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Healthy Diet Study
Official Title A prospective randomized unblinded study of ketogenetic versus mixed diet on exercise tolerance in subjects with the metabolic phenotype of heart failure with preserved ejection fractionPurpose
The purpose of this study is to compare the effects of a well-formulated ketogenic diet with a low-fat diet on exercise tolerance in patients with diabetes or pre-diabetes or obesity; with shortness of breath or heart failure.
Could this study be right for you?
Inclusions:
- Age ≥ 18 years old and ≤ 80 years old & willingness to be randomized to either diet.
- NYHA class I – III for at least 3 months.
- Ejection fraction ≥40% by biplane 2D, or 3D echo, or CMR.
- Echo findings of abnormal or indeterminant diastolic function or RHC data: At rest: mean pulmonary capillary wedge pressure (PCWP) > 15 mmHg. Pulmonary vascular resistance (PVR) < 3 Wood Units.
- Stable medical therapy for at least 3 months as determined by the treating physician (no new cardiac or diabetic medications within 3 months of enrollment or during enrollment and dosage should be stable for 1 month prior to enrollment).
- Dose of oral diuretics changes allowed but must be stable for 1 week prior to randomization.
- Body Mass Index (BMI) ≥ 25 and ≤ 50 or Type 2 Diabetes Mellitus or prediabetes (fasting glucose of 100 - 125 mg/dL or hemoglobin A1C 5.7-6.4%) or metabolic syndrome.
- Ability to participate in exercise treadmill testing.
- Ability to sign written consent.
Exclusions:
- Women who are pregnant, current breast-feeding, or have intention to become pregnant while in the study.
- Known allergy or sensitivity to gadolinium-based contrast agents.
- Implanted pacemaker, cardioverter defibrillator, Cardiac resynchronization therapy, left ventricular assist devices.
- Other metallic implants/aneurysm clips that are contraindicated in MRI.
- Claustrophobia
- History of severe kidney disease of eGFR < 30 ml/kg/1.73m2.
Exclusion Criteria varies, please contact Study Coordinator.
Age Range
18 - 80 years -
PREVENTABLE
Official Title PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adultsPurpose
The purpose of PREVENTABLE is to learn if taking a statin could help older adults live well for longer by preventing dementia, disability, or heart disease. The duration of the study will last 5 years.
Could this study be right for you?
Inclusion Criteria:
- Community-dwelling adults
- Age ≥75 years
- English or Spanish as primary language
Exclusion Criteria:
- Clinically evident cardiovascular disease defined as prior myocardial Infarction (MI), prior stroke, prior revascularization procedure, or a secondary prevention indication for a statin (clinician determined)
- Hospitalization for a primary diagnosis of heart failure in the prior 12 months (Note: History of heart failure in the absence of recent hospitalization or clinically evident cardiovascular disease is not an exclusion)
- Dementia (clinically evident or previously diagnosed)
- Dependence in any Katz Basic Activities of Daily Living [ADL] (with the exception of urinary or bowel continence)
- Severe hearing impairment (preventing phone follow up)
- Unable to talk (preventing phone follow up)
Exclusion Criteria varies, please contact Study Coordinator for more information.
Age Range
75 years and up -
Buckeye Concussion Knowledge Survey (BUCKS)
Official Title BUckeye Concussion Knowledge Survey (BUCKS)Purpose
The purpose of this study is to examine health outcomes in former Ohio State University athletes who played a varsity sport during their time at OSU. The objective is to determine whether athletes who sustained a concussion have different health outcomes than those who did not sustain a concussion. Any former OSU varsity athlete can participate in a 20-minute online survey.
Could this study be right for you?
- Anyone who has played a varsity sport as an undergraduate student at OSU, and they have now graduated (i.e., OSU athlete alumni). There are no other restrictions in terms of age, sex/gender, type of sport, etc.
Age Range
18 years and up -
Ohio Teen Driver Study
Official Title Leveraging DRVN driver training app to reduce risky driving intentions in novice teen driversPurpose
The purpose of this study is to see if the bonus safety messages and the amount of app use predicts safe driving attitudes and behaviors at licensure. We are recruiting Ohio teens with learner's permits to use a free driver training app called DRVN.
Could this study be right for you?
- Must have learner's permit to drive in Ohio
Age Range
15 - 17 -
Decision Making Among Couples Concerning "Permanent/Irreversible" Birth Control
Official Title Couple Dynamics Surrounding Contraceptive SterilizationPurpose
This study aims to understand people’s experiences with contraceptive sterilization (such as tubal ligations or vasectomies).
The purpose of this study is to better understand how adults decide to use sterilization as
their main form of birth control. By examining sterilization decisions, this study will
provide a better understanding of how individuals describe and explain their decision
making process.In this study we are interested in learning how people discuss these decisions with their partner, as
well as everyday interactions with their partner, other forms of birth control, and attitudes
about gender more generally.Could this study be right for you?
- Ages 21-55
- Have used tubal ligation or vasectomy as primary contraception, WITHIN the last five (5) years
Participants will be asked to answer a series of questions regarding their experience with sterilization. Interviews will be digitally recorded by audiotape and will remain confidential. The duration of the interview will last approximately one hour to one hour and thirty minutes.
Age Range
21 and up