Official Title Developing Rumination-Focused Treatment to Reduce Risk for Depression Recurrence (RDR) in Adolescence (RuMeChange)

Purpose

We are conducting a study looking at how therapy strategies can help teenagers stay healthy, reduce rumination, or overthinking and worrying, and prevent depression relapse. If eligible, the teenager would complete assessments which include clinical interviews over Zoom, surveys, cognitive testing, and an MRI.

A parent/guardian is required to enroll in the study and will complete questionnaires and a clinical interview as well.

Could this study be right for you?

Inclusion Criteria:

• 14-18 years of age at enrollment
• Youth assent and parent consent

Exclusion Criteria:

• Metal braces, tattoos with metal
• Claustrophobia
• Current pregnancy

Age Range

14 - 18 years

Contact Information

Caty Escobar

Caty.Escobar@osumc.edu

Official Title Progression of Social Cognitive Deficits in Mid- and Late-Life Schizophrenia Spectrum Disorders

Purpose

This research is being done to investigate the effects of age on social cognition in schizophrenia spectrum disorder. The study also hopes to examine potential neural bases of social cognition. The findings of the research will help develop effective treatment strategies by identifying who, when, and how to intervene.

Could this study be right for you?

Patients:

• Diagnosis of a schizophrenia spectrum disorder (includes schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, schizophreniform disorder, unspecified or other-specified psychotic disorders)

Healthy Controls:

• No history of any psychotic disorder
• No psychiatric diagnosis in the last 5 years
• Not taking psychotropic medication

 

Age Range

35 - 75 years

Contact Information

Olivia Williamson

aging.study@osumc.edu

614-685-1387

Official Title The mom and infant outcomes (MOMI) study: A trial of perinatal outpatient delivery systems

Purpose

​To improve our ability to provide the best possible care to every mom and infant, we are testing two different models of primary care during the first year after childbirth.

Could this study be right for you?

• You may qualify if you’re currently pregnant – AND – you’ve ever had high blood pressure, diabetes, depression, or anxiety, including during pregnancy.

If you participate, you’ll be randomly assigned to an Ohio State location that delivers one of two models of care. Providers at all locations can help you manage your health, but the models differ in several ways.

• You’ll complete three study visits with surveys, several measurements, and blood and hair sampling. We’ll collect cord blood and review medical records.

Contact Information

Columbus, OH

Ana Wong

momistudy@osu.edu

614-427-2785

Official Title An Open-Label, Randomized Controlled Trial of Pramipexole versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD with Mild Neurocognitive Disorder (MND) in Persons Living with HIV

Purpose

This study will evaluate the safety & efficacy of pramipexole vs. escitalopram for treatment of major depressive disorder (MDD) and comorbid MDD/mild neurocognitive disorder (MND) in people living with HIV.

Could this study be right for you?

• People living with HIV ages 18-70
• Diagnosis of MDD alone or with comorbid MDD/MND
• On ART for at least 3 months with HIV RNA <200 copies within 90 days

Age Range

18 - 70 years

Contact Information

McCampbell Hall

Robyn Cicarella

Robyn.Patrick@osumc.edu

Official Title Ohio Mood Disorder Registry and Repository

Purpose

Mood disorders like Major Depressive Disorder and Bipolar Disorder can be chronic, recurrent illnesses. Our treatments to date can help many people but are often trial and error, and continuity and access to care form major barriers. Our purpose is to create a research registry and repository of individuals with mood disorders who are willing to provide clinical data yearly, and who are willing to be contacted to participate in current and future studies of mood disorders.

Could this study be right for you?

Inclusion Criteria

• 8-70 years of age.
• Fluency or advanced conversational English abilities, by self-report.
• Eligible individuals will have a history of two or more mood disorder episodes (depression events of at least 2 weeks meeting 5 of the criteria for major depressive disorder).

Exclusion Criteria

• Head injury with loss of consciousness of five minutes or greater.
• Hospitalization for drug-related concerns.
• Evidence of intellectual disability.
• Diagnosis of a developmental condition like autism spectrum disorder.
• Evidence of psychosis outside of a mood episode (e.g., schizophrenia).
• Hospitalization or infusion for eating condition.

Age Range

8 - 70 years

Contact Information

The Ohio State University

Caty Escobar

caty.escobar@osumc.edu

Official Title An open-label clinical trial evaluating the ExAblate Model 4000 Type-1 focused ultrasound unilateral thalamotomy for patients with treatment-refractory focal onset epilepsy and comorbid anxiety

Purpose

The purpose of the study is to learn more about whether an ultrasound treatment for epilepsy and anxiety is safe and effective.

Could this study be right for you?

• Age: 18-65 years old
• Treatment resistant Epilepsy (focal or partial-onset seizures)
• ≥ 3 seizures/month
• Moderate-to-severe Anxiety

 

 

Age Range

18 - 65 years

Contact Information

Ohio State Wexner Medical Center

Shiane Toleson

toleson.1@osu.edu

614-366-3523

Official Title Understanding the Neurodevelopmental Effects of Youth Tackle Football Participation

Purpose

In this study we are aiming to identify risk factors for higher exposure to football-related neurotrauma in youth tackle football players and to determine the effects of football-related neurotrauma exposure on neurodevelopment in children with no previous tackle football participation.

For this specific posting, we are looking for boys ages 8-12 who are non-athletes or athletes who play non-contact sports to serve as control subjects for our fMRI study. 

Could this study be right for you?

We are looking for boys ages 8-12 who are either non-athletes or do not participate in any contact sports.

• Boys must have no metal implanted in the body
• Have no prior history of head trauma
• Have no serious health or mental health diagnoses
• Must not have a fear of enclosed spaces

Age Range

8 - 12 years

Contact Information

1835 Neil Ave, Columbus

Nii-Ayi Aryeetey

zlab@osu.edu

Official Title Exploring the Connectivity and Functional Organization of the Infant Brain

Purpose

The purpose of the study is to investigate how the brain that we are each born with leads to our own unique behavior later in life, and the similarities and differences between maternal and child brains. We are studying infants prenatally and postnatally, following up with them as they grow and develop, and studying their mothers to understand how similar/different they are to their child.

Could this study be right for you?

• Infants under 3 years of age, and pregnant persons who are at least 20 weeks pregnant
• All participants must have no metal implanted in the body
• Have no significant health conditions or history of serious mental illness
• Not suffer from a (fear of enclosed spaces)
• Pregnancies must be without complication.

Age Range

Up to 40 years

Contact Information

1835 Neil Ave, Columbus

Anna Quatrale

zlab@osu.edu

Official Title The Tree of Hope: A Method to Reduce Burnout, Improved Hope and Increase Resilience

Purpose

The purpose of this study is to improve the sense of hope and build resilience through creating one’s Tree of Hope. This study is being done because we see that today’s environment is quite stressful and this can lead to people feeling less hopeful in their present and the future. 

 

Could this study be right for you?

• At least 18 years old
• Able to read and understand English
• Healthy people and patients will be eligible for this research study
• Participants will be eligible even if they are not seen at OSU for their care.
• We will not abstract any data from electronic health records. Patients will complete a survey that asks them questions about their health conditions

Exclusion Criteria

• Any physical or mental condition that the principal investigator considers as impacting the ability of the patient to participate in the research study. Examples include visual or hearing impairment, arthritis, weakness or other medical problem that impairs their ability to write.

Age Range

18 years and up

Contact Information

SUBHANKAR CHAKRABORTY

subhankar.chakraborty@osumc.edu

19788105992

Official Title Treatment of Stress and Anxiety in mild cognitive impairment (MCI)/Mild Alzheimer's Disease and related dementias (ADRD) and their care partners: A Randomized Controlled Trial

Purpose

The purpose of this study is to assess the impact of a treatment on anxiety and stress in individuals with memory concerns and those already with a diagnosis of Mild Cognitive Impairment (MCI), Mild Alzheimer's Disease and related dementias. 

Could this study be right for you?

The primary participant must:

• Be at least 60 years of age
• Have a “care-partner” that is willing to participate in the full program (such as a spouse, child or a good friend)
• NOT have a terminal illness or severe motor impairment
• Be able to use a computer and smartphone and read English at the 6th grade level

The care partner must:

• Be at least 18 years of age
• Be able to use a computer and smartphone and read English at the 6th grade level

Age Range

60 - 99 years

Contact Information

The Ohio State University, Ohio University, and Florida State University

Sarah Irvin

sarah.irvin@osumc.edu

614-379-3173