Official Title

Characterizing Occupational Therapy Intervention for Children with Autism Spectrum Disorders

Purpose

We are actively recruiting typically developing children (ages 6 – 13 years) to participate in a new study looking at attention and sensory processing. In this study, we are investigating what occupational therapy practitioners are doing during therapy for children with autism and to see the effect of occupational therapy on brainwaves and behavior. We will identify differences in brainwaves in children with and without autism. You and your child will be asked to schedule one visit to the EEG lab at Ohio State University. Your visit will last about 2.5 hours and include an hour of EEG testing and one hour of paper-pencil game-like activities measuring attention. We need parent consent, and the parent/guardian will complete assessments about their child as well.

Could this study be right for you?

- Children with no autism or any other medical diagnosis - Your child is between 6 - 13 years of age

Age Range

6 and up

Official Title

Mechanisms of Self and Other Evaluation (MeSO Study)

Purpose

The purpose of this study is to better understand the way the brain works in people who have depression and people who have previously been depressed. We are also testing healthy subjects for comparison. We hope our findings will lead to better ways to diagnose and treat mood disorders in the future. Participation involves an initial phone call and a 2 to 4 hour visit to find out if you are eligible. This visit will include completing questionnaires and interviews. If eligible, participants will have a second 3-5 hour visit for an MRI scan. Two months after the scan, participants will complete daily online questionnaires for 7 days. This process is repeated 2 months later (4 months after the scan). 

Could this study be right for you?

You may be eligible for this study if you: • Are between the ages of 18-40 • Are right-handed • Do not have a history of neurological disorders (e.g., seizures, head injury, etc.) • Do not have major medical problems (e.g., stroke, heart disease, high blood pressure, endocrine disorders, etc.) • Have normal vision, vision that is corrected to normal with glasses or contacts • Are willing and able to undergo fMRI scanning (not claustrophobic, no non-removable metal in your body) • Are not pregnant

Age Range

18 and up

Official Title

Play and Learning Across a Year

Purpose

The primary goal of this research is to learn how children and mothers interact at home and how that interaction and the home environment affect learning and development. (1) We will film you and your child playing and going about daily activities for an hour in your home (2) We will film the rooms in your home, create floor plans of the rooms and spaces that are accessible to your child, and record the noise level in your home (3) We may ask you questions about your child’s movement, language, emotion, health, toys and animals and media use in the home, and racial and ethnic background as well questions about family health, division of household labor, and education. (4) We may ask you and your child to play with a set of child-friendly toys for a few minutes. This single session study will last between 2 and 3 hours.

Could this study be right for you?

- healthy children less than 2 years old - children born full-term - only child living in household - primary language is English

Official Title

Collaborative Research: Learning and Improving Alzheimer's Patient-Caregiver Relationships via Smart Healthcare Technology

Purpose

The purpose of this study is to explore how family caregivers and persons with memory loss communicate and if certain ways of handling stress, such as mindfulness-based self managements, are helpful for family caregivers. You will be in the study for up to four months from the time of consent to the time of final study data collection. There will be 4 telephone or video calls, and each will take approximately 30 – 135 minutes.

Could this study be right for you?

Caregivers who will participate in this study need to: 1) be aged 21 years or older 2) be an informal, unpaid caregiver who lives with the care recipient 3) be fluent in English 4) have functioning home Wifi The inclusion criteria for care recipients (persons with memory loss) are: 1) females and males age 60-99 years 2) history of memory loss 3) community-dwelling (living in the home) 4) fluent in English

Age Range

21 and up

Official Title

Strategies for the Development of Social Cognitive Training for Impulsive Aggression (Brain Exercise Study or BES).

Purpose

The purpose of this study is to see if brain exercise done on the computer can reduce aggression in those with “anger issues”. The study is a six-week clinical trial using selected brain exercises versus other computer-based exercises.

Could this study be right for you?

- Medically healthy man or woman - You are between 21 and 55 years of age - With a current history of “anger issues” - You have regular access to a computer and a smart phone

Age Range

21 and up

Official Title

Aggression and Social-Emotional Information Processing: Neural Correlates During Alcohol Intoxication (Columbus Brain Activity Study or CBA)

Purpose

The purpose of this study is to see how alcohol changes brain activity in different groups of study participants who currently drink at least 10 drinks a week and who have (or do not have) “anger issues”. Brain activity will be measured by Magnetic Resonance Imaging (MRI). Total time you will be in the research study will be for about 4-8 weeks from your initial visit.

Could this study be right for you?

- Healthy men and women 21-55 years of age - Drink on a regular basis (~ 10 alcoholic beverages per week) - With a current history of "anger issues" - Able to complete study sessions during the week

Age Range

21 and up

Official Title

Comprehensive Protocol for Cognitive Development Research

Purpose

The purpose of this study is to better understand learning, memory and attention development from childhood to adulthood using eye-tracking techniques.

This study will include one lab visit which will take place on Ohio State's main campus and will last approximately 40-60 minutes.

Could this study be right for you?

Eligibility Criteria:

- Must be 18 and 35 years of age
- Have normal or corrected to normal vision

Age Range

18 and up

Official Title

Modeling Cognition and Aging

Purpose

The goal of this study is to develop models to better understand decision-making for young adults, older adults, and adults with early Alzheimer’s disease and Mild Cognitive Impairment.

This study involves making simple decisions (such as “are there more blue dots or more yellow dots?”) on a computer. Healthy volunteers will also complete basic tasks such as solving puzzles, questionnaires involving numbers, and will be asked to provide basic demographic and health information.

Could this study be right for you?

You may be eligible for this study if:

- You are ages 18-25 OR
- You are age 60-90 and have NOT been diagnosed with a memory disorder OR
- You are age 60-90 and HAVE been diagnosed with either Mild Cognitive Impairment OR mild Alzheimer's disease
- You are a native English speaker
- You are able to see a computer screen and use hands on keyboard/screen

Age Range

18 and up

Official Title

Booster Seats Interview

Purpose

To explore how parents make the decision on transitioning their children from booster seats to seat belts; what factors may influence parents’ decision on the transition.

Could this study be right for you?

Inclusion criteria: o At least 18 years of age o A parent or legal guardian who is responsible for transporting their child routinely o Have a child stopped using booster seats within 1 year prior to the interview date, and the child who made the transition must be the first child of the parent o Drive with a child at least once per week o In good general health o Fluent in English.

Age Range

20 and up

Official Title

Development and Testing of Ferumoxytol-enhanced MRI Protocol in Healthy Subjects

Purpose

This study is being done to develop a Magnetic resonance imaging (MRI) test that provides better-quality whole-heart pictures. MRI is a non-invasive machine that collects detailed pictures inside your body. Healthy volunteers will be tested in the MRI scanner while being given a dose of a medicine called Ferumoxytol into an IV (intravenous catheter) that will be placed in your arm or hand. Ferumoxytol is a medicine usually used in patients with iron deficiencies and has recently been used as an alternative to other MRI contrast agents and has successfully been applied in adult and pediatric patient populations.

Could this study be right for you?

Inclusion: • Males and females ages 18 years and older • No history of cardiovascular disease Exclusion: • Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including: • Reactions to MRI including metallic foreign body, orbital metal, cerebral aneurysm clip, pacemaker, defibrillator, coronary artery stent, neurostimulator, any other medical metallic implant • History of cardiovascular disease or uncontrolled high blood pressure • Claustrophobia • Inability to lie flat for up to 1 hour • Weight exceeding 300 pounds • Pregnancy

Age Range

18 and up