SOAR (State of Ohio Adversity and Resilience) Brain Health Study

Official Title
State of Ohio Adversity and Resilience Study (SOAR)- Deep Phenotyping
Purpose

The purpose of this study is to develop effective mental health and preventing suicide and substance use disorder, we must better understand risks, which lead to mental illness, and resilience, which allows us to grow even in presence of adversity. This study is looking at how people live and how they deal with distress, depression or drugs and alcohol in Ohio. Family members living in Ohio are asked to participate.

Could this study be right for you?

Eligibility:

Inclusion criteria:

  • Adults, age 18-72, and adolescents, age 12-17.

Exclusion criteria:

  • Inability to functionally communicate in English.
  • Unwilling/unable to sign informed consent or assent document or obtain parental authorization from a parent or legal guardian (subjects <18 years old).
  • Inability to understand/follow instructions for study procedures.
  • Participants without at least 1 other family member who is willing to participate
    • The definition of family member is subjective to the participant and may not be a blood relative.
Age Range
12 - 72 years

Ohio Mood Disorder Registry and Repository

Official Title
Ohio Mood Disorder Registry and Repository
Purpose

Mood disorders like Major Depressive Disorder and Bipolar Disorder can be chronic, recurrent illnesses. Our treatments to date can help many people but are often trial and error, and continuity and access to care form major barriers. Our purpose is to create a research registry and repository of individuals with mood disorders who are willing to provide clinical data yearly, and who are willing to be contacted to participate in current and future studies of mood disorders.

Could this study be right for you?

Inclusion Criteria

  • 8-70 years of age.
  • Fluency or advanced conversational English abilities, by self-report.
  • Eligible individuals will have a history of two or more mood disorder episodes (depression events of at least 2 weeks meeting 5 of the criteria for major depressive disorder).

Exclusion Criteria

  • Head injury with loss of consciousness of five minutes or greater.
  • Hospitalization for drug-related concerns.
  • Evidence of intellectual disability.
  • Diagnosis of a developmental condition like autism spectrum disorder.
  • Evidence of psychosis outside of a mood episode (e.g., schizophrenia).
  • Hospitalization or infusion for eating condition.
Age Range
8 - 70 years

A Study for those with Treatment Resistant Epilepsy & Anxiety

Official Title
An open-label clinical trial evaluating the ExAblate Model 4000 Type-1 focused ultrasound unilateral thalamotomy for patients with treatment-refractory focal onset epilepsy and comorbid anxiety
Purpose

The purpose of the study is to learn more about whether an ultrasound treatment for epilepsy and anxiety is safe and effective.

Could this study be right for you?
  • Age: 18-65 years old
  • Treatment resistant Epilepsy (focal or partial-onset seizures)
  • ≥ 3 seizures/month
  • Moderate-to-severe Anxiety

 

 

Age Range
18 - 65 years

A Study Evaluating How Dietary Fat Affects Cognition

Official Title
Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study: Dietary Fat Quality and Cognitive Impairment
Purpose

The purpose of the EFFECT Study is to determine how dietary fats influence cognitive (mental) function in adults.

 

During the 7-week study participants will

  • Consume one study food per day for a total of 3 weeks
  • Have their blood drawn
  • Have their body weight and shape measured
  • Complete cognitive tests
  • Fill out questionnaires
  • Complete diet and physical activity recalls
Could this study be right for you?
  • Feel your memory or concentration is not as good as you'd like it to be
  • Are overweight
  • Do NOT have diabetes
  • Do NOT have dementia or Alzheimer's
  • Do NOT have food allergies 
  • Are NOT pregnant or nursing an infant
Age Range
40 - 75 years

A Study Investigating a Medicine to Improve Social Communication in Adolescents and Adults with Autism Spectrum Disorder (ASD).

Official Title
MapLight Study (IRIS Clinical Trial)
Purpose

The purpose of this study is to investigate a medication intended to improve social communication in adolescents and adults with ASD.

Could this study be right for you?
  • Have an autism diagnosis or suspect you have an autism diagnosis
  • Have a caregiver or study partner willing to enroll in the study with you
Age Range
18 - 45 years

A Feasibility Study to Assess the Effect of a Ketogenic Diet as a Co-Therapy for Major Depressive Disorder

Official Title
Ketogenic Intervention in Depression (KIND)
Purpose

The overarching goal of this pilot study is to: (1) demonstrate that a well-formulated KD can be implemented in treatment program for major depression, and (2) test whether such a program results in reductions of symptoms of depression. 

Could this study be right for you?

Inclusion Criteria:

  • OSU students (age 18-30 years at the time of enrollment) with confirmed major depressive disorder as determined by SCID-5 diagnosis at baseline testing.
  • Currently engaged in counseling and or mediation treatment for depression
  • Available for a 12-week period and indicate willingness and ability to eat KD foods as prescribed

Exclusion Criteria:

  • Disordered eating, as evidenced by meeting criteria for Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder, Other Specified Eating Disorder, Unspecified Eating Disorder, or Avoidant Restrictive Eating Disorder during the SCID-5 interview at baseline testing.
  • Substantial imminent risk of suicide as assessed during the SCID-5 interview.
  • Body mass index (BMI) < 20 kg/m2
  • Habitual consumption of a structured low-carbohydrate diet in the last 6-months

Exclusion Criteria varies, please contact Study Coordinator.

 

Age Range
18 - 30 years

Neurodevelopmental Effects of Youth Tackle Football

Official Title
Understanding the Neurodevelopmental Effects of Youth Tackle Football Participation
Purpose

In this study we are aiming to identify risk factors for higher exposure to football-related neurotrauma in youth tackle football players and to determine the effects of football-related neurotrauma exposure on neurodevelopment in children with no previous tackle football participation.

For this specific posting, we are looking for boys ages 8-12 who are non-athletes or athletes who play non-contact sports to serve as control subjects for our fMRI study. 

Could this study be right for you?

We are looking for boys ages 8-12 who are either non-athletes or do not participate in any contact sports

  • Boys must have no metal implanted in the body
  • Have no prior history of head trauma
  • Have no serious health or mental health diagnoses
  • Must not have a fear of enclosed spaces
Age Range
8 - 12 years

Exploring the Development of the Infant and Fetal Brain

Official Title
Exploring the Connectivity and Functional Organization of the Infant Brain
Purpose

The purpose of the study is to investigate how the brain that we are each born with leads to our own unique behavior later in life, and the similarities and differences between maternal and child brains. We are studying infants prenatally and postnatally, following up with them as they grow and develop, and studying their mothers to understand how similar/different they are to their child.

Could this study be right for you?
  • Infants under 3 years of age, and pregnant persons who are at least 20 weeks pregnant
  • All participants must have no metal implanted in the body
  • Have no significant health conditions or history of serious mental illness
  • Not suffer froma (fear of enclosed spaces)
  • Pregnancies must be without complication.
Age Range
Up to 40 years

The Tree of Hope: A Method to Reduce Burnout, Improved Hope and Increase Resilience

Official Title
The Tree of Hope: A Method to Reduce Burnout, Improved Hope and Increase Resilience
Purpose

The purpose of this study is to improve the sense of hope and build resilience through creating one’s Tree of Hope. This study is being done because we see that today’s environment is quite stressful and this can lead to people feeling less hopeful in their present and the future. 

 

Could this study be right for you?
  • At least 18 years old 
  • Able to read and understand English 
  • Healthy people and patients will be eligible for this research study 
  • Participants will be eligible even if they are not seen at OSU for their care.
  • We will not abstract any data from electronic health records. Patients will complete a survey that asks them questions about their health conditions

Exclusion Criteria

  • Any physical or mental condition that the principal investigator considers as impacting the ability of the patient to participate in the research study. Examples include visual or hearing impairment, arthritis, weakness or other medical problem that impairs their ability to write. 
Age Range
18 years and up

Brains, Emotion Regulation and Adolescent Moods (BEAM) Study

Official Title
Neurodevelopmental Mechanisms Underlying the Onset of Depression among At-Risk Youth: The Role of Dysregulation in the Negative Valence System
Purpose

The purpose of this study is to test whether changes in the way in which we react and respond to emotional or stressful information represent a risk factor for depression in kids of mothers with and without depression. Findings from the study have the potential to decrease the high rates of depression observed in children of depressed mothers.  

Could this study be right for you?

You may be eligible for this study if:

  • You are 18-65 years old and female.
  • You have a biological child who is between 9 and 14 years of age.