclosed spaces

Age Range

8 - 12 years

Official Title Exploring the Connectivity and Functional Organization of the Infant Brain

Purpose

The purpose of the study is to investigate how the brain that we are each born with leads to our own unique behavior later in life, and the similarities and differences between maternal and child brains. We are studying infants prenatally and postnatally, following up with them as they grow and develop, and studying their mothers to understand how similar/different they are to their child.

Could this study be right for you?

• Infants under 3 years of age, and pregnant persons who are at least 20 weeks pregnant
• All participants must have no metal implanted in the body
• Have no significant health conditions or history of serious mental illness
• Not suffer from a (fear of enclosed spaces)
• Pregnancies must be without complication.

Age Range

Up to 40 years