Other

Official Title

Nitrous Oxide and Cortico-Limbic Function in Aggression (Laughing Gas Study or LGS).

Purpose

The purpose of this study is to see how laughing gas (nitrous oxide) changes brain activity in study participants with and without “anger issues”. Brain activity is measured by Magnetic Resonance Imaging.

The length of time you will be involved in this study will be 4-8 weeks.

Could this study be right for you?

- You are a medically healthy man or woman
- You are between the ages of 21 and 55 years of age
- Do not abuse alcohol or other drugs
- With a current history of “anger issues”
- Able to complete study sessions during the week

Age Range

21 and up

Official Title

Adjusting to Life After COVID-19

Purpose

This study looks at what is helping people adjust to the changes caused by the COVID-19 pandemic so that we may understand what could help people adapt to crises in the future. This information could benefit with the understanding and improvement of treatments for conditions such as depression and anxiety.

The study will examine the experience of psychological symptoms, adaptability, and coping over time.

Could this study be right for you?

You may eligible for this study if you are:
• 18 years of age or older
• Currently unemployed or laid off
• Be considered high risk if infected with COVID-19 (e.g., being 65 or older or having an underlying health condition).
• Have NOT had a positive COVID-19 test result
• Do NOT have an immunity to COVID-19

Age Range

18 and up

Official Title

Booster Seats Interview

Purpose

To explore how parents make the decision on transitioning their children from booster seats to seat belts; what factors may influence parents’ decision on the transition.

Could this study be right for you?

Inclusion criteria: o At least 18 years of age o A parent or legal guardian who is responsible for transporting their child routinely o Have a child stopped using booster seats within 1 year prior to the interview date, and the child who made the transition must be the first child of the parent o Drive with a child at least once per week o In good general health o Fluent in English.

Age Range

20 and up

Official Title

M16-046: A Phase 3b Multicenter, Randomized, Double-Blind, Double-Dummy, Active Controlled Study Comparing the Safety and Efficacy of Upadacitinib to Dupilumab in Adult Subjects with Moderate to Severe Atopic Dermatitis

Purpose

The purpose of this study is to compare the effectiveness and safety of upadacitinib (ABT-494) versus dupilumab for the treatment of adult subjects (18-75 years of age) with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.

Could this study be right for you?

- Subject must have chronic Atopic Dermatitis (AD) with onset at least 3 years prior to study participation - Subject must have > or = 10% body surface area involvement of atopic dermatitis - Subject must have had inadequate response to topical corticosteroids or topical calcineurin inhibitors within the past 6 months - OR documented systemic treatment for AD within the past 6 months - OR for whom topical treatments are otherwise medically inadvisable - No prior exposure to any JAK inhibitor ( eg. ruxolitinib, tofacitinib, baricitinib, upadacitinib, PF-04965842, and filgotinib) - No prior exposure to dupilumab

Age Range

18 and up

Official Title

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Operationally Seamless, Adaptive Phase 2/3 Study to Evaluate the Efficacy and Safety of Baricitinib in Adult Patients with Severe or Very Severe Alopecia Areata (JAHO)

Purpose

The main reason for you to take part in this study is not to treat you for your condition but to help in answering the following research questions:
• Whether baricitinib is better than placebo in the treatment of patients with severe alopecia areata (AA)
• The safety of baricitinib and any side effects you may have when you take it.

Could this study be right for you?

- Are at least 18 years and ≤60 years for males (≤70 years of age for females) at
the time of informed consent

- Are able to read, understand, and give documented (electronic or paper
signature) informed consent

- Current AA episode of more than 6 months’ duration and hair loss
encompassing ≥50% of the scalp

- No spontaneous improvement over the past 6 months

Age Range

18 and up

Official Title

ANB019-003: A Phase II, Randomized, Placebo-controlled, Double-blind, Multiple Dose Study to Evaluate the Efficacy and Safety of ANB019 in Subjects with Palmoplantar Pustulosis

Purpose

This study is being done to assess the effects of the experimental study drug (ANB019) in patients with PPP.

Could this study be right for you?

- Must have a clinical diagnosis of PPP for at least 6 months prior to screening
- Must have active pustules on palms and/or soles of feet
- BMI must be within the range of 18-36 kg/m2
- Subjects must be in otherwise good health
- Must not have any suspected autoimmune disorder or immune deficiency
- No major surgeries in the past 4 weeks
- No history of malignancy in the past 5 years
- No history of drug, alcohol, or other substance abuse

Age Range

18 and up

Official Title

Economic Insecurity of Adult Caregivers

Purpose

This study examines the financial hardship experienced by adult children who provide care to parents with Alzheimer's and dementia. The research questions for this study explore how adult children navigate the economic and financial hardship associated with being a caregiver: financial sacrifices or economic hardships they may face due to caregiving responsibilities and how they think this will affect them in the future.

Could this study be right for you?

Eligible participants include adult children in Central Ohio (from urban and rural areas) who are caregivers to a parent or parent-in-law with Alzheimer's or dementia.

Age Range

18 and up

Official Title

Transcranial Direct Current Stimulation Therapy for Sleepiness Related to Shift Work Disorder (tDCS-SWORD)

Purpose

This research study aims to determine the effects of a noninvasive form of brain stimulation on alertness for night shift workers.

Could this study be right for you?

• You are age 18 to 65
• You are currently working the night shift at least 3x/week
• You are suffering from sleepiness at work
• You do not have significant heart and lung problems
• You work within the Columbus, OH area

Age Range

18 and up

Official Title

Patient perceptions about the role of spirituality and faith during cancer treatment

Purpose

The purpose of the current study is to characterize the perspectives of cancer patients who have undergone a cancer-directed surgery on the role of spirituality and/or religion during their cancer journey in order to better define the desired access to related resources during cancer care. Results from this study will inform future research aimed at addressing patient-centered spirituality/faith needs of cancer patients.

Could this study be right for you?

If you’ve had or will have surgery to treat a cancer diagnosis, you can help researchers at Ohio State examine how patient spirituality and/or religion influences the cancer journey by taking an online survey.

Participants should be:

• Over 18 years old.

• Diagnosed with cancer (all types).

• At least four months past the initial cancer diagnosis.

• Underwent or will receive a surgical procedure related to their cancer

• Able read and write in the English language.

Age Range

18 and up

Official Title

Couple Dynamics Surrounding Contraceptive Sterilization

Purpose

This study aims to understand people’s experiences with contraceptive sterilization (such as tubal ligations or vasectomies).
The purpose of this study is to better understand how adults decide to use sterilization as
their main form of birth control. By examining sterilization decisions, this study will
provide a better understanding of how individuals describe and explain their decision
making process.

In this study we are interested in learning how people discuss these decisions with their partner, as
well as everyday interactions with their partner, other forms of birth control, and attitudes
about gender more generally.

Could this study be right for you?

-Ages 21-55
-Have used tubal ligation or vasectomy as primary contraception, WITHIN the last five (5) years

Participants will be asked to answer a series of questions regarding their experience with
sterilization. Interviews will be digitally recorded by audiotape and will remain
confidential. The duration of the interview will last approximately one hour to one hour
and thirty minutes.

Age Range

21 and up