• A Study Using the Medication Ferumoxytol to Develop an Enhanced MRI Test

    Official Title Development and Testing of Ferumoxytol-enhanced MRI Protocol in Healthy Subjects

    Purpose

    This study is being done to develop a Magnetic resonance imaging (MRI) test that provides better-quality whole-heart pictures. MRI is a non-invasive machine that collects detailed pictures inside your body. Healthy volunteers will be tested in the MRI scanner while being given a dose of a medicine called Ferumoxytol into an IV (intravenous catheter) that will be placed in your arm or hand. Ferumoxytol is a medicine usually used in patients with iron deficiencies and has recently been used as an alternative to other MRI contrast agents and has successfully been applied in adult and pediatric patient populations.

    Could this study be right for you?

    Inclusion: • Males and females ages 18 years and older • No history of cardiovascular disease Exclusion: • Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including: • Reactions to MRI including metallic foreign body, orbital metal, cerebral aneurysm clip, pacemaker, defibrillator, coronary artery stent, neurostimulator, any other medical metallic implant • History of cardiovascular disease or uncontrolled high blood pressure • Claustrophobia • Inability to lie flat for up to 1 hour • Weight exceeding 300 pounds • Pregnancy

    Age Range

    18 and up
  • Decision-Making Abilities and Testamentary Capacity Among Older Adults

    Official Title Decision-Making Abilities and Testamentary Capacity Among Older Adults

    Purpose

    The overall goal of this research is to examine factors such as social resources, personality characteristics, and neurocognitive functioning in relation to decision-making abilities testamentary capacity among healthy older adults.

    Another purpose of this research study is to evaluate the impact of Problem-Solving Treatment-Primary Care (PST-PC), a cognitive-behavioral therapeutic approach, on decision making among healthy older adults. PST-PC involves a seven-step model, in which participants identify problems to be solved, discuss and evaluate different resolutions to reach desired goals; create action plans to accomplish determined goals; and evaluate their effectiveness in resolving designated problems.

    We will compare the effectiveness of PST-PC on individuals who will not receive any intervention.

    A no treatment control group of older adult participants will also be recruited to compare the effectiveness of PST-PC to individuals who do not receive the intervention. This no treatment control group will composed of participants who do not receive the PST-PC sessions.

    Could this study be right for you?

    Inclusion Criteria:
    -adults aged 65 and older
    - Must be independently-living and community-dwelling
    - Participants must be willing to undergo a health interview to rule out outstanding medical and psychiatric conditions
    - Adequate sensory abilities

    Exclusion Criteria:

    - A history of psychiatric illness necessitating inpatient treatment
    - Participants with self-reported depression and/or anxiety exceeding mild levels of clinical severity

    Age Range

    65 and up
  • A Study to Evaluate If Real-Time Visual Feedback on Breathing Influences Time to Exhaustion

    Official Title The influence of receiving real-time visual feedback on breathing during treadmill running to exhaustion

    Purpose

    The purpose of this research is to assess if receiving real-time visual feedback on your breathing pattern during a run has any influence on time to exhaustion.

    The feedback will be provided through animations on a screen placed in front of the treadmill that open and close as the chest and abdomen expand and contract. Research has shown that you want the chest and abdomen to expand and contract at the same time to achieve the most efficient breathing possible, meaning you will want the animations to open and close at the same time.

    The ultimate objective is to see if this feedback allowed the participant to last longer until reaching their exhaustion point.

    Could this study be right for you?

    - Healthy adults who run 5 to 20 miles per week
    - Have NOT been injured while running in the past six months
    - Have NOT been medically diagnosed with breathing deficiencies
    - must be age 18 or older
    Those who are interested in participating will be directed to complete a survey, found at go.osu.edu/RunningAndBreathing, to ensure that they meet the previously mentioned criteria.

    Age Range

    18 and up
  • A Study Utilizing Functional Feedback for Focused Ultrasound Thalamotomy for Tremor Surgery

    Official Title Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy for Tremor Surgery

    Purpose

    The goal of this study is to understand if there are any changes to the connections between the cells in the brain before and after the ultrasound surgery for the treatment of Essential Tremor. This will be done by comparing patients who have had ultrasound surgery and Essential Tremor with healthy individuals. This study may help us to better target the tremor region in the brain during the ultrasound surgery.

    Could this study be right for you?

    - You must be between the ages of 40 and 85
    - Willing to have MRI imaging of the brain

    Age Range

    40 and up
  • Healthy New Albany: Breast Cancer Project

    Official Title Healthy New Albany: Breast Cancer Project

    Purpose

    Determine the feasibility of delivering a community-based, lifestyle weight management intervention in producing meaningful improvements in weight loss and relevant clinical and patient-reported outcomes in Breast Cancer survivors.

    Could this study be right for you?

    Female breast cancer survivor within 60 months after cessation of active treatment. Overweight/Obese (BMI > 25). Ability to understand and willing to sign a written informed consent. Willing and physically able to participate in physical activity. Obtain physician consent via primary care physician and/or treating oncologist.

    Age Range

    30 and up
  • A Study for Night Shift Workers

    Official Title Transcranial Direct Current Stimulation Therapy for Sleepiness Related to Shift Work Disorder (tDCS-SWORD)

    Purpose

    This research study aims to determine the effects of a noninvasive form of brain stimulation on alertness for night shift workers.

    Could this study be right for you?

    • You are age 18 to 65
    • You are currently working the night shift at least 3x/week
    • You are suffering from sleepiness at work
    • You do not have significant heart and lung problems
    • You work within the Columbus, OH area

    Age Range

    18 and up
  • Metabolism Research Study--Healthy Volunteers Needed

    Official Title Adipocyte-T Cell Interactions Modulate Adipose Inflammation and Insulin Sensitivity Following Weight Gain

    Purpose

    The purpose of this research study is to better understand the role of fat tissue, how cells in fat tissue communicate, and determine what signals specific cells use to cause inflammation and insulin resistance during weight gain. This may help researchers better understand the process that happens in Type 2 Diabetes.

    As a result, through the course of six--nine weeks, participants will be asked to gain at least 10% of their starting body weight. A dietitian will meet with participants to give advice to help with meeting the study weight gain goals, as well as provide additional meal vouchers and supplemental shakes as needed. Following the study, participants will receive guidance how to lose the weight they've gained if they would like to do that.

    Could this study be right for you?

    You may be eligible if you:
    - Are 18-60 years of age
    - Are lean; Have a BMI 18-24.9 kg/m2 (*see link below for calculating your BMI --Body Mass Index)
    - Have healthy levels of cholesterol and triglycerides (These will be tested at screening)
    - Are a non-smoker
    - Are non-diabetic
    - Are free of chronic illness
    - Are not pregnant or breastfeeding

    *If you want to calculate your BMI https://www.cdc.gov/healthyweight/assessing/bmi/adult_bmi/english_bmi_c…

    Exclusion Criteria:
    - Fasting triglycerides > 150 mg/dL or nonfasting triglycerides ˃ 250 mg/dl
    - LDL-Cholesterol level > 150 mg/dL,
    - Presence of significant anemia (hemoglobin <10.0 gm/dL),
    - Currently or planning to take blood thinners ,
    - Current smokers
    - Have taken steroids or anti-inflammatory meds for >6 months in the last 6 months
    - >10% body weight loss within 3 months of enrollment
    *Other exclusions may apply

    Age Range

    18 and up
  • A Study for Those with Chronic Pancreatitis - The PROCEED Study

    Official Title Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies PROCEED Study)

    Purpose

    This study is done for researchers to understand pancreatitis and learn how the disease progresses naturally over time.

    From the results of this study, researchers hope to develop some lab tests to support early diagnosis of chronic pancreatitis and to also discover any genetic factors that may affect your chances of developing chronic pancreatitis. The results of this study may also provide information that will open opportunities for new drug discovery.

    Could this study be right for you?

    • You have a history of acute or chronic pancreatitis OR
    • You have experienced pain in your abdomen that a doctor has suggested could be due to pancreatitis
    • You are between the ages of 18 and 75

    Age Range

    18 and up
  • Parent-Infant Eye Tracking Study for Children With and Without Hearing Loss

    Official Title Development of Parent-Child Interactions

    Purpose

    This study will examine how a child’s hearing loss may affect the dynamics of parent-child interactions. The study will observe how normal-hearing and hearing-impaired child learn novel words during videotaped parent-child interactions.

    Individual study visits may last 30-45 minutes, and there may be multiple study visits per year.

    Could this study be right for you?

    - Families with children 9 months to 6 years of age
    - Children who do and do not have hearing loss may be eligible to participate in this study

  • Decision Making Among Couples Concerning "Permanent/Irreversible" Birth Control

    Official Title Couple Dynamics Surrounding Contraceptive Sterilization

    Purpose

    This study aims to understand people’s experiences with contraceptive sterilization (such as tubal ligations or vasectomies).
    The purpose of this study is to better understand how adults decide to use sterilization as
    their main form of birth control. By examining sterilization decisions, this study will
    provide a better understanding of how individuals describe and explain their decision
    making process.

    In this study we are interested in learning how people discuss these decisions with their partner, as
    well as everyday interactions with their partner, other forms of birth control, and attitudes
    about gender more generally.

    Could this study be right for you?

    -Ages 21-55
    -Have used tubal ligation or vasectomy as primary contraception, WITHIN the last five (5) years

    Participants will be asked to answer a series of questions regarding their experience with
    sterilization. Interviews will be digitally recorded by audiotape and will remain
    confidential. The duration of the interview will last approximately one hour to one hour
    and thirty minutes.

    Age Range

    21 and up