Other

Official Title

Where Do Franklin County Residents Overdose and What Supports Do They Need?

Purpose

The purpose of this study is to identify places where Franklin County residents have had an opioid-related overdose (e.g. home, workplace, coffee shop, grocery story). We also want to identify what resources people want to see in these places (e.g. NaloxBoxes, vending machines, a motion monitoring device) to help people stay safe.

Could this study be right for you?

• Male and females aged 18 years or older
• Resident of Franklin County
• Experienced at least one overdose in Franklin County, OH between January 2021 and December 2022
• You suspected your overdose was opioid-related or someone gave you Narcan
• Willing to discuss your overdose experience in a one-on-one interview
• Have access to a private room and an Internet connection, or able to travel to a local public library for the interview

Age Range

18 and up

Official Title

Orexin Receptor Antagonists as Modulators of Threat Sensitivity in individuals with Alcohol Use Disorder

Purpose

The purpose of this study is to see if BELSOMRA, an FDA approved medication that is prescribed to treat insomnia, changes the body’s response to stress. Participation in the study includes 3 or 5 in-person lab visits (depending on randomization), which include EEG and MRI. Nearly all visits are 1.5 hours long, with the exception of one that is 4-5 hours in duration. Visits are flexible and scheduled at your convenience. Participants take the medication (or placebo) for 4 weeks, during which participation is only composed of virtual surveys via a smartphone app.

The total length of participation in the study is 1.5-2 months depending on scheduling/availability.

Could this study be right for you?

Eligibility Criteria:

• 18-65 years old
• Generally medically and physically healthy
• Regular alcohol use

Exclusion Criteria:

• Diagnosis of bipolar disorder, schizophrenia, mania, or psychosis
• Currently pregnant or trying to become pregnant (female)
• Presence of ferrous-containing metal in the body
• Inability to tolerate enclosed spaces
   

Exclusion Criteria varies, please contact Study Coordinator for more information.

Age Range

18 - 65

Official Title

Ontogenesis of Categorization; Linking development, mechanisms, and biology

Purpose

The purpose of this study is to investigate the early development of attention, learning, and memory during childhood. Participation in this study includes 4, 90-minute-long visits to the lab per year. During these visits, your child will play 2-3 fun, computerized games. These games are designed to assess various aspects of their cognitive ability. 

The duration of the study will last 4 years.

Could this study be right for you?

Eligibility Criteria: 

• African-American/Black children who are 4 years old 

Age Range

4 - 4

Official Title

FASED (Footstool in Alleviating Symptoms of Evacuation Disorder)

Purpose

The purpose of this research study is to see if using a footstool can make it easier to have bowel movements in patients who suffer from chronic constipation. The participants will be given a free footstool to use. They will be asked to keep a record of their bowel symptoms and answer some surveys about their symptoms on a phone or computer. 

You will be in the study for approximately 12 weeks. This includes 2 weeks before you start using the footstool, followed by 8 weeks where you will be using the footstool and up to 2 weeks to complete your initial and final surveys. 

Could this study be right for you?

• At least 18 years old 

• Able to understand English 

• Symptoms such as feeling incompletely empty after a bowel movement, needing to strain a lot when having a bowel movement or needing to use maneuvers such as rocking one's body back and forth or using their finger to remove stool. 

 

Age Range

18 - 99

Official Title

Sex Differences in Pain Reports and Brain Activation in Older Adults with Alzheimer's Disease

Purpose

The purpose of this study is to examine how men and women with and without dementia might perceive and respond to pain or discomfort.

Participants may complete various questionnaires by phone or video conferencing once a week for up to 8 weeks with an optional MRI screening.

Could this study be right for you?

• Men and women aged 60 years or older
• Dementia or memory issues

Participants and their caregiver (if applicable) may complete only 1 day of the study, or they may complete as many as they would like for up to 8 days total.

Age Range

60 and up

Official Title

A multicenter, randomized, double-blind, parallel group, placebo-controlled study to assess safety, tolerability, pharmacokinetics and pharmacodynamics of BI 764198 administered orally once daily for 12 weeks in patients with focal segmental glomerulosclerosis.

Purpose

The overall objective is to investigate to investigate how safe, how well tolerated, and how effective R3R01 is in treating uncontrolled proteinuria in patients with Alport syndrome and steroid-resistant Focal Segmental Glomerulosclerosis. All eligible participants will be enrolled to receive R3R01 over a treatment period of 12 weeks. The study will consist of 3 periods, including a screening period of 3 weeks, a treatment period of 12 weeks, and a follow up of period of 12 weeks.

Could this study be right for you?

You may be eligible to participate if: • You are aged 18 years or older • Female patients and female partners of male patients willing to not become pregnant for the duration of the study • Have not had an organ transplant and/or on a organ transplant list • Have high protein in urine Alport Syndrome (AS) specific: • Have X-linked AS and autosomal recessive AS • Confirmed diagnosis of AS be genetic testing or kidney biopsy • Do not have another kidney disease FSGS specific: • Not older than 75 years of age • Primary Focal segmental glomerulosclerosis (FSGS) (not caused by other condition) that is confirmed by kidney biopsy or documentation of genetic mutation • Steroid-resistance: previous steroid treatment without remission

Age Range

18 and up

Official Title

"What do physicians know about intellectual disability?" Getting information to design better medical training

Purpose

The purpose of this study is to explore the physicians’ knowledge of intellectual disabilities (ID) and their medical training and practice. The information resulting from this study will help to design adequate interventions and training programs for medical students and physicians aimed to improve their ID knowledge and the health care services provided to patients with ID. This is an observational cross-sectional study of physicians in the US using an anonymous online survey. The entire survey has 156 items and will require 15-20 minutes to complete.

Could this study be right for you?

- You are an American medical resident, an attending physician, or a medical educator in any type of medical specialization, and - You have or do not have experience with patients with intellectual disabilities

Age Range

24 and up

Official Title

Laying the Groundwork for Personalized Medicine in Aphasia Therapy: Genetic and Cognitive Predictors of Restorative Treatment Response

Purpose

This NIH-funded project will investigate patient-specific factors that may influence response to therapy for language impairment after stroke, or aphasia. Results from this work will assist with better estimation of prognosis for stroke survivors with aphasia, which could empower patients and families to make more informed health care decisions about how to pursue the most appropriate rehabilitation services based on their unique characteristics, such as genetics, cognitive skills, and brain structure after stroke.

Could this study be right for you?

Participants must meet the following criteria:
- Native English speaker
- Able to have an MRI
- Had only one stroke (in the left hemisphere of the brain)

Age Range

18 and up

Official Title

Healthy Lifestyle Behaviors and Beliefs of African American Women

Purpose

Evaluate factors that influence African American women’s healthy lifestyle behaviors and beliefs. A descriptive study using anonymous survey data.

Could this study be right for you?

Adult African American/Black women

Age Range

18 and up

Official Title

A Hybrid Effectiveness-Implementation Trial to Improve Safe Driving among Teen Drivers with Traffic Violations

Purpose

The purpose of this study is to test the effects of an in-vehicle driving feedback technology, with and without parent training, on parent-teen communications as well as teens' risky driving behaviors, unsafe driving behaviors, and subsequent traffic violations.

Could this study be right for you?

In order to be eligible:
- You must be 16 -18 years of age
- Need a valid State of Ohio driver's license (no learner's permit)
- Proof of car insurance
- Must drive more than one hour per week

Age Range

16 and up