Other

Official Title

Laying the Groundwork for Personalized Medicine in Aphasia Therapy: Genetic and Cognitive Predictors of Restorative Treatment Response

Purpose

This NIH-funded project will investigate patient-specific factors that may influence response to therapy for language impairment after stroke, or aphasia. Results from this work will assist with better estimation of prognosis for stroke survivors with aphasia, which could empower patients and families to make more informed health care decisions about how to pursue the most appropriate rehabilitation services based on their unique characteristics, such as genetics, cognitive skills, and brain structure after stroke.

Could this study be right for you?

Participants must meet the following criteria:
- Native English speaker
- Able to have an MRI
- Had only one stroke (in the left hemisphere of the brain)

Age Range

18 and up

Official Title

Healthy Lifestyle Behaviors and Beliefs of African American Women

Purpose

Evaluate factors that influence African American women’s healthy lifestyle behaviors and beliefs. A descriptive study using anonymous survey data.

Could this study be right for you?

Adult African American/Black women

Age Range

18 and up

Official Title

A Hybrid Effectiveness-Implementation Trial to Improve Safe Driving among Teen Drivers with Traffic Violations

Purpose

The purpose of this study is to test the effects of an in-vehicle driving feedback technology, with and without parent training, on parent-teen communications as well as teens' risky driving behaviors, unsafe driving behaviors, and subsequent traffic violations.

Could this study be right for you?

In order to be eligible:
- You must be 16 -18 years of age
- Need a valid State of Ohio driver's license (no learner's permit)
- Proof of car insurance
- Must drive more than one hour per week

Age Range

16 and up

Official Title

Nitrous Oxide and Cortico-Limbic Function in Aggression (Laughing Gas Study or LGS).

Purpose

The purpose of this study is to see how laughing gas (nitrous oxide) changes brain activity in study participants with and without “anger issues”. Brain activity is measured by Magnetic Resonance Imaging.

The length of time you will be involved in this study will be 4-8 weeks.

Could this study be right for you?

- You are a medically healthy man or woman
- You are between the ages of 21 and 55 years of age
- Do not abuse alcohol or other drugs
- With a current history of “anger issues”
- Able to complete study sessions during the week

Age Range

21 and up

Official Title

Adjusting to Life After COVID-19

Purpose

This study looks at what is helping people adjust to the changes caused by the COVID-19 pandemic so that we may understand what could help people adapt to crises in the future. This information could benefit with the understanding and improvement of treatments for conditions such as depression and anxiety.

The study will examine the experience of psychological symptoms, adaptability, and coping over time.

Could this study be right for you?

You may eligible for this study if you are:
• 18 years of age or older
• Currently unemployed or laid off
• Be considered high risk if infected with COVID-19 (e.g., being 65 or older or having an underlying health condition).
• Have NOT had a positive COVID-19 test result
• Do NOT have an immunity to COVID-19

Age Range

18 and up

Official Title

Booster Seats Interview

Purpose

To explore how parents make the decision on transitioning their children from booster seats to seat belts; what factors may influence parents’ decision on the transition.

Could this study be right for you?

Inclusion criteria: o At least 18 years of age o A parent or legal guardian who is responsible for transporting their child routinely o Have a child stopped using booster seats within 1 year prior to the interview date, and the child who made the transition must be the first child of the parent o Drive with a child at least once per week o In good general health o Fluent in English.

Age Range

20 and up

Official Title

M16-046: A Phase 3b Multicenter, Randomized, Double-Blind, Double-Dummy, Active Controlled Study Comparing the Safety and Efficacy of Upadacitinib to Dupilumab in Adult Subjects with Moderate to Severe Atopic Dermatitis

Purpose

The purpose of this study is to compare the effectiveness and safety of upadacitinib (ABT-494) versus dupilumab for the treatment of adult subjects (18-75 years of age) with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.

Could this study be right for you?

- Subject must have chronic Atopic Dermatitis (AD) with onset at least 3 years prior to study participation - Subject must have > or = 10% body surface area involvement of atopic dermatitis - Subject must have had inadequate response to topical corticosteroids or topical calcineurin inhibitors within the past 6 months - OR documented systemic treatment for AD within the past 6 months - OR for whom topical treatments are otherwise medically inadvisable - No prior exposure to any JAK inhibitor ( eg. ruxolitinib, tofacitinib, baricitinib, upadacitinib, PF-04965842, and filgotinib) - No prior exposure to dupilumab

Age Range

18 and up

Official Title

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Operationally Seamless, Adaptive Phase 2/3 Study to Evaluate the Efficacy and Safety of Baricitinib in Adult Patients with Severe or Very Severe Alopecia Areata (JAHO)

Purpose

The main reason for you to take part in this study is not to treat you for your condition but to help in answering the following research questions:
• Whether baricitinib is better than placebo in the treatment of patients with severe alopecia areata (AA)
• The safety of baricitinib and any side effects you may have when you take it.

Could this study be right for you?

- Are at least 18 years and ≤60 years for males (≤70 years of age for females) at
the time of informed consent

- Are able to read, understand, and give documented (electronic or paper
signature) informed consent

- Current AA episode of more than 6 months’ duration and hair loss
encompassing ≥50% of the scalp

- No spontaneous improvement over the past 6 months

Age Range

18 and up

Official Title

ANB019-003: A Phase II, Randomized, Placebo-controlled, Double-blind, Multiple Dose Study to Evaluate the Efficacy and Safety of ANB019 in Subjects with Palmoplantar Pustulosis

Purpose

This study is being done to assess the effects of the experimental study drug (ANB019) in patients with PPP.

Could this study be right for you?

- Must have a clinical diagnosis of PPP for at least 6 months prior to screening
- Must have active pustules on palms and/or soles of feet
- BMI must be within the range of 18-36 kg/m2
- Subjects must be in otherwise good health
- Must not have any suspected autoimmune disorder or immune deficiency
- No major surgeries in the past 4 weeks
- No history of malignancy in the past 5 years
- No history of drug, alcohol, or other substance abuse

Age Range

18 and up

Official Title

Economic Insecurity of Adult Caregivers

Purpose

This study examines the financial hardship experienced by adult children who provide care to parents with Alzheimer's and dementia. The research questions for this study explore how adult children navigate the economic and financial hardship associated with being a caregiver: financial sacrifices or economic hardships they may face due to caregiving responsibilities and how they think this will affect them in the future.

Could this study be right for you?

Eligible participants include adult children in Central Ohio (from urban and rural areas) who are caregivers to a parent or parent-in-law with Alzheimer's or dementia.

Age Range

18 and up