• Mapping Individual Differences in Mood and Personality - The MindMap Study

    Official Title Mechanisms of Negative Affectivity

    Purpose

    Symptoms related to depression and anxiety can affect a person’s daily life and relationships. Some research suggests that people with mood and anxiety disorders process information differently than people without these types of disorders.

    The purpose of this study is to better understand the way the brain works in people who have depression and anxiety. Researchers hope their findings will lead to better ways to diagnose and treat mood and anxiety disorders in the future.

    Participation involves an initial phone call and a 3 to 5 hour visit to find out if you are eligible. This visit will include completing questionnaires and interviews. If eligible, participants will have a second 3-5 hour visit for an MRI scan.

    The 3rd and 4th visits (at 6 and 12 months) will include 1.5 to 3 hours of questionnaires and interviews each.

    Following the scan, the 6-month follow-up, and the 12-month follow-up, participants will also complete daily online questionnaires for 7 days.

    Could this study be right for you?

    You may be eligible for this study if you are:

    • 18-25 years of age
    • Right-handed
    • Currently experiencing symptoms of depression or anxiety (feeling down or depressed, anxious, nervous, or tense, having no interest in things you used to enjoy, or feeling hopeless)
    • Not currently receiving treatment (psychiatric medications or therapy)
    • No major medical problems (e.g., stroke, heart disease, high blood pressure, endocrine disorders, etc.)
    • No history of neurological disorders (e.g., seizures, head injury, etc.)
    • Normal vision, vision that is corrected to normal with glasses or contacts
    • Willing and able to undergo fMRI scanning (not claustrophobic, no non-removable metal in your body)
    • Not pregnant

    Participation involves an initial phone call and a 3 to 5 hour visit to find out if you are eligible. This visit will include completing questionnaires and interviews. If eligible, participants will have a second 3-5 hour visit for an MRI scan.

    The 3rd and 4th visits (at 6 and 12 months) will include 1.5 to 3 hours of questionnaires and interviews each.

    Following the scan, the 6-month follow-up, and the 12-month follow-up, participants will also complete daily online questionnaires for 7 days.

    Age Range

    18 and up
  • The Family Risk Study

    Official Title Parental History of Suicidal Behavior and Early Markers of Risk in Pre-pubescent Youth

    Purpose

    The purpose of this study is to learn what factors may be related to suicide attempt(s) in children (ages 6 - 9) that have a parental history of suicidal behavior in hopes that this information will help prevent and treat self-harm behavior in youth at high risk.

    Both parents and children will complete questionnaires, interview questions, and a family discussion in addition to problem solving tasks and computer games.

    There are multiple study visits. The first will last about 2.5 to 3 hours and all other appointments will occur annually from your first appointment. Due to COVID-19, families will have the option to conduct annual follow-up appointments via telephone. These annual telephone visits will last approximately 30-45 minutes. If the annual visit is conducted in-person, it will last 1.5 to 2.5 hours.

    Could this study be right for you?

    • Parents and children must be able to read and understand English fluently
    • Child is 6 to 9 years of age
    • Meet other criteria (e.g., no traumatic brain injury) for the study

    Age Range

    6 and up
  • Decision-Making Abilities and Testamentary Capacity Among Older Adults

    Official Title Decision-Making Abilities and Testamentary Capacity Among Older Adults

    Purpose

    The overall goal of this research is to examine factors such as social resources, personality characteristics, and neurocognitive functioning in relation to decision-making abilities testamentary capacity among healthy older adults.

    Another purpose of this research study is to evaluate the impact of Problem-Solving Treatment-Primary Care (PST-PC), a cognitive-behavioral therapeutic approach, on decision making among healthy older adults. PST-PC involves a seven-step model, in which participants identify problems to be solved, discuss and evaluate different resolutions to reach desired goals; create action plans to accomplish determined goals; and evaluate their effectiveness in resolving designated problems.

    We will compare the effectiveness of PST-PC on individuals who will not receive any intervention.

    A no treatment control group of older adult participants will also be recruited to compare the effectiveness of PST-PC to individuals who do not receive the intervention. This no treatment control group will composed of participants who do not receive the PST-PC sessions.

    Could this study be right for you?

    Inclusion Criteria:

    • adults aged 65 and older
    • Must be independently-living and community-dwelling
    • Participants must be willing to undergo a health interview to rule out outstanding medical and psychiatric conditions
    • Adequate sensory abilities

    Exclusion Criteria:

    • A history of psychiatric illness necessitating inpatient treatment
    • Participants with self-reported depression and/or anxiety exceeding mild levels of clinical severity

    Age Range

    65 and up
  • A Study for those with Type 2 Diabetes AND Depression

    Official Title Mindfulness-based cognitive therapy for comorbid depression and type 2 diabetes

    Purpose

    The aim of this study is to improve mood and diabetes-related outcomes for those with type 2 diabetes mellitus (T2DM) AND symptoms of depression. The present study will examine the effect of mindfulness-based cognitive therapy (MBCT) on symptoms of depression and diabetes.

    Your participation in this study will last 8 weeks.

    Could this study be right for you?

    You may qualify if:

    • You are between the ages 18-75
    • You have type 2 diabetes
    • You are feeling symptoms of depression

    Age Range

    18 and up
  • A Treatment Study for Those with Moderate to Severe Postpartum Depression--The Hummingbird Study

    Official Title A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating the Efficacy, Safety, and Pharmacokinetics of SAGE-547 Injection in the Treatment of Adult Female Subjects with Severe or Moderate Post-partum Depression

    Purpose

    The purpose of this study is to evaluate the safety and effectiveness of an investigational medication in women with moderate to severe postpartum depression. The investigational medication is called SAGE-547 (allopregnanolone) . An investigational medication is one that is not yet approved by the United States Food and Drug Administration (FDA).

    Could this study be right for you?

    • Ages 18-45
    • Currently depressed
    • Less than 6 months postpartum

    We will ask you to complete 4 study visits, including a Screening visit, a 3-day and night stay at the study center, and 2 follow-up visits.

    Age Range

    18 and up