Official Title Linking Age, Balance, Vestibular Function, and Falls

Purpose

The purpose of this study is to learn how aging in different sensory systems, including the vestibular system (that portion of the inner ear that measures both motion and orientation of the head), influences maintaining balance while standing and walking, and contributes to fall risk. 

Could this study be right for you?

• Must be able to stand
• No leg or foot amputations
• No lower limb braces
• Not currently feeling dizzy/lightheaded
• Not currently pregnant by self-report
  • Due to potentially nauseogenic nature of some motions and to protect fetus and mother, pregnant women will also be excluded from this study
• Weight <= 275 pounds
• No past or current history of:
  • Severe head trauma or traumatic brain injury
  • Any vestibular disorder (e.g., Meniere’s Disease, Vestibular Migraine, Unresolved BPPV/BPPN, Vestibular hypofunction, except that due to aging, PPPD) as assessed using clinical diagnostic tests described in proposal
  • History of seizures
  • Neurologic illness or conditions known to impact vestibular or balance function(e.g., stroke, neurodegenerative disorders, demyelinating illness)
  • Major psychiatric (e.g., panic disorder, psychosis, etc.) disorder
  • Any of the following eye diseases or conditions: amblyopia (or “lazy eye”) or history of amblyopia, diagnosis of age-related macular degeneration, retina dystrophy, glaucoma, cataracts, or any other eye condition that limits vision to worse than 20/40
  • Recent (<6 months) orthopedic injuries of the lower extremities (e.g., plantar fasciitis, ankle, knee or hip injury, back strain/herniated disc, …).
  • Upper extremity injuries requiring current sling immobilization
  • Recent surgery
  • Any other severe health problem (heart disease, pulmonary disease, cancer, etc.).
  • Vision in both eyes must be better than 20/40 with best correction
  • Outer and/or middle ear pathologies
  • Otologic pathologies or diagnoses (e.g. Meniere’s disease, otosclerosis, conductive or mixed hearing losses)
• Must be able to walk unassisted for 30 minutes
• No current use of ambulatory assistive devices
• Normal hearing bilaterally, air conduction pure-tone thresholds ≤ 25 dB HL at all octave frequencies between 250 and 8000 Hz
• Bilaterally, symmetric sensorineural hearing loss with four-frequency pure-tone average (500, 1000, 2000, 4000) less than 71 dB HL
• If interested, please go to go.osu.edu/vestibular to be screened for eligibility

Age Range

18 - 89 years

Official Title Contribution of Glutamate Excess and Inflammation to Progressive White Matter Changes in Psychosis

Purpose

The purpose of this study is to assess the extent of white matter abnormalities, glutamate alterations, and inflammation in unmedicated patients with psychosis at different illness stages compared to healthy controls.

Could this study be right for you?

• No major medical conditions
• No history of significant head trauma 
• Not currently using medications for mental health purposes (anxiety, depression, other psychiatric diagnosis)
• No metal implants that would present a risk to complete an MRI

*We are only enrolling male participants at this time.

Age Range

16 - 45 years

Official Title The Knowledge and Perceptions of Gen Zs Regarding the Dietary Guidelines for Americans

Purpose

1. Use ideas from Social Cognitive Theory to describe Gen Zs regarding the Dietary Guidelines for Americans (DGA) 2020 to 2025
2. Explain what Gen Z knows and believes regarding the MyPlate recommendations for healthy eating related to:

• Filling half their plate with fruit and vegetables
• Filling one-quarter of their plate with lean protein, and varying the sources of protein
• Filling one-quarter of their plate with grains, making half of the grains whole grains

3. To describe the associations between demographic variables (ethnicity, education, household income, and home environment) and Gen Zs perceptions and knowledge of the DGA

Could this study be right for you?

18 to 28 years old

Live in the US

English speaker

Have access to a device that supports Zoom

Age Range

18 - 28 years

Official Title The ICE Study: Perceptions of E-Cigarettes and Synthetic Cooling Agents

Purpose

This study will examine the influence of synthetic cooling agents in e-cigarettes on vaping behavior and aims to find out how adding artificial cooling ingredients affects how people use a product and their exposure to harmful chemicals.

Your participation in this study will last for 4 sessions, 1 session per week for 4 weeks.

 

 

Could this study be right for you?

• Must be a current e-cigarette user
• Must be willing to attend four in-person study sessions

Age Range

21 - 29 years

Official Title Radiotracer Imaging of Lower Extremity Skeletal Muscle Perfusion in Patients with Peripheral Arterial Disease

Purpose

The purpose of this study is to look at a new method to evaluate blood flow to the calves and feet. 

Peripheral Artery Disease (PAD) patient outcomes will be evaluated for up to 12 months after their revascularization procedure to assess how early changes in SPECT-derived foot perfusion relate to rates of diabetic wound healing and limb salvage. Outcomes will be specifically evaluated at 3, 6, 9, and 12 months after revascularization at the time of their follow-up clinic visits to the OSU Comprehensive Wound Center at OSU Hospital East. Primary outcomes of interest will be 1) changes in wound size and healing, 2) minor or major amputations of the lower extremity, and 3) any subsequent interventional procedures, such as balloon angioplasty, stenting, or surgical bypass.

 

Could this study be right for you?

Heathly Volunteers with out previous cardiovascular disease

Or 

PAD

Age Range

18 years and up

Official Title Digital Transformation of CRC Screening: Revolutionizing Access and Saving Lives

Purpose

The purpose of this study is to conduct usability testing to evaluate ease of use and overall user experience of a website designed to promote colorectal (CRC) awareness and screening uptake among adults 45-64.

Could this study be right for you?

Inclusion Criteria: Eligible participants will 1) be between the ages of 45-64, 2) at average risk for CRC and 3) from diverse racial/ethnic and socioeconomic backgrounds 

 

Those who are ineligible fall under the following categories:  

1. Age: Individuals outside the age range of 45-64 will be excluded

2. Pregnancy Status: Pregnant individuals will be excluded from the study. since CRC screening is not recommended for pregnant individuals

Age Range

45 - 64 years

Official Title Evaluation of Wear Experience with PRECISION7® For Astigmatism Contact Lenses in Neophyte Lens Wearers

Purpose

The purpose of this study is to explore the wear experience with PRECISION7® For Astigmatism lenses in adults who have not previously worn contact lenses.

Could this study be right for you?

1. Adults who have never worn contact lenses.
2. Adults who have astigmatism
3. Ability to attend 3 visits over the course of 3 weeks.
4. Satisfy all other study eligibility and exclusion criteria.

Age Range

18 - 40 years

Official Title The KOBRA Study: The Effects of Knee Osteoarthritis on Brain Activation

Purpose

The purpose of this study is to assess changes in brain activation and processing in those with right knee osteoarthritis compared to healthy controls. 

Could this study be right for you?

• Either two healthy knees OR those with right knee pain from a diagnosis of right knee osteoarthritis with a healthy left knee
• No metal implants that prevent you from having an MRI
• No foot/ankle/leg/hip surgeries in the past year
• No neurologic conditions
• No conditions that prevent athletic participation or maximal effort exercise
• Able to provide informed consent
• Speak and read English

Age Range

45 - 70 years

Official Title Establishing Reference Values and Clinical Decision Points for Quantitative Videofluoroscopic Measures of Swallowing

Purpose

This study will help create healthy reference values clinicians can use to evaluate adult patients of all ages and is sponsored by the National Institute on Aging.  During this study, we will perform an x-ray swallowing exam and breathing tests with persons who do not have a personal history of swallowing problems or any disorders that could contribute to a swallowing problem.  Study participation will consist of a screening meeting (approximately 15 minutes) via phone call, video chat, or email to verify eligibility, and one in-person visit to our laboratory (approximately 1 hour).

Could this study be right for you?

• If you are biologically female and of child-bearing age (<63), you must not be pregnant or breastfeeding.
• No personal history of surgery or radiation therapy to the head or neck (mouth, jaw, neck, brain, nose, face, thyroid, throat, or voice box) other than having your tonsils, adenoids, or teeth removed.
• No personal history of cancer involving structures of the head, neck, spine, respiratory, or lymphatic system.
• No personal history of stroke or other progressive nerve disease.
• No current diagnosis or personal history of Chronic Obstructive Pulmonary Disease (COPD).
• No known allergies to barium.

Age Range

54 - 89 years

Official Title A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single Escalating Doses of LH-001 in Healthy Subjects

Purpose

The purpose of this study is to evaluate the safety and tolerability of an investigational new drug in healthy participants aged 18-60 years.

Could this study be right for you?

• In good health and BMI (ratio of body weight to height) between 18-29.9 kg/m2
• Willing to participate in various research assessments including blood collection, urine collection, electrocardiogram, and vital signs
• Willing to stay overnight (~30 hours) in the OSU Hospital Clinical Research Center
• If sexually active, willing to utilize highly effective birth control during the study period
• Not currently pregnant or breast-feeding
• No significant medical condition involving any major organs (heart, lung, liver, brain, or endocrine)
• No to any of the following: alcohol or substance abuse, spleen problems, or drug hypersensitivity
• No history of or undergoing treatment for: major psychiatric illness, seizures, or autoimmune disease
• Not currently taking immunosuppressive drugs
• No active Hepatitis B, Hepatitis C, or HIV
• No cancer history within 5 years (squamous and basal cell skin cancer excluded)

Age Range

18 - 60 years