• A Study about Fitness, Aging, and Stress in People with Traumatic Brain Injury

    Official Title Fitness, Aging, Stress & TBI Exposure Repository (FASTER)

    Purpose

    The purpose of this study is to examine how individual differences in health changes (muscle strength, blood pressure) and behavioral changes (sleep, physical activity) impact memory, attention, and the brain. We study these relationships among a variety of older adults, including those with a history of concussion, traumatic brain injury (TBI), and posttraumatic stress disorder (PTSD). The long-term goal of this project is to identify modifiable factors that exacerbate or protect from age-related cognitive decline.

    Could this study be right for you?

    Eligibility Criteria: • Aged 18 years and older • Speak English • History of concussion, traumatic brain injury, and/or posttraumatic stress disorder • Must have primary care physician

    Age Range

    18 and up
  • Studying a New Method to Evaluate Blood Flow in Patients with Peripheral Artery Disease (PAD)

    Official Title Radiotracer Imaging of Lower Extremity Skeletal Muscle Perfusion in Patients with Peripheral Arterial Disease

    Purpose

    The purpose of this study is to study a new method to evaluate blood flow to the calves and feet. We hope this information can help evaluate the effectiveness of treatments and predict clinical outcomes. Participants will be required to attend one (2 hr) session at Nationwide Children's Hospital.

    Could this study be right for you?

    -Diagnosis of Peripheral Arterial Disease (PAD) OR leg symptoms, such as muscle pain or cramping AND/OR foot wound that has required medical consultation Healthy volunteers - must be at least 40 years of age - no history of cardiovascular disease (including high blood pressure) - no history of diabetes mellitus - non-smoker - normal BMI

    Age Range

    40 and up
  • A Study Evaluating Cognition, Insulin Resistance and Omega-3s (RACIR O-3) in Breast Cancer Survivors

    Official Title Remote assessment of cognition, insulin resistance and omega-3s (RACIR O-3) in breast cancer survivors

    Purpose

    We are studying the relationships between cognitive function, insulin resistance, and omega-3 fatty acids in the blood and from the diet among breast cancer survivors and women without a history of cancer diagnoses. We hope to learn more about how to potentially protect breast cancer patients from uncomfortable mental changes during and after treatment for breast cancer, such as “chemo brain”.

    This is a completely remote study, meaning all study tasks can be completed from the comfort of home. Enrolled participants will complete several online surveys and questionnaires, a Zoom video call for additional assessments, and will be sent materials to complete finger-stick blood sample collections from the comfort of home over a period of 3-4 weeks.

    The information we gain from this research study will help us design a future clinical trial to test if dietary interventions can help reduce or prevent cognitive changes like chemo brain in breast cancer patients.

    Could this study be right for you?

    - Accepts healthy volunteers - YES
    - Females
    - Age 45-75 years
    - Post-menopausal (at least 12 months no menses)
    - Stage I-III Breast Cancer diagnosis
    - 1-4 years post initial breast cancer diagnosis
    - No diagnosis of diabetes
    - English speaking

    Age Range

    45 and up
  • A Study Evaluating Occupational Therapy Interventions for Children with Autism Spectrum Disorders

    Official Title Characterizing Occupational Therapy Intervention for Children with Autism Spectrum Disorders

    Purpose

    We are actively recruiting typically developing children (ages 6 – 13 years) to participate in a new study looking at attention and sensory processing. In this study, we are investigating what occupational therapy practitioners are doing during therapy for children with autism and to see the effect of occupational therapy on brainwaves and behavior. We will identify differences in brainwaves in children with and without autism. You and your child will be asked to schedule one visit to the EEG lab at Ohio State University. Your visit will last about 2.5 hours and include an hour of EEG testing and one hour of paper-pencil game-like activities measuring attention. We need parent consent, and the parent/guardian will complete assessments about their child as well.

    Could this study be right for you?

    - Children with no autism or any other medical diagnosis - Your child is between 6 - 13 years of age

    Age Range

    6 and up
  • MeSo Study

    Official Title Mechanisms of Self and Other Evaluation (MeSO Study)

    Purpose

    The purpose of this study is to better understand the way the brain works in people who have depression and people who have previously been depressed. We are also testing healthy subjects for comparison. We hope our findings will lead to better ways to diagnose and treat mood disorders in the future. Participation involves an initial phone call and a 2 to 4 hour visit to find out if you are eligible. This visit will include completing questionnaires and interviews. If eligible, participants will have a second 3-5 hour visit for an MRI scan. Two months after the scan, participants will complete daily online questionnaires for 7 days. This process is repeated 2 months later (4 months after the scan). 

    Could this study be right for you?

    You may be eligible for this study if you: • Are between the ages of 18-40 • Are right-handed • Do not have a history of neurological disorders (e.g., seizures, head injury, etc.) • Do not have major medical problems (e.g., stroke, heart disease, high blood pressure, endocrine disorders, etc.) • Have normal vision, vision that is corrected to normal with glasses or contacts • Are willing and able to undergo fMRI scanning (not claustrophobic, no non-removable metal in your body) • Are not pregnant

    Age Range

    18 and up
  • The Brain Exercise Study

    Official Title Strategies for the Development of Social Cognitive Training for Impulsive Aggression (Brain Exercise Study or BES).

    Purpose

    The purpose of this study is to see if brain exercise done on the computer can reduce aggression in those with “anger issues”. The study is a six-week clinical trial using selected brain exercises versus other computer-based exercises.

    Could this study be right for you?

    - Medically healthy man or woman - You are between 21 and 55 years of age - With a current history of “anger issues” - You have regular access to a computer and a smart phone

    Age Range

    21 and up
  • A Study Evaluating Alcohol Use and Anger

    Official Title Aggression and Social-Emotional Information Processing: Neural Correlates During Alcohol Intoxication (Columbus Brain Activity Study or CBA)

    Purpose

    The purpose of this study is to see how alcohol changes brain activity in different groups of study participants who currently drink at least 10 drinks a week and who have (or do not have) “anger issues”. Brain activity will be measured by Magnetic Resonance Imaging (MRI). Total time you will be in the research study will be for about 4-8 weeks from your initial visit.

    Could this study be right for you?

    - Healthy men and women 21-55 years of age - Drink on a regular basis (~ 10 alcoholic beverages per week) - With a current history of "anger issues" - Able to complete study sessions during the week

    Age Range

    21 and up
  • Adult Eye Tracking Study

    Official Title Comprehensive Protocol for Cognitive Development Research

    Purpose

    The purpose of this study is to better understand learning, memory and attention development from childhood to adulthood using eye-tracking techniques.

    This study will include one lab visit which will take place on Ohio State's main campus and will last approximately 40-60 minutes.

    Could this study be right for you?

    Eligibility Criteria:

    - Must be 18 and 35 years of age
    - Have normal or corrected to normal vision

    Age Range

    18 and up
  • A Study Evaluating Decision-making for Young Adults, Older Adults, and Adults with Early Alzheimer’s Disease and Mild Cognitive Impairment

    Official Title Modeling Cognition and Aging

    Purpose

    The goal of this study is to develop models to better understand decision-making for young adults, older adults, and adults with early Alzheimer’s disease and Mild Cognitive Impairment. This study involves making simple decisions (such as “are there more blue dots or more yellow dots?”) on a computer. Healthy volunteers will also complete basic tasks such as solving puzzles, questionnaires involving numbers, and will be asked to provide basic demographic and health information.

    Could this study be right for you?

    You may be eligible for this study if: - You are ages 18-25 OR - You are age 60-90 and have NOT been diagnosed with a memory disorder OR - You are age 60-90 and HAVE been diagnosed with either Mild Cognitive Impairment OR mild Alzheimer's disease - You are a native English speaker - You are able to see a computer screen and use hands on keyboard/screen

    Age Range

    18 and up
  • Transitioning From Booster Seats to Seat Belts

    Official Title Booster Seats Interview

    Purpose

    To explore how parents make the decision on transitioning their children from booster seats to seat belts; what factors may influence parents’ decision on the transition.

    Could this study be right for you?

    Inclusion criteria: o At least 18 years of age o A parent or legal guardian who is responsible for transporting their child routinely o Have a child stopped using booster seats within 1 year prior to the interview date, and the child who made the transition must be the first child of the parent o Drive with a child at least once per week o In good general health o Fluent in English.

    Age Range

    20 and up