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Targeting Aging with a Ketone Ester for Function in Frailty
Official Title A randomized, double-blind, placebo-controlled, parallel group, pilot study to evaluate the effect of a ketone ester on muscle and immune function in older men and women who are at risk for strength and mobility declinePurpose
The purpose of this study is to measure the effect of 20 weeks of Ketone Ester consumption on a composite score of vigor-frailty in older adults who are at risk for mobility and strength decline and to investigate the effect of 20 weeks of Ketone Ester consumption on additional physical function measures, cognitive and immune function, muscle metabolism, safety, tolerability, gut microbiome, and quality of life in older adults who are at risk for mobility and strength decline.
Could this study be right for you?
65 years of age or older
- living independently
- English speaking and able to understand study procedures and provide Informed Consent
- women must be post menopause
- ambulatory and able to pass the walk speed criteria at screening
- minimum body weight of 50kgs (110 lbs.) at time of screening
- able to fast and abstain from alcohol, cannabis products and not exercise for 10 hours prior to study visits
- maintain current diet, exercise, medication and supplement use
- must not have a known allergy, intolerance, or sensitivity to any soy or milk protein
- must not be under active surveillance or treatment for cancer
- has not followed a ketogenic diet or used any ketone products within 30 days of screening or at anytime during the study period
- does not work night shifts or shifts that do not allow for a consistent meal schedule during the day
- does not take any immunosuppressive medications, weight loss medications or supplements, chronic antibiotic usage or receiving chemotherapy
- must not adhere to any extreme dietary habits, including intermittent fasting, Atkins, vegan, high protein low carbohydrate
- must not be a heavy alcohol drinker (women 8 drinks or more per week; men 15 drinks or more per week)
- must not have uncontrolled elevated cholesterol upon results of screening laboratory results
Age Range
65 - 99 years -
Sex Differences in Alcohol Use
Official Title Sex Differences in Alcohol Use: Neural and Hormonal InfluencesPurpose
The goal of the study is to gain a better understanding of how hormonal fluctuation across the female menstrual cycle impact brain activity and associated drinking behaviors.
Participation includes:
• One orientation session (2 hours)
• Three brain imaging (fMRI)/alcohol and saline administration sessions (7 hours each)
• Six follow-up online surveys (30 mins each)
• Two follow-up sessions (1 hour each)The total time commitment of the study is 28 hours over the course of 21 months.
Could this study be right for you?
- Age: 21–26 years old (must bring proof of age to Orientation, e.g., driver’s license or passport)
- In good health, as confirmed by responses to the Screening Interview
- No contraindications for fMRI (e.g., no metal in the body, as confirmed by MRI screening form)
- Reports typical weekly alcohol consumption
- No current or past treatment for a drug or alcohol use disorder
- Not currently pregnant, breastfeeding, or planning to become in the next 3 months (women only)
- Regular menstrual cycles (women only)
- No use of hormonal contraception or plans to begin use within the next 3 months (women only)
Age Range
21 - 26 years -
Pain Response Study in Autistic and Non-autistic Adults Ages 30-70.
Official Title Pain Sensitivity and Endogenous Pain Modulation in Autistic Adults (R21)Purpose
The purpose of this project is to study how pain may differ in adults with or without autism. Our goal is to study whether or not pain is experienced of felt differently in autistic adults compared to non-autistic adults.
Participants will be screened by phone. After meeting the initial screening criteria, the study visit will be scheduled. Participants can expect one study visit lasting 2-3 hours with time built in for breaks.
Could this study be right for you?
- Not currently on any daily pain medications
Age Range
30 - 70 years -
Can Soft Soy Pretzels Help Fight Inflammation and Change Immune Health?
Official Title Examining the efficacy of a soft soy pretzel intervention in altering chronic inflammation and immune profiles in obese individualsPurpose
The objective of this study is to evaluate if soy isoflavones, delivered via soft soy pretzels (SSP), can be an effective, feasible intervention for chronic inflammation.
All study visits will be at The Ohio State University Medical Center and the study will last 8 weeks and involve 7 clinic visits.
Could this study be right for you?
You may be eligible if you:
- Are a male between 18 and 49 years old
- Have a body mass index (BMI) less than 25 or greater than or equal to 30
- Are not allergic to soy or soy-containing products
- Are not actively trying to lose weight
Exclusion criteria:
- Current or prior history of Type 2 diabetes mellitus as defined by ICD-10-CM E11
- Current or prior history of cancer (excluding non-melanoma skin cancers)
- History of blood clotting disorders or adverse events relating to blood draws
- Use of antibiotic regime lasting longer than one week within the last six months
- Strict veganism (no consumption of animal, fish, or egg products)
- Heavy alcohol consumption (defined as consumption of >14 drinks/week on average)
- Current or prior history of any condition that causes altered immunity such as chronic inflammatory disease, autoimmune disorders, cancer, anemia, and blood dyscrasias
- Regular usage of inflammation lowering medications which include but not limited to nonsteroidal anti-inflammatory drugs such as aspirin, ibuprofen, and naproxen, or anti-pyretic medications such as acetaminophen
Age Range
18 - 49 years -
FAVOR Study - Aging Influences on Balance and Falls
Official Title Linking Age, Balance, Vestibular Function, and FallsPurpose
The purpose of this study is to learn how aging in different sensory systems, including the vestibular system (that portion of the inner ear that measures both motion and orientation of the head), influences maintaining balance while standing and walking, and contributes to fall risk.
Could this study be right for you?
- Must be able to stand
- No leg or foot amputations
- No lower limb braces
- Not currently feeling dizzy/lightheaded
- Not currently pregnant by self-report
- Due to potentially nauseogenic nature of some motions and to protect fetus and mother, pregnant women will also be excluded from this study
- Weight <= 275 pounds
- No past or current history of:
- Severe head trauma or traumatic brain injury
- Any vestibular disorder (e.g., Meniere’s Disease, Vestibular Migraine, Unresolved BPPV/BPPN, Vestibular hypofunction, except that due to aging, PPPD) as assessed using clinical diagnostic tests described in proposal
- History of seizures
- Neurologic illness or conditions known to impact vestibular or balance function(e.g., stroke, neurodegenerative disorders, demyelinating illness)
- Major psychiatric (e.g., panic disorder, psychosis, etc.) disorder
- Any of the following eye diseases or conditions: amblyopia (or “lazy eye”) or history of amblyopia, diagnosis of age-related macular degeneration, retina dystrophy, glaucoma, cataracts, or any other eye condition that limits vision to worse than 20/40
- Recent (<6 months) orthopedic injuries of the lower extremities (e.g., plantar fasciitis, ankle, knee or hip injury, back strain/herniated disc, …).
- Upper extremity injuries requiring current sling immobilization
- Recent surgery
- Any other severe health problem (heart disease, pulmonary disease, cancer, etc.).
- Vision in both eyes must be better than 20/40 with best correction
- Outer and/or middle ear pathologies
- Otologic pathologies or diagnoses (e.g. Meniere’s disease, otosclerosis, conductive or mixed hearing losses)
- Must be able to walk unassisted for 30 minutes
- No current use of ambulatory assistive devices
- Normal hearing bilaterally, air conduction pure-tone thresholds ≤ 25 dB HL at all octave frequencies between 250 and 8000 Hz
- Bilaterally, symmetric sensorineural hearing loss with four-frequency pure-tone average (500, 1000, 2000, 4000) less than 71 dB HL
- If interested, please go to go.osu.edu/vestibular to be screened for eligibility
Age Range
18 - 89 years -
White Matter Study
Official Title Contribution of Glutamate Excess and Inflammation to Progressive White Matter Changes in PsychosisPurpose
The purpose of this study is to assess the extent of white matter abnormalities, glutamate alterations, and inflammation in unmedicated patients with psychosis at different illness stages compared to healthy controls.
Could this study be right for you?
- No major medical conditions
- No history of significant head trauma
- Not currently using medications for mental health purposes (anxiety, depression, other psychiatric diagnosis)
- No metal implants that would present a risk to complete an MRI
*We are only enrolling male participants at this time.
Age Range
16 - 45 years -
The Perceptions of Gen Zs Regarding the Dietary Guidelines for Americans (DGA)
Official Title The Knowledge and Perceptions of Gen Zs Regarding the Dietary Guidelines for AmericansPurpose
- Use ideas from Social Cognitive Theory to describe Gen Zs regarding the Dietary Guidelines for Americans (DGA) 2020 to 2025
- Explain what Gen Z knows and believes regarding the MyPlate recommendations for healthy eating related to:
- Filling half their plate with fruit and vegetables
- Filling one-quarter of their plate with lean protein, and varying the sources of protein
- Filling one-quarter of their plate with grains, making half of the grains whole grains
- To describe the associations between demographic variables (ethnicity, education, household income, and home environment) and Gen Zs perceptions and knowledge of the DGA
Could this study be right for you?
18 to 28 years old
Live in the US
English speaker
Have access to a device that supports Zoom
Age Range
18 - 28 years -
The Ice E-Cigarette Study
Official Title The ICE Study: Perceptions of E-Cigarettes and Synthetic Cooling AgentsPurpose
This study will examine the influence of synthetic cooling agents in e-cigarettes on vaping behavior and aims to find out how adding artificial cooling ingredients affects how people use a product and their exposure to harmful chemicals.
Your participation in this study will last for 4 sessions, 1 session per week for 4 weeks.
Could this study be right for you?
- Must be a current e-cigarette user
- Must be willing to attend four in-person study sessions
Age Range
21 - 29 years -
Radiotracer Imaging of Lower Extremity Skeletal Muscle Perfusion in Patients with Peripheral Arterial Disease (PAD)
Official Title Radiotracer Imaging of Lower Extremity Skeletal Muscle Perfusion in Patients with Peripheral Arterial DiseasePurpose
The purpose of this study is to look at a new method to evaluate blood flow to the calves and feet.
Peripheral Artery Disease (PAD) patient outcomes will be evaluated for up to 12 months after their revascularization procedure to assess how early changes in SPECT-derived foot perfusion relate to rates of diabetic wound healing and limb salvage. Outcomes will be specifically evaluated at 3, 6, 9, and 12 months after revascularization at the time of their follow-up clinic visits to the OSU Comprehensive Wound Center at OSU Hospital East. Primary outcomes of interest will be 1) changes in wound size and healing, 2) minor or major amputations of the lower extremity, and 3) any subsequent interventional procedures, such as balloon angioplasty, stenting, or surgical bypass.
Could this study be right for you?
Heathly Volunteers with out previous cardiovascular disease
Or
PAD
Age Range
18 years and up -
Making Colorectal Cancer Screening Simple and Accessible Through Technology
Official Title Digital Transformation of CRC Screening: Revolutionizing Access and Saving LivesPurpose
The purpose of this study is to conduct usability testing to evaluate ease of use and overall user experience of a website designed to promote colorectal (CRC) awareness and screening uptake among adults 45-64.
Could this study be right for you?
Inclusion Criteria: Eligible participants will 1) be between the ages of 45-64, 2) at average risk for CRC and 3) from diverse racial/ethnic and socioeconomic backgrounds
Those who are ineligible fall under the following categories:
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Age: Individuals outside the age range of 45-64 will be excluded
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Pregnancy Status: Pregnant individuals will be excluded from the study. since CRC screening is not recommended for pregnant individuals
Age Range
45 - 64 years -