• Creating Culturally Responsive Early Childhood Programs: Hearing from Parents about what they want

    Official Title An Examination of Culturally Responsive, Inclusive, and Socially Just Practices Parent Feedback

    Purpose

    The research study will examine parents’ - or a child’s primary caregiver - perspectives on an online professional development (PD) training for teachers, targeting early care and education (ECE) teachers’ use of culturally responsive, inclusive, and socially just practices. Parents of young children will be recruited to review the online PD course and complete surveys about the course. A subset of participants will participate in a focus group to share their feedback on the course.

    Could this study be right for you?

    Parent or caregiver to a child who:

    - Is between 3 and 5 years old

    - Is identified as Black/African American

    - Attends a center-based early care and education program (pre-kindergarten, Head Start, child care, preschool, etc.)

    Age Range

    17 - 99 years
  • Social Abilities and Aging Study

    Official Title Progression of Social Cognitive Deficits in Mid- and Late-Life Schizophrenia Spectrum Disorders

    Purpose

    This research is being done to investigate the effects of age on social cognition in schizophrenia spectrum disorder. The study also hopes to examine potential neural bases of social cognition. The findings of the research will help develop effective treatment strategies by identifying who, when, and how to intervene.

    Could this study be right for you?

    Patients:

    • Diagnosis of a schizophrenia spectrum disorder (includes schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, schizophreniform disorder, unspecified or other-specified psychotic disorders)

    Healthy Controls:

    • No history of any psychotic disorder
    • No psychiatric diagnosis in the last 5 years
    • Not taking psychotropic medication 

     

    Age Range

    35 - 75 years
  • MOMI Study

    Official Title The mom and infant outcomes (MOMI) study: A trial of perinatal outpatient delivery systems

    Purpose

    ​To improve our ability to provide the best possible care to every mom and infant, we are testing two different models of primary care during the first year after childbirth.

    Could this study be right for you?

    - You may qualify if you’re currently pregnant – AND – you’ve ever had high blood pressure, diabetes, depression, or anxiety, including during pregnancy.

    If you participate, you’ll be randomly assigned to an Ohio State location that delivers one of two models of care. Providers at all locations can help you manage your health, but the models differ in several ways.

    - You’ll complete three study visits with surveys, several measurements, and blood and hair sampling. We’ll collect cord blood and review medical records. 

  • A Study for Veterans with Post-Traumatic Stress Disorder (PTSD)

    Official Title Examining the safety and clinical efficacy of psilocybin therapy for Veterans with PTSD: An open label proof-of-concept trial

    Purpose

    The study will demonstrate the safety and efficacy of psilocybin in treating post-traumatic stress disorder (PTSD) in veterans. Psilocybin-assisted therapy has shown great promise in treating anxiety symptoms that comprise post-traumatic stress disorder (PTSD).  Current therapeutic treatments for PTSD are difficult to tolerate and limited in efficacy, especially in the US military veteran population. This study will examine the safety and efficacy of two psilocybin sessions, combined with psychotherapy, among military veterans with severe, treatment resistant PTSD.

    Could this study be right for you?

    Inclusion criteria:

    • Be a United States military veteran 

    • 21 to 64 years old  

    • Have at least a high-school level of education or equivalent (e.g. GED)

    • Current diagnosis of PTSD

    • Be medically stable as determined by screening for medical problems via a personal interview, a medical questionnaire, a physical examination, an electrocardiogram (ECG), and routine medical blood and urinalysis laboratory tests  

    Exclusion criteria:  

    • Women who are pregnant

    • Cardiovascular conditions: coronary artery disease, stroke, angina, uncontrolled hypertension, a clinically significant ECG abnormality (e.g., atrial fibrilation), artificial heart valve, or TIA in the past year  

    • High blood pressure

    • History of seizures or epilepsy

    Exclusion Criteria varies, please contact Study Coordinator.

     

    Age Range

    21 - 64 years
  • Eye Gaze Study

    Official Title Disrupted eye gaze perception as a biobehavioral marker of social dysfunction: An RDoC investigation

    Purpose

    This study seeks to understand social functioning across mental health conditions. Social dysfunction is very common in people with mental health conditions; it can negatively impact employment, independent living, and maintaining meaningful relationships. This research is being done to learn if a person's ability to process visual information (including distinguishing other people's eye gaze direction) is a clue to social functioning regardless of diagnosis. This research will identify clinical and brain characteristics in relation to social functioning.

    Could this study be right for you?

    Patients:

    • Diagnosis of a schizophrenia-spectrum disorder or autism spectrum disorder
    • Receiving treatment in a mental health or primary care setting
    • Experience difficulty in social functioning

    Health Volunteers: 

    • No history of past or current mental health disorder diagnosis
    • Experience no difficulty in social functioning

    Age Range

    14 - 30 years
  • SOAR (State of Ohio Adversity and Resilience) Brain Health Study

    Official Title State of Ohio Adversity and Resilience Study (SOAR)- Deep Phenotyping

    Purpose

    The purpose of this study is to develop effective mental health and preventing suicide and substance use disorder, we must better understand risks, which lead to mental illness, and resilience, which allows us to grow even in presence of adversity. This study is looking at how people live and how they deal with distress, depression or drugs and alcohol in Ohio. Family members living in Ohio are asked to participate.

    Could this study be right for you?

    Eligibility:

    Inclusion criteria:

    • Adults, age 18-72, and adolescents, age 12-17.

    Exclusion criteria:

    • Inability to functionally communicate in English.
    • Unwilling/unable to sign informed consent or assent document or obtain parental authorization from a parent or legal guardian (subjects <18 years old).
    • Inability to understand/follow instructions for study procedures.
    • Participants without at least 1 other family member who is willing to participate
      • The definition of family member is subjective to the participant and may not be a blood relative.

    Age Range

    12 - 72 years
  • Ohio Mood Disorder Registry and Repository

    Official Title Ohio Mood Disorder Registry and Repository

    Purpose

    Mood disorders like Major Depressive Disorder and Bipolar Disorder can be chronic, recurrent illnesses. Our treatments to date can help many people but are often trial and error, and continuity and access to care form major barriers. Our purpose is to create a research registry and repository of individuals with mood disorders who are willing to provide clinical data yearly, and who are willing to be contacted to participate in current and future studies of mood disorders.

    Could this study be right for you?

    Inclusion Criteria

    • 8-70 years of age.
    • Fluency or advanced conversational English abilities, by self-report.
    • Eligible individuals will have a history of two or more mood disorder episodes (depression events of at least 2 weeks meeting 5 of the criteria for major depressive disorder).

    Exclusion Criteria

    • Head injury with loss of consciousness of five minutes or greater.
    • Hospitalization for drug-related concerns.
    • Evidence of intellectual disability.
    • Diagnosis of a developmental condition like autism spectrum disorder.
    • Evidence of psychosis outside of a mood episode (e.g., schizophrenia).
    • Hospitalization or infusion for eating condition.

    Age Range

    8 - 70 years
  • A Study for those with Treatment Resistant Epilepsy & Anxiety

    Official Title An open-label clinical trial evaluating the ExAblate Model 4000 Type-1 focused ultrasound unilateral thalamotomy for patients with treatment-refractory focal onset epilepsy and comorbid anxiety

    Purpose

    The purpose of the study is to learn more about whether an ultrasound treatment for epilepsy and anxiety is safe and effective.

    Could this study be right for you?

    • Age: 18-65 years old
    • Treatment resistant Epilepsy (focal or partial-onset seizures)
    • ≥ 3 seizures/month
    • Moderate-to-severe Anxiety

     

     

    Age Range

    18 - 65 years
  • A Study Evaluating How Dietary Fat Affects Cognition

    Official Title Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study: Dietary Fat Quality and Cognitive Impairment

    Purpose

    The purpose of the EFFECT Study is to determine how dietary fats influence cognitive (mental) function in adults.

     

    During the 7-week study participants will

    • Consume one study food per day for a total of 3 weeks
    • Have their blood drawn
    • Have their body weight and shape measured
    • Complete cognitive tests
    • Fill out questionnaires
    • Complete diet and physical activity recalls

    Could this study be right for you?

    • Feel your memory or concentration is not as good as you'd like it to be
    • Are overweight
    • Do NOT have diabetes
    • Do NOT have dementia or Alzheimer's
    • Do NOT have food allergies 
    • Are NOT pregnant or nursing an infant

    Age Range

    40 - 75 years
  • A Study Investigating a Medicine to Improve Social Communication in Adolescents and Adults with Autism Spectrum Disorder (ASD).

    Official Title MapLight Study (IRIS Clinical Trial)

    Purpose

    The purpose of this study is to investigate a medication intended to improve social communication in adolescents and adults with ASD.

    Could this study be right for you?

    • Have an autism diagnosis or suspect you have an autism diagnosis
    • Have a caregiver or study partner willing to enroll in the study with you

    Age Range

    18 - 45 years