• A Feasibility Study to Assess the Effect of a Ketogenic Diet as a Co-Therapy for Major Depressive Disorder

    Official Title Ketogenic Intervention in Depression (KIND)

    Purpose

    The overarching goal of this pilot study is to: (1) demonstrate that a well-formulated KD can be implemented in treatment program for major depression, and (2) test whether such a program results in reductions of symptoms of depression. 

    Could this study be right for you?

    Inclusion Criteria:

    • OSU students (age 18-30 years at the time of enrollment) with confirmed major depressive disorder as determined by SCID-5 diagnosis at baseline testing.
    • Currently engaged in counseling and or mediation treatment for depression
    • Available for a 12-week period and indicate willingness and ability to eat KD foods as prescribed

    Exclusion Criteria:

    • Disordered eating, as evidenced by meeting criteria for Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder, Other Specified Eating Disorder, Unspecified Eating Disorder, or Avoidant Restrictive Eating Disorder during the SCID-5 interview at baseline testing.
    • Substantial imminent risk of suicide as assessed during the SCID-5 interview.
    • Body mass index (BMI) < 20 kg/m2
    • Habitual consumption of a structured low-carbohydrate diet in the last 6-months

    Exclusion Criteria varies, please contact Study Coordinator.

     

    Age Range

    18 - 30 years
  • Neurodevelopmental Effects of Youth Tackle Football

    Official Title Understanding the Neurodevelopmental Effects of Youth Tackle Football Participation

    Purpose

    In this study we are aiming to identify risk factors for higher exposure to football-related neurotrauma in youth tackle football players and to determine the effects of football-related neurotrauma exposure on neurodevelopment in children with no previous tackle football participation.

    For this specific posting, we are looking for boys ages 8-12 who are non-athletes or athletes who play non-contact sports to serve as control subjects for our fMRI study. 

    Could this study be right for you?

    We are looking for boys ages 8-12 who are either non-athletes or do not participate in any contact sports

    • Boys must have no metal implanted in the body
    • Have no prior history of head trauma
    • Have no serious health or mental health diagnoses
    • Must not have a fear of enclosed spaces

    Age Range

    8 - 12 years
  • Exploring the Development of the Infant and Fetal Brain

    Official Title Exploring the Connectivity and Functional Organization of the Infant Brain

    Purpose

    The purpose of the study is to investigate how the brain that we are each born with leads to our own unique behavior later in life, and the similarities and differences between maternal and child brains. We are studying infants prenatally and postnatally, following up with them as they grow and develop, and studying their mothers to understand how similar/different they are to their child.

    Could this study be right for you?

    • Infants under 3 years of age, and pregnant persons who are at least 20 weeks pregnant
    • All participants must have no metal implanted in the body
    • Have no significant health conditions or history of serious mental illness
    • Not suffer froma (fear of enclosed spaces)
    • Pregnancies must be without complication.

    Age Range

    Up to 40 years
  • The Tree of Hope: A Method to Reduce Burnout, Improved Hope and Increase Resilience

    Official Title The Tree of Hope: A Method to Reduce Burnout, Improved Hope and Increase Resilience

    Purpose

    The purpose of this study is to improve the sense of hope and build resilience through creating one’s Tree of Hope. This study is being done because we see that today’s environment is quite stressful and this can lead to people feeling less hopeful in their present and the future. 

     

    Could this study be right for you?

    • At least 18 years old 
    • Able to read and understand English 
    • Healthy people and patients will be eligible for this research study 
    • Participants will be eligible even if they are not seen at OSU for their care.
    • We will not abstract any data from electronic health records. Patients will complete a survey that asks them questions about their health conditions

    Exclusion Criteria

    • Any physical or mental condition that the principal investigator considers as impacting the ability of the patient to participate in the research study. Examples include visual or hearing impairment, arthritis, weakness or other medical problem that impairs their ability to write. 

    Age Range

    18 years and up
  • Brains, Emotion Regulation and Adolescent Moods (BEAM) Study

    Official Title Neurodevelopmental Mechanisms Underlying the Onset of Depression among At-Risk Youth: The Role of Dysregulation in the Negative Valence System

    Purpose

    The purpose of this study is to test whether changes in the way in which we react and respond to emotional or stressful information represent a risk factor for depression in kids of mothers with and without depression. Findings from the study have the potential to decrease the high rates of depression observed in children of depressed mothers.  

    Could this study be right for you?

    You may be eligible for this study if:

    1. Are 18-65 years old and female.

    2. Have a biological child who is between 9 and 14 years of age.

    3. Have a history of major depressive disorder

  • A Study for Active Military Service Members (or recently served); Examining Uncertainty, Health, and Home Safety Practices

    Official Title Uncertainty and Firearms: Obtaining Secure Storage (UFOS)

    Purpose

    The purpose of this study is to examine whether fear of uncertainty plays a role in home safety practices among firearm owners who are currently or have recently served in the U.S. military.

    Could this study be right for you?

    • Currently serving in any Branch or Component of the U.S. military, or were discharged from the U.S. military within the past 90 days
    • 18 years or older
    • Own at least one firearm located in your home or vehicle
    • Are able to speak and understand the English language
    • Have an Apple or Android smartphone 

    Age Range

    18 - 99 years
  • A study assessing the impact of a treatment on anxiety and stress in individuals with memory concerns.

    Official Title Treatment of Stress and Anxiety in mild cognitive impairment (MCI)/Mild Alzheimer's Disease and related dementias (ADRD) and their care partners: A Randomized Controlled Trial

    Purpose

    The purpose of this study is to assess the impact of a treatment on anxiety and stress in individuals with memory concerns and those already with a diagnosis of Mild Cognitive Impairment (MCI), Mild Alzheimer's Disease and related dementias. 

    Could this study be right for you?

    The primary participant must:
    · Be at least 60 years of age
    · Have a “care-partner” that is willing to participate in the full program (such as a spouse, child or a good friend)
    · NOT have a terminal illness or severe motor impairment
    · Be able to use a computer and smartphone and read English at the 6th grade level

    The care partner must:
    · Be at least 18 years of age
    · Be able to use a computer and smartphone and read English at the 6th grade level

    Age Range

    60 - 99 years
  • Buckeye Concussion Knowledge Survey (BUCKS)

    Official Title BUckeye Concussion Knowledge Survey (BUCKS)

    Purpose

    The purpose of this study is to examine health outcomes in former Ohio State University athletes who played a varsity sport during their time at OSU. The objective is to determine whether athletes who sustained a concussion have different health outcomes than those who did not sustain a concussion. Any former OSU varsity athlete can participate in a 20-minute online survey.

    Could this study be right for you?

    • Anyone who has played a varsity sport as an undergraduate student at OSU, and they have now graduated (i.e., OSU athlete alumni). There are no other restrictions in terms of age, sex/gender, type of sport, etc.

    Age Range

    18 years and up
  • Clinical Trial Testing if an FDA Approved Medication Changes Stress Responses

    Official Title Orexin Receptor Antagonists as Modulators of Threat Sensitivity in individuals with Alcohol Use Disorder

    Purpose

    The purpose of this study is to see if BELSOMRA, an FDA approved medication that is prescribed to treat insomnia, changes the body’s response to stress. Participation in the study includes 3 or 5 in-person lab visits (depending on randomization), which include EEG and MRI. Nearly all visits are 1.5 hours long, with the exception of one that is 4-5 hours in duration. Visits are flexible and scheduled at your convenience. Participants take the medication (or placebo) for 4 weeks, during which participation is only composed of virtual surveys via a smartphone app.

    The total length of participation in the study is 1.5-2 months depending on scheduling/availability.

    Could this study be right for you?

    Eligibility Criteria:

    • 18-65 years old
    • Generally medically and physically healthy
    • Regular alcohol use

    Exclusion Criteria:

    • Diagnosis of bipolar disorder, schizophrenia, mania, or psychosis
    • Currently pregnant or trying to become pregnant (female)
    • Presence of ferrous-containing metal in the body
    • Inability to tolerate enclosed spaces
       

    Exclusion Criteria varies, please contact Study Coordinator for more information.

    Age Range

    18 - 65
  • A Study About the Development of Learning in African-American/Black Children

    Official Title Ontogenesis of Categorization; Linking development, mechanisms, and biology

    Purpose

    The purpose of this study is to investigate the early development of attention, learning, and memory during childhood. Participation in this study includes 4, 90-minute-long visits to the lab per year. During these visits, your child will play 2-3 fun, computerized games. These games are designed to assess various aspects of their cognitive ability. 

    The duration of the study will last 4 years.

    Could this study be right for you?

    Eligibility Criteria: 

    • African-American/Black children who are 4 years old 

    Age Range

    4 - 4